Search Results - "Eaddy, J"

Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse by Church, Rachel J, Schomaker, Shelli J, Eaddy, J Scott, Boucher, Germaine G, Kreeger, John M, Aubrecht, Jiri, Watkins, Paul B

“…Glutamate dehydrogenase (GLDH) is a liver-specific biomarker of hepatocellular damage currently undergoing qualification as a drug development tool. Since GLDH…”
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The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers by Harrill, A H, Roach, J, Fier, I, Eaddy, J S, Kurtz, C L, Antoine, D J, Spencer, D M, Kishimoto, T K, Pisetsky, D S, Park, B K, Watkins, P B

“…Heparins have been reported to cause elevations in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) but have not been associated with…”
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Human-relevant mechanisms and risk factors for TAK-875-Induced liver injury identified via a gene pathway-based approach in Collaborative Cross mice by Mosedale, Merrie, Cai, Yanwei, Eaddy, J. Scott, Kirby, Patrick J., Wolenski, Francis S., Dragan, Yvonne, Valdar, William

“…[Display omitted] Development of TAK-875 was discontinued when a small number of serious drug-induced liver injury (DILI) cases were observed in Phase 3…”
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Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice by Church, Rachel J, Gatti, Daniel M, Urban, Thomas J, Long, Nanye, Yang, Xi, Shi, Qiang, Eaddy, J Scott, Mosedale, Merrie, Ballard, Shawn, Churchill, Gary A, Navarro, Victor, Watkins, Paul B, Threadgill, David W, Harrill, Alison H

“…Consumer use of herbal and dietary supplements has recently grown in the United States and, with increased use, reports of rare adverse reactions have emerged…”
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Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach by Mosedale, Merrie, Kim, Yunjung, Brock, William J., Roth, Sharin E., Wiltshire, Tim, Scott Eaddy, J., Keele, Gregory R., Corty, Robert W., Xie, Yuying, Valdar, William, Watkins, Paul B.

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miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model by Mosedale, Merrie, Eaddy, J Scott, Trask, O Joseph, Holman, Natalie S, Wolf, Kristina K, LeCluyse, Edward, Ware, Brenton R, Khetani, Salman R, Lu, Jingtao, Brock, William J, Roth, Sharin E, Watkins, Paul B

“…Abstract Idiosyncratic drug-induced liver injury (IDILI) is thought to often result from an adaptive immune attack on the liver. However, it has been proposed…”
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A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models by Harrill, Alison H, Desmet, Kristina D, Wolf, Kristina K, Bridges, Arlene S, Eaddy, J Scott, Kurtz, C Lisa, Hall, J Ed, Paine, Mary F, Tidwell, Richard R, Watkins, Paul B

“…DB289 is the first oral drug shown in clinical trials to have efficacy in treating African trypanosomiasis (African sleeping sickness). Mild liver toxicity was…”
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Editor's Highlight: Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach by Mosedale, Merrie, Kim, Yunjung, Brock, William J, Roth, Sharin E, Wiltshire, Tim, Eaddy, J Scott, Keele, Gregory R, Corty, Robert W, Xie, Yuying, Valdar, William, Watkins, Paul B

“…Clinical trials of tolvaptan showed it to be a promising candidate for the treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) but also revealed…”
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Relative biological effectiveness and microdosimetry of a mixed energy field of protons up to 200 MeV by Robertson, J B, Eaddy, J M, Archambeau, J O, Coutrakon, G B, Miller, D W, Moyers, M F, Siebers, J V, Slater, J M, Dicello, J F

“…We have studied radiation effects utilizing the new 250 MeV Synchrotron at Loma Linda University Medical Center. In this paper we present the data collected…”
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A nursing home rotation in a family practice residency by Moon, J B, Davis, L E, Eaddy, J A, Shacklett, G E, Stockton, M D

“…A nursing home rotation can be a complementary component of geriatrics education in a family practice residency curriculum. Using nursing homes in teaching…”
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2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 9. Lipophilic trimethoprim analogs as antigonococcal agents by Roth, B, Baccanari, D. P, Sigel, C. W, Hubbell, J. P, Eaddy, J, Kao, J. C, Grace, M. E, Rauckman, B. S

“…Lipophilic analogues of trimethoprim (1) bearing 3,5-dialkyl-4-hydroxy substituents in the benzene ring are much more active in vitro against Neisseria…”
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Confidentially and the family physician by Eaddy, J A, Graber, G C

“…The principle of confidentiality is one of the clearest and firmest rules of professional ethics. However, situations can arise in which confidentiality ought…”
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Basolateral amygdala involvement in memory reconsolidation processes that facilitate drug context-induced cocaine seeking by Fuchs, Rita A., Bell, Guinevere H., Ramirez, Donna R., Eaddy, Jessica L., Su, Zu-In

“…Understanding the neurobiological underpinnings of putative memory stabilization processes that maintain context–response–cocaine associations in long‐term…”
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Enzymic acylation of 506U78 (2-amino-9-β-D-arabinofuranosyl-6-methoxy-9H-purine), a powerful new anti-leukaemic agent by Mahmoudian, Mahmoud, Eaddy, John, Dawson, Mike

“…A practical enzymic approach for acylation of 506U78 (2‐amino‐9‐β‐D‐arabinofuranosyl‐6‐methoxy‐9H‐purine), a powerful anti‐leukaemic agent, is described…”
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Medical ethics: "zebras" vs. "horses" by Graber, G C, Eaddy, J A

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Practical acid-catalyzed acylation of sulfonamides with carboxylic acid anhydrides by Martin, Michael T, Roschangar, Frank, Eaddy, John F

“…A highly efficient reaction between sterically and electronically diverse sulfonamides and carboxylic acid anhydrides to furnish monoacylated…”
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2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. IX: Lipophilic trimethoprim analogues as antigonococcal agents by ROTH, B, BACCANARI, D. P, SIGEL, C. W, HUBBELL, J. P, EADDY, J, KAO, J. C, GRACE, M. E, RAUCKMAN, B. S

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Canine esophageal achalasia corrected by retrograde dilatation--a case report by KNECHT, C D, EADDY, J A

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Repetitive multifocal paroxysmal atrial tachycardia: With second degree A-V block, type I, and concealed and aberrant A-V conduction by Abrams, David L., Eaddy, Joseph A.

“…What is believed to be the first patient with repetitive multifocal paroxysmal atrial tachycardia with second degree A-V block, type I, and concealed and…”
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Reaction of ortho esters with secondary amines by Swaringen, Roy A, Eaddy, John F, Henderson, Thomas R

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