Search Results - "EYUNNI, SURESH"

Functional evaluation of synthetic flavonoids and chalcones for potential antiviral and anticancer properties by Mateeva, Nelly, Eyunni, Suresh V.K., Redda, Kinfe K., Ononuju, Ucheze, Hansberry, Tony D., Aikens, Cecilia, Nag, Anita

“…[Display omitted] Flavonoids, stilbenes, and chalcones are plant secondary metabolites that often possess diverse biological activities including…”
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Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents by Peprah, Kwakye, Zhu, Xue Y., Eyunni, Suresh V.K., Setola, Vincent, Roth, Bryan L., Ablordeppey, Seth Y.

“…Using haloperidol as a scaffold, new agents were designed to investigate the structural contributions of various groups to binding at CNS receptors associated…”
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The Antiproliferative Effects of Flavonoid MAO Inhibitors on Prostate Cancer Cells by Zarmouh, Najla O, Messeha, Samia S, Mateeva, Nelly, Gangapuram, Madhavi, Flowers, Kacy, Eyunni, Suresh V K, Zhang, Wang, Redda, Kinfe K, Soliman, Karam F A

“…Prostate cancer (PCa) patients commonly experience clinical depression. Recent reports indicated that monoamine oxidase-A (MAO-A) levels elevate in PCa, and…”
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Structure–activity relationship studies of SYA 013, a homopiperazine analog of haloperidol by Peprah, Kwakye, Zhu, Xue Y., Eyunni, Suresh V.K., Etukala, Jagan R., Setola, Vincent, Roth, Bryan L., Ablordeppey, Seth Y.

“…Structure–activity relationship studies on 4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluorophenyl)butan-1-one (SYA 013), a homopiperazine analog of…”
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Identification of 7,8‐dihydroxy‐3‐phenylcoumarin as a reversible monoamine oxidase enzyme inhibitor by Musa, Musiliyu A., Badisa, Veera L. D., Aghimien, Monica O., Eyunni, Suresh V. K., Latinwo, Lekan M.

“…We herein report the biological evaluation of 3‐arylcoumarin derivatives (3a‐l) as potential human monoamine oxidase‐A and ‐B (hMAO‐A and hMAO‐B) inhibitors…”
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Evaluation of the Inhibitory Effects of Bavachinin and Bavachin on Human Monoamine Oxidases A and B by Eyunni, Suresh, Messeha, Samia S., Elshami, Faisel, Mazzio, Elizabeth, Zarmouh, Najla O., Soliman, Karam F. A.

“…Monoamine oxidase B inhibitors (MAO-BIs) are used in the early management of Parkinson’s disease (PD). Long-term suspected side effects of MAO-B classical…”
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A study of the structure-affinity relationship in SYA16263; is a D2 receptor interaction essential for inhibition of apormorphine-induced climbing behavior in mice? by Onyameh, Edem K., Bricker, Barbara A., Eyunni, Suresh V.K., Voshavar, Chandrashekhar, Gonela, Uma M., Ofori, Edward, Jenkins, Andrea, Ablordeppey, Seth Y.

“…[Display omitted] Dopamine (DA) and serotonin (5-HT) receptors are prime targets for the development of antipsychotics. The specific role of each receptor…”
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Benzothieno[3,2-b]quinolinium and 3-(phenylthio)quinolinium compounds: Synthesis and evaluation against opportunistic fungal pathogens by Boateng, Comfort A., Eyunni, Suresh V.K., Zhu, Xue Y., Etukala, Jagan R., Bricker, Barbara A., Ashfaq, M.K., Jacob, Melissa R., Khan, Shabana I., Walker, Larry A., Ablordeppey, Seth Y.

“…Substitution around 5-methyl benzothieno[3,2-b]quinolinium (2) ring system was explored in order to identify positions of substitution that could improve its…”
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A study of the structure-affinity relationship in SYA16263; is a D 2 receptor interaction essential for inhibition of apormorphine-induced climbing behavior in mice? by Onyameh, Edem K, Bricker, Barbara A, Eyunni, Suresh V K, Voshavar, Chandrashekhar, Gonela, Uma M, Ofori, Edward, Jenkins, Andrea, Ablordeppey, Seth Y

“…Dopamine (DA) and serotonin (5-HT) receptors are prime targets for the development of antipsychotics. The specific role of each receptor subtype to the…”
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Design and Synthesis of Tetrahydroisoquinoline Derivatives as Anti-Angiogenesis and Anti-Cancer Agents by Gangapuram, Madhavi, Eyunni, Suresh, Zhang, Wang, Redda, Kinfe K

“…The aim of our research work is the synthesis of tetrahydroisoquinoline derivatives as anti-Angiogenesis and anti-cancer agents. Cancer is the second leading…”
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Design and discovery of a high affinity, selective and β-arrestin biased 5-HT7 receptor agonist by Onyameh, Edem K., Ofori, Edward, Bricker, Barbara A., Gonela, Uma M., Eyunni, Suresh V. K., Kang, Hye J., Voshavar, Chandrashekar, Ablordeppey, Seth Y.

“…Compound 1c , 5-chloro-2-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)-2,3-dihydro-1H-inden-1-one was previously reported from our laboratory showing high…”
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Indolo[3,2-b]quinolines: synthesis, biological evaluation and structure activity-relationships by Kumar, Eyunni V K Suresh, Etukala, Jagan R, Ablordeppey, Seth Y

“…The tetracyclic indolo[3,2-b]quinoline ring system constitutes an important structural moiety in natural products exhibiting numerous biological activities. In…”
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Identification of a new selective dopamine D4 receptor ligand by Sampson, Dinithia, Zhu, Xue Y., Eyunni, Suresh V.K., Etukala, Jagan R., Ofori, Edward, Bricker, Barbara, Lamango, Nazarius S., Setola, Vincent, Roth, Bryan L., Ablordeppey, Seth Y.

“…The dopamine D4 receptor has been shown to play key roles in certain CNS pathologies including addiction to cigarette smoking. Thus, selective D4 ligands may…”
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1,2,3,4,6-Penta-O-galloylglucose within Galla Chinensis Inhibits Human LDH-A and Attenuates Cell Proliferation in MDA-MB-231 Breast Cancer Cells by Soliman, Karam F. A., Mateeva, Nelly, McTier, Oshlii, Eyunni, Suresh, Mazzio, Elizabeth, Deiab, Shihab, Elshami, Faisel

“…A characteristic feature of aggressive malignancy is the overexpression of lactic acid dehydrogenase- (LDH-) A, concomitant to pericellular accumulation of…”
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Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores by Etukala, Jagan R., Zhu, Xue Y., Eyunni, Suresh V.K., Onyameh, Edem K., Ofori, Edward, Bricker, Barbara A., Kang, Hye J., Huang, Xi-Ping, Roth, Bryan L., Ablordeppey, Seth Y.

“…[Display omitted] Several known D2 pharmacophores have been explored as templates for identifying ligands with multiple binding affinities at dopamine and…”
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CoMFA studies and in vitro evaluation of some 3-substituted benzylthio quinolinium salts as anticryptococcal agents by Bolden, Sidney, Boateng, Comfort A., Zhu, Xue Y., Etukala, Jagan R., Eyunni, Suresh K., Jacob, Melissa R., Khan, Shabana I., Ablordeppey, Seth Y.

“…3-Substituted quinolinium salts. The 3-dimensional quantitative structure–activity relationship (3D-QSAR) molecular modeling technique or comparative molecular…”
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Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-Chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one by Ablordeppey, Seth Y., Altundas, Ramazan, Bricker, Barbara, Zhu, Xue Y., Suresh Kumar, Eyunni V.K., Jackson, Tanise, Khan, Abdul, Roth, Bryan L.

“…The synthesis and exploration of novel butyrophenones have led to the identification of a diazepane analogue of haloperidol,…”
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Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): A search for new dual-acting agents as potential antidepressants by Zhu, Xue Y., Etukala, Jagan R., Eyunni, Suresh V.K., Setola, Vincent, Roth, Bryan L., Ablordeppey, Seth Y.

“…The synthesis and evaluation of several benzothiazole-based compounds are described in an attempt to identify novel dual-acting 5HT1A receptor and SERT…”
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The Benzopyrone Biochanin-A as a reversible, competitive, and selective monoamine oxidase B inhibitor by Zarmouh, Najla O, Eyunni, Suresh K, Soliman, Karam F A

“…Monoamine oxidase-B (MAO-B) inhibitors are widely used in the treatment of Parkinson's disease. They increase vital monoamine neurotransmitters in the brain…”
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Lead Optimization of Tetrahydropyridines as Potential Breast Cancer Agents by Henderson, Elizabeth, Messersmith, Amy, Eyunni, Suresh, Ardley, Tiffany

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