Search Results - "EYRE, D. R"

Distinct post‐translational features of type I collagen are conserved in mouse and human periodontal ligament by Hudson, D. M., Garibov, M., Dixon, D. R., Popowics, T., Eyre, D. R.

“…Background and Objective Specifics of the biochemical pathways that modulate collagen cross‐links in the periodontal ligament (PDL) are not fully defined…”
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Articular cartilage collagen: an irreplaceable framework? by Eyre, D R, Weis, M A, Wu, J-J

“…Adult articular cartilage by dry weight is two-thirds collagen. The collagen has a unique molecular phenotype. The nascent type II collagen fibril is a…”
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Collagen polymorphisms of the intervertebral disc by Eyre, D R, Matsui, Y, Wu, J-J

“…The mechanical function and the collagen phenotype of the disc are complex, each a hybrid of elements of ligament and cartilage. In detail, the collagen…”
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Severe osteogenesis imperfecta caused by a small in‐frame deletion in CRTAP by Amor, I.M. Ben, Rauch, F., Gruenwald, K., Weis, M., Eyre, D.R., Roughley, P., Glorieux, F.H., Morello, R.

“…Mutations of proteins involved in posttranslational modification of collagen type I can cause osteogenesis imperfecta (OI) inherited in a recessive pattern…”
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Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis by Fernandes, R J, Hirohata, S, Engle, J M, Colige, A, Cohn, D H, Eyre, D R, Apte, S S

“…The amino and carboxyl propeptides of procollagens I and II are removed by specific enzymes as a prerequisite for fibril assembly. Null mutations in…”
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Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors by Ellsworth, J L, Berry, J, Bukowski, T, Claus, J, Feldhaus, A, Holderman, S, Holdren, M S, Lum, K D, Moore, E E, Raymond, F, Ren, HongPing, Shea, P, Sprecher, C, Storey, H, Thompson, D L, Waggie, K, Yao, L, Fernandes, R J, Eyre, D R, Hughes, S D

“…The aim of this study was to examine the effects of recombinant human Fgf18 on chondrocyte proliferation and matrix production in vivo and in vitro. In…”
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Proteolysis of human bone collagen by cathepsin K: characterization of the cleavage sites generating the cross-linked N-telopeptide neoepitope by Atley, L.M, Mort, J.S, Lalumiere, M, Eyre, D.R

“…An immunoassay for cross-linked N-telopeptides of type I collagen (NTx) in urine or serum has proven to give a sensitive index of osteoclast-mediated bone…”
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Evidence for enhanced collagen type III deposition focally in the territorial matrix of osteoarthritic hip articular cartilage by Hosseininia, S, Weis, M.A, Rai, J, Kim, L, Funk, S, Dahlberg, L.E, Eyre, D.R

“…Summary Objective To determine if type III collagen is concentrated in the chymotrypsin-extractable collagen pool from osteoarthritic articular cartilage to…”
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Soft-tissue aging and musculoskeletal function by Buckwalter, J A, Woo, S L, Goldberg, V M, Hadley, E C, Booth, F, Oegema, T R, Eyre, D R

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Identification of cross-linking sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type IX bonding by JIANN-JIU WU, WOODS, P. E, EYRE, D. R

“…Type IX collagen functions in covalent cross-linkage to type II collagen in cartilage (Eyre, D. R., Apone, S., Wu, J. J., Ericsson, L. H., and Walsh, K. A…”
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Evidence that serum NTx (collagen-type I N-telopeptides) can act as an immunochemical marker of bone resorption by Clemens, J. Daniel, Herrick, Michael V, Singer, Frederick R, Eyre, David R

“…Previous studies have shown that immunoassay of urinary NTx (cross-linked N-telopeptides of type I collagen) provides a responsive index of human bone…”
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Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men--a clinical research center study by Wang, C, Eyre, D R, Clark, R, Kleinberg, D, Newman, C, Iranmanesh, A, Veldhuis, J, Dudley, R E, Berman, N, Davidson, T, Barstow, T J, Sinow, R, Alexander, G, Swerdloff, R S

“…To study the effects of androgen replacement therapy on muscle mass and strength and bone turnover markers in hypogonadal men, we administered sublingual…”
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Osteoclasts generate cross-linked collagen N-telopeptides (NTx) but not free pyridinolines when cultured on human bone by Apone, S., Lee, M.Y., Eyre, D.R.

“…Urinary excretion of the cross-linked α2(I) N-telopeptide (NTx) of type I collagen has proven in clinical studies to provide a highly responsive and specific…”
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Monitoring bone resorption in early postmenopausal women by an immunoassay for cross‐linked collagen peptides in urine by Gertz, B.J., Shao, P., Hanson, D.A., Quan, H., Harris, S.T., Genant, H.K., Chesnut, C.H., Eyre, D.R.

“…A new immunoassay using an ELISA approach for measuring urinary excretion of cross‐linked N‐telopeptides of type 1 collagen was evaluated as a specific measure…”
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Recent developments in cartilage research: matrix biology of the collagen II/IX/XI heterofibril network by Eyre, D R, Wu, J J, Fernandes, R J, Pietka, T A, Weis, M A

“…Research on cartilage is intensifying as efforts expand to discover disease-modifying drugs to treat or prevent osteoarthritis. Proteolytic damage to the…”
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A specific immunoassay for monitoring human bone resorption: Quantitation of type I collagen cross‐linked N‐telopeptides in urine by Hanson, Dennis A., Weis, Mary Ann E., Bollen, Anne‐Marie, Maslan, Shoshana L., Singer, Frederick R., Eyre, David R.

“…Peptides of low molecular weight that contain pyridinoline cross‐links were isolated from adolescent human urine. A fraction was selected that was enriched in…”
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Collagen cross-linking in human bone and articular cartilage. Age-related changes in the content of mature hydroxypyridinium residues by Eyre, D R, Dickson, I R, Van Ness, K

“…The concentration in collagen of hydroxypyridinium cross-linking amino acids was measured in samples of bone and cartilage from human subjects aged from 1…”
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Bone resorption rates in children monitored by the urinary assay of collagen type I cross-linked peptides by Bollen, A M, Eyre, D R

“…When bone is resorbed, cross-linking amino acids from collagen type I (pyridinolines) are excreted in the urine as small peptides. The purpose of this…”
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Using biochemical markers of bone turnover in clinical practice by Singer, Frederick R, Eyre, David R

“…Biochemical markers of bone turnover provide clinically useful evidence of the normal and pathologic processes that reflect bone cell activity in the skeleton…”
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Urinary pyridinoline cross-links in Ehlers-Danlos syndrome type VI by Steinmann, B, Eyre, D R, Shao, P

“…The Ehlers-Danlos syndrome (EDS) is a heterogeneous group of heritable disorders of connective tissue, affecting skin, ligaments, joints, blood vessels, and…”
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