Search Results - "EXLEY, Andrew"

Clinical development of cell therapies for cancer: The regulators' perspective by Exley, Andrew R., Rantell, Khadija, McBlane, James

“…Novel cell therapies for haematological malignancies and solid tumours address pressing clinical need while offering potentially paradigm shifts in efficacy…”
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Regulating innovation in the early development of cell therapies by Exley, Andrew R, McBlane, James

“…Clinical need for paradigm shifts in efficacy and safety is driving the rapid and wide-ranging innovation in cell therapies for cancer beyond existing…”
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Evidence of Dysfunction of Endothelial Progenitors in Pulmonary Arterial Hypertension by Toshner, Mark, Voswinckel, Robert, Southwood, Mark, Al-Lamki, Rafia, Howard, Luke S. G, Marchesan, Denis, Yang, Jun, Suntharalingam, Jay, Soon, Elaine, Exley, Andrew, Stewart, Susan, Hecker, Markus, Zhu, Zhenping, Gehling, Ursula, Seeger, Werner, Pepke-Zaba, Joanna, Morrell, Nicholas W

“…Severe pulmonary arterial hypertension (PAH) is characterized by the formation of plexiform lesions and concentric intimal fibrosis in small pulmonary…”
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Impaired Natural Killer Cell Phenotype and Function in Idiopathic and Heritable Pulmonary Arterial Hypertension by ORMISTON, Mark L, CHIWEN CHANG, SOUTHWOOD, Mark, PEPKE-ZABA, Joanna, EXLEY, Andrew, TREMBATH, Richard C, COLUCCI, Francesco, WILLS, Mark, TROWSDALE, John, MORRELL, Nicholas W, LONG, Lu L, SOON, Elaine, JONES, Des, MACHADO, Rajiv, TREACY, Carmen, TOSHNER, Mark R, CAMPBELL, Kate, RIDING, Alex

“…Beyond their role as innate immune effectors, natural killer (NK) cells are emerging as important regulators of angiogenesis and vascular remodeling. Pulmonary…”
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Definitions of non-response and response to biological therapy for severe asthma: a systematic review by Khaleva, Ekaterina, Rattu, Anna, Brightling, Chris, Bush, Andrew, Bourdin, Arnaud, Bossios, Apostolos, Chung, Kian Fan, Chaudhuri, Rekha, Coleman, Courtney, Djukanovic, Ratko, Dahlén, Sven-Erik, Exley, Andrew, Fleming, Louise, Fowler, Stephen J, Gupta, Atul, Hamelmann, Eckard, Koppelman, Gerard H, Melén, Erik, Mahler, Vera, Seddon, Paul, Singer, Florian, Porsbjerg, Celeste, Ramiconi, Valeria, Rusconi, Franca, Yasinska, Valentyna, Roberts, Graham

“…Biologics have proven efficacy for patients with severe asthma but there is lack of consensus on defining response. We systematically reviewed and appraised…”
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The outcomes of lung transplantation in patients with bronchiectasis and antibody deficiency by Nathan, James A, Sharples, Linda D, Exley, Andrew R, Sivasothy, Pasupathy, Wallwork, John

“…Lung transplantation is an established treatment for end-stage bronchiectasis. A proportion of patients with bronchiectasis have an associated antibody…”
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Streamlined approval of biosimilars: moving on from the confirmatory efficacy trial by Bielsky, Marie-Christine, Cook, Anne, Wallington, Andrea, Exley, Andrew, Kauser, Shahin, Hay, Justin L., Both, Leonard, Brown, David

“…•Licensing of biosimilars promotes wider patient access to essential medicines.•Currently, regulators require comparative efficacy trials for complex…”
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Widespread Coronary Inflammation in Unstable Angina by Russell, Craig J.H, Exley, Andrew R, Ritchie, Andrew J

“…To the Editor: We share Buffon and colleagues' belief in widespread coronary inflammation (July 4 issue). 1 However, believing in a hypothesis is not the same…”
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Multi-Parameter Analysis (MPA) of Cells and Serum Using a Standard Flow Cytometer by Hallam, Robert, Senior Biomedical Scientist, Papworth Hospital, Immunology Department, Cambridgeshire, England, Balmer, Paul, Clinical Scientist, HPA, Vaccine Evaluation Department, Manchester, England, Borrow, Ray, Clinical Scientist, HPA, Vaccine Evaluation Department, Manchester, England, Exley, Andrew, Consultant Immunologist, Papworth Hospital/Immunology Department, Cambridge, England

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480: HIERARCHY OF VALUES IN RECOVERY OF RESPIRATORY FAILURE: PROSPECTIVE STUDY OF PATIENTS AND CAREGIVERS by Capers, Krystal, Banner-Goodspeed, Valerie, Dwyer, julia, Tokoz-Exley, Andrew, Licht, Andre De Souza, Brown, Samuel, Bose, Somnath

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Normal Adult Ranges and Diversity of Serotype Specific Anti-Pneumococcal Antibodies (SSAPAbs) after Immunisation with 23-Valent Polysaccharide Vaccine by Hallam, Robert, Senior Biomedical Scientist, Papworth Hospital/Immunology Department, Cambridgeshire, England, Balmer, Paul, Clinical Scientist, HPA, Vaccine Evaluation Department, Manchester, England, Borrow, Ray, Clinical Scientist, HPA-Vaccine Evaluation Department, Manchester, England, Bilton, Diana, Consultant Respiratory Physician, Papworth Hospital, Respiratory Infection, Inflammation and Immunology (RIII) Department, Cambridgeshire, England, Haworth, Charles, Consultant Respiratory Physician, Papworth Hospital, Respiratory Infection, Inflammation and Immunology (RIII) Department, Cambridgeshire, England, Exley, Andrew, Consultant Immunologist, Papworth Hospital/Immunology Department, Cambridge

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Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA) by Khaleva, Ekaterina, Rattu, Anna, Brightling, Chris, Bush, Andrew, Bossios, Apostolos, Bourdin, Arnaud, Chung, Kian Fan, Chaudhuri, Rekha, Coleman, Courtney, Dahlén, Sven-Erik, Djukanovic, Ratko, Deschildre, Antoine, Fleming, Louise, Fowler, Stephen J, Gupta, Atul, Hamelmann, Eckard, Hashimoto, Simone, Hedlin, Gunilla, Koppelman, Gerard H, Melén, Erik, Murray, Clare S, Pilette, Charles, Porsbjerg, Celeste, Pike, Katharine C, Rusconi, Franca, Williams, Clare, Ahrens, Birgit, Alter, Peter, Anckers, Freja, van den Berge, Maarten, Blumchen, Katharina, Brusselle, Guy, Clarke, Graham W, Cunoosamy, Danen, Dahlén, Barbro, Dixey, Piers, Exley, Andrew, Frey, Urs, Gaillard, Erol A, Giovannini-Chami, Lisa, Grigg, Jonathan, Hartenstein, Diana, Heaney, Liam G, Karadag, Bülent, Kaul, Susanne, Kull, Inger, Licari, Amelia, Maitland-van der Zee, Anke H, Mahler, Vera, Schoos, Ann-Marie M, Nagakumar, Prasad, Negus, Jenny, Nielsen, Hanna, Paton, James, Pijnenburg, Mariëlle, Ramiconi, Valeria, Romagosa Vilarnau, Sofia, Principe, Stefania, Rutjes, Niels, Saglani, Sejal, Seddon, Paul, Singer, Florian, Staudinger, Heribert, Turner, Steve, Vijverberg, Susanne, Winders, Tonya, Yasinska, Valentyna, Roberts, Graham

“…Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult…”
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Recommendations for the Development and Validation of Immunogenicity Assays in Support of Biosimilar Programs by Civoli, Francesca, Kasinath, Aparna, Cai, Xiao-Yan, Wadhwa, Meenu, Exley, Andrew, Oldfield, Philip, Alvandkouhi, Safa, Schaffar, Gregor, Chappell, John, Bowsher, Ronald, Devanarayan, Viswanath, Marini, Joseph, Rebarchak, Shannon, Anderson, Michael, Koppenburg, Vera, Lester, Todd

“…For biosimilar drug development programs, it is essential to demonstrate that there are no clinically significant differences between the proposed biosimilar…”
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Revisiting Human IL-12Rβ1 Deficiency: A Survey of 141 Patients From 30 Countries by de Beaucoudrey, Ludovic, Samarina, Arina, Bustamante, Jacinta, Cobat, Aurélie, Boisson-Dupuis, Stéphanie, Feinberg, Jacqueline, Al-Muhsen, Saleh, Jannière, Lucile, Rose, Yoann, de Suremain, Maylis, Filipe-Santos, Orchidée, Chapgier, Ariane, Picard, Capucine, Dogu, Figen, Ikinciogullari, Aydan, Tanir, Gonul, Al-Hajjar, Sami, Frayha, Husn H., AlSum, Zobaida, Al-Ajaji, Sulaiman, Alangari, Abdullah, Al-Ghonaium, Abdulaziz, Adimi, Parisa, Mansouri, Davood, Ben-Mustapha, Imen, Yancoski, Judith, Garty, Ben-Zion, Rodriguez-Gallego, Carlos, Caragol, Isabel, Kumararatne, Dinakantha S., Patel, Smita, Doffinger, Rainer, Jeppsson, Olle, Reichenbach, Janine, Nadal, David, Boyko, Yaryna, Pietrucha, Barbara, Anderson, Suzanne, Levin, Michael, Schandené, Liliane, Schepers, Kinda, Efira, André, Mascart, Françoise, Matsuoka, Masao, Siegrist, Claire-Anne, Frecerova, Klara, Blüetters-Sawatzki, Renate, Freihorst, Joachim, Baumann, Ulrich, Richter, Darko, Haerynck, Filomeen, Novelli, Vas, Lammas, David, Vermylen, Christiane, Tuerlinckx, David, Fleckenstein, Bernhard, Levy, Jacob, Raj, Revathi, Cohen, Aileen Cleary, Lewis, David B., Yang, Kuender D., Jiang, Liping, Yang, Xiqiang, Xie, Yuanyuan, Lee, Pamela Pui Wah, Chan, Koon Wing, Chen, Tong-Xin, Castro, Gabriela, Natera, Ivelisse, Codoceo, Ana, King, Alejandra, Bezrodnik, Liliana, Gaillard, Maria Isabel, Grumach, Anete Sevciovic, da Silva Duarte, Alberto Jose, Aldana, Ruth, Espinosa-Rosales, Francisco Javier, Bousfiha, Ahmed Aziz, Baghdadi, Jamila El, Aksu, Guzide, Keser, Melike, Somer, Ayper, Hatipoglu, Nevin, Aydogmus, Çigdem, Asilsoy, Suna, Camcioglu, Yildiz, Gülle, Saniye, Ozgur, Tuba T., Ozen, Meteran, Oleastro, Matias, Bernasconi, Andrea, Mamishi, Setareh, Parvaneh, Nima, Rosenzweig, Sergio, Barbouche, Ridha, Pedraza, Sigifredo, Lau, Yu Lung, Ehlayel, Mohammad S., Fieschi, Claire, Casanova, Jean-Laurent

“…Interleukin-12 receptor β1 (IL-12Rβ1) deficiency is the most common form of Mendelian susceptibility to mycobacterial disease (MSMD). We undertook an…”
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Revisiting Human IL-12R beta 1 Deficiency A Survey of 141 Patients From 30 Countries by Beaucoudrey, Ludovic De, Samarina, Arina, Bustamante, Jacinta, Cobat, Aurélie, Boisson-Dupuis, Stephanie, Feinberg, Jacqueline, Al-Muhsen, Saleh, Janniere, Lucile, Rose, Yoann, Suremain, Maylis De, Kong, Xiao-Fei, Filipe-Santos, Orchidée, Chapgier, Ariane, Picard, Capucine, Fischer, Alain, Dogu, Figen, Ikinciogullari, Aydan, Tanir, Gonul, Al-Hajjar, Sami, Al-Jumaah, Suliman, Frayha, Husn H., Alsum, Zobaida, Al-Ajaji, Sulaiman, Alangari, Abdullah, Al-Ghonaium, Abdulaziz, Adimi, Parisa, Mansouri, Davood, Ben-Mustapha, Imen, Yancoski, Judith, Garty, Ben-Zion, Rodriguez-Gallego, Carlos, Caragol, Isabel, Kutukculer, Necil, Kumararatne, Dinakantha S., Patel, Smita, Döffinger, Rainer, Exley, Andrew, Jeppsson, Olle, Reichenbach, Janine, Nadal, David, Boyko, Yaryna, Anderson, Suzanne, Pietrucha, Barbara, Levin, Michael, Schandene, Liliane, Schepers, Kinda, Efira, Andre, Mascart, Francoise, Sakai, Tatsunori, Matsuoka, Masao, Siegrist, Claire-Anne, Frecerova, Klara, Blueetters-Sawatzki, Renate, Bernhoeft, Jutta, Freihorst, Joachim, Baumann, Ulrich, Richter, Darko, Haerynck, Filomeen, de Baets, Frans, Novelli, Vas, Lammas, David, Vermylen, Christiane, Tuerlinckx, David, Nieuwhof, Chris, Pac, Malgorzata, Haas, Walther H., Mueller-Fleckenstein, Ingrid, Fleckenstein, Bernhard, Levy, Jacob, Cohen, Aileen Cleary, Lewis, David B., Holland, Steven M., Yang, Kuender D., Wang, Xiaochuan, Wang, Xiaohong, Raj, Revathi, Jiang, Liping, Yang, Xiqiang, Zhu, Chaomin, Xie, Yuanyuan, Lee, Pamela Pui Wah, Chan, Koon Wing, Castro, Gabriela, Chen, Tong-Xin, Natera, Ivelisse, Codoceo, Ana, King, Alejandra, Bezrodnik, Liliana, Di Giovani, Daniela, Isabel Gaillard, Maria, Moraes-Vasconcelos, Dewton De, Grumach, Anete Sevciovic, Silva Duarte, Alberto Jose Da, Aldana, Ruth, Javier Espinosa-Rosales, Francisco, Bejaoui, Mohammed, Bousfiha, Ahmed Aziz, El Baghdadi, Jamila, Ozbek, Namik, Aksu, Guzide

“…Interleukin-12 receptor beta 1 (IL-12R beta 1) deficiency is the most common form of Mendelian susceptibility to mycobacterial disease (MSMD). We undertook an…”
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Identifying and appraising outcome measures for severe asthma: a systematic review by Rattu, Anna, Khaleva, Ekaterina, Brightling, Chris, Dahlén, Sven-Erik, Bossios, Apostolos, Fleming, Louise, Chung, Kian Fan, Melén, Erik, Djukanovic, Ratko, Chaudhuri, Rekha, Exley, Andrew, Koppelman, Gerard H, Bourdin, Arnaud, Rusconi, Franca, Porsbjerg, Celeste, Coleman, Courtney, Williams, Clare, Nielsen, Hanna, Davin, Elizabeth, Taverner, Phil, Romagosa Vilarnau, Sofia, Roberts, Graham

“…Valid outcome measures are imperative to evaluate treatment response, yet the suitability of existing end-points for severe asthma is unclear. This review…”
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Health Expectations and Quality of Life After Acute Respiratory Failure by Turnbull, Alison E., Lee, Emma M., Dinglas, Victor D., Beesley, Sarah, Bose, Somnath, Banner-Goodspeed, Valerie, Hopkins, Ramona O., Jackson, James C., Mir-Kasimov, Mustafa, Sevin, Carla M., Brown, Samuel M., Needham, Dale M., Caraker, Elise, Cherukuri, Sai Phani Sree, Kadiri, Naga Preethi, Kalva, Tejaswi, Koneru, Mounica, Kota, Pooja, Lee, Emma Maelian, Mahmoud, Mazin Ali, Malik, Albahi, Nikooie, Roozbeh, Roberts, Darin, Singu, Sriharsha, Vaziri, Parvaneh, Brown, Katie, Daw, Austin, Merrill, Mardee, Smith, Rilee, Hirshberg, Ellie, Butler, Jorie, Hoenig, Benjamin, Karamourtopoulos, Maria, Hays, Margaret, Abel, Rebecca, High, Craig, Beck, Emily, Armbruster, Brent, Applegate, Darrin, Fergus, Melissa, Kumar, Naresh, Roth, Megan, Mogan, Susan, De Souza Licht, Andre, Londono, Isabel, Larson, Julia, Capers, Krystal, Toksoz-Exley, Andrew, Crane, Julia, Tsai, Lauren

“…Patients often have high expectations for recovery after critical illness, but the impact of these expectations on subsequent quality of life (QoL) after…”
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Health Expectations and Quality of Life After Acute Respiratory Failure: A Multicenter Prospective Cohort Study by Turnbull, Alison E, Lee, Emma M, Dinglas, Victor D, Beesley, Sarah, Bose, Somnath, Banner-Goodspeed, Valerie, Hopkins, Ramona O, Jackson, James C, Mir-Kasimov, Mustafa, Sevin, Carla M, Brown, Samuel M, Needham, Dale M

“…Patients often have high expectations for recovery after critical illness, but the impact of these expectations on subsequent quality of life (QoL) after…”
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2020 White Paper on Recent Issues in Bioanalysis: Vaccine Assay Validation, qPCR Assay Validation, QC for CAR-T Flow Cytometry, NAb Assay Harmonization and ELISpot Validation by Corsaro, Bart, Yang, Tong-yuan, Murphy, Rocio, Sonderegger, Ivo, Exley, Andrew, Bertholet, Sylvie, Dakappagari, Naveen, Dessy, Francis, Garofolo, Fabio, Kierstead, Lisa, Koch, Holger, Sarikonda, Ghanashyam, Savoie, Natasha, Siggers, Richard, Solstad, Therese, Lu, Yanmei, Milton, Mark, Marshall, Jean-Claude, DelCarpini, Jason, Gorovits, Boris, Gupta, Swati, Jesaitis, Lynne, Kamerud, John, Kromminga, Arno, Ma, Anna, McNally, Jim, Yan, Haoheng, Wu, Bonnie, Verthelyi, Daniela, Kirshner, Susan, Pedras-Vasconcelos, Joao, Rajadhyaksha, Manoj, Staack, Roland F., Cherry, Elana, Cludts, Isabelle, Dahlbäck, Madeleine, Gunn, George R., Ishii-Watabe, Akiko, Jawa, Vibha, Kubiak, Robert, Partridge, Michael, Petrillo, Marco, Pine, Samuel O., Poetzl, Johann, Song, Sam, Stebbins, Chris, Wu, Yuling, Zhang, Lucia, Kar, Sumit, Liang, Meina, Abhari, Mohsen Rajabi, Schweighardt, Becky, Stubenrauch, Kay, Xu, Yuanxin

“…The 14 edition of the Workshop on Recent Issues in Bioanalysis (14 WRIB) was held virtually on June 15-29, 2020 with an attendance of over 1000 representatives…”
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Association between unmet medication needs after hospital discharge and readmission or death among acute respiratory failure survivors: the addressing post-intensive care syndrome (APICS-01) multicenter prospective cohort study by Brown, Samuel M, Dinglas, Victor D, Akhlaghi, Narjes, Bose, Somnath, Banner-Goodspeed, Valerie, Beesley, Sarah, Groat, Danielle, Greene, Tom, Hopkins, Ramona O, Mir-Kasimov, Mustafa, Sevin, Carla M, Turnbull, Alison E, Jackson, James C, Needham, Dale M

“…Survivors of acute respiratory failure (ARF) commonly experience long-lasting physical, cognitive, and/or mental health impairments. Unmet medication needs…”
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