Search Results - "EWING, Charles"

Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death by Na, Rong, Zheng, S. Lilly, Han, Misop, Yu, Hongjie, Jiang, Deke, Shah, Sameep, Ewing, Charles M, Zhang, Liti, Novakovic, Kristian, Petkewicz, Jacqueline, Gulukota, Kamalakar, Helseth Jr, Donald L, Quinn, Margo, Humphries, Elizabeth, Wiley, Kathleen E, Isaacs, Sarah D, Wu, Yishuo, Liu, Xu, Zhang, Ning, Wang, Chi-Hsiung, Khandekar, Janardan, Hulick, Peter J, Shevrin, Daniel H, Cooney, Kathleen A, Shen, Zhoujun, Partin, Alan W, Carter, H. Ballentine, Carducci, Michael A, Eisenberger, Mario A, Denmeade, Sam R, McGuire, Michael, Walsh, Patrick C, Helfand, Brian T, Brendler, Charles B, Ding, Qiang, Xu, Jianfeng, Isaacs, William B

“…Abstract Background Germline mutations in BRCA1/2 and ATM have been associated with prostate cancer (PCa) risk. Objective To directly assess whether germline…”
Get full text

Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer by Bova, G Steven, Liu, Wennuan, Laitinen, Sari, Khan, Sofia, Vihinen, Mauno, Kowalski, Jeanne, Yu, Guoqiang, Chen, Li, Ewing, Charles M, Eisenberger, Mario A, Carducci, Michael A, Nelson, William G, Yegnasubramanian, Srinivasan, Luo, Jun, Wang, Yue, Xu, Jianfeng, Isaacs, William B, Visakorpi, Tapio

“…Many studies have shown that primary prostate cancers are multifocal and are composed of multiple genetically distinct cancer cell clones. Whether or not…”
Get full text

Germline Mutations in HOXB13 and Prostate-Cancer Risk by Ewing, Charles M, Ray, Anna M, Lange, Ethan M, Zuhlke, Kimberly A, Robbins, Christiane M, Tembe, Waibhav D, Wiley, Kathleen E, Isaacs, Sarah D, Isaacs, William B, Johng, Dorhyun, Wang, Yunfei, Bizon, Chris, Yan, Guifang, Gielzak, Marta, Partin, Alan W, Shanmugam, Vijayalakshmi, Izatt, Tyler, Sinari, Shripad, Craig, David W, Zheng, S. Lilly, Walsh, Patrick C, Montie, James E, Xu, Jianfeng, Carpten, John D, Cooney, Kathleen A

“…Prostate cancer runs in families. However, the genes that affect the incidence remain largely undefined. The authors have identified a rare germline variant of…”
Get full text

HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer by Johng, Dorhyun, Torga, Gonzalo, Ewing, Charles M., Jin, Kideok, Norris, John D., McDonnell, Donald P., Isaacs, William B.

“…Background The recurrent p.Gly84Glu germline mutation (G84E) in HOXB13 is consistently associated with prostate cancer (PCa), although the mechanisms…”
Get full text

Identification of miR-30b-3p and miR-30d-5p as direct regulators of androgen receptor signaling in prostate cancer by complementary functional microRNA library screening by Kumar, Binod, Khaleghzadegan, Salar, Mears, Brian, Hatano, Koji, Kudrolli, Tarana A, Chowdhury, Wasim H, Yeater, David B, Ewing, Charles M, Luo, Jun, Isaacs, William B, Marchionni, Luigi, Lupold, Shawn E

“…The Androgen Receptor (AR) plays a key role in prostate biology and in the progression of prostate cancer (PCa) to castration resistance. The role of microRNAs…”
Get full text

The HOXB13 G84E Mutation Is Associated with an Increased Risk for Prostate Cancer and Other Malignancies by Beebe-Dimmer, Jennifer L, Hathcock, Matthew, Yee, Cecilia, Okoth, Linda A, Ewing, Charles M, Isaacs, William B, Cooney, Kathleen A, Thibodeau, Stephen N

“…A rare nonconservative substitution (G84E) in the HOXB13 gene has been shown to be associated with risk of prostate cancer. DNA samples from male patients…”
Get full text

Immunomodulatory IL‐18 binding protein is produced by prostate cancer cells and its levels in urine and serum correlate with tumor status by Fujita, Kazutoshi, Ewing, Charles M., Isaacs, William B., Pavlovich, Christian P.

“…Cytokines may play a role in the initiation and progression of prostate cancer. A cytokine antibody array was previously applied to prostatic fluid obtained…”
Get full text

Germline mutations in PPFIBP2 are associated with lethal prostate cancer by Wu, Yishuo, Yu, Hongjie, Zheng, Siqun Lilly, Feng, Bingjian, Kapron, Ashley L., Na, Rong, Boyle, Julie L., Shah, Sameep, Shi, Zhuqing, Ewing, Charles M., Wiley, Kathleen E., Luo, Jun, Walsh, Patrick C., Carter, Herbert Ballentine, Helfand, Brian T., Cooney, Kathleen A., Xu, Jianfeng, Isaacs, William B.

“…Background Few genes have germline mutations which predispose men to more aggressive prostate cancer (PCa). This study evaluated the contribution of germline…”
Get full text

Genetic factors influencing prostate cancer risk in Norwegian men by Chen, Haitao, Ewing, Charles M., Zheng, Sigun, Grindedaal, Eli M., Cooney, Kathleen A., Wiley, Kathleen, Djurovic, Srdjan, Andreassen, Ole A., Axcrona, Karol, Mills, Ian G., Xu, Jianfeng, Maehle, Lovise, Fosså, Sophie D., Isaacs, William B.

“…Norway has one of the highest rates of death due to prostate cancer (PCa) in the world. To assess the contribution of both common and rare single nucleotide…”
Get full text

Homozygous Deletions and Recurrent Amplifications Implicate New Genes Involved in Prostate Cancer by Liu, Wennuan, Xie, Chunmei Carol, Zhu, Yi, Li, Tao, Sun, Jishan, Cheng, Yu, Ewing, Charles M., Dalrymple, Sue, Turner, Aubrey R., Sun, Jielin, Isascs, John T., Chang, Bao-Li, Zheng, Siqun Lilly, Isaacs, William B., Xu, Jianfeng

“…Prostate cancer cell lines provide ideal in vitro systems for the identification and analysis of prostate tumor suppressors and oncogenes. A detailed…”
Get full text

α-Methylacyl-CoA racemase: A new molecular marker for prostate cancer by JUN LUO, SHAN ZHA, TRENT, Jeffrey M, ISAACS, William B, DE MARZO, Angelo M, GAGE, Wesley R, DUNN, Thomas A, HICKS, Jessica L, BENNETT, Christina J, EWING, Charles M, PLATZ, Elizabeth A, FERDINANDUSSE, Sacha, WANDERS, Ronald J

“…Identification of genes that are dysregulated in association with prostate carcinogenesis can provide disease markers and clues relevant to disease etiology…”
Get full text

Monocyte chemotactic protein-1 (MCP-1/CCL2) is associated with prostatic growth dysregulation and benign prostatic hyperplasia by Fujita, Kazutoshi, Ewing, Charles M., Getzenberg, Robert H., Parsons, J. Kellogg, Isaacs, William B., Pavlovich, Christian P.

“…BACKGROUND Chronic inflammation is commonly observed in benign prostate hyperplasia (BPH), and prostate tissue often contains increased inflammatory…”
Get full text

A Novel Role of Myosin VI in Human Prostate Cancer by Dunn, Thomas A., Chen, Shenglin, Faith, Dennis A., Hicks, Jessica L., Platz, Elizabeth A., Chen, Yidong, Ewing, Charles M., Sauvageot, Jurga, Isaacs, William B., De Marzo, Angelo M., Luo, Jun

“…Myosin VI is an actin motor that moves to the minus end of the polarized actin filament, a direction opposite to all other characterized myosins. Using…”
Get full text

Human prostate cancer and benign prostatic hyperplasia : Molecular dissection by gene expression profiling by JUN LUO, DUGGAN, David J, YIDONG CHEN, SAUVAGEOT, Jurga, EWING, Charles M, BITTNER, Michael L, TRENT, Jeffrey M, ISAACS, William B

“…Critical aspects of the biology and molecular basis for prostate malignancy remain poorly understood. To reveal fundamental differences between benign and…”
Get full text

Endoglin (CD105) as a urinary and serum marker of prostate cancer by Fujita, Kazutoshi, Ewing, Charles M., Chan, David Y.S., Mangold, Leslie A., Partin, Alan W., Isaacs, William B., Pavlovich, Christian P.

“…We have previously shown that endoglin (CD105) is upregulated in prostatic fluid of men with large volume prostate cancer. We chose to assess endoglin levels…”
Get full text

Somatic molecular subtyping of prostate tumors from HOXB13 G84E carriers by Lotan, Tamara L, Torres, Alba, Zhang, Miao, Tosoian, Jeffrey J, Guedes, Liana B, Fedor, Helen, Hicks, Jessica, Ewing, Charles M, Isaacs, Sarah D, Johng, Dorhyun, De Marzo, Angelo M, Isaacs, William B

“…A recurrent germline mutation (G84E) in the HOXB13 gene is associated with early onset and family history-positive prostate cancer in patients of European…”
Get full text

Prevalence of the HOXB13 G84E prostate cancer risk allele in men treated with radical prostatectomy by Beebe‐Dimmer, Jennifer L., Isaacs, William B., Zuhlke, Kimberly A., Yee, Cecilia, Walsh, Patrick C., Isaacs, Sarah D., Johnson, Anna M., Ewing, Charles E., Humphreys, Elizabeth B., Chowdhury, Wasim H., Montie, James E., Cooney, Kathleen A.

“…Objective To determine the prevalence and clinical correlates of the G84E mutation in the homeobox transcription factor, or HOXB13, gene using DNA samples from…”
Get full text

In vitro evidence for complex modes of nuclear β-catenin signaling during prostate growth and tumorigenesis by CHESIRE, Dennis R, EWING, Charles M, GAGE, Wesley R, ISAACS, William B

“…Understanding the molecular etiology of prostate cancer (CaP) progression is paramount for broadening current diagnostic and therapeutic modalities. Current…”
Get full text

Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk by Isaacs, William B, Xu, Jianfeng, Zheng, S. Lilly, Komiya, Akira, Mychaleckyj, Josyf C, Isaacs, Sarah D, Hu, Jennifer J, Sterling, David, Lange, Ethan M, Hawkins, Gregory A, Turner, Aubrey, Ewing, Charles M, Faith, Dennis A, Johnson, Jill R, Suzuki, Hiroyoshi, Bujnovszky, Piroska, Wiley, Kathleen E, DeMarzo, Angelo M, Bova, G. Steven, Chang, Baoli, Hall, M. Craig, McCullough, David L, Partin, Alan W, Kassabian, Vahan S, Carpten, John D, Bailey-Wilson, Joan E, Trent, Jeffrey M, Ohar, Jill, Bleecker, Eugene R, Walsh, Patrick C, Meyers, Deborah A

“…Deletions on human chromosome 8p22-23 in prostate cancer cells and linkage studies in families affected with hereditary prostate cancer (HPC) have implicated…”
Get full text

Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma by SHAN ZHA, GAGE, Wesley R, SAUVAGEOT, Jurga, SARIA, Elizabeth A, PUTZI, Mathew J, EWING, Charles M, FAITH, Dennis A, NELSON, William G, DE MARZO, Angelo M, ISAACS, William B

“…Cyclooxygenase-2 (COX-2) is the inducible isoform of the rate-limiting enzymes that convert arachidonic acid to proinflammatory prostaglandins as well as a…”
Get full text