Search Results - "EWART, G"

Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride by Premkumar, A, Wilson, L, Ewart, G.D, Gage, P.W

“…A 63 residue peptide, p7, encoded by hepatitis C virus was synthesised and tested for ion channel activity in lipid bilayer membranes. Ion channels formed by…”
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1208 BIT225, AN HCV-P7 INHIBITOR, WITH ENHANCED ANTI-HCV ACTIVITY IN COMBINATION WITH PEGYLATED INTERFERONalfa- 2b AND RIBAVIRIN IN HCV GENOTYPE-1 TREATMENT NAÏVE SUBJECTS: PHARMACOKINETIC AND RESISTANCE STUDIES by Ewart, G, Luscombe, C, Huang, Z, Miller, M, Wilkinson, J, Murphy, R, Tanwandee, T

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Improved HIV-1 clearance with BIT225 in the HIV-1 infected humanised mouse model by J. Wilkinson, G. Ewart, S. Tabruyn, K. Howangyin, C. Luscombe

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The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels by Ewart, G D, Sutherland, T, Gage, P W, Cox, G B

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A 2a/1b full-length p7 inter-genotypic chimeric genome of hepatitis C virus is infectious in vitro by Haqshenas, G, Dong, X, Ewart, G, Bowden, S, Gowans, E.J

“…Abstract The p7 protein of hepatitis C virus (HCV) functions as an ion channel in planar lipid bilayers, and its function is vital for the virus life cycle. In…”
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The Amino-Terminal Region of Vpr from Human Immunodeficiency Virus Type 1 Forms Ion Channels and Kills Neurons by Piller, S C, Ewart, G D, Jans, D A, Gage, P W, Cox, G B

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Vpr Protein of Human Immunodeficiency Virus Type 1 Forms Cation-Selective Channels in Planar Lipid Bilayers by Piller, S. C., Ewart, G. D., Premkumar, A., Cox, G. B., Gage, P. W.

“…A small (96-aa) protein, virus protein R (Vpr), of human immunodeficiency virus type 1 contains one hydrophobic segment that could form a membrane-spanning…”
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Mutational analysis of the Traffic ATPase (ABC) transporters involved in uptake of eye pigment precursors in Drosophila melanogaster: implications for structure-function relationships by Ewart, G.D, Cannell, D, Cox, G.B, Howells, A.J

“…The white, brown, and scarlet genes of Drosophila melanogaster encodes three proteins that belong to the Traffic ATPase superfamily of transmembrane permeases…”
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Alphavirus 6K Proteins Form Ion Channels by Melton, Julian V., Ewart, Gary D., Weir, Ronald C., Board, Philip G., Lee, Eva, Gage, Peter W.

“…Ross River virus and Barmah Forest virus are Australian arboviruses of the Alphavirus genus. Features of alphavirus infection include an increased permeability…”
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ABC transporters involved in transport of eye pigment precursors in Drosophila melanogaster by Ewart, G D, Howells, A J

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Mutations in the white gene of Drosophila melanogaster affecting ABC transporters that determine eye colouration by Mackenzie, Susan M., Brooker, Michael R., Gill, Timothy R., Cox, Graeme B., Howells, Antony J., Ewart, Gary D.

“…The white, brown and scarlet genes of Drosophila melanogaster encode proteins which transport guanine or tryptophan (precursors of the red and brown eye colour…”
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An amino-acid substitution in the influenza-B NB protein affects ion-channel gating by Premkumar, A, Ewart, G D, Cox, G B, Gage, P W

“…The effects of site-directed mutations in NB, a protein encoded by the influenza B virus that has been shown to form cation-selective ion channels at pH 6.0,…”
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Potential New Anti-Human Immunodeficiency Virus Type 1 Compounds Depress Virus Replication in Cultured Human Macrophages by EWART, Gary D, NASR, Najla, NAIF, Hassan, COX, Graeme B, CUNNINGHAM, Anthony L, GAGE, Peter W

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Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure by Tang, Anthony S.L, Wells, George A, Talajic, Mario, Arnold, Malcolm O, Sheldon, Robert, Connolly, Stuart, Hohnloser, Stefan H, Nichol, Graham, Birnie, David H, Sapp, John L, Yee, Raymond, Healey, Jeffrey S, Rouleau, Jean L

“…In this trial, patients with mild-to-moderate heart failure were randomly assigned to receive an implantable cardioverter–defibrillator (ICD) alone or an ICD…”
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Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication by Wilson, Lauren, Gage, Peter, Ewart, Gary

“…All coronaviruses encode a small hydrophobic envelope (E) protein, which mediates viral assembly and morphogenesis by an unknown mechanism. We have previously…”
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Sub-cellular localisation of the white/scarlet ABC transporter to pigment granule membranes within the compound eye of Drosophila melanogaster by Mackenzie, S M, Howells, A J, Cox, G B, Ewart, G D

“…The white, scarlet, and brown genes of Drosophila melanogaster encode ABC transporters involved with the uptake and storage of metabolic precursors to the red…”
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SARS coronavirus E protein forms cation-selective ion channels by Wilson, Lauren, Mckinlay, Carolyn, Gage, Peter, Ewart, Gary

“…Severe Acute Respiratory Syndrome (SARS) is caused by a novel coronavirus (SARS-CoV). Coronaviruses including SARS-CoV encode an envelope (E) protein, a small,…”
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Structure of the C123S mutant of dienelactone hydrolase (DLH) bound with the PMS moiety of the protease inhibitor phenylmethylsulfonyl fluoride (PMSF) by Robinson, Anna, Edwards, Karen J., Carr, Paul D., Barton, John D., Ewart, Gary D., Ollis, David L.

“…The structure of DLH (C123S) with PMS bound was solved to 2.5 Å resolution (R factor = 15.1%). PMSF in 2‐propanol was delivered directly to crystals in drops…”
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Switching of bovine cytochrome c oxidase subunit VIa isoforms in skeletal muscle during development by Ewart, G.D., Zhang, Y.-Z., Capaldi, R.A.

“…A cDNA encoding the liver isoform of bovine cytochrome c oxidase subunit VIa (VIaL) was cloned from bovine liver RNA by reverse transcription and the…”
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Crystallization and preliminary X-ray analysis of the complex of the epsilon-subunit and the central domain of the gamma-subunit from the Escherichia coli ATP synthase by Rodgers, A, Ewart, G, Cox, G, Wilce, M

“…A complex of the epsilon-subunit and the central domain of the gamma-subunit from the ATP synthase of Escherichia coli has been purified and crystallized and…”
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