Search Results - "EWAN, Eric E"

Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration by Oh, Young Mi, Mahar, Marcus, Ewan, Eric E., Leahy, Kathleen M., Zhao, Guoyan, Cavalli, Valeria

“…Injured peripheral sensory neurons switch to a regenerative state after axon injury, which requires transcriptional and epigenetic changes. However, the roles…”
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Ascending dorsal column sensory neurons respond to spinal cord injury and downregulate genes related to lipid metabolism by Ewan, Eric E., Avraham, Oshri, Carlin, Dan, Gonçalves, Tassia Mangetti, Zhao, Guoyan, Cavalli, Valeria

“…Regeneration failure after spinal cord injury (SCI) results in part from the lack of a pro-regenerative response in injured neurons, but the response to SCI…”
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Differential Suppression of Intracranial Self-Stimulation, Food-Maintained Operant Responding, and Open Field Activity by Paw Incision and Spinal Nerve Ligation in Rats by Ewan, Eric E., Martin, Thomas J.

“…Detection of ongoing spontaneous pain behaviors in laboratory animals remains a research challenge. Most preclinical pain studies measure elicited behavioral…”
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Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat by Peters, Christopher M, Hayashida, Ken-ichiro, Ewan, Eric E, Nakajima, Kunie, Obata, Hideaki, Xu, Qinghao, Yaksh, Tony L, Eisenach, James C

“…Abstract The balance between descending inhibition and facilitation is thought to be disturbed in chronic pain states. Increased facilitation by spinally…”
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Involvement of the Lateral Amygdala in the Antiallodynic and Reinforcing Effects of Heroin in Rats after Peripheral Nerve Injury by MARTIN, Thomas J, BUECHLER, Nancy L, KIM, Susy A, EWAN, Eric E, RUOYU XIAO, CHILDERS, Steven R

“…Neuropathic pain alters opioid self-administration in rats. The brain regions altered in the presence of neuropathic pain mediating these differences have not…”
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Intrathecal Acetyl-L-Carnitine Protects Tissue and Improves Function after a Mild Contusive Spinal Cord Injury in Rats by Ewan, Eric E, Hagg, Theo

“…Primary and secondary ischemia after spinal cord injury (SCI) contributes to tissue and axon degeneration, which may result from decreased energy substrate…”
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Analgesics as reinforcers with chronic pain: Evidence from operant studies by Ewan, Eric E., Martin, Thomas J.

“…•Rats with nerve injury self-administer opioids for relief of spontaneous pain.•Neuropathic pain alters supraspinal mechanisms of opioid…”
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Dorsal column sensory axons degenerate due to impaired microvascular perfusion after spinal cord injury in rats by Muradov, Johongir M., Ewan, Eric E., Hagg, Theo

“…The mechanisms contributing to axon loss after spinal cord injury (SCI) are largely unknown but may involve microvascular loss as we have previously suggested…”
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Opioid Facilitation of Rewarding Electrical Brain Stimulation Is Suppressed in Rats with Neuropathic Pain by EWAN, Eric E, MARTIN, Thomas J

“…Opioids are powerful analgesics, but are also common drugs of abuse. Few studies have examined how neuropathic pain alters the pharmacology of opioids in…”
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Rewarding Electrical Brain Stimulation in Rats after Peripheral Nerve Injury: Decreased Facilitation by Commonly Abused Prescription Opioids by EWAN, Eric E, MARTIN, Thomas J

“…Prescription opioid abuse is a significant concern in treating chronic pain, yet few studies examine how neuropathic pain alters the abuse liability of…”
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Effects of opioid receptor ligands in rats trained to discriminate 22 from 2 hours of food deprivation suggest a lack of opioid involvement in eating for hunger by Jewett, David C., Klockars, Anica, Smith, Travis R., Brunton, Chloe, Head, Mitchell A., Tham, Rachel L., Kwilasz, Andrew J., Hahn, Thomas W., Wiebelhaus, Jason M., Ewan, Eric E., Carroll, Regina M., Grace, Martha K., Levine, Allen S., Olszewski, Pawel K.

“…•Opioid agonists do not induce hunger-driven, subjective effects in sated animals.•Naltrexone did not alter the discriminative stimulus effects of hunger in…”
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Nociceptor Deletion of Tsc2 Enhances Axon Regeneration by Inducing a Conditioning Injury Response in Dorsal Root Ganglia by Carlin, Dan, Halevi, Alexandra E, Ewan, Eric E, Moore, Amy M, Cavalli, Valeria

“…Neurons of the PNS are able to regenerate injured axons, a process requiring significant cellular resources to establish and maintain long-distance growth…”
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Intracranial Self-stimulation of the Paraventricular Nucleus of the Hypothalamus: Increased Faciliation by Morphine Compared to Cocaine by EWAN, Eric E, MARTIN, Thomas J

“…Neuropathic pain attenuates opioid facilitation of rewarding electrical stimulation of limbic dopaminergic pathways originating from the ventral tegmental…”
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Toward an animal model of gambling: delay discounting and the allure of unpredictable outcomes by Madden, Gregory J, Ewan, Eric E, Lagorio, Carla H

“…Laboratory investigations of gambling are sometimes criticized as lacking ecological validity because the stakes wagered by human subjects are not real or no…”
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TESTS OF BEHAVIORAL-ECONOMIC ASSESSMENTS OF RELATIVE REINFORCER EFFICACY: ECONOMIC SUBSTITUTES by Madden, Gregory J., Smethells, John R., Ewan, Eric E., Hursh, Steven R.

“…This experiment was conducted to test predictions of two behavioral‐economic approaches to quantifying relative reinforcer efficacy. According to the first of…”
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TESTS OF BEHAVIORAL-ECONOMIC ASSESSMENTS OF RELATIVE REINFORCER EFFICACY II: ECONOMIC COMPLEMENTS by Madden, Gregory J., Smethells, John R., Ewan, Eric E., Hursh, Steven R.

“…This experiment was conducted to test the predictions of two behavioral‐economic approaches to quantifying relative reinforcer efficacy. The normalized demand…”
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Intracranial Self-stimulation of the Paraventricular Nucleus of the Hypothalamus by Ewan, Eric E., Martin, Thomas J.

“…Background Neuropathic pain attenuates opioid facilitation of rewarding electrical stimulation of limbic dopaminergic pathways originating from the ventral…”
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INTRACRANIAL SELF-STIMULATION OF THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS: INCREASED FACILITATON BY MORPHINE COMPARED TO COCAINE by Ewan, Eric E., Martin, Thomas J.

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Rewarding Electrical Brain Stimulation in Rats after Peripheral Nerve Injury by Ewan, Eric E., Martin, Thomas J.

“…Background Prescription opioid abuse is a significant concern in treating chronic pain, yet few studies examine how neuropathic pain alters the abuse liability…”
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EFFECTS OF DAMGO AND DSLET IN RATS TRAINED TO DISCRIMINATE 22 FROM 2 HOURS FOOD DEPRIVATION by Jewett, David C., Kwilasz, A.J., Wiebelhaus, Jason M., Stein, Lacey J., Dunn, Adam T., Ewan, Eric E., Tham, Rachel L., Grace, Martha K., Levine, Allen S.

“…Opioid agonists increase eating under a variety of conditions. We tested the effects of the mu‐opioid agoinst DAMGO and the delta‐opioid agonist DSLET in rats…”
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