Search Results - "EVERS, B. M"

ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer by Ye, Q, Cai, W, Zheng, Y, Evers, B M, She, Q-B

“…The mitogen-activated extracellular signal-regulated kinase/extracellular signal-regulated kinase (MEK/ERK) and phosphatidylinositol 3-kinase (PI3K)/AKT…”
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Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis by Liu, J, Weiss, H L, Rychahou, P, Jackson, L N, Evers, B M, Gao, T

“…PHLPP (PH domain leucine-rich repeats protein phosphatase) represents a family of novel Ser/Thr protein phosphatases. Two highly related isoforms in this…”
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TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium by Zhou, Y, Rychahou, P, Wang, Q, Weiss, H L, Evers, B M

“…The intestinal mucosa undergoes a continual process of proliferation, differentiation and apoptosis, which is regulated by multiple signaling pathways. Notch…”
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N-myc is a novel regulator of PI3K-mediated VEGF expression in neuroblastoma by Kang, J, Rychahou, P G, Ishola, T A, Mourot, J M, Evers, B M, Chung, D H

“…Angiogenesis in neuroblastoma (NB) correlates with increased expression of vascular endothelial growth factor (VEGF) and a worse clinical outcome. Other…”
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Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells by Sheng, H, Shao, J, Townsend, C M, Evers, B M

“…Background and aims: Determination of intracellular signalling pathways that mediate intestinal epithelial proliferation is fundamental to the understanding of…”
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Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer by Dong, C, Wu, Y, Wang, Y, Wang, C, Kang, T, Rychahou, P G, Chi, Y-I, Evers, B M, Zhou, B P

“…Expression of E-cadherin, a hallmark of epithelial–mesenchymal transition (EMT), is often lost due to promoter DNA methylation in basal-like breast cancer…”
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Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase by Wang, Q, Zhou, Y, Wang, X, Evers, B M

“…Glycogen-synthase kinase-3 (GSK-3) and extracellular signal-regulated kinase (ERK) are critical downstream signaling proteins for the PI3-kinase/Akt and…”
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The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer by Li, X, Stevens, P D, Yang, H, Gulhati, P, Wang, W, Evers, B M, Gao, T

“…PH domain leucine-rich-repeats protein phosphatase (PHLPP) is a family of Ser/Thr protein phosphatases that serve as tumor suppressors by negatively regulating…”
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Age-Associated Increase in Cytokine Production During Systemic Inflammation: Adipose Tissue as a Major Source of IL-6 by Starr, Marlene E., Evers, B. Mark, Saito, Hiroshi

“…Increased mortality and overexpression of interleukin-6 (IL-6) during inflammatory stress are well-documented age-associated phenomena; however, the site of…”
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Regulation of growth of human gastric cancer by gastrin and glycine- extended progastrin by Iwase, K, Evers, BM, Hellmich, MR, Guo, YS, Higashide, S, Kim, HJ, Townsend, CM

“…BACKGROUND & AIMS: Gastrin (G-17) stimulates the growth of certain gastric and colon cancers mostly through gastrin/cholecystokinin (CCK)- B receptors…”
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NFAT5 represses canonical Wnt signaling via inhibition of β-catenin acetylation and participates in regulating intestinal cell differentiation by Wang, Q, Zhou, Y, Rychahou, P, Liu, C, Weiss, H L, Evers, B M

“…The intestinal mucosa undergoes a continual process of proliferation, differentiation, and apoptosis, which is regulated by multiple signaling pathways. The…”
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Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells by Domon-Dell, C, Wang, Q, Kim, S, Kedinger, M, Evers, B M, Freund, J-N

“…Background: The transcription factor encoded by the intestinal Cdx2 homeobox gene and treatment with sodium butyrate (NaB), a byproduct of fibre fermentation…”
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KLF4 deletion alters gastric cell lineage and induces MUC2 expression by Yu, T, Chen, X, Lin, T, Liu, J, Li, M, Zhang, W, Xu, X, Zhao, W, Liu, M, Napier, D L, Wang, C, Evers, B M, Liu, C

“…Gastric cancer is one of the most common types of cancer in the world, particularly in underdeveloped countries. The mechanism of gastric cancer is less…”
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FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer by Modur, Vijayanand, Nagarajan, Rakesh, Evers, B Mark, Milbrandt, Jeffrey

“…Mutations in PTEN occur in 60-80% of prostate cancers and lead to a constitutive activation of the phosphatidylinositol 3-kinase pathway and a resultant loss…”
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Inhibition of heat-shock protein 70 induction in intestinal cells overexpressing cyclooxygenase 2 by Ethridge, Richard T., Hellmich, Mark R., DuBois, Raymond N., Evers, B.Mark

“…Background & Aims: The cyclooxygenase (COX) enzymes catalyze the initial step of prostaglandin formation; the inducible form, COX-2, plays a role in…”
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Downregulation of mitogen-activated protein kinases in human colon cancers by Wang, Q, Ding, Q, Dong, Z, Ehlers, R A, Evers, B M

“…Activation of the mitogen-activated protein kinases (MAPKs) appears to play an important role in both proliferation and transformation of various cells; the…”
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Organ physiology of aging by Evers, B M, Townsend, Jr, C M, Thompson, J C

“…With improvements in medical care over the last several decades, individuals are living longer and, as a result, more surgical procedures will be performed in…”
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Mitochondrial DNA damage and altered membrane potential (ΔΨ) in pancreatic acinar cells induced by reactive oxygen species by Ehlers, Richard A., Hernandez, Ambrosio, Bloemendal, L.Scott, Ethridge, Richard T., Farrow, Buckminster, Evers, B.Mark

“…Background: Reactive oxygen species (ROS) have been implicated in the induction of acute pancreatitis. Mitochondria possess a distinct genome (mtDNA) that is…”
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Cell cycle protein suppression and p21 induction in differentiating Caco-2 cells by Evers, B M, Ko, T C, Li, J, Thompson, E A

“…Despite intensive efforts, the exact cellular mechanisms leading to gut differentiation and development remain largely undefined. The cyclins, the…”
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Cytokine-mediated differential induction of hepatic activator protein-1 genes by Wang, Shan, Evers, B.Mark

“…Background: Tumor necrosis factor–α (TNF-α) and interleukin-6 (IL-6) increase the synthesis of hepatic acute-phase proteins; these effects appear mediated by…”
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