Search Results - "EVENOU, PIERRE"

The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation by Evenou, Jean-Pierre, Wagner, Jürgen, Zenke, Gerhard, Brinkmann, Volker, Wagner, Kathrin, Kovarik, Jiri, Welzenbach, Karl A, Weitz-Schmidt, Gabriele, Guntermann, Christine, Towbin, Harry, Cottens, Sylvain, Kaminski, Sandra, Letschka, Thomas, Lutz-Nicoladoni, Christina, Gruber, Thomas, Hermann-Kleiter, Natascha, Thuille, Nikolaus, Baier, Gottfried

“…There is a pressing need for immunosuppressants with an improved safety profile. The search for novel approaches to blocking T-cell activation led to the…”
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Discovery of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes by Wagner, Jürgen, von Matt, Peter, Sedrani, Richard, Albert, Rainer, Cooke, Nigel, Ehrhardt, Claus, Geiser, Martin, Rummel, Gabriele, Stark, Wilhelm, Strauss, Andre, Cowan-Jacob, Sandra W, Beerli, Christian, Weckbecker, Gisbert, Evenou, Jean-Pierre, Zenke, Gerhard, Cottens, Sylvain

“…A series of novel maleimide-based inhibitors of protein kinase C (PKC) were designed, synthesized, and evaluated. AEB071 (1) was found to be a potent,…”
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A Streaming Distance Transform Algorithm for Neighborhood-Sequence Distances by Normand, Nicolas, Strand, Robin, Evenou, Pierre, Arlicot, Aurore

“…We describe an algorithm that computes a “translated” 2D Neighborhood-Sequence Distance Transform (DT) using a look up table approach. It requires a single…”
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Rational Design, Synthesis, and X-ray Structure of Selective Noncovalent Thrombin Inhibitors by Wagner, Jürgen, Kallen, Jörg, Ehrhardt, Claus, Evenou, Jean-Pierre, Wagner, Dieter

“…We have designed, synthesized, and tested in vitro a novel class of noncovalent thrombin inhibitors. The main feature of these inhibitors is a 6,5-fused…”
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Structure–Activity Relationship and Pharmacokinetic Studies of Sotrastaurin (AEB071), a Promising Novel Medicine for Prevention of Graft Rejection and Treatment of Psoriasis by Wagner, Jürgen, von Matt, Peter, Faller, Bernard, Cooke, Nigel G, Albert, Rainer, Sedrani, Richard, Wiegand, Hansjörg, Jean, Christian, Beerli, Christian, Weckbecker, Gisbert, Evenou, Jean-Pierre, Zenke, Gerhard, Cottens, Sylvain

“…Protein kinase C (PKC) isotypes have emerged as key targets for the blockade of early T-cell activation. Herein, we report on the structure–activity…”
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128-LB: Insulin Glargine 300 U/mL (Gla-300) vs. First-Generation Basal Insulins (BI) in Insulin-Naïve Type 2 Diabetes (T2D) Patients (Pts) With and Without Cardiovascular Disease (CVD): Outcomes of the Randomized Pragmatic Real-Life Clinical Trial ACHIEVE Control by FRIAS, JUAN P., EVENOU, PIERRE, DALTON, DAVID, DUNGAN, KATHLEEN M.

“…ACHIEVE Control demonstrated superiority of Gla-300 vs. standard of care (SOC) BIs (glargine 100 U/mL and detemir), with a significantly greater proportion of…”
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Bridging β‐Cyclodextrin Prevents Self‐Inclusion, Promotes Supramolecular Polymerization, and Promotes Cooperative Interaction with Nucleic Acids by Evenou, Pierre, Rossignol, Julien, Pembouong, Gaëlle, Gothland, Adélie, Colesnic, Dmitri, Barbeyron, Renaud, Rudiuk, Sergii, Marcelin, Anne‐Geneviève, Ménand, Mickaël, Baigl, Damien, Calvez, Vincent, Bouteiller, Laurent, Sollogoub, Matthieu

“…A bridge to assemble: Cyclodextrins bridged with an ammonium linker bearing a hydrophobic substituent can efficiently form supramolecular polymers and avoid…”
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1038-P: Insulin Glargine 300 U/ml (Gla-300) vs. First-Generation Standard-of-Care Basal Insulin Analogs (SOC-BI) in Insulin-Naïve Patients with Type 2 Diabetes (T2D): Impact of Renal Function on the Outcomes of the Randomized Pragmatic Real-Life Achieve Control S by MENEGHINI, LUIGI, CHENG, ALICE, EVENOU, PIERRE, GILL, JASVINDER, MOHAMED, AYAD, UMPIERREZ, GUILLERMO E.

“…In the 12-month ACHIEVE Control study, significantly more insulin-naive patients with T2D treated with Gla-300 vs. SOC-BI (glargine 100 U/mL or detemir)…”
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2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes by van Eis, Maurice J., Evenou, Jean-Pierre, Floersheim, Philipp, Gaul, Christoph, Cowan-Jacob, Sandra W., Monovich, Lauren, Rummel, Gabriele, Schuler, Walter, Stark, Wilhelm, Strauss, Andre, Matt, Anette von, Vangrevelinghe, Eric, Wagner, Juergen, Soldermann, Nicolas

“…Compound 11 potently inhibits the novel PKC isozymes δ, ε, η, θ, with IC 50 values of 20, 5, 5 and 77 nM, respectively, and displays a 11–180-fold selectivity…”
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Target attainment in insulin-naive patients at high risk for hypoglycemia: Results from ACHIEVE Control by Anderson, John, Meneghini, Luigi, Hinnen, Debbie, Gill, Jasvinder, Coudert, Mathieu, Evenou, Pierre, Munshi, Medha

“…To better understand outcomes in people with type 2 diabetes at high risk of hypoglycemia, we conducted post hoc analyses in subgroups of participants from the…”
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Medial axis lookup table and test neighborhood computation for 3D chamfer norms by Normand, Nicolas, Evenou, Pierre

“…Chamfer distances are discrete distances based on the propagation of local distances, or weights, defined in a mask. The medial axis, i.e. the centers of…”
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Medial axis lookup table and test neighborhood computation for 3D chamfer norms: Selected Papers from the 14th IAPR International Conference on Discrete Geometry for Computer Imagery 2008 by NORMAND, Nicolas, EVENOU, Pierre

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Minimal-delay distance transform for neighborhood-sequence distances in 2D and 3D by Normand, Nicolas, Strand, Robin, Evenou, Pierre, Arlicot, Aurore

“…► New class of discrete distances that includes neighborhood-sequences distances and chamfer distances. ► Application to neighborhood-sequence distance…”
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Post Hoc Analysis Evaluating the Impact of Antihyperglycemic Background Therapies on Attainment of A1C Targets Without Hypoglycemia in the ACHIEVE Control Pragmatic, Real-Life Study by Bailey, Timothy S, Evenou, Pierre, Gill, Jasvinder, Berhanu, Paulos, Raymond, Romain, Strong, Jodi, Wright, Jr, Eugene E

“…ACHIEVE Control, a prospective, open-label, randomized, pragmatic, real-life study in insulin-naive people with type 2 diabetes (A1C 8.0-11.0%), demonstrated…”
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Minimal-delay distance transform for neighborhood-sequence distances in 2D and 3D: Discrete Geometry for Computer Imagery by NORMAND, Nicolas, STRAND, Robin, EVENOU, Pierre, ARLICOT, Aurore

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Discovery of Novel (Imidazo[1,2-a]pyrazin-6-yl)ureas as Antiproliferative Agents Targeting P53 in Non-small Cell Lung Cancer Cell Lines by Bazin, Marc-Antoine, Rousseau, Bénédicte, Marhadour, Sophie, Tomasoni, Christophe, Evenou, Pierre, Piessard, Sylvie, Vaisberg, Abraham J, Ruchaud, Sandrine, Bach, Stéphane, Roussakis, Christos, Marchand, Pascal

“…A series of (imidazo[1,2-a]pyrazin-6-yl)ureas were synthesized through 6-aminoimidazo[1,2-a]pyrazine as a key intermediate…”
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Bridging β‐Cyclodextrin Prevents Self‐Inclusion, Promotes Supramolecular Polymerization, and Promotes Cooperative Interaction with Nucleic Acids by Evenou, Pierre, Rossignol, Julien, Pembouong, Gaëlle, Gothland, Adélie, Colesnic, Dmitri, Barbeyron, Renaud, Rudiuk, Sergii, Marcelin, Anne‐Geneviève, Ménand, Mickaël, Baigl, Damien, Calvez, Vincent, Bouteiller, Laurent, Sollogoub, Matthieu

“…Cyclodextrine, die von einem Ammoniumlinker mit hydrophoben Substituenten überbrückt sind, können effizient supramolekulare Polymere bilden und den…”
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Bridging β‐Cyclodextrin Prevents Self‐Inclusion, Promotes Supramolecular Polymerization, and Promotes Cooperative Interaction with Nucleic Acids by Evenou, Pierre, Rossignol, Julien, Pembouong, Gaëlle, Gothland, Adélie, Colesnic, Dmitri, Barbeyron, Renaud, Rudiuk, Sergii, Anne‐Geneviève Marcelin, Ménand, Mickaël, Baigl, Damien, Calvez, Vincent, Bouteiller, Laurent, Sollogoub, Matthieu

“…Cyclodextrine, die von einem Ammoniumlinker mit hydrophoben Substituenten überbrückt sind, können effizient supramolekulare Polymere bilden und den…”
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Indolyl-naphthyl-maleimides as potent and selective inhibitors of protein kinase C-α/β by van Eis, Maurice J., Evenou, JeanPierre, Schuler, Walter, Zenke, Gerhard, Vangrevelinghe, Eric, Wagner, Juergen, von Matt, Peter

“…[Display omitted] The indolyl-naphthyl maleimide 7 is a potent inhibitor of the classical PKC isotypes α,β and shows excellent selectivity over the novel PKC…”
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Binding of a Bolton-Hunter substituted homostatine analog to affinity-immobilized human renin by Evenou, J P, Weidmann, B, Hagenbach, A, Metternich, R, Pfenninger, E, Wagner, H

“…The binding of a Bolton-Hunter reagent substituted homostatine analog, SDZ 213-776, to human renin was investigated at pH 6.5 and 7.4. At both pH values, SDZ…”
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