Search Results - "EVEN, C"

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo by Foretz, Marc, Even, Patrick C, Viollet, Benoit

“…The energy sensor AMP-activated protein kinase (AMPK) is a key player in the control of energy metabolism. AMPK regulates hepatic lipid metabolism through the…”
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Hyperprogression during anti-PD-1/PD-L1 therapy in patients with recurrent and/or metastatic head and neck squamous cell carcinoma by Saâda-Bouzid, E., Defaucheux, C., Karabajakian, A., Coloma, V.P., Servois, V., Paoletti, X., Even, C., Fayette, J., Guigay, J., Loirat, D., Peyrade, F., Alt, M., Gal, J., Le Tourneau, C.

“…Pembrolizumab and nivolumab are immune checkpoint inhibitors targeting PD-1 that have recently been approved in pretreated recurrent and/or metastatic head and…”
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Durvalumab with or without tremelimumab in patients with recurrent or metastatic head and neck squamous cell carcinoma: EAGLE, a randomized, open-label phase III study by Ferris, R.L., Haddad, R., Even, C., Tahara, M., Dvorkin, M., Ciuleanu, T.E., Clement, P.M., Mesia, R., Kutukova, S., Zholudeva, L., Daste, A., Caballero-Daroqui, J., Keam, B., Vynnychenko, I., Lafond, C., Shetty, J., Mann, H., Fan, J., Wildsmith, S., Morsli, N., Fayette, J., Licitra, L.

“…Targeting the programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) axis has demonstrated clinical benefit in recurrent/metastatic head…”
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ESMO–EURACAN Clinical Practice Guideline update for nasopharyngeal carcinoma: adjuvant therapy and first-line treatment of recurrent/metastatic disease by Bossi, P., Chan, A.T., Even, C., Machiels, J.-P.

“…•This special article provides updated treatment recommendations for nasopharyngeal carcinoma.•In high-risk locoregionally advanced NPC, adding metronomic or…”
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Plasma proteomics identifies leukemia inhibitory factor (LIF) as a novel predictive biomarker of immune-checkpoint blockade resistance by Loriot, Y., Marabelle, A., Guégan, J.P., Danlos, F.X., Besse, B., Chaput, N., Massard, C., Planchard, D., Robert, C., Even, C., Khettab, M., Tselikas, L., Friboulet, L., André, F., Nafia, I., Le Loarer, F., Soria, J.C., Bessede, A., Italiano, A.

“…Immune checkpoint blockers (ICBs) are now widely used in oncology. Most patients, however, do not derive benefit from these agents. Therefore, there is a…”
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Low-protein and methionine, high-starch diets increase energy intake and expenditure, increase FGF21, decrease IGF-1, and have little effect on adiposity in mice by Chaumontet, Catherine, Azzout-Marniche, Dalila, Blais, Anne, Piedcoq, Julien, Tomé, Daniel, Gaudichon, Claire, Even, Patrick C

“…Low-protein diets most often induce increased energy intake in an attempt to increase protein intake to meet protein needs with a risk of accumulation as fat…”
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Circulating L-arginine predicts the survival of cancer patients treated with immune checkpoint inhibitors by Peyraud, F., Guégan, J.-P., Bodet, D., Nafia, I., Fontan, L., Auzanneau, C., Cousin, S., Roubaud, G., Cabart, M., Chomy, F., Le Loarer, F., Chaput, N., Danlos, F.-X., Planchard, D., Even, C., Khettab, M., Tselikas, L., Besse, B., Barlesi, F., Soria, J.-C., Marabelle, A., Bessede, A., Italiano, A.

“…The discovery of immune checkpoint inhibitors (ICIs) has revolutionized the systemic approach to cancer treatment. Most patients receiving ICIs, however, do…”
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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice by Holzenberger, Martin, Dupont, Joëlle, Ducos, Bertrand, Leneuve, Patricia, Géloën, Alain, Even, Patrick C, Cervera, Pascale, Le Bouc, Yves

“…Studies in invertebrates have led to the identification of a number of genes that regulate lifespan, some of which encode components of the insulin or…”
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Salivary gland cancer: ESMO–European Reference Network on Rare Adult Solid Cancers (EURACAN) Clinical Practice Guideline for diagnosis, treatment and follow-up by van Herpen, C., Vander Poorten, V., Skalova, A., Terhaard, C., Maroldi, R., van Engen, A., Baujat, B., Locati, L.D., Jensen, A.D., Smeele, L., Hardillo, J., Martineau, V. Costes, Trama, A., Kinloch, E., Even, C., Machiels, J.-P.

“…•This ESMO–EURACAN Clinical Practice Guideline provides key recommendations for managing salivary gland cancer.•The guideline covers clinical and pathological…”
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Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats by Moro, Joanna, Chaumontet, Catherine, Even, Patrick C., Blais, Anne, Piedcoq, Julien, Gaudichon, Claire, Tomé, Daniel, Azzout-Marniche, Dalila

“…To study, in young growing rats, the consequences of different levels of dietary protein deficiency on food intake, body weight, body composition, and energy…”
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Safety and clinical activity of the Notch inhibitor, crenigacestat (LY3039478), in an open-label phase I trial expansion cohort of advanced or metastatic adenoid cystic carcinoma by Even, C., Lassen, U., Merchan, J., Le Tourneau, C., Soria, J-C, Ferte, C., Ricci, F., Diener, J. T., Yuen, E., Smith, C., Oakley, G. J., Benhadji, K. A., Massard, Christophe

“…Summary Background Deregulated Notch signaling is implicated in multiple cancers. The phase I trial (I6F-MC-JJCA) investigated the safety and anti-tumor…”
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Protein Status Modulates an Appetite for Protein To Maintain a Balanced Nutritional StateA Perspective View by Tomé, Daniel, Chaumontet, Catherine, Even, Patrick C, Darcel, Nicolas, Thornton, Simon N, Azzout-Marniche, Dalila

“…Protein sufficiency is tightly controlled through different sensing and signaling processes that modulate and adapt protein and energy metabolism and feeding…”
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Lysine or Threonine Deficiency Decreases Body Weight Gain in Growing Rats despite an Increase in Food Intake without Increasing Energy Expenditure in Response to FGF21 by Moro, Joanna, Roisné-Hamelin, Gaëtan, Chaumontet, Catherine, Even, Patrick C, Blais, Anne, Cansell, Celine, Piedcoq, Julien, Gaudichon, Claire, Tomé, Daniel, Azzout-Marniche, Dalila

“…The objective of this study is to evaluate the effects of a strictly essential amino acid (lysine or threonine; EAA) deficiency on energy metabolism in growing…”
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High dietary protein decreases fat deposition induced by high-fat and high-sucrose diet in rats by Chaumontet, Catherine, Even, Patrick C., Schwarz, Jessica, Simonin-Foucault, Angélique, Piedcoq, Julien, Fromentin, Gilles, Azzout-Marniche, Dalila, Tomé, Daniel

“…High-protein diets are known to reduce adiposity in the context of high carbohydrate and Western diets. However, few studies have investigated the specific…”
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Radiotherapy for salivary gland cancer: REFCOR recommendations by the formal consensus method by Thariat, J., Ferrand, F.-R., Fakhry, N., Even, C., Vergez, S., Chabrillac, E., Sarradin, V., Digue, L., Troussier, I., Bensadoun, R.-J.

“…To determine the indications for radiotherapy in salivary gland cancer and to specify the modalities and target radiation volumes. The French Network of Rare…”
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Systemic therapies for salivary gland cancer: Adenoid cystic carcinoma. REFCOR recommendations by the formal consensus method by Ferrand, F.-R., Even, C., Chabrillac, E., Thariat, J., Fakhry, N., Vergez, S., Bensadoun, R.-J., Sarradin, V., Digue, L.

“…To determine the therapeutic indications for systemic medical treatment in the management of adenoid cystic carcinoma (ACC) according to the clinical…”
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Systemic therapies for salivary gland carcinoma (excluding adenoid cystic carcinoma): REFCOR recommendations by the formal consensus method by Sarradin, V., Digue, L., Vergez, S., Thariat, J., Fakhry, N., Chabrillac, E., Bensadoun, R.-J., Ferrand, F.-R., Even, C.

“…To determine the therapeutic indications for systemic medical treatment in the management of salivary gland carcinoma (excluding adenoid cystic carcinoma)…”
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Long-term outcomes and safety after reirradiation in locally recurrent nasopharyngeal carcinoma in a non-endemic area by Boustani, J., Ruffier, A., Moya-Plana, A., Tao, Y., Nguyen, F., Even, C., Berthold, C., Casiraghi, O., Temam, S., Blanchard, P.

“…Purpose To determine outcomes and toxicities after reirradiation for locally recurrent nasopharyngeal carcinoma (rNPC) and to apply a prognostic index in…”
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Multiple immune-related toxicities in cancer patients treated with anti-programmed cell death protein 1 immunotherapies: a new surrogate marker for clinical trials? by Laparra, A., Kfoury, M., Champiat, S., Danlos, F.X., Martin-Romano, P., Simonaggio, A., Baldini, C., Vuagnat, P., Mateus, C., Voisin, A.L., Albiges, L., Besse, B., Even, C., Robert, C., Laghouati, S., Massard, C., Marabelle, A., Lambotte, O., Michot, J.M.

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Detection of extracellular glucose by GLUT2 contributes to hypothalamic control of food intake by Stolarczyk, Emilie, Guissard, Christophe, Michau, Aurélien, Even, Patrick C, Grosfeld, Alexandra, Serradas, Patricia, Lorsignol, Anne, Pénicaud, Luc, Brot-Laroche, Edith, Leturque, Armelle, Le Gall, Maude

“…The sugar transporter GLUT2, present in several tissues of the gut-brain axis, has been reported to be involved in the control of food intake. GLUT2 is a sugar…”
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