Search Results - "EVANS, William E"

A 50-Year Journey to Cure Childhood Acute Lymphoblastic Leukemia by Pui, Ching-Hon, Evans, William E

“…The 50th anniversary of Seminars in Hematology coincides with the 50th anniversary of St. Jude Children's Research Hospital, and both milestones are inexorably…”
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Improving the treatment of childhood acute lymphoblastic leukemia by optimizing the use of 70-year-old drugs by Evans, William E

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Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update by Relling, Mary V., Schwab, Matthias, Whirl‐Carrillo, Michelle, Suarez‐Kurtz, Guilherme, Pui, Ching‐Hon, Stein, Charles M., Moyer, Ann M., Evans, William E., Klein, Teri E., Antillon‐Klussmann, Federico Guillermo, Caudle, Kelly E., Kato, Motohiro, Yeoh, Allen E.J., Schmiegelow, Kjeld, Yang, Jun J.

“…Thiopurine methyltransferase (TPMT) activity exhibits a monogenic codominant inheritance and catabolizes thiopurines. TPMT variant alleles are associated with…”
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Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration by Pui, Ching-Hon, Yang, Jun J, Hunger, Stephen P, Pieters, Rob, Schrappe, Martin, Biondi, Andrea, Vora, Ajay, Baruchel, André, Silverman, Lewis B, Schmiegelow, Kjeld, Escherich, Gabriele, Horibe, Keizo, Benoit, Yves C M, Izraeli, Shai, Yeoh, Allen Eng Juh, Liang, Der-Cherng, Downing, James R, Evans, William E, Relling, Mary V, Mullighan, Charles G

“…To review the impact of collaborative studies on advances in the biology and treatment of acute lymphoblastic leukemia (ALL) in children and adolescents. A…”
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Improved CNS Control of Childhood Acute Lymphoblastic Leukemia Without Cranial Irradiation: St Jude Total Therapy Study 16 by Jeha, Sima, Pei, Deqing, Choi, John, Cheng, Cheng, Sandlund, John T, Coustan-Smith, Elaine, Campana, Dario, Inaba, Hiroto, Rubnitz, Jeffrey E, Ribeiro, Raul C, Gruber, Tanja A, Raimondi, Susana C, Khan, Raja B, Yang, Jun J, Mullighan, Charles G, Downing, James R, Evans, William E, Relling, Mary V, Pui, Ching-Hon

“…Despite contemporary treatment, up to 10% of children with acute lymphoblastic leukemia still experience relapse. We evaluated whether a higher dosage of…”
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Preemptive Clinical Pharmacogenetics Implementation: Current Programs in Five US Medical Centers by Dunnenberger, Henry M, Crews, Kristine R, Hoffman, James M, Caudle, Kelly E, Broeckel, Ulrich, Howard, Scott C, Hunkler, Robert J, Klein, Teri E, Evans, William E, Relling, Mary V

“…Although the field of pharmacogenetics has existed for decades, practioners have been slow to implement pharmacogenetic testing in clinical care. Numerous…”
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Methotrexate-Induced Neurotoxicity and Leukoencephalopathy in Childhood Acute Lymphoblastic Leukemia by BHOJWANI, Deepa, SABIN, Noah D, HOWARD, Scott C, RIBEIRO, Raul C, CHENG CHENG, REDDICK, Wilburn E, JEHA, Sima, SANDLUND, John T, EVANS, William E, PUI, Ching-Hon, RELLING, Mary V, DEQING PEI, YANG, Jun J, KHAN, Raja B, PANETTA, John C, KRULL, Kevin R, INABA, Hiroto, RUBNITZ, Jeffrey E, METZGER, Monika L

“…Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and…”
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Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective study by Pui, Ching-Hon, Prof, Pei, Deqing, MS, Coustan-Smith, Elaine, MS, Jeha, Sima, Prof, Cheng, Cheng, Prof, Bowman, W Paul, MD, Sandlund, John T, Prof, Ribeiro, Raul C, Prof, Rubnitz, Jeffrey E, Prof, Inaba, Hiroto, MD PhD, Bhojwani, Deepa, MD, Gruber, Tanja A, MD PhD, Leung, Wing H, Prof, Downing, James R, Prof, Evans, William E, Prof, Relling, Mary V, Prof, Campana, Dario, Prof

“…Summary Background The level of minimal residual disease during remission induction is the most important prognostic indicator in patients with acute…”
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Antibodies Predict Pegaspargase Allergic Reactions and Failure of Rechallenge by Liu, Yiwei, Smith, Colton A, Panetta, John C, Yang, Wenjian, Thompson, Lauren E, Counts, Jacob P, Molinelli, Alejandro R, Pei, Deqing, Kornegay, Nancy M, Crews, Kristine R, Swanson, Hope, Cheng, Cheng, Karol, Seth E, Evans, William E, Inaba, Hiroto, Pui, Ching-Hon, Jeha, Sima, Relling, Mary V

“…Pegaspargase (PEG-ASP) has largely replaced native asparaginase (L-ASP) in the treatment of acute lymphoblastic leukemia because of its longer half-life and…”
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Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia by Meyer, Julia A, Wang, Jinhua, Hogan, Laura E, Yang, Jun J, Dandekar, Smita, Patel, Jay P, Tang, Zuojian, Zumbo, Paul, Li, Sheng, Zavadil, Jiri, Levine, Ross L, Cardozo, Timothy, Hunger, Stephen P, Raetz, Elizabeth A, Evans, William E, Morrison, Debra J, Mason, Christopher E, Carroll, William L

“…William Carroll and colleagues report the identification of mutations in NT5C2 , encoding cytosolic 5′-nucleotidase II, which are specific for relapsed…”
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PG4KDS: A model for the clinical implementation of pre-emptive pharmacogenetics by Hoffman, James M., Haidar, Cyrine E., Wilkinson, Mark R., Crews, Kristine R., Baker, Donald K., Kornegay, Nancy M., Yang, Wenjian, Pui, Ching-Hon, Reiss, Ulrike M., Gaur, Aditya H., Howard, Scott C., Evans, William E., Broeckel, Ulrich, Relling, Mary V.

“…Pharmacogenetics is frequently cited as an area for initial focus of the clinical implementation of genomics. Through the PG4KDS protocol, St. Jude Children's…”
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Pharmacotypes across the genomic landscape of pediatric acute lymphoblastic leukemia and impact on treatment response by Lee, Shawn H. R., Yang, Wenjian, Gocho, Yoshihiro, John, August, Rowland, Lauren, Smart, Brandon, Williams, Hannah, Maxwell, Dylan, Hunt, Jeremy, Yang, Wentao, Crews, Kristine R., Roberts, Kathryn G., Jeha, Sima, Cheng, Cheng, Karol, Seth E., Relling, Mary V., Rosner, Gary L., Inaba, Hiroto, Mullighan, Charles G., Pui, Ching-Hon, Evans, William E., Yang, Jun J.

“…Contemporary chemotherapy for childhood acute lymphoblastic leukemia (ALL) is risk-adapted based on clinical features, leukemia genomics and minimal residual…”
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Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk by Vijayakrishnan, Jayaram, Qian, Maoxiang, Studd, James B., Yang, Wenjian, Kinnersley, Ben, Law, Philip J., Broderick, Peter, Raetz, Elizabeth A., Allan, James, Pui, Ching-Hon, Vora, Ajay, Evans, William E., Moorman, Anthony, Yeoh, Allen, Yang, Wentao, Li, Chunliang, Bartram, Claus R., Mullighan, Charles G., Zimmerman, Martin, Hunger, Stephen P., Schrappe, Martin, Relling, Mary V., Stanulla, Martin, Loh, Mignon L., Houlston, Richard S., Yang, Jun J.

“…There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk…”
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Treating Childhood Acute Lymphoblastic Leukemia without Cranial Irradiation by Pui, Ching-Hon, Campana, Dario, Pei, Deqing, Bowman, W. Paul, Sandlund, John T, Kaste, Sue C, Ribeiro, Raul C, Rubnitz, Jeffrey E, Raimondi, Susana C, Onciu, Mihaela, Coustan-Smith, Elaine, Kun, Larry E, Jeha, Sima, Cheng, Cheng, Howard, Scott C, Simmons, Vickey, Bayles, Amy, Metzger, Monika L, Boyett, James M, Leung, Wing, Handgretinger, Rupert, Downing, James R, Evans, William E, Relling, Mary V

“…This large trial of acute lymphoblastic leukemia in children aimed to determine whether intensive systemic and intrathecal chemotherapy could obviate the need…”
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Pharmacogenomics — Drug Disposition, Drug Targets, and Side Effects by Evans, William E, McLeod, Howard L

“…It is well recognized that different patients respond in different ways to the same medication. These differences are often greater among members of a…”
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Genome-wide study of methotrexate clearance replicates SLCO1B1 by Ramsey, Laura B., Panetta, John C., Smith, Colton, Yang, Wenjian, Fan, Yiping, Winick, Naomi J., Martin, Paul L., Cheng, Cheng, Devidas, Meenakshi, Pui, Ching-Hon, Evans, William E., Hunger, Stephen P., Loh, Mignon, Relling, Mary V.

“…Methotrexate clearance can influence the cure of and toxicity in children with acute lymphoblastic leukemia (ALL). We estimated methotrexate plasma clearance…”
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Pharmacogenomics and individualized drug therapy by Eichelbaum, Michel, Ingelman-Sundberg, Magnus, Evans, William E

“…Pharmacogenetics deals with inherited differences in the response to drugs. The best-recognized examples are genetic polymorphisms of drug-metabolizing…”
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Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition by Ramsey, Laura B, Bruun, Gitte H, Yang, Wenjian, Treviño, Lisa R, Vattathil, Selina, Scheet, Paul, Cheng, Cheng, Rosner, Gary L, Giacomini, Kathleen M, Fan, Yiping, Sparreboom, Alex, Mikkelsen, Torben S, Corydon, Thomas J, Pui, Ching-Hon, Evans, William E, Relling, Mary V

“…Methotrexate is used to treat autoimmune diseases and malignancies, including acute lymphoblastic leukemia (ALL). Inter-individual variation in clearance of…”
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Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects by Treviño, Lisa R, Shimasaki, Noriko, Yang, Wenjian, Panetta, John C, Cheng, Cheng, Pei, Deqing, Chan, Diana, Sparreboom, Alex, Giacomini, Kathleen M, Pui, Ching-Hon, Evans, William E, Relling, Mary V

“…Methotrexate plasma concentration is related to its clinical effects. Our aim was to identify the genetic basis of interindividual variability in methotrexate…”
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ARID5B Influences Antimetabolite Drug Sensitivity and Prognosis of Acute Lymphoblastic Leukemia by Xu, Heng, Zhao, Xujie, Bhojwani, Deepa, E, Shuyu, Goodings, Charnise, Zhang, Hui, Seibel, Nita L, Yang, Wentao, Li, Chunliang, Carroll, William L, Evans, William E, Yang, Jun J

“…Treatment outcomes for childhood acute lymphoblastic leukemia (ALL) have improved steadily, but a significant proportion of patients still experience relapse…”
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