Search Results - "EVANS, Paul C."

Vascular dysfunction in the pathogenesis of Alzheimer's disease — A review of endothelium-mediated mechanisms and ensuing vicious circles by Di Marco, Luigi Yuri, Venneri, Annalena, Farkas, Eszter, Evans, Paul C, Marzo, Alberto, Frangi, Alejandro F

“…Abstract Late-onset dementia is a major health concern in the ageing population. Alzheimer's disease (AD) accounts for the largest proportion (65–70%) of…”
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Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science by Evans, Paul C, Rainger, G Ed, Mason, Justin C, Guzik, Tomasz J, Osto, Elena, Stamataki, Zania, Neil, Desley, Hoefer, Imo E, Fragiadaki, Maria, Waltenberger, Johannes, Weber, Christian, Bochaton-Piallat, Marie-Luce, Bäck, Magnus

“…Abstract The COVID-19 pandemic is an unprecedented healthcare emergency causing mortality and illness across the world. Although primarily affecting the lungs,…”
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Role of biomechanical forces in the natural history of coronary atherosclerosis by Brown, Adam J., Teng, Zhongzhao, Evans, Paul C., Gillard, Jonathan H., Samady, Habib, Bennett, Martin R.

“…Key Points Atherosclerotic plaques are not uniformly distributed throughout the coronary tree, indicating that local mechanical factors might determine plaque…”
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Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium by Gomez, Ingrid, Ward, Ben, Souilhol, Celine, Recarti, Chiara, Ariaans, Mark, Johnston, Jessica, Burnett, Amanda, Mahmoud, Marwa, Luong, Le Anh, West, Laura, Long, Merete, Parry, Sion, Woods, Rachel, Hulston, Carl, Benedikter, Birke, Niespolo, Chiara, Bazaz, Rohit, Francis, Sheila, Kiss-Toth, Endre, van Zandvoort, Marc, Schober, Andreas, Hellewell, Paul, Evans, Paul C., Ridger, Victoria

“…Neutrophils are implicated in the pathogenesis of atherosclerosis but are seldom detected in atherosclerotic plaques. We investigated whether…”
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Biomechanical factors in atherosclerosis: mechanisms and clinical implications by Kwak, Brenda R, Bäck, Magnus, Bochaton-Piallat, Marie-Luce, Caligiuri, Giuseppina, Daemen, Mat J A P, Davies, Peter F, Hoefer, Imo E, Holvoet, Paul, Jo, Hanjoong, Krams, Rob, Lehoux, Stephanie, Monaco, Claudia, Steffens, Sabine, Virmani, Renu, Weber, Christian, Wentzel, Jolanda J, Evans, Paul C

“…Blood vessels are exposed to multiple mechanical forces that are exerted on the vessel wall (radial, circumferential and longitudinal forces) or on the…”
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Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail by Mahmoud, Marwa M., Serbanovic-Canic, Jovana, Feng, Shuang, Souilhol, Celine, Xing, Rouyu, Hsiao, Sarah, Mammoto, Akiko, Chen, Jing, Ariaans, Markus, Francis, Sheila E., Van der Heiden, Kim, Ridger, Victoria, Evans, Paul C.

“…Blood flow influences atherosclerosis by generating wall shear stress, which alters endothelial cell (EC) physiology. Low shear stress induces…”
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Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart by Davidson, Sean M, Padró, Teresa, Bollini, Sveva, Vilahur, Gemma, Duncker, Dirk J, Evans, Paul C, Guzik, Tomasz, Hoefer, Imo E, Waltenberger, Johannes, Wojta, Johann, Weber, Christian

“…Abstract We review some of the important discoveries and advances made in basic and translational cardiac research in 2020. For example, in the field of…”
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Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway by Warboys, Christina M, de Luca, Amalia, Amini, Narges, Luong, Le, Duckles, Hayley, Hsiao, Sarah, White, Alex, Biswas, Shukti, Khamis, Ramzi, Chong, Chuh K, Cheung, Wai-Mun, Sherwin, Spencer J, Bennett, Martin R, Gil, Jesus, Mason, Justin C, Haskard, Dorian O, Evans, Paul C

“…OBJECTIVE—Although atherosclerosis is associated with systemic risk factors such as age, high cholesterol, and obesity, plaque formation occurs predominately…”
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Mechanoresponsive Networks Controlling Vascular Inflammation by Bryan, Matthew T, Duckles, Hayley, Feng, Shuang, Hsiao, Sarah T, Kim, Hyejeong R, Serbanovic-Canic, Jovana, Evans, Paul C

“…Atherosclerosis is a chronic inflammatory disease of arteries that develops preferentially at branches and bends that are exposed to disturbed blood flow…”
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Correction: Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents by Boldock, Luke, Inzoli, Amanda, Bonardelli, Silvia, Hsiao, Sarah, Marzo, Alberto, Narracott, Andrew, Gunn, Julian, Dubini, Gabriele, Chiastra, Claudio, Halliday, Ian, Morris, Paul D, Evans, Paul C, C. M., Perrault

“…[This corrects the article DOI: 10.1371/journal.pone.0271469.].[This corrects the article DOI: 10.1371/journal.pone.0271469.]…”
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Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology by Tuñón, José, Badimón, Lina, Bochaton-Piallat, Marie-Luce, Cariou, Bertrand, Daemen, Mat J, Egido, Jesus, Evans, Paul C, Hoefer, Imo E, Ketelhuth, Daniel F J, Lutgens, Esther, Matter, Christian M, Monaco, Claudia, Steffens, Sabine, Stroes, Erik, Vindis, Cécile, Weber, Christian, Bäck, Magnus

“…Abstract Dysregulated lipid metabolism induces an inflammatory and immune response leading to atherosclerosis. Conversely, inflammation may alter lipid…”
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Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents by Boldock, Luke, Inzoli, Amanda, Bonardelli, Silvia, Hsiao, Sarah, Marzo, Alberto, Narracott, Andrew, Gunn, Julian, Dubini, Gabriele, Chiastra, Claudio, Halliday, Ian, Morris, Paul D, Evans, Paul C, C M, Perrault

“…Coronary artery stents have profound effects on arterial function by altering fluid flow mass transport and wall shear stress. We developed a new integrated…”
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The effects of stenting on shear stress: relevance to endothelial injury and repair by Van der Heiden, Kim, Gijsen, Frank J H, Narracott, Andrew, Hsiao, Sarah, Halliday, Ian, Gunn, Julian, Wentzel, Jolanda J, Evans, Paul C

“…Stent deployment following balloon angioplasty is used routinely to treat coronary artery disease. These interventions cause damage and loss of endothelial…”
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Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State by ZAKKAR, Mustafa, VAN DER HEIDEN, Kim, HASKARD, Dorian O, MASON, Justin C, EVANS, Paul C, LUONG, Le Anh, CHAUDHURY, Hera, CUHLMANN, Simon, HAMDULAY, Shahir S, KRAMS, Rob, EDIRISINGHE, Indika, RAHMAN, Irfan, CARLSEN, Harald

“…Proinflammatory mediators influence atherosclerosis by inducing adhesion molecules (eg, VCAM-1) on endothelial cells (ECs) via signaling intermediaries…”
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Editorial: Endothelial-to-mesenchymal transition in cardiovascular disease by Alfaidi, Mabruka, Evans, Paul C, Pickering, J Geoffrey

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Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells by Pfenniger, Anna, Wong, Cindy, Sutter, Esther, Cuhlmann, Simon, Dunoyer-Geindre, Sylvie, Mach, François, Horrevoets, Anton J, Evans, Paul C, Krams, Rob, Kwak, Brenda R

“…Abstract High laminar shear stress (HLSS) is vasculoprotective partly through induction of Kruppel-like factor 2 (KLF2). Connexin37 (Cx37) is highly expressed…”
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Endothelial-mesenchymal transition in atherosclerosis by Souilhol, Celine, Harmsen, Martin C, Evans, Paul C, Krenning, Guido

“…Abstract Atherosclerosis is an inflammatory disease resulting in the hardening and thickening of the wall of arteries and the formation of plaques, which…”
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Sulforaphane induces neurovascular protection against a systemic inflammatory challenge via both Nrf2-dependent and independent pathways by Holloway, Paul M., PhD, Gillespie, Scarlett, PhD, Becker, Felix, MD, Vital, Shantel A., MS, Nguyen, Victoria, Alexander, J. Steven, PhD, Evans, Paul C., PhD, Gavins, Felicity N.E., PhD

“…Abstract Sepsis is often characterized by an acute brain inflammation and dysfunction, which is associated with increased morbidity and mortality worldwide…”
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Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination by Luong, Le A, Fragiadaki, Maria, Smith, Jennifer, Boyle, Joseph, Lutz, Jens, Dean, Jonathan L.E, Harten, Sarah, Ashcroft, Margaret, Walmsley, Sarah R, Haskard, Dorian O, Maxwell, Patrick H, Walczak, Henning, Pusey, Charles, Evans, Paul C

“…RATIONALE:Hypoxia followed by reoxygenation promotes inflammation by activating nuclear factor κB transcription factors in endothelial cells (ECs). This…”
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Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL-1-Mediated Mechanism by Alfaidi, Mabruka A, Chamberlain, Janet, Rothman, Alexander, Crossman, David, Villa-Uriol, Maria-Cruz, Hadoke, Patrick, Wu, Junxi, Schenkel, Torsten, Evans, Paul C, Francis, Sheila E

“…Hypertension is a complex condition and a common cardiovascular risk factor. Dietary docosahexaenoic acid (DHA) modulates atherosclerosis and hypertension,…”
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