Search Results - "EVANS, Derek N"

Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides by WYATT, Paul G, COOMBER, Barry A, EVANS, Derek N, JACK, Torquil I, FULTON, Heather E, WONACOTT, Alan J, COLMAN, Peter, VARGHESE, Jose

“…SAR investigations of the 4- and 5-positions of a series of 4-amino-4H-pyran-2-carboxylic acid 6-carboxamides are reported. Potent inhibitors of influenza A…”
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Benzophenone Derivatives: A Novel Series of Potent and Selective Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by Wyatt, Paul G, Bethell, Richard C, Cammack, Nicholas, Charon, Daniel, Dodic, Nerina, Dumaitre, Bernard, Evans, Derek N, Green, Darren V. S, Hopewell, Philippa L

“…A series of benzophenone derivatives has been synthesized and evaluated as inhibitors of HIV-1 reverse transcriptase (RT) and the growth of HIV-1 in MT-4…”
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Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil by Borthwick, Alan D, Evans, Derek N, Kirk, Barrie E, Biggadike, Keith, Exall, Anne M, Youds, Peter, Roberts, Stanley M, Knight, David J, Coates, Jonathan A. V

“…The racemic carbocyclic 2'-fluoroarabinosyl pyrimidine nucleosides 8, 9 (C-FIAU), 12, and 13 (C-FMAU) and the 2'-fluororibosyl pyrimidine nucleosides 17, 20,…”
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4-Acetylamino-3-(imidazol-1-yl)-benzoic acids as novel inhibitors of influenza sialidase by Howes, Peter D, Cleasby, Anne, Evans, Derek N, Feilden, Helen, Smith, Paul W, Sollis, Steven L, Taylor, Neil, Wonacott, Alan J

“…Two methods for the synthesis of 4-acetylamino benzoic acids substituted at the 3-position with imidazoles are described. Many of the compounds are inhibitors…”
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Synthesis and Structure-Activity Relationships of a Series of Penicillin-Derived HIV Proteinase Inhibitors: Heterocyclic Ring Systems Containing P1' and P2' Substituents by Kitchin, John, Bethell, Richard C, Cammack, Nicholas, Dolan, Simon, Evans, Derek N, Holman, Stuart, Holmes, Duncan S, McMeekin, Peter, Mo, Chi L

“…As an extension of our earlier work based upon a single penicillin-derived thiazolidine moiety we have found that the decahydroisoquinoline grouping, also…”
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A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: synthesis, mode of interaction, and structure-activity relationships by Humber, David C, Bamford, Mark J, Bethell, Richard C, Cammack, Nicholas, Cobley, Kevin, Evans, Derek N, Gray, Norman M, Hann, Michael M, Orr, David C

“…The C2-symmetric diester 1 was identified by random screening as a novel inhibitor of HIV-1 proteinase. This led to the preparation of a series of related more…”
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Sialidase inhibitors related to zanamivir: Synthesis and biological evaluation of 4H-pyran 6-ether and ketone by Smith, Paul W., Robinson, J.Ed, Evans, Derek N., Sollis, Steven L., Howes, Peter D., Trivedi, Naimisha, Bethell, Richard C.

“…Synthesis of 5R-Acetamido-4S-amino-4H-pyran-6R-O-(1-ethyl)propyl and 6R-(1-oxo-2-ethyl)butyl 2-carboxylic acids ( 4 and 5) and their evaluation as inhibitors…”
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Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4 H-pyran-2-carboxylic acid-6-propylamides by Wyatt, Paul G, Coomber, Barry A, Evans, Derek N, Jack, Torquil I, Fulton, Heather E, Wonacott, Alan J, Colman, Peter, Varghese, Jose

“…SAR investigations of the 4- and 5-positions of a series of 4-amino-4 H-pyran-2-carboxylic acid 6-carboxamides are reported. Potent inhibitors of influenza A…”
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