Search Results - "ESTES, Jacob"

Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues by Estes, Jacob D.

“…Summary Acquired immunodeficiency syndrome (AIDS) is principally a disease of lymphoid tissues (LTs), due to the fact that the main target cell of human…”
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Nonhuman primate models of human viral infections by Estes, Jacob D., Wong, Scott W., Brenchley, Jason M.

“…Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share many physiological parallels, such as highly similar immune systems, with…”
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Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease by Forsyth, Christopher B, Shannon, Kathleen M, Kordower, Jeffrey H, Voigt, Robin M, Shaikh, Maliha, Jaglin, Jean A, Estes, Jacob D, Dodiya, Hemraj B, Keshavarzian, Ali

“…Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy…”
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In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation by Jensen, Björn-Erik Ole, Knops, Elena, Cords, Leon, Lübke, Nadine, Salgado, Maria, Busman-Sahay, Kathleen, Estes, Jacob D., Huyveneers, Laura E. P., Perdomo-Celis, Federico, Wittner, Melanie, Gálvez, Cristina, Mummert, Christiane, Passaes, Caroline, Eberhard, Johanna M., Münk, Carsten, Hauber, Ilona, Hauber, Joachim, Heger, Eva, De Clercq, Jozefien, Vandekerckhove, Linos, Bergmann, Silke, Dunay, Gábor A., Klein, Florian, Häussinger, Dieter, Fischer, Johannes C., Nachtkamp, Kathrin, Timm, Joerg, Kaiser, Rolf, Harrer, Thomas, Luedde, Tom, Nijhuis, Monique, Sáez-Cirión, Asier, Schulze zur Wiesch, Julian, Wensing, Annemarie M. J., Martinez-Picado, Javier, Kobbe, Guido

“…Despite scientific evidence originating from two patients published to date that CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure human…”
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Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques by Aid, Malika, Busman-Sahay, Kathleen, Vidal, Samuel J., Maliga, Zoltan, Bondoc, Stephen, Starke, Carly, Terry, Margaret, Jacobson, Connor A., Wrijil, Linda, Ducat, Sarah, Brook, Olga R., Miller, Andrew D., Porto, Maciel, Pellegrini, Kathryn L., Pino, Maria, Hoang, Timothy N., Chandrashekar, Abishek, Patel, Shivani, Stephenson, Kathryn, Bosinger, Steven E., Andersen, Hanne, Lewis, Mark G., Hecht, Jonathan L., Sorger, Peter K., Martinot, Amanda J., Estes, Jacob D., Barouch, Dan H.

“…The COVID-19 pandemic has led to extensive morbidity and mortality throughout the world. Clinical features that drive SARS-CoV-2 pathogenesis in humans include…”
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Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation by Schuetz, Alexandra, Deleage, Claire, Sereti, Irini, Rerknimitr, Rungsun, Phanuphak, Nittaya, Phuang-Ngern, Yuwadee, Estes, Jacob D, Sandler, Netanya G, Sukhumvittaya, Suchada, Marovich, Mary, Jongrakthaitae, Surat, Akapirat, Siriwat, Fletscher, James L K, Kroon, Eugene, Dewar, Robin, Trichavaroj, Rapee, Chomchey, Nitiya, Douek, Daniel C, O Connell, Robert J, Ngauy, Viseth, Robb, Merlin L, Phanuphak, Praphan, Michael, Nelson L, Excler, Jean-Louis, Kim, Jerome H, de Souza, Mark S, Ananworanich, Jintanat

“…Mucosal Th17 cells play an important role in maintaining gut epithelium integrity and thus prevent microbial translocation. Chronic HIV infection is…”
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CD8+ Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy by Cartwright, Emily K., Spicer, Lori, Smith, S. Abigail, Lee, David, Fast, Randy, Paganini, Sara, Lawson, Benton O., Nega, Melon, Easley, Kirk, Schmitz, Joern E., Bosinger, Steven E., Paiardini, Mirko, Chahroudi, Ann, Vanderford, Thomas H., Estes, Jacob D., Lifson, Jeffrey D., Derdeyn, Cynthia A., Silvestri, Guido

“…Infection with HIV persists despite suppressive antiretroviral therapy (ART), and treatment interruption results in rapid viral rebound. Antibody-mediated CD8+…”
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Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells by McBrien, Julia Bergild, Mavigner, Maud, Franchitti, Lavinia, Smith, S. Abigail, White, Erick, Tharp, Gregory K., Walum, Hasse, Busman-Sahay, Kathleen, Aguilera-Sandoval, Christian R., Thayer, William O., Spagnuolo, Rae Ann, Kovarova, Martina, Wahl, Angela, Cervasi, Barbara, Margolis, David M., Vanderford, Thomas H., Carnathan, Diane G., Paiardini, Mirko, Lifson, Jeffrey D., Lee, John H., Safrit, Jeffrey T., Bosinger, Steven E., Estes, Jacob D., Derdeyn, Cynthia A., Garcia, J. Victor, Kulpa, Deanna A., Chahroudi, Ann, Silvestri, Guido

“…Human immunodeficiency virus (HIV) persists indefinitely in individuals with HIV who receive antiretroviral therapy (ART) owing to a reservoir of latently…”
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B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers by Fukazawa, Yoshinori, Lum, Richard, Okoye, Afam A, Park, Haesun, Matsuda, Kenta, Bae, Jin Young, Hagen, Shoko I, Shoemaker, Rebecca, Deleage, Claire, Lucero, Carissa, Morcock, David, Swanson, Tonya, Legasse, Alfred W, Axthelm, Michael K, Hesselgesser, Joseph, Geleziunas, Romas, Hirsch, Vanessa M, Edlefsen, Paul T, Piatak, Michael, Estes, Jacob D, Lifson, Jeffrey D, Picker, Louis J

“…Fukazawa et al . report that SIV persists in follicular helper T cells in elite controller macaques, evading clearance by CD8+ T cells Chronic-phase HIV and…”
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Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy by Fennessey, Christine M, Pinkevych, Mykola, Immonen, Taina T, Reynaldi, Arnold, Venturi, Vanessa, Nadella, Priyanka, Reid, Carolyn, Newman, Laura, Lipkey, Leslie, Oswald, Kelli, Bosche, William J, Trivett, Matthew T, Ohlen, Claes, Ott, David E, Estes, Jacob D, Del Prete, Gregory Q, Lifson, Jeffrey D, Davenport, Miles P, Keele, Brandon F

“…HIV and SIV infection dynamics are commonly investigated by measuring plasma viral loads. However, this total viral load value represents the sum of many…”
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Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections by Estes, Jacob D, Harris, Levelle D, Klatt, Nichole R, Tabb, Brian, Pittaluga, Stefania, Paiardini, Mirko, Barclay, G Robin, Smedley, Jeremy, Pung, Rhonda, Oliveira, Kenneth M, Hirsch, Vanessa M, Silvestri, Guido, Douek, Daniel C, Miller, Christopher J, Haase, Ashley T, Lifson, Jeffrey, Brenchley, Jason M

“…The chronic phase of HIV infection is marked by pathological activation of the immune system, the extent of which better predicts disease progression than…”
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Tissue Myeloid Cells in SIV-Infected Primates Acquire Viral DNA through Phagocytosis of Infected T Cells by Calantone, Nina, Wu, Fan, Klase, Zachary, Deleage, Claire, Perkins, Molly, Matsuda, Kenta, Thompson, Elizabeth A., Ortiz, Alexandra M., Vinton, Carol L., Ourmanov, Ilnour, Loré, Karin, Douek, Daniel C., Estes, Jacob D., Hirsch, Vanessa M., Brenchley, Jason M.

“…The viral accessory protein Vpx, expressed by certain simian and human immunodeficiency viruses (SIVs and HIVs), is thought to improve viral infectivity of…”
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Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption by Rothenberger, Meghan K., Keele, Brandon F., Wietgrefe, Stephen W., Fletcher, Courtney V., Beilman, Gregory J., Chipman, Jeffrey G., Khoruts, Alexander, Estes, Jacob D., Anderson, Jodi, Callisto, Samuel P., Schmidt, Thomas E., Thorkelson, Ann, Reilly, Cavan, Perkey, Katherine, Reimann, Thomas G., Utay, Netanya S., Makamdop, Krystelle Nganou, Stevenson, Mario, Douek, Daniel C., Haase, Ashley T., Schacker, Timothy W.

“…Significance Antiretroviral therapy (ART) effectively suppresses HIV replication; however, treatment cannot be stopped, because latently infected CD4+ T cells…”
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African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity by Raehtz, Kevin D, Barrenäs, Fredrik, Xu, Cuiling, Busman-Sahay, Kathleen, Valentine, Audrey, Law, Lynn, Ma, Dongzhu, Policicchio, Benjamin B, Wijewardana, Viskam, Brocca-Cofano, Egidio, Trichel, Anita, Gale, Jr, Michael, Keele, Brandon F, Estes, Jacob D, Apetrei, Cristian, Pandrea, Ivona

“…Unlike HIV infection, SIV infection is generally nonpathogenic in natural hosts, such as African green monkeys (AGMs), despite life-long high viral…”
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Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes by Watson, Dionysios C, Moysi, Eirini, Valentin, Antonio, Bergamaschi, Cristina, Devasundaram, Santhi, Fortis, Sotirios P, Bear, Jenifer, Chertova, Elena, Bess, Jr, Julian, Sowder, Ray, Venzon, David J, Deleage, Claire, Estes, Jacob D, Lifson, Jeffrey D, Petrovas, Constantinos, Felber, Barbara K, Pavlakis, George N

“…B cell follicles in secondary lymphoid tissues represent an immune privileged sanctuary for AIDS viruses, in part because cytotoxic CD8+ T cells are mostly…”
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CTLA-4+PD-1− Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques by McGary, Colleen S., Deleage, Claire, Harper, Justin, Micci, Luca, Ribeiro, Susan P., Paganini, Sara, Kuri-Cervantes, Leticia, Benne, Clarisse, Ryan, Emily S., Balderas, Robert, Jean, Sherrie, Easley, Kirk, Marconi, Vincent, Silvestri, Guido, Estes, Jacob D., Sekaly, Rafick-Pierre, Paiardini, Mirko

“…Antiretroviral therapy (ART) suppresses viral replication in HIV-infected individuals but does not eliminate the reservoir of latently infected cells. Recent…”
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The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques by Webb, Gabriela M, Molden, Jhomary, Busman-Sahay, Kathleen, Abdulhaqq, Shaheed, Wu, Helen L, Weber, Whitney C, Bateman, Katherine B, Reed, Jason S, Northrup, Mina, Maier, Nicholas, Tanaka, Shiho, Gao, Lina, Davey, Brianna, Carpenter, Benjamin L, Axthelm, Michael K, Stanton, Jeffrey J, Smedley, Jeremy, Greene, Justin M, Safrit, Jeffrey T, Estes, Jacob D, Skinner, Pamela J, Sacha, Jonah B

“…Despite the success of antiretroviral therapy (ART) to halt viral replication and slow disease progression, this treatment is not curative and there remains an…”
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Defining total-body AIDS-virus burden with implications for curative strategies by Estes, Jacob D, Kityo, Cissy, Ssali, Francis, Swainson, Louise, Makamdop, Krystelle Nganou, Del Prete, Gregory Q, Deeks, Steven G, Luciw, Paul A, Chipman, Jeffrey G, Beilman, Gregory J, Hoskuldsson, Torfi, Khoruts, Alexander, Anderson, Jodi, Deleage, Claire, Jasurda, Jacob, Schmidt, Thomas E, Hafertepe, Michael, Callisto, Samuel P, Pearson, Hope, Reimann, Thomas, Schuster, Jared, Schoephoerster, Jordan, Southern, Peter, Perkey, Katherine, Shang, Liang, Wietgrefe, Stephen W, Fletcher, Courtney V, Lifson, Jeffrey D, Douek, Daniel C, McCune, Joseph M, Haase, Ashley T, Schacker, Timothy W

“…Quantifying the total-body virus burden in HIV-infected individuals is necessary to understand viral persistence and guide development of cure strategies…”
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Zika viral dynamics and shedding in rhesus and cynomolgus macaques by Osuna, Christa E, Lim, So-Yon, Deleage, Claire, Griffin, Bryan D, Stein, Derek, Schroeder, Lukas T, Omange, Robert, Best, Katharine, Luo, Ma, Hraber, Peter T, Andersen-Elyard, Hanne, Ojeda, Erwing Fabian Cardozo, Huang, Scott, Vanlandingham, Dana L, Higgs, Stephen, Perelson, Alan S, Estes, Jacob D, Safronetz, David, Lewis, Mark G, Whitney, James B

“…Both rhesus and cynomolgus macaques are susceptible to subcutaneous infection with Zika virus; longitudinal studies of infected animals provide information…”
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CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells by Micci, Luca, Alvarez, Xavier, Iriele, Robin I, Ortiz, Alexandra M, Ryan, Emily S, McGary, Colleen S, Deleage, Claire, McAtee, Brigitte B, He, Tianyu, Apetrei, Cristian, Easley, Kirk, Pahwa, Savita, Collman, Ronald G, Derdeyn, Cynthia A, Davenport, Miles P, Estes, Jacob D, Silvestri, Guido, Lackner, Andrew A, Paiardini, Mirko

“…In rhesus macaques (RMs), experimental depletion of CD4+ T-cells prior to SIV infection results in higher viremia and emergence of CD4-independent…”
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