Search Results - "ESSERS, Jeroen"

DNA Double Strand Break Repair Pathways in Response to Different Types of Ionizing Radiation by van de Kamp, Gerarda, Heemskerk, Tim, Kanaar, Roland, Essers, Jeroen

“…The superior dose distribution of particle radiation compared to photon radiation makes it a promising therapy for the treatment of tumors. However, the…”
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MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation by Boon, Reinier A, Seeger, Timon, Heydt, Susanne, Fischer, Ariane, Hergenreider, Eduard, Horrevoets, Anton J.G, Vinciguerra, Manlio, Rosenthal, Nadia, Sciacca, Sergio, Pilato, Michele, van Heijningen, Paula, Essers, Jeroen, Brandes, Ralf P, Zeiher, Andreas M, Dimmeler, Stefanie

“…RATIONALE:Aging represents a major risk factor for coronary artery disease and aortic aneurysm formation. MicroRNAs (miRs) have emerged as key regulators of…”
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Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells by Roobol, Stefan J, van den Bent, Irene, van Cappellen, Wiggert A, Abraham, Tsion E, Paul, Maarten W, Kanaar, Roland, Houtsmuller, Adriaan B, van Gent, Dik C, Essers, Jeroen

“…High-linear-energy-transfer (LET) radiation is more lethal than similar doses of low-LET radiation types, probably a result of the condensed energy deposition…”
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BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination by Ghouil, Rania, Miron, Simona, Koornneef, Lieke, Veerman, Jasper, Paul, Maarten W., Le Du, Marie-Hélène, Sleddens-Linkels, Esther, van Rossum-Fikkert, Sari E., van Loon, Yvette, Felipe-Medina, Natalia, Pendas, Alberto M., Maas, Alex, Essers, Jeroen, Legrand, Pierre, Baarends, Willy M., Kanaar, Roland, Zinn-Justin, Sophie, Zelensky, Alex N.

“…BRCA2 and its interactors are required for meiotic homologous recombination (HR) and fertility. Loss of HSF2BP, a BRCA2 interactor, disrupts HR during…”
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Synergistic Roles of Non-Homologous End Joining and Homologous Recombination in Repair of Ionizing Radiation-Induced DNA Double Strand Breaks in Mouse Embryonic Stem Cells by van de Kamp, Gerarda, Heemskerk, Tim, Kanaar, Roland, Essers, Jeroen

“…DNA double strand breaks (DSBs) are critical for the efficacy of radiotherapy as they lead to cell death if not repaired. DSBs caused by ionizing radiation…”
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Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation by van der Pluijm, Ingrid, Burger, Joyce, van Heijningen, Paula M, IJpma, Arne, van Vliet, Nicole, Milanese, Chiara, Schoonderwoerd, Kees, Sluiter, Willem, Ringuette, Lea-Jeanne, Dekkers, Dirk H W, Que, Ivo, Kaijzel, Erik L, te Riet, Luuk, MacFarlane, Elena G, Das, Devashish, van der Linden, Reinier, Vermeij, Marcel, Demmers, Jeroen A, Mastroberardino, Pier G, Davis, Elaine C, Yanagisawa, Hiromi, Dietz, Harry C, Kanaar, Roland, Essers, Jeroen

“…Abstract Aim Thoracic aortic aneurysms are a life-threatening condition often diagnosed too late. To discover novel robust biomarkers, we aimed to better…”
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Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition by Krawczyk, Przemek M, Eppink, Berina, Essers, Jeroen, Stap, Jan, Rodermond, Hans, Odijk, Hanny, Zelensky, Alex, van Bree, Chris, Stalpers, Lukas J, Buist, Marrije R, Soullié, Thomas, Rens, Joost, Verhagen, Hence J.M, O'Connor, Mark J, Franken, Nicolaas A.P, ten Hagen, Timo L.M, Kanaar, Roland, Aten, Jacob A

“…Defective homologous recombination (HR) DNA repair imposed by BRCA1 or BRCA2 deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP)-1 inhibition…”
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RTEL1 contributes to DNA replication and repair and telomere maintenance by Uringa, Evert-Jan, Lisaingo, Kathleen, Pickett, Hilda A, Brind'Amour, Julie, Rohde, Jan-Hendrik, Zelensky, Alex, Essers, Jeroen, Lansdorp, Peter M

“…Telomere maintenance and DNA repair are important processes that protect the genome against instability. mRtel1, an essential helicase, is a dominant factor…”
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Transforming Growth Factor-β and the Renin-Angiotensin System in Syndromic Thoracic Aortic Aneurysms: Implications for Treatment by van Dorst, Daan C.H., de Wagenaar, Nathalie P., van der Pluijm, Ingrid, Roos-Hesselink, Jolien W., Essers, Jeroen, Danser, A.H. Jan

“…Thoracic aortic aneurysms (TAAs) are permanent pathological dilatations of the thoracic aorta, which can lead to life-threatening complications, such as aortic…”
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HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis by Brandsma, Inger, Sato, Koichi, van Rossum-Fikkert, Sari E., van Vliet, Nicole, Sleddens, Esther, Reuter, Marcel, Odijk, Hanny, van den Tempel, Nathalie, Dekkers, Dick H.W., Bezstarosti, Karel, Demmers, Jeroen A.A., Maas, Alex, Lebbink, Joyce, Wyman, Claire, Essers, Jeroen, van Gent, Dik C., Baarends, Willy M., Knipscheer, Puck, Kanaar, Roland, Zelensky, Alex N.

“…The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability, and DNA interstrand crosslink repair in vertebrates. We…”
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Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner by Zelensky, Alex N, Schoonakker, Mascha, Brandsma, Inger, Tijsterman, Marcel, van Gent, Dik C, Essers, Jeroen, Kanaar, Roland

“…Extrachromosomal DNA can integrate into the genome with no sequence specificity producing an insertional mutation. This process, which is referred to as random…”
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Nuclear Dynamics of PCNA in DNA Replication and Repair by Essers, Jeroen, Theil, Arjan F., Baldeyron, Céline, van Cappellen, Wiggert A., Houtsmuller, Adriaan B., Kanaar, Roland, Vermeulen, Wim

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Extracellular Matrix and Cardiac Pressure Overload: Focus on Novel Treatment Targets by Snelders, Matthijs, Yildirim, Meltem, Danser, A H Jan, van der Pluijm, Ingrid, Essers, Jeroen

“…Heart failure is a significant health issue in developed countries, often stemming from conditions like hypertension, which imposes a pressure overload on the…”
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Longitudinal assessment of bleomycin-induced lung fibrosis by Micro-CT correlates with histological evaluation in mice by Ruscitti, Francesca, Ravanetti, Francesca, Essers, Jeroen, Ridwan, Yanto, Belenkov, Sasha, Vos, Wim, Ferreira, Francisca, KleinJan, Alex, van Heijningen, Paula, Van Holsbeke, Cedric, Cacchioli, Antonio, Villetti, Gino, Stellari, Franco Fabio

“…The intratracheal instillation of bleomycin in mice induces early damage to alveolar epithelial cells and development of inflammation followed by fibrotic…”
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ATP-dependent and independent functions of Rad54 in genome maintenance by Agarwal, Sheba, van Cappellen, Wiggert A, Guénolé, Aude, Eppink, Berina, Linsen, Sam E.V, Meijering, Erik, Houtsmuller, Adriaan, Kanaar, Roland, Essers, Jeroen

“…Rad54, a member of the SWI/SNF protein family of DNA-dependent ATPases, repairs DNA double-strand breaks (DSBs) through homologous recombination. Here we…”
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Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains by Aten, Jacob A., Stap, Jan, Krawczyk, Przemek M., van Oven, Carel H., Hoebe, Ron A., Essers, Jeroen, Kanaar, Roland

“…Interactions between ends from different DNA double-strand breaks (DSBs) can produce tumorigenic chromosome translocations. Two theories for the juxtaposition…”
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Activation of multiple DNA repair pathways by sub-nuclear damage induction methods by Dinant, Christoffel, de Jager, Martijn, Essers, Jeroen, van Cappellen, Wiggert A, Kanaar, Roland, Houtsmuller, Adriaan B, Vermeulen, Wim

“…Live cell studies of DNA repair mechanisms are greatly enhanced by new developments in real-time visualization of repair factors in living cells. Combined with…”
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Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice by van Thiel, Bibi S., de Boer, Martine, Ridwan, Yanto, de Kleijnen, Marion G. J., van Vliet, Nicole, van der Linden, Janette, de Beer, Isa, van Heijningen, Paula M., Vermeij, Wilbert P., Hoeijmakers, Jan H. J., Danser, A. H. Jan, Kanaar, Roland, Duncker, Dirk J., van der Pluijm, Ingrid, Essers, Jeroen

“…Purpose In this study, we explored the role of apoptosis as a potential biomarker for cardiac failure using functional micro-CT and fluorescence molecular…”
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In Vivo Renin Activity Imaging in the Kidney of Progeroid Ercc1 Mutant Mice by van Thiel, Bibi S, van der Linden, Janette, Ridwan, Yanto, Garrelds, Ingrid M, Vermeij, Marcel, Clahsen-van Groningen, Marian C, Qadri, Fatimunnisa, Alenina, Natalia, Bader, Michael, Roks, Anton J M, Danser, A H Jan, Essers, Jeroen, van der Pluijm, Ingrid

“…Changes in the renin-angiotensin system, known for its critical role in the regulation of blood pressure and sodium homeostasis, may contribute to aging and…”
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Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice by Xu, Huiling, Balakrishnan, Kuhendra, Malaterre, Jordane, Beasley, Matthew, Yan, Yuqian, Essers, Jeroen, Appeldoorn, Esther, Tomaszewski, Jonathan M, Thomaszewski, Jonathan M, Vazquez, Melisa, Verschoor, Sandra, Lavin, Martin F, Bertoncello, Ivan, Bertonchello, Ivan, Ramsay, Robert G, McKay, Michael J

“…Approximately half of cancer-affected patients receive radiotherapy (RT). The doses delivered have been determined upon empirical experience based upon average…”
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