Search Results - "ESPARZA, B"

The mitochondrial ATP synthase is a shared drug target for aging and dementia by Goldberg, Joshua, Currais, Antonio, Prior, Marguerite, Fischer, Wolfgang, Chiruta, Chandramouli, Ratliff, Eric, Daugherty, Daniel, Dargusch, Richard, Finley, Kim, Esparza‐Moltó, Pau B., Cuezva, José M., Maher, Pamela, Petrascheck, Michael, Schubert, David

“…Summary Aging is a major driving force underlying dementia, such as that caused by Alzheimer's disease (AD). While the idea of targeting aging as a therapeutic…”
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Manipulating mitochondrial electron flow enhances tumor immunogenicity by Mangalhara, Kailash Chandra, Varanasi, Siva Karthik, Johnson, Melissa A, Burns, Mannix J, Rojas, Gladys R, Esparza Moltó, Pau B, Sainz, Alva G, Tadepalle, Nimesha, Abbott, Keene L, Mendiratta, Gaurav, Chen, Dan, Farsakoglu, Yagmur, Kunchok, Tenzin, Hoffmann, Filipe Araujo, Parisi, Bianca, Rincon, Mercedes, Vander Heiden, Matthew G, Bosenberg, Marcus, Hargreaves, Diana C, Kaech, Susan M, Shadel, Gerald S

“…Although tumor growth requires the mitochondrial electron transport chain (ETC), the relative contribution of complex I (CI) and complex II (CII), the…”
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Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition by Esparza-Moltó, Pau B, Romero-Carramiñana, Inés, Núñez de Arenas, Cristina, Pereira, Marta P, Blanco, Noelia, Pardo, Beatriz, Bates, Georgina R, Sánchez-Castillo, Carla, Artuch, Rafael, Murphy, Michael P, Esteban, José A, Cuezva, José M

“…The mitochondrial ATP synthase emerges as key hub of cellular functions controlling the production of ATP, cellular signaling, and fate. It is regulated by the…”
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The Role of Mitochondrial H + -ATP Synthase in Cancer by Esparza-Moltó, Pau B, Cuezva, José M

“…Cancer cells reprogram energy metabolism by boosting aerobic glycolysis as a main pathway for the provision of metabolic energy and of precursors for anabolic…”
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IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype by Domínguez-Zorita, Sonia, Romero-Carramiñana, Inés, Santacatterina, Fulvio, Esparza-Moltó, Pau B., Simó, Carolina, del-Arco, Araceli, Núñez de Arenas, Cristina, Saiz, Jorge, Barbas, Coral, Cuezva, José M.

“…ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP synthase. The expression of IF1 in differentiated human and mouse cells is highly…”
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The ATPase Inhibitory Factor 1 is a Tissue-Specific Physiological Regulator of the Structure and Function of Mitochondrial ATP Synthase: A Closer Look Into Neuronal Function by Domínguez-Zorita, Sonia, Romero-Carramiñana, Inés, Cuezva, José M, Esparza-Moltó, Pau B

“…The ATP synthase is an essential multifunctional enzyme complex of mitochondria that produces most of cellular ATP, shapes the structure of the inner membrane…”
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Ablation of Atp5if1 impairs metabolic reprogramming and proliferation of T lymphocytes and compromises mouse survival by Romero-Carramiñana, Inés, Dominguez-Zorita, Sonia, Esparza-Moltó, Pau B., Cuezva, José M.

“…T cells experience metabolic reprogramming to an enhanced glycolysis upon activation. Herein, we have investigated whether ATPase Inhibitory Factor 1 (IF1),…”
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IF1 promotes oligomeric assemblies of sluggish ATP synthase and outlines the heterogeneity of the mitochondrial membrane potential by Romero-Carramiñana, Inés, Esparza-Moltó, Pau B., Domínguez-Zorita, Sonia, Nuevo-Tapioles, Cristina, Cuezva, José M.

“…The coexistence of two pools of ATP synthase in mitochondria has been largely neglected despite in vitro indications for the existence of reversible…”
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Analysis of the metabolic proteome of lung adenocarcinomas by reverse-phase protein arrays (RPPA) emphasizes mitochondria as targets for therapy by Torresano, Laura, Santacatterina, Fulvio, Domínguez-Zorita, Sonia, Nuevo-Tapioles, Cristina, Núñez-Salgado, Alfonso, Esparza-Moltó, Pau B., González-Llorente, Lucía, Romero-Carramiñana, Inés, Núñez de Arenas, Cristina, Sánchez-Garrido, Brenda, Nájera, Laura, Salas, Clara, Provencio, Mariano, Cuezva, José M.

“…Lung cancer is the leading cause of cancer-related death worldwide despite the success of therapies targeting oncogenic drivers and immune-checkpoint…”
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Regulation of the H+-ATP synthase by IF1: a role in mitohormesis by Esparza-Moltó, Pau B., Nuevo-Tapioles, Cristina, Cuezva, José M.

“…The mitochondrial H + -ATP synthase is a primary hub of cellular homeostasis by providing the energy required to sustain cellular activity and regulating the…”
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EVALUACIÓN TÉRMICA, LUMÍNICA Y TERMOGRÁFICA DE UNA SOLUCIÓN HABITACIONAL DE MADERA EN CLIMA TEMPLADO CÁLIDO PARA EL HÁBITAT POPULAR by Viegas, Graciela Melisa, Esparza, Jesica B., San Juan, Gustavo Alberto

“…RESUMEN El acceso a la vivienda en los sectores sociales de bajos ingresos plantea la necesidad de una reflexión relevante para América Latina. En este…”
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Tissue‐specific expression and post‐transcriptional regulation of the ATPase inhibitory factor 1 (IF1) in human and mouse tissues by Esparza-Moltó, Pau B., Nuevo-Taρioles, Cristina, Chamorro, Margarita, Nájera, Laura, Torresano, Laura, Santacatterina, Fulvio, Cuezva, José M.

“…ABSTRACT The ATPase inhibitory factor 1 (IF1) is an intrinsically disordered protein that regulates the activity of the mitochondrial ATP synthase…”
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Thermal Spray Deposition, Phase Stability and Mechanical Properties of La2Zr2O7/LaAlO3 Coatings by Lozano-Mandujano, D., Poblano-Salas, C. A., Ruiz-Luna, H., Esparza-Esparza, B., Giraldo-Betancur, A. L., Alvarado-Orozco, J. M., Trápaga-Martínez, L. G., Muñoz-Saldaña, J.

“…This paper deals with the deposition of La 2 Zr 2 O 7 (LZO) and LaAlO 3 (LAO) mixtures by air plasma spray (APS). The raw material for thermal spray, single…”
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ATPase Inhibitory Factor 1 (IF1): A main driver of metabolic reprogramming and nuclear signaling in cancer by Cuezva, José M., Formentini, Laura, Santacatterina, Fulvio, Soldevilla, Beatriz, Nuevo-Tapioles, Cristina, Esparza, Pau B., González, Lucía

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A Generalized Townsend's Theory for Paschen Curves in Planar, Cylindrical, and Spherical Geometries in Planetary Atmospheres by Riousset, Jeremy A., Méndez Harper, Joshua S., Dufek, Josef, Nelson, Jared P., Esparza, Annelisa B.

“…In this work, we focus on plasma discharges produced between two electrodes with a high potential difference, resulting in the ionization of the neutral…”
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Neutrophil function in elderly persons assessed by flow cytometry by Esparza, B, Sanchez, H, Ruiz, M, Barranquero, M, Sabino, E, Merino, F

“…It is well known that the immune response declines with senescence and it is suggested that these changes render an individual susceptible to infection,…”
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Different mitochondrial genetic defects exhibit the same protein signature of metabolism in skeletal muscle of PEO and MELAS patients: A role for oxidative stress by Santacatterina, Fulvio, Torresano, Laura, Núñez-Salgado, Alfonso, Esparza-Molto, Pau B., Olive, Montse, Gallardo, Eduard, García-Arumi, Elena, Blazquez, Alberto, González-Quintana, Adrián, Martín, Miguel A., Cuezva, José M.

“…A major challenge in mitochondrial diseases (MDs) is the identification of biomarkers that could inform of the mechanisms involved in the phenotypic expression…”
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DETAILED ANALYSIS OF URBAN-ENVIRONMENTAL ASPECTS IN AN URBAN LIFE QUALITY MODEL by ESPARZA, Jesica B., DICROCE, Luciano, MARTINI, Irene, DISCOLI, Carlos A.

“…The problems in both urban and environment are those that originate from the increase of urban growth and are the result of the deterioration of environmental…”
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Chediak-Higashi syndrome natural killer cells: a protein kinase C defective activation/regulation defect? by Merino, F, Esparza, B, Sabino, E

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T Cell Receptor V-Segment Frequencies in Peripheral CD8+ T Cells in Aging by Esparza, B., Rodriguez, A., Puente, M., Sabino, E., Merino, F.

“…Infections are a major cause of illness and death amongst elderly people. Peripheral blood CD8+ T lymphocytes -which play a crucial role in host defence…”
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