Search Results - "ESCHE, Clemens"

Exon 15 BRAF Mutations Are Uncommon in Melanomas Arising in Nonsun-Exposed Sites by COHEN, Yoram, ROSENBAUM, Eli, BEGUM, Shahnaz, GOLDENBERG, David, ESCHE, Clemens, LAVIE, Ofer, SIDRANSKY, David, WESTRA, William H

“…Purpose: An activating point mutation of the BRAF oncogene has been identified in a high proportion of cutaneous nevi and cutaneous melanomas, but its…”
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Keratinocytes in atopic dermatitis: inflammatory signals by Esche, Clemens, de Benedetto, Anna, Beck, Lisa A

“…Atopic dermatitis (AD) is a chronic inflammatory skin disorder that usually predates the development of allergic airway disease. In most cases, this is thought…”
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Cytokine knockouts in contact hypersensitivity research by Wang, Binghe, Esche, Clemens, Mamelak, Adam, Freed, Irwin, Watanabe, Hideaki, Sauder, Daniel N

“…Contact hypersensitivity (CHS) is a Langerhans cell (LC)-dependent, T cell-mediated cutaneous immune response. CHS reflects a culmination of LC activities in…”
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Effect of Vascular Endothelial Growth Factor and FLT3 Ligand on Dendritic Cell Generation In Vivo by Ohm, Joyce E, Shurin, Michael R, Esche, Clemens, Lotze, Michael T, Carbone, David P, Gabrilovich, Dmitry I

“…The cytokine FLT3 ligand (FL) enhances dendritic cell (DC) generation and has therefore been proposed as a means to boost antitumor immunity. Vascular…”
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Tumor's other immune targets: dendritic cells by Esche, Clemens, Lokshin, Anna, Shurin, Galina V., Gastman, Brian R., Rabinowich, Hannah, Watkins, Simon C., Lotze, Michael T., Shurin, Michael R.

“…The induction of apoptosis in T cells is one of several mechanisms by which tumors escape immune recognition. We have investigated whether tumors induce…”
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FLT3-Ligand Administration Inhibits Liver Metastases: Role of NK Cells by Peron, Jean-Marie, Esche, Clemens, Subbotin, Vladimir M, Maliszewski, Charles, Lotze, Michael T, Shurin, Michael R

“…FLT3-ligand (FL) is a recently described cytokine that stimulates the proliferation and differentiation of hematopoietic progenitors both in vivo and in vitro…”
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Identification of delta- and mu-type opioid receptors on human and murine dendritic cells by Makarenkova, Valeria P, Esche, Clemens, Kost, Natalia V, Shurin, Galina V, Rabin, Bruce S, Zozulya, Andrey A, Shurin, Michael R

“…The purpose of this study was to evaluate μ- and δ-opioid receptors (OR) on human and murine dendritic cells (DC). Expression of μ- and δ-OR mRNA on DC was…”
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Tumor Necrosis Factor-α-promoted Expression of Bcl-2 and Inhibition of Mitochondrial Cytochrome c Release Mediate Resistance of Mature Dendritic Cells to Melanoma-induced Apoptosis by ESCHE, Clemens, SHURIN, Galina V, KIRKWOOD, John M, WANG, Gui-Qiang, RABINOWICH, Hannah, PIRTSKHALAISHVILI, Georgi, SHURIN, Michael R

“…Melanoma escapes host defenses through a variety of means, including the elimination of immune effector cells within the tumor microenvironment. We have…”
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Regulation of dendritic cell expansion in aged athymic nude mice by FLT3 ligand by Shurin, Galina V, Chatta, Gurkamal S, Tourkova, Irina L, Zorina, Tatiana D, Esche, Clemens, Shurin, Michael R

“…This report describes age-related alterations of dendritic cells (DC) distribution in nude athymic mice in vivo and reversal of certain age-dependent defects…”
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Chemokines: Key Players in Innate and Adaptive Immunity by Esche, Clemens, Stellato, Cristiana, Beck, Lisa A.

“…Healthy individuals initiate an immediate immune response to microbes by using a set of germline-encoded receptors that recognize common molecular patterns…”
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Interleukin-12 and Flt3 ligand differentially promote dendropoiesisin vivo by Esche, Clemens, Cai, Quan, Peron, Jean-Marie, Hunter, Oriana, Subbotin, Vladimir M., Lotze, Michael T., Shurin, Michael R.

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FLT3 ligand administration inhibits tumor growth in murine melanoma and lymphoma by ESCHE, C, SUBBOTIN, V. M, MALISZEWSKI, C, LOTZE, M. T, SHURIN, M. R

“…Successful treatment of melanoma and lymphoma may result from the induction of specific antitumor immunity. Dendritic cells (DCs) are powerful…”
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FLT3: Receptor and Ligand. Biology and Potential Clinical Application by Shurin, Michael R, Esche, Clemens, Lotze, Michael T

“…Flt3 ligand (FL) is a recently identified cytokine having a central role in the proliferation, survival and differentiation of early murine and human…”
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Anti-vascular endothelial growth factor receptor-2 (Flk-1/KDR) antibody suppresses contact hypersensitivity by Watanabe, Hideaki, Mamelak, Adam J., Wang, Binghe, Howell, Brandon G., Freed, Irwin, Esche, Clemens, Nakayama, Masashi, Nagasaki, Go, Hicklin, Daniel J., Kerbel, Robert S., Sauder, Daniel N.

“…:  The angiogenic mediator vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) have been studied extensively in neoplastic disease and some…”
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Human prostate cancer regulates generation and maturation of monocyte-derived dendritic cells by Aalamian, Maryam, Pirtskhalaishvili, Georgi, Nunez, Anthony, Esche, Clemens, Shurin, Galina V., Huland, Edith, Huland, Hartwig, Shurin, Michael R.

“…Background The progression of prostate cancer is accompanied by a marked suppression of the immune system, including the apoptotic death of dendritic cells…”
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CD154 inhibits tumor‐induced apoptosis in dendritic cells and tumor growth by Esche, Clemens, Gambotto, Andrea, Satoh, Yuji, Gerein, Valentin, Robbins, Paul D., Watkins, Simon C., Lotze, Michael T., Shurin, Michael R.

“…We have recently demonstrated that murine and human tumors induce apoptosis of dendritic cells (DC). Here, we evaluated the effect of CD40 ligation on the…”
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Local administration of IL-12-transfected dendritic cells induces antitumor immune responses to colon adenocarcinoma in the liver in mice by Satoh, Yuji, Esche, Clemens, Gambotto, Andrea, Shurin, Galina V, Yurkovetsky, Zoya R, Robbins, Paul D, Watkins, Simon C, Todo, Satoru, Herberman, Ronald B, Lotze, Michael T, Shurin, Michael R

“…Colorectal cancer is one of the most common fatal malignancies in the United States, with an incidence second only to lung cancer. The liver is the most common…”
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Is the mismatch repair deficient type of Muir-Torre syndrome confined to mutations in the hMSH2 gene? by Kruse, R, Lamberti, C, Wang, Y, Ruelfs, C, Bruns, A, Esche, C, Lehmann, P, Ruzicka, T, Rütten, A, Friedl, W, Propping, P

“…The Muir-Torre syndrome (MTS) is a rare autosomal-dominant condition characterized by the occurrence of sebaceous skin lesions and internal tumours in a…”
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Interleukin‐12 and Flt3 ligand differentially promote dendropoiesis in vivo by Esche, Clemens, Cai, Quan, Peron, Jean‐Marie, Hunter, Oriana, Subbotin, Vladimir M., Lotze, Michael T., Shurin, Michael R.

“…Interleukin‐12 (IL‐12) and Flt3 ligand (FL) regulate hematopoiesis by stimulating proliferation, differentiation and migration of progenitor and/or stem cells…”
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Differential Regulation of Epidermal and Dermal Dendritic Cells by IL-12 and Flt3 Ligand by Esche, Clemens, Subbotin, Vladimir M., Hunter, Oriana, Peron, Jean-Marie, Maliszewski, Charles, Lotze, Michael T., Shurin, Michael R.

“…An abrogation of the decline in epidermal Langerhans cell numbers above melanoma might significantly improve the efficacy of immunotherapy for melanoma…”
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