Search Results - "ESBRIT, Pedro"

Current perspectives on parathyroid hormone (PTH) and PTH-related protein (PTHrP) as bone anabolic therapies by Esbrit, Pedro, Alcaraz, María José

“…[Display omitted] Osteoporosis is characterized by low bone mineral density and/or poor bone microarchitecture leading to an increased risk of fractures. The…”
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Mesoporous Bioglasses Enriched with Bioactive Agents for Bone Repair, with a Special Highlight of María Vallet-Regí's Contribution by Salinas, Antonio J, Esbrit, Pedro

“…Throughout her impressive scientific career, Prof. María Vallet-Regí opened various research lines aimed at designing new bioceramics, including mesoporous…”
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Role of the Parathyroid Hormone Type 1 Receptor (PTH1R) as a Mechanosensor in Osteocyte Survival by Maycas, Marta, Ardura, Juan A, de Castro, Luis F, Bravo, Beatriz, Gortázar, Arancha R, Esbrit, Pedro

“…Osteocytes have a major role in the control of bone remodeling. Mechanical stimulation decreases osteocyte apoptosis and promotes bone accrual, whereas…”
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Presence of a functional receptor for GLP-1 in osteoblastic cells, independent of the cAMP-linked GLP-1 receptor by Nuche-Berenguer, Bernardo, Portal-Núñez, Sergio, Moreno, Paola, González, Nieves, Acitores, Alicia, López-Herradón, Ana, Esbrit, Pedro, Valverde, Isabel, Villanueva-Peñacarrillo, María L.

“…Glucagon‐like peptide 1 (GLP‐1) controls glucose metabolism in extrapancreatic tissues through receptors other than the pancreatic cAMP‐linked GLP‐1 receptor;…”
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Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function by Bartolomé, Alberto, López-Herradón, Ana, Portal-Núñez, Sergio, García-Aguilar, Ana, Esbrit, Pedro, Benito, Manuel, Guillén, Carlos

“…Autophagy is a highly regulated homoeostatic process involved in the lysosomal degradation of damaged cell organelles and proteins. This process is considered…”
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GLP-1 and exendin-4 can reverse hyperlipidic-related osteopenia by Nuche-Berenguer, Bernardo, Lozano, Daniel, Gutiérrez-Rojas, Irene, Moreno, Paola, Mariñoso, María L, Esbrit, Pedro, Villanueva-Peñacarrillo, María L

“…Increased fat mass contributes to bone deterioration. Glucagon-like peptide 1 (GLP-1) and its related peptide exendin 1–39 amide (Ex-4), two lipid-lowering…”
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Effect of GLP-1 Treatment on Bone Turnover in Normal, Type 2 Diabetic, and Insulin-Resistant States by Nuche-Berenguer, Bernardo, Moreno, Paola, Esbrit, Pedro, Dapía, Sonia, Caeiro, José R., Cancelas, Jesús, Haro-Mora, Juan J., Villanueva-Peñacarrillo, María L.

“…It has been suggested that hormones released after nutrient absorption, such as glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide 2…”
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Comparison of the skeletal effects induced by daily administration of PTHrP (1-36) and PTHrP (107-139) to ovariectomized mice by de Castro, Luis Fernández, Lozano, Daniel, Portal-Núñez, Sergio, Maycas, Marta, De la Fuente, Mónica, Caeiro, José R., Esbrit, Pedro

“…We here compared the changes induced by subcutaneous injection of PTHrP (1–36) or PTHrP (107–139) (80 µg/kg/day, 5 days/week for 4 or 8 weeks) in bone…”
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Exendin-4 exerts osteogenic actions in insulin-resistant and type 2 diabetic states by Nuche-Berenguer, Bernardo, Moreno, Paola, Portal-Nuñez, Sergio, Dapía, Sonia, Esbrit, Pedro, Villanueva-Peñacarrillo, María L.

“…Poor control of glucose homeostasis accounts for diabetes-related bone loss. Incretins – GLP-1 and GIP – have been proposed to affect bone turnover. GLP-1,…”
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Parathyroid hormone-related protein protects renal tubuloepithelial cells from apoptosis by activating transcription factor Runx2 by Ardura, Juan A, Sanz, Ana B, Ortiz, Alberto, Esbrit, Pedro

“…Runx2 is a key transcription factor in bone development regulating several processes, including osteoblast apoptosis. The antiapoptotic effects of parathyroid…”
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High glucose alters the secretome of mechanically stimulated osteocyte‐like cells affecting osteoclast precursor recruitment and differentiation by Maycas, Marta, Portolés, María Teresa, Matesanz, María Concepción, Buendía, Irene, Linares, Javier, Feito, María José, Arcos, Daniel, Vallet‐Regí, María, Plotkin, Lilian I., Esbrit, Pedro, Gortázar, Arancha R.

“…Diabetes mellitus (DM) induces bone deterioration, while mechanical stimulation promotes osteocyte‐driven bone formation. We aimed to evaluate the interaction…”
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Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation by Lozano, Daniel, Manzano, Miguel, Doadrio, Juan Carlos, Salinas, Antonio J., Vallet-Regí, María, Gómez-Barrena, Enrique, Esbrit, Pedro

“…Parathyroid hormone-related protein (PTHrP) is an important regulator of bone remodeling. Recent studies show that this protein can induce osteogenic features…”
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Recombinant Proteins-Based Strategies in Bone Tissue Engineering by Paulini, Marina, Camal Ruggieri, Iván Nadir, Ramallo, Melina, Alonso, Matilde, Rodriguez-Cabello, José Carlos, Esbrit, Pedro, Mardegan Issa, João Paulo, Feldman, Sara

“…The increase in fracture rates and/or problems associated with missing bones due to accidents or various pathologies generates socio-health problems with a…”
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Osteogenic Effect of ZnO-Mesoporous Glasses Loaded with Osteostatin by Pérez, Rebeca, Sanchez-Salcedo, Sandra, Lozano, Daniel, Heras, Clara, Esbrit, Pedro, Vallet-Regí, María, Salinas, Antonio J

“…Mesoporous Bioactive Glasses (MBGs) are a family of bioceramics widely investigated for their putative clinical use as scaffolds for bone regeneration. Their…”
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Molecular evidence of field cancerization initiated by diabetes in colon cancer patients by Del Puerto‐Nevado, Laura, Minguez, Pablo, Corton, Marta, Solanes‐Casado, Sonia, Prieto, Isabel, Mas, Sebastian, Sanz, Ana Belen, Gonzalez‐Alonso, Paula, Villaverde, Cristina, Portal‐Nuñez, Sergio, Aguilera, Oscar, Gomez‐Guerrero, Carmen, Esbrit, Pedro, Vivanco, Fernando, Gonzalez, Nieves, Ayuso, Carmen, Ortiz, Alberto, Rojo, Federico, Egido, Jesus, Alvarez‐Llamas, Gloria, Garcia‐Foncillas, Jesus

“…The potential involvement of type 2 diabetes mellitus (T2DM) as a risk factor for colon cancer (CC) has been previously reported. While several clinical…”
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Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice by Rodríguez-de la Rosa, Lourdes, López-Herradón, Ana, Portal-Núñez, Sergio, Murillo-Cuesta, Silvia, Lozano, Daniel, Cediel, Rafael, Varela-Nieto, Isabel, Esbrit, Pedro

“…Insulin-like growth factor-I (IGF-I) deficiency causes growth delay, and IGF-I has been shown to partially mediate bone anabolism by parathyroid hormone (PTH)…”
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Parathyroid Hormone-Related Protein Promotes Epithelial-Mesenchymal Transition by ARDURA, Juan Antonio, RAYEGO-MATEOS, Sandra, RAMILA, David, RUIZ-ORTEGA, Marta, ESBRIT, Pedro

“…Epithelial-mesenchymal transition (EMT) is an important process that contributes to renal fibrogenesis. TGF-beta1 and EGF stimulate EMT. Recent studies…”
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Colon cancer modulation by a diabetic environment: A single institutional experience by Prieto, Isabel, Del Puerto-Nevado, Laura, Gonzalez, Nieves, Portal-Nuñez, Sergio, Zazo, Sandra, Corton, Marta, Minguez, Pablo, Gomez-Guerrero, Carmen, Arce, Jose Miguel, Sanz, Ana Belen, Mas, Sebastian, Aguilera, Oscar, Alvarez-Llamas, Gloria, Esbrit, Pedro, Ortiz, Alberto, Ayuso, Carmen, Egido, Jesus, Rojo, Federico, Garcia-Foncillas, Jesus

“…Multiple observational studies suggest an increased risk of colon cancer in patients with diabetes mellitus (DM). This can theoretically be the result of an…”
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Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2 by Alonso, Verónica, de Gortázar, Arancha R., Ardura, Juan A., Andrade-Zapata, Irene, Alvarez-Arroyo, M. Victoria, Esbrit, Pedro

“…Parathyroid hormone‐related protein (PTHrP) (107–139), in contrast to the N‐terminal fragment PTHrP (1–36), has been shown to interact with the vascular…”
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Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic acid-induced nephrotoxicity by ORTEGA, Arantxa, RAMILA, David, ARDURA, Juan Antonio, ESTEBAN, Vanesa, RUIZ-ORTEGA, Marta, BARAT, Antonio, GAZAPO, Rosa, BOSCH, Ricardo J, ESBRIT, Pedro

“…Parathyroid hormone-related protein (PTHrP) is shortly upregulated in acute renal injury, but its pathophysiologic role is unclear. Investigated was whether…”
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