Search Results - "ERTL, Linda S"

C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN by HONG XIAO, DAIRAGHI, Daniel J, BAO LU, GERARD, Norma P, GERARD, Craig, SCHALL, Thomas J, JAEN, Juan C, FALK, Ronald J, JENNETTE, J. Charles, POWERS, Jay P, ERTL, Linda S, BAUMGART, Trageen, YU WANG, SEITZ, Lisa C, PENFOLD, Mark E. T, LIN GAN, PEIQI HU

“…Necrotizing and crescentic GN (NCGN) with a paucity of glomerular immunoglobulin deposits is associated with ANCA. The most common ANCA target antigens are…”
Get full text

CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity by Sullivan, Kathleen M C, Vilalta, Marta, Ertl, Linda S, Wang, Yu, Dunlap, Carolyn, Ebsworth, Karen, Zhao, Bin N, Li, Shijie, Zeng, Yibin, Miao, Zhenhua, Fan, Pingchen, Mali, Venkat, Lange, Christopher, McMurtrie, Darren, Yang, Ju, Lui, Rebecca, Scamp, Ryan, Chhina, Vicky, Kumamoto, Alice, Yau, Simon, Dang, Ton, Easterday, Ashton, Liu, Shirley, Miao, Shichang, Charo, Israel, Schall, Thomas J, Zhang, Penglie

“…The interaction of PD-L1 with PD-1 is a major immune checkpoint that limits effector T cell function against cancer cells; monoclonal antibodies that block…”
Get full text

CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice by Sullivan, Timothy, Miao, Zhenhua, Dairaghi, Daniel J, Krasinski, Antoni, Wang, Yu, Zhao, Bin N, Baumgart, Trageen, Ertl, Linda S, Pennell, Andrew, Seitz, Lisa, Powers, Jay, Zhao, Ruiping, Ungashe, Solomon, Wei, Zheng, Boring, Landin, Tsou, Chia-Lin, Charo, Israel, Berahovich, Robert D, Schall, Thomas J, Jaen, Juan C

“…Chemokine (C-C motif) receptor 2 (CCR2) is central for the migration of monocytes into inflamed tissues. The novel CCR2 antagonist CCX140-B, which is currently…”
Get more information

Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease by Walters, Matthew J, Wang, Yu, Lai, Nu, Baumgart, Trageen, Zhao, Bin N, Dairaghi, Daniel J, Bekker, Pirow, Ertl, Linda S, Penfold, Mark E T, Jaen, Juan C, Keshav, Satish, Wendt, Emily, Pennell, Andrew, Ungashe, Solomon, Wei, Zheng, Wright, J J Kim, Schall, Thomas J

“…The chemokine system represents a diverse group of G protein-coupled receptors responsible for orchestrating cell recruitment under both homeostatic and…”
Get more information

CCR2 antagonism leads to marked reduction in proteinuria and glomerular injury in murine models of focal segmental glomerulosclerosis (FSGS) by Miao, Zhenhua, Ertl, Linda S, Newland, Dale, Zhao, Bin, Wang, Yu, Zang, Xiaoping, Campbell, James J, Liu, Xiaoli, Dang, Ton, Miao, Shichang, Krasinski, Antoni, Punna, Sreenivas, Zeng, Yibin, McMahon, Jeffrey, Zhang, Penglie, Charo, Israel F, Schall, Thomas J, Singh, Rajinder

“…Focal segmental glomerulosclerosis (FSGS) comprises a group of uncommon disorders that present with marked proteinuria, nephrotic syndrome, progressive renal…”
Get full text

Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes by Sullivan, Timothy J, Miao, Zhenhua, Zhao, Bin N, Ertl, Linda S, Wang, Yu, Krasinski, Antoni, Walters, Matthew J, Powers, Jay P, Dairaghi, Daniel J, Baumgart, Trageen, Seitz, Lisa C, Berahovich, Robert D, Schall, Thomas J, Jaen, Juan C

“…Abstract Objective CCR2 inhibition has produced promising experimental and clinical anti-hyperglycemic effects. These results support the thesis that insulin…”
Get full text

CCR9 Antagonists in the Treatment of Ulcerative Colitis by Sullivan, Timothy J., Jaen, Juan C., Schall, Thomas J., Powers, Jay P., Punna, Sreenivas, Charvat, Trevor T., Ertl, Linda S., Berahovich, Robert D., Walters, Matthew J., Ebsworth, Karen, Bekker, Pirow, Campbell, James J.

“…While it has long been established that the chemokine receptor CCR9 and its ligand CCL25 are essential for the movement of leukocytes into the small intestine…”
Get full text

Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells by Demir, Ihsan Ekin, Kujundzic, Kristina, Pfitzinger, Paulo L., Saricaoglu, Ömer Cemil, Teller, Steffen, Kehl, Timo, Reyes, Carmen Mota, Ertl, Linda S., Miao, Zhenhua, Schall, Thomas J., Tieftrunk, Elke, Haller, Bernhard, Diakopoulos, Kalliope Nina, Kurkowski, Magdalena U., Lesina, Marina, Krüger, Achim, Algül, Hana, Friess, Helmut, Ceyhan, Güralp O.

“…Pancreatic ductal adenocarcinoma (PDAC) cells (PCC) have an exceptional propensity to metastasize early into intratumoral, chemokine-secreting nerves. However,…”
Get full text

CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood by Zhao, Bin N, Campbell, James J, Salanga, Catherina L, Ertl, Linda S, Wang, Yu, Yau, Simon, Dang, Ton, Zeng, Yibin, McMahon, Jeffrey P, Krasinski, Antoni, Zhang, Penglie, Kufareva, Irina, Handel, Tracy M, Charo, Israel F, Singh, Rajinder, Schall, Thomas J

“…C-C chemokine receptor 2 (CCR2) is a key driver of monocyte/macrophage trafficking to sites of inflammation and has long been considered a target for…”
Get full text

IL-17-Secreting γδ T Cells Are Completely Dependent upon CCR6 for Homing to Inflamed Skin by Campbell, James J, Ebsworth, Karen, Ertl, Linda S, McMahon, Jeffrey P, Newland, Dale, Wang, Yu, Liu, Shirley, Miao, Zhenhua, Dang, Ton, Zhang, Penglie, Charo, Israel F, Singh, Rajinder, Schall, Thomas J

“…mAbs that neutralize IL-17 or its receptor have proven efficacious in treating moderate-to-severe psoriasis, confirming IL-17 as an important driver of this…”
Get full text

Efficacy of Chemokine Receptor Inhibition in Treating IL-36α-Induced Psoriasiform Inflammation by Campbell, James J, Ebsworth, Karen, Ertl, Linda S, McMahon, Jeffrey P, Wang, Yu, Yau, Simon, Mali, Venkat R, Chhina, Vicky, Kumamoto, Alice, Liu, Shirley, Dang, Ton, Newland, Dale, Charo, Israel F, Zhang, Penglie, Schall, Thomas J, Singh, Rajinder

“…Several types of psoriasiform dermatitis are associated with increased IL-36 cytokine activity in the skin. A rare, but severe, psoriasis-like disorder,…”
Get full text

Antagonists of chemokine receptor CCR9 synergize with anti-TNFα immunotherapy to reduce inflammation in the MDR1a−/− mouse model of colitis by Campbell, James J, Ertl, Linda S, Ebsworth, Karen J, McMahon, Jeffrey P, Zhang, Penglie J, Chhina, Vicky J, Charo, Israel F, Schall, Thomas J

“…Abstract The development of anti-TNFα immunotherapies has led to great advances in quality of life for Crohn’s and colitis patients, and has allowed a…”
Get full text

P0336INHIBITION C-C CHEMOKINE RECEPTOR TYPE 2 (CCR2) ON ACTIVATED KIDNEY PARIETAL EPITHELIAL CELLS REVEALS A NEW THERAPEUTIC APPROACH FOR CHRONIC KIDNEY DISEASES by Zhao, Bin, Miao, Zhenhua, Campbell, James, Ertl, Linda S, Wang, Yu, Li, Chris, Singh, Rajinder, Charo, Israel F, Schall, Thomas J

“…Abstract Background and Aims We have recently demonstrated that small molecule inhibitors of CCR2 rapidly reduced proteinuria and preserved renal structure in…”
Get full text

Abstract 1274: CCX559 is a potent orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity by Li, Chris, Vilalta, Marta, Ertl, Linda S., Wang, Yu, Zeng, Yibin, Fan, Pingchen, Lange, Christopher, McMurtrie, Darren, Yang, Ju, Lui, Rebecca, Scamp, Ryan, Chhina, Vicky, Kumamoto, Alice, Ong, Ryan, Dang, Ton, Easterday, Ashton, Zhao, Niky, Liu, Shirley, Singh, Rajinder, Charo, Israel, Sullivan, Kathleen, Schall, Thomas J., Zhang, Penglie

“…Abstract Introduction: Cancer cells can escape tumor-specific T cell responses via engagement of inhibitory immune checkpoints. PD-L1/PD-1 interaction is one…”
Get full text

P0973ALLOSTERIC C-C CHEMOKINE RECEPTOR TYPE 2 (CCR2) INHIBITION IMPROVES RENAL FUNCTION IN A MURINE MODEL OF DIABETIC NEPHROPATHY by Miao, Zhenhua, Ertl, Linda S, Zhao, Bin, Wang, Yu, Newland, Dale, Zeng, Yibin, McMahon, Jeffrey, Liu, Xiaoli, Dang, Ton, Miao, Shichang, Zhang, Penglie, Li, Chris, Campbell, James, Singh, Rajinder, Charo, Israel F, Schall, Thomas J

“…Abstract Background and Aims Diabetic nephropathy (DN) is a syndrome characterized by pathological levels of proteinuria, glomerular lesions and reduction in…”
Get full text

IL36-Mediated Skin Inflammation Requires Signaling Through Chemokine Receptor CCR6 by Campbell, James J., Ebsworth, Karen, Ertl, Linda S., McMahon, Jeffrey P., Yau, Simon, Wang, Yu, Liu, Shirley, Dang, Ton, Zhang, Penglie, Schall, Thomas J., Singh, Rajinder

“…Abstract Generalized pustular psoriasis (GPP) is a rare inflammatory skin disorder with an etiology distinct from common plaque psoriasis. GPP patients often…”
Get full text

Abstract 5693: Anti-tumor effect of orally available small molecule PD-L1 inhibitors in a murine model of colon adenocarcinoma by Li, Shijie "Chris", Vilalta, Marta, Ertl, Linda S., Wang, Yu, Zeng, Yibin, Fan, Pingchen, Lange, Christopher, McMurtrie, Darren, Yang, Ju, Lui, Rebecca, Ong, Ryan, Chhina, Vicky, Kumamoto, Alice, Yau, Simon, Dang, Ton, Easterday, Ashton, Liu, Shirley, Singh, Rajinder, Charo, Israel, Schall, Thomas J., Zhang, Penglie

“…Abstract Introduction: Antibody-based therapies targeting the Programmed cell Death-1/ Programmed Death-Ligand 1 (PD-1/PD-L1) immune checkpoint axis have…”
Get full text

The effect of the CXCR7 inhibitor CCX662 on survival in the ENU rat model of glioblastoma by Ebsworth, Karen, Walters, Matthew J., Ertl, Linda S, Wang, Yu, Zhang, Penglie, Powers, Jay P, Sullivan, Timothy J., Jaen, Juan C., Brown, Martin, Schall, Thomas J.

“…Abstract only e13580 Background: Glioblastoma (GBM) is the most common form of malignant brain cancer. Despite aggressive therapy, consisting of radiotherapy,…”
Get full text