Search Results - "ERNST, Robert K"

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock by Hagar, Jon A., Powell, Daniel A., Aachoui, Youssef, Ernst, Robert K., Miao, Edward A.

“…Inflammatory caspases, such as caspase-1 and -11, mediate innate immune detection of pathogens. Caspase-11 induces pyroptosis, a form of programmed cell death,…”
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Structural basis of MsbA-mediated lipopolysaccharide transport by Mi, Wei, Li, Yanyan, Yoon, Sung Hwan, Ernst, Robert K., Walz, Thomas, Liao, Maofu

“…Lipopolysaccharide (LPS) in the outer membrane of Gram-negative bacteria is critical for the assembly of their cell envelopes. LPS synthesized in the…”
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Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens by Knodler, Leigh A., Crowley, Shauna M., Sham, Ho Pan, Yang, Hyungjun, Wrande, Marie, Ma, Caixia, Ernst, Robert K., Steele-Mortimer, Olivia, Celli, Jean, Vallance, Bruce A.

“…Inflammasome-mediated host defenses have been extensively studied in innate immune cells. Whether inflammasomes function for innate defense in intestinal…”
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Analysis of Pseudomonas aeruginosa biofilm membrane vesicles supports multiple mechanisms of biogenesis by Cooke, Adam C, Nello, Alexander V, Ernst, Robert K, Schertzer, Jeffrey W

“…Outer Membrane Vesicles (OMVs) are ubiquitous in bacterial environments and enable interactions within and between species. OMVs are observed in lab-grown and…”
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Colistin-Resistant Acinetobacter baumannii: Beyond Carbapenem Resistance by Qureshi, Zubair A., Hittle, Lauren E., O'Hara, Jessica A., Rivera, Jesabel I., Syed, Alveena, Shields, Ryan K., Pasculle, Anthony W., Ernst, Robert K., Doi, Yohei

“…Background. With an increase in the use of colistin methansulfonate (CMS) to treat carbapenem-resistant Acinetobacter baumannii infections, colistin resistance…”
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Guanylate binding proteins promote caspase-11–dependent pyroptosis in response to cytoplasmic LPS by Pilla, Danielle M., Hagar, Jon A., Haldar, Arun K., Mason, Ashley K., Degrandi, Daniel, Pfeffer, Klaus, Ernst, Robert K., Yamamoto, Masahiro, Miao, Edward A., Coers, Jörn

“…IFN receptor signaling induces cell-autonomous immunity to infections with intracellular bacterial pathogens. Here, we demonstrate that IFN-inducible guanylate…”
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Probing the sRNA regulatory landscape of P. aeruginosa: post‐transcriptional control of determinants of pathogenicity and antibiotic susceptibility by Zhang, Yi‐Fan, Han, Kook, Chandler, Courtney E., Tjaden, Brian, Ernst, Robert K., Lory, Stephen

“…Summary During environmental adaptation bacteria use small regulatory RNAs (sRNAs) to repress or activate expression of a large fraction of their proteome. We…”
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The TLR4 antagonist Eritoran protects mice from lethal influenza infection by Shirey, Kari Ann, Lai, Wendy, Scott, Alison J., Lipsky, Michael, Mistry, Pragnesh, Pletneva, Lioubov M., Karp, Christopher L., McAlees, Jaclyn, Gioannini, Theresa L., Weiss, Jerrold, Chen, Wilbur H., Ernst, Robert K., Rossignol, Daniel P., Gusovsky, Fabian, Blanco, Jorge C. G., Vogel, Stefanie N.

“…TLR4 stimulation is known to contribute to acute lung injury after administration of inactivated influenza virus; here, the synthetic TLR4 antagonist Eritoran…”
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Lipid A structural modifications in extreme conditions and identification of unique modifying enzymes to define the Toll-like receptor 4 structure-activity relationship by Scott, Alison J., Oyler, Benjamin L., Goodlett, David R., Ernst, Robert K.

“…Strategies utilizing Toll-like receptor 4 (TLR4) agonists for treatment of cancer, infectious diseases, and other targets report promising results. Potent TLR4…”
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Unique Structural Modifications Are Present in the Lipopolysaccharide from Colistin-Resistant Strains of Acinetobacter baumannii by PELLETIER, Mark R, CASELLA, Leila G, JONES, Jace W, ADAMS, Mark D, ZURAWSKI, Daniel V, HAZLETT, Karsten R. O, DOI, Yohei, ERNST, Robert K

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Identification of the ESKAPE pathogens by mass spectrometric analysis of microbial membrane glycolipids by Leung, Lisa M., Fondrie, William E., Doi, Yohei, Johnson, J. Kristie, Strickland, Dudley K., Ernst, Robert K., Goodlett, David R.

“…Rapid diagnostics that enable identification of infectious agents improve patient outcomes, antimicrobial stewardship, and length of hospital stay. Current…”
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Rapid microbial identification and colistin resistance detection via MALDI-TOF MS using a novel on-target extraction of membrane lipids by Sorensen, Matthew, Chandler, Courtney E., Gardner, Francesca M., Ramadan, Salma, Khot, Prasanna D., Leung, Lisa M., Farrance, Christine E., Goodlett, David R., Ernst, Robert K., Nilsson, Erik

“…Rapid infection diagnosis is critical to improving patient treatment and outcome. Recent studies have shown microbial lipids to be sensitive and selective…”
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A pH-sensitive motif in an outer membrane protein activates bacterial membrane vesicle production by Dehinwal, Ruchika, Gopinath, Tata, Smith, Richard D., Ernst, Robert K., Schifferli, Dieter M., Waldor, Matthew K., Marassi, Francesca M.

“…Outer membrane vesicles (OMVs) produced by Gram-negative bacteria have key roles in cell envelope homeostasis, secretion, interbacterial communication, and…”
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Characterization of the AggR Regulon in Enteroaggregative Escherichia coli by Morin, Nicholas, Santiago, Araceli E, Ernst, Robert K, Guillot, Stacey J, Nataro, James P

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pseudomonas aeruginosa activates caspase 1 through Ipaf by Miao, Edward A, Ernst, Robert K, Dors, Monica, Mao, Dat P, Aderem, Alan

“…The innate immune system encodes cytosolic Nod-like receptors (NLRs), several of which activate caspase 1 processing and IL-1β and IL-18 secretion. Macrophages…”
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Antimicrobial peptide activity is anticorrelated with lipid a leaflet affinity by Nelson, Nathaniel, Opene, Belita, Ernst, Robert K, Schwartz, Daniel K

“…The activity of antimicrobial peptides (AMPs) has significant bacterial species bias, the mechanisms of which are not fully understood. We employed…”
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Bacterial lipids: powerful modifiers of the innate immune response by Chandler, Courtney E, Ernst, Robert K

“…The innate immune system serves as a first line of defense against microbial pathogens. The host innate immune response can be triggered by recognition of…”
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Remodeling of Lipid A in Pseudomonas syringae pv. phaseolicola In Vitro by Gerster, Tim, Wröbel, Michelle, Hofstaedter, Casey E, Schwudke, Dominik, Ernst, Robert K, Ranf, Stefanie, Gisch, Nicolas

“…species infect a variety of organisms, including mammals and plants. Mammalian pathogens of the Pseudomonas family modify their lipid A during host entry to…”
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Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery by Gregg, Kelsey A, Harberts, Erin, Gardner, Francesca M, Pelletier, Mark R, Cayatte, Corinne, Yu, Li, McCarthy, Michael P, Marshall, Jason D, Ernst, Robert K

“…Adjuvant properties of bacterial cell wall components like MPLA (monophosphoryl lipid A) are well described and have gained FDA approval for use in vaccines…”
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Increased long chain acyl-Coa synthetase activity and fatty acid import is linked to membrane synthesis for development of picornavirus replication organelles by Nchoutmboube, Jules A, Viktorova, Ekaterina G, Scott, Alison J, Ford, Lauren A, Pei, Zhengtong, Watkins, Paul A, Ernst, Robert K, Belov, George A

“…All positive strand (+RNA) viruses of eukaryotes replicate their genomes in association with membranes. The mechanisms of membrane remodeling in infected cells…”
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