Search Results - "ERNST, K"

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock by Hagar, Jon A., Powell, Daniel A., Aachoui, Youssef, Ernst, Robert K., Miao, Edward A.

“…Inflammatory caspases, such as caspase-1 and -11, mediate innate immune detection of pathogens. Caspase-11 induces pyroptosis, a form of programmed cell death,…”
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Structural basis of MsbA-mediated lipopolysaccharide transport by Mi, Wei, Li, Yanyan, Yoon, Sung Hwan, Ernst, Robert K., Walz, Thomas, Liao, Maofu

“…Lipopolysaccharide (LPS) in the outer membrane of Gram-negative bacteria is critical for the assembly of their cell envelopes. LPS synthesized in the…”
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Soft perches in an aviary system reduce incidence of keel bone damage in laying hens by Stratmann, Ariane, Fröhlich, Ernst K F, Harlander-Matauschek, Alexandra, Schrader, Lars, Toscano, Michael J, Würbel, Hanno, Gebhardt-Henrich, Sabine G

“…Keel bone fractures and deviations are one of the major welfare and health issues in commercial laying hens. In non-cage housing systems like aviaries, falls…”
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Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens by Knodler, Leigh A., Crowley, Shauna M., Sham, Ho Pan, Yang, Hyungjun, Wrande, Marie, Ma, Caixia, Ernst, Robert K., Steele-Mortimer, Olivia, Celli, Jean, Vallance, Bruce A.

“…Inflammasome-mediated host defenses have been extensively studied in innate immune cells. Whether inflammasomes function for innate defense in intestinal…”
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The third dimension bridges the gap between cell culture and live tissue by Stelzer, Ernst H. K, Pampaloni, Francesco, Reynaud, Emmanuel G

“…Moving from cell monolayers to three-dimensional (3D) cultures is motivated by the need to work with cellular models that mimic the functions of living…”
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Analysis of Pseudomonas aeruginosa biofilm membrane vesicles supports multiple mechanisms of biogenesis by Cooke, Adam C, Nello, Alexander V, Ernst, Robert K, Schertzer, Jeffrey W

“…Outer Membrane Vesicles (OMVs) are ubiquitous in bacterial environments and enable interactions within and between species. OMVs are observed in lab-grown and…”
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High-resolution deep imaging of live cellular spheroids with light-sheet-based fluorescence microscopy by Pampaloni, Francesco, Ansari, Nariman, Stelzer, Ernst H. K

“…Conventional two-dimensional cell monolayers do not provide the geometrical, biochemical and mechanical cues found in real tissues. Cells in real tissues…”
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Colistin-Resistant Acinetobacter baumannii: Beyond Carbapenem Resistance by Qureshi, Zubair A., Hittle, Lauren E., O'Hara, Jessica A., Rivera, Jesabel I., Syed, Alveena, Shields, Ryan K., Pasculle, Anthony W., Ernst, Robert K., Doi, Yohei

“…Background. With an increase in the use of colistin methansulfonate (CMS) to treat carbapenem-resistant Acinetobacter baumannii infections, colistin resistance…”
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Reconstruction of Zebrafish Early Embryonic Development by Scanned Light Sheet Microscopy by Keller, Philipp J, Schmidt, Annette D, Wittbrodt, Joachim, Stelzer, Ernst H.K

“…A long-standing goal of biology is to map the behavior of all cells during vertebrate embryogenesis. We developed digital scanned laser light sheet…”
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Essential fatty acid deficiency during parenteral soybean oil lipid minimization by Ernst, K D

“…Objective: To determine if parenteral lipid minimization in infants results in essential fatty acid (EFA) deficiency. Study Design: Prospective study of…”
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Guanylate binding proteins promote caspase-11–dependent pyroptosis in response to cytoplasmic LPS by Pilla, Danielle M., Hagar, Jon A., Haldar, Arun K., Mason, Ashley K., Degrandi, Daniel, Pfeffer, Klaus, Ernst, Robert K., Yamamoto, Masahiro, Miao, Edward A., Coers, Jörn

“…IFN receptor signaling induces cell-autonomous immunity to infections with intracellular bacterial pathogens. Here, we demonstrate that IFN-inducible guanylate…”
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Optical sectioning deep inside live embryos by selective plane illumination microscopy by Huisken, J, Swoger, J, Del Bene, F, Wittbrodt, J, Stelzer, E.H.K

“…Large, living biological specimens present challenges to existing optical imaging techniques because of their absorptive and scattering properties. We…”
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Action spectra associated with inelastic two-electron tunneling through a single molecule: Propene on Cu(211) by Ueba, H., Passerone, D., Parschau, M., Ernst, K.-H.

“…•New DFT calculations on the system propene/Cu(211).•Single molecule manipulation with the STM.•New theoretical modeling for a single electron and two-electron…”
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Author Correction: A deterministic genotyping workflow reduces waste of transgenic individuals by two-thirds by Strobl, Frederic, Stelzer, Ernst H. K.

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Light sheet-based fluorescence microscopy (LSFM) for the quantitative imaging of cells and tissues by Pampaloni, Francesco, Chang, Bo-Jui, Stelzer, Ernst H. K

“…In light sheet-based fluorescence microscopy (LSFM), only the focal plane is illuminated by a laser light sheet. Hence, only the fluorophores within a thin…”
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Probing the sRNA regulatory landscape of P. aeruginosa: post‐transcriptional control of determinants of pathogenicity and antibiotic susceptibility by Zhang, Yi‐Fan, Han, Kook, Chandler, Courtney E., Tjaden, Brian, Ernst, Robert K., Lory, Stephen

“…Summary During environmental adaptation bacteria use small regulatory RNAs (sRNAs) to repress or activate expression of a large fraction of their proteome. We…”
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The TLR4 antagonist Eritoran protects mice from lethal influenza infection by Shirey, Kari Ann, Lai, Wendy, Scott, Alison J., Lipsky, Michael, Mistry, Pragnesh, Pletneva, Lioubov M., Karp, Christopher L., McAlees, Jaclyn, Gioannini, Theresa L., Weiss, Jerrold, Chen, Wilbur H., Ernst, Robert K., Rossignol, Daniel P., Gusovsky, Fabian, Blanco, Jorge C. G., Vogel, Stefanie N.

“…TLR4 stimulation is known to contribute to acute lung injury after administration of inactivated influenza virus; here, the synthetic TLR4 antagonist Eritoran…”
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A deterministic genotyping workflow reduces waste of transgenic individuals by two-thirds by Strobl, Frederic, Stelzer, Ernst H. K.

“…We present a deterministic workflow for genotyping single and double transgenic individuals directly upon nascence that prevents overproduction and reduces…”
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Lipid A structural modifications in extreme conditions and identification of unique modifying enzymes to define the Toll-like receptor 4 structure-activity relationship by Scott, Alison J., Oyler, Benjamin L., Goodlett, David R., Ernst, Robert K.

“…Strategies utilizing Toll-like receptor 4 (TLR4) agonists for treatment of cancer, infectious diseases, and other targets report promising results. Potent TLR4…”
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The molecular recognition of phosphatidic acid by an amphipathic helix in Opi1 by Hofbauer, Harald F, Gecht, Michael, Fischer, Sabine C, Seybert, Anja, Frangakis, Achilleas S, Stelzer, Ernst H K, Covino, Roberto, Hummer, Gerhard, Ernst, Robert

“…A key event in cellular physiology is the decision between membrane biogenesis and fat storage. Phosphatidic acid (PA) is an important intermediate at the…”
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