Search Results - "ERKER, Thomas"

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy by Töllner, Kathrin, Brandt, Claudia, Töpfer, Manuel, Brunhofer, Gerda, Erker, Thomas, Gabriel, Mario, Feit, Peter W., Lindfors, Jenna, Kaila, Kai, Löscher, Wolfgang

“…Objective There is considerable interest in using bumetanide, a chloride importer Na‐K‐Cl cotransporter antagonist, for treatment of neurological diseases,…”
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Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study by Bankstahl, Jens P, Bankstahl, Marion, Römermann, Kerstin, Wanek, Thomas, Stanek, Johann, Windhorst, Albert D, Fedrowitz, Maren, Erker, Thomas, Müller, Markus, Löscher, Wolfgang, Langer, Oliver, Kuntner, Claudia

“…Elacridar (ELC) and tariquidar (TQD) are generally thought to be nontransported inhibitors of P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP),…”
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PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo by Mairinger, Severin, Erker, Thomas, Muller, Markus, Langer, Oliver

“…Adenosine triphosphate-binding cassette (ABC) transporters, such as P-glycoprotein (Pgp, ABCB1), breast cancer resistance protein (BCRP, ABCG2) and multidrug…”
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Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity by Bollmann, Franziska, Art, Julia, Henke, Jenny, Schrick, Katharina, Besche, Verena, Bros, Matthias, Li, Huige, Siuda, Daniel, Handler, Norbert, Bauer, Florian, Erker, Thomas, Behnke, Felix, Mönch, Bettina, Härdle, Lorena, Hoffmann, Markus, Chen, Ching-Yi, Förstermann, Ulrich, Dirsch, Verena M, Werz, Oliver, Kleinert, Hartmut, Pautz, Andrea

“…Resveratrol shows beneficial effects in inflammation-based diseases like cancer, cardiovascular and chronic inflammatory diseases. Therefore, the molecular…”
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Role of NKCC1 Activity in Glioma K+ Homeostasis and Cell Growth: New Insights With the Bumetanide-Derivative STS66 by Luo, Lanxin, Wang, Jun, Ding, Dawei, Hasan, Md Nabiul, Yang, Sung-Sen, Lin, Shih-Hua, Schreppel, Philipp, Sun, Baoshan, Yin, Yan, Erker, Thomas, Sun, Dandan

“…Introduction: Na + -K + -2Cl − cotransporter isoform 1 (NKCC1) is important in regulating intracellular K + and Cl − homeostasis and cell volume. In this…”
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GABAA receptor modulation by piperine and a non-TRPV1 activating derivative by Khom, Sophia, Strommer, Barbara, Schöffmann, Angela, Hintersteiner, Juliane, Baburin, Igor, Erker, Thomas, Schwarz, Thomas, Schwarzer, Christoph, Zaugg, Janine, Hamburger, Matthias, Hering, Steffen

“…The action of piperine (the pungent component of pepper) and its derivative SCT-66 ((2E,4E)-5-(1,3-benzodioxol-5-yl))-N,N-diisobutyl-2,4-pentadienamide) on…”
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Novel Promising Estrogenic Receptor Modulators: Cytotoxic and Estrogenic Activity of Benzanilides and Dithiobenzanilides by Kucinska, Malgorzata, Giron, Maria-Dolores, Piotrowska, Hanna, Lisiak, Natalia, Granig, Walter H, Lopez-Jaramillo, Francisco-Javier, Salto, Rafael, Murias, Marek, Erker, Thomas

“…The cytotoxicity of 27 benzanilides and dithiobenzanilides built on a stilbene scaffold and possessing various functional groups in aromatic rings previously…”
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Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor by Bauer, Florian, Kuntner, Claudia, Bankstahl, Jens P., Wanek, Thomas, Bankstahl, Marion, Stanek, Johann, Mairinger, Severin, Dörner, Bernd, Löscher, Wolfgang, Müller, Markus, Erker, Thomas, Langer, Oliver

“…The aim of this study was to develop a positron emission tomography (PET) tracer based on the dual P-glycoprotein (P-gp) breast cancer resistance protein…”
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Synthesis and Small-Animal Positron Emission Tomography Evaluation of [11C]-Elacridar As a Radiotracer to Assess the Distribution of P-Glycoprotein at the Blood−Brain Barrier by Dörner, Bernd, Kuntner, Claudia, Bankstahl, Jens P, Bankstahl, Marion, Stanek, Johann, Wanek, Thomas, Stundner, Gloria, Mairinger, Severin, Löscher, Wolfgang, Müller, Markus, Langer, Oliver, Erker, Thomas

“…With the aim to develop a positron emission tomography (PET) tracer to assess the distribution of P-glycoprotein (P-gp) at the blood−brain barrier (BBB) in…”
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Foam cell specific LXRα ligand by Feldmann, Radmila, Geikowski, Anne, Weidner, Christopher, Witzke, Annabell, Kodelja, Vitam, Schwarz, Thomas, Gabriel, Mario, Erker, Thomas, Sauer, Sascha

“…The liver X receptor α (LXRα) is a ligand-dependent nuclear receptor and the major regulator of reverse cholesterol transport in macrophages. This makes it an…”
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Resveratrol blocks Akt activation in angiotensin II-or EGF-stimulated vascular smooth muscle cells in a redox-independent manner by SCHREINER, Cornelia E, KUMERZ, Mario, GESSLBAUER, Julia, SCHACHNER, Daniel, JOA, Helge, ERKER, Thomas, ATANASOV, Atanas G, HEISS, Elke H, DIRSCH, Verena M

“…Resveratrol (RV), an antioxidant, inhibits angiotensin II (Ang II)-induced hypertrophy and Ang II- or epidermal growth factor (EGF)-induced Akt phosphorylation…”
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Synthesis of Novel Curcumin Analogues and Their Evaluation as Selective Cyclooxygenase-1 (COX-1) Inhibitors by Handler, Norbert, Jaeger, Walter, Puschacher, Helmut, Leisser, Klaus, Erker, Thomas

“…Curcumin, a major yellow pigment and active component of turmeric, has been shown to possess anti-inflammatory and anti-cancer activities. Recent studies have…”
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Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines by OVESNA, Zdenka, KOZICS, Katarina, BADER, Yvonne, SAIKO, Philipp, HANDLER, Norbert, ERKER, Thomas, SZEKERES, Thomas

“…trans-Resveratrol (t-RES) is one of the most relevant and extensively investigated stilbenes with a broad spectrum of biological activities. In contrast to the…”
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Using structural and mechanistic information to design novel inhibitors/substrates of P-glycoprotein by Klepsch, Freya, Stockner, Thomas, Erker, Thomas, Müller, Markus, Chiba, Peter, Ecker, Gerhard F

“…Design of inhibitors of P-glycoprotein still represents a challenging task for medicinal chemists. The polyspecificity of the transporter combined with the…”
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Novel Resveratrol Derivatives Induce Apoptosis and Cause Cell Cycle Arrest in Prostate Cancer Cell Lines by Horvath, Z, Marihart-Fazekas, S, Saiko, P, Grusch, M, Oezsuey, M, Harik, M, Handler, N, Erker, T, Jaeger, W, Fritzer-Szekeres, M, Djavan, B, Szekeres, T

“…Background: Resveratrol (RV), a naturally occurring phytoalexin, exerts manifold biological effects against a variety of human tumor cell lines. In this study,…”
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Impaired chloride homeostasis in epilepsy: Molecular basis, impact on treatment, and current treatment approaches by Auer, Theresa, Schreppel, Philipp, Erker, Thomas, Schwarzer, Christoph

“…Epilepsies represent one of the most common neurological diseases worldwide. They are characterized by recurrent spontaneous seizures with severe impact on a…”
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Functional characterization of novel bumetanide derivatives for epilepsy treatment by Auer, Theresa, Schreppel, Philipp, Erker, Thomas, Schwarzer, Christoph

“…Temporal lobe epilepsy (TLE) is the most common type of focal epilepsies, affecting approximately 35 million people worldwide. Despite the introduction of…”
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Synthesis of 1,2-Disubstituted Imidazoles via Cross-Coupling and Substitution Reactions by Erker, Thomas, Langhammer, Ingo

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Effects of Novel Synthesized Pyridothiazines on Various Guinea Pig Heart Muscle Preparations by Schade, Bettina, Erker, Thomas, Weber, Manuela, Studenik, Christian

“…Calcium channel blockers have become important tools in the treatment of cardiovascular disorders and other diseases. Hybridization of well established calcium…”
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Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain by Römermann, Kerstin, Fedrowitz, Maren, Hampel, Philip, Kaczmarek, Edith, Töllner, Kathrin, Erker, Thomas, Sweet, Douglas H., Löscher, Wolfgang

“…There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including…”
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