Search Results - "ERIKSSON, Lennart C"

Autopsies and quality of cause of death diagnoses by Rosendahl, Anders, Mjörnheim, Berit, Eriksson, Lennart C

“…Objective: The consequences of a low autopsy rate are not considered in determining the cause of death. Method: We have analyzed the Cause of Death Register of…”
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The effect of sodium selenite on liver growth and thioredoxin reductase expression in regenerative and neoplastic liver cell proliferation by Erkhembayar, Suvd, Mollbrink, Annelie, Eriksson, Lennart C.

“…Sodium selenite inhibits growth of liver tumours but not liver regeneration after partial hepatectomy (PH). An experimental rat study. Selenium in…”
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Expression of iron regulatory genes in a rat model of hepatocellular carcinoma by Holmström, Petra, Gåfvels, Mats, Eriksson, Lennart C., Dzikaite, Vijole, Hultcrantz, Rolf, Eggertsen, Gösta, Stål, Per

“…: Background/Aims: The altered iron metabolism in hepatocellular carcinomas (HCCs), characterized by the iron‐deficient phenotype, is suggested to be of…”
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Selenite-induced apoptosis in doxorubicin-resistant cells and effects on the thioredoxin system by Jönsson-Videsäter, Kerstin, Björkhem-Bergman, Linda, Hossain, Akter, Söderberg, Anita, Eriksson, Lennart C, Paul, Christer, Rosén, Anders, Björnstedt, Mikael

“…Selenium treatment of the doxorubicin-resistant cell line, U-1285dox, derived from human small cell carcinoma of the lung, resulted in massive apoptosis. This…”
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Sorafenib prolongs liver regeneration after hepatic resection in rats by Mollbrink, Annelie, MSc, Augsten, Martin, PhD, Hultcrantz, Rolf, MD, PhD, Eriksson, Lennart C., MD, PhD, Stål, Per, MD, PhD

“…Abstract Background The multikinase inhibitor sorafenib inhibits angiogenesis and tumor cell proliferation. Sorafenib targets signaling pathways involved in…”
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Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma by Rohr-Udilova, Nataliya, Sieghart, Wolfgang, Eferl, Robert, Stoiber, Dagmar, Björkhem-Bergman, Linda, Eriksson, Lennart C., Stolze, Klaus, Hayden, Hubert, Keppler, Bernhard, Sagmeister, Sandra, Grasl-Kraupp, Bettina, Schulte-Hermann, Rolf, Peck-Radosavljevic, Markus

“…Activation of the activator protein 1 (AP‐1) transcription factor as well as increased serum levels of vascular endothelial growth factor (VEGF) and…”
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Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase by Nordman, Tomas, Xia, Ling, Björkhem-Bergman, Linda, Damdimopoulos, Anastassios, Nalvarte, Ivan, Arnér, Elias S. J., Spyrou, Giannis, Eriksson, Lennart C., Björnstedt, Mikael, Olsson, Jerker M.

“…Ubiquinol is a powerful antioxidant, which is oxidized in action and needs to be replaced or regenerated to be capable of a sustained effort. This article…”
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Statins inhibit expression of Thioredoxin reductase 1 in rat and human liver and reduce tumour development by Skogastierna, Cristine, Johansson, Maria, Parini, Paolo, Eriksson, Mats, Eriksson, Lennart C., Ekström, Lena, Björkhem-Bergman, Linda

“…► Statins inhibits expression of Thioredoxin reductase 1 in rat and human liver tissue. ► Statin-mediated inhibition of Thioredoxin reductases may explain…”
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Attitudes of Nurses and Physicians About Clinical Autopsy in Neonatal and Adult Hospital Care: A Survey in Sweden by Mjörnheim, Berit, Rosendahl, Anders, Eriksson, Lennart C, Takman, Christina

“…BACKGROUNDThe rate of autopsies has dropped to low levels in Western countries. OBJECTIVEThe aim of this study was to describe the experiences and attitudes of…”
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The anti-carcinogenic effect of statins in a rat model correlates with levels and synthesis of ubiquinone by Acimovic, Jure, Lövgren-Sandblom, Anita, Eriksson, Lennart C., Björkhem-Bergman, Linda

“…► Ubiquinone levels correlates with inhibited carcinogenesis mediated by statins. ► Statin treatment leads to a shift to ubiquinone isoforms with shorter…”
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Lovastatin Prevents Carcinogenesis in a Rat Model for Liver Cancer. Effects of Ubiquinone Supplementation by BJÖRKHEM-BERGMAN, Linda, ACIMOVIC, Jure, TORNDAL, Ulla-Britta, PARINI, Paolo, ERIKSSON, Lennart C

“…This study tests the hypothesis that statins (HMGCoA reductase inhibitors) inhibit carcinogenesis and that this effect may be mediated by the statin-induced…”
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The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress by Xia, Ling, Nordman, Tomas, Olsson, Jerker M, Damdimopoulos, Anastassios, Björkhem-Bergman, Linda, Nalvarte, Ivan, Eriksson, Lennart C, Arnér, Elias S J, Spyrou, Giannis, Björnstedt, Mikael

“…The selenoprotein thioredoxin reductase (TrxR1) is an essential antioxidant enzyme known to reduce many compounds in addition to thioredoxin, its principle…”
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Iron-regulatory gene expression during liver regeneration by Mollbrink, Annelie, Holmström, Petra, Sjöström, Mattias, Hultcrantz, Rolf, Eriksson, Lennart C, Stål, Per

“…Abstract Background. In rat, the first 18-24 h after partial hepatectomy (PH) are characterized by an acute-phase reaction, after which liver regeneration…”
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Selenium homeostasis and induction of thioredoxin reductase during long term selenite supplementation in the rat by Erkhembayar, Suvd, Mollbrink, Annelie, Eriksson, Malin, Larsen, Erik H., Eriksson, Lennart C.

“…Selenium is a candidate treatment for liver tumour prevention in chronic liver disease. In this study, we have studied selenium uptake, distribution and…”
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Selenium prevents tumor development in a rat model for chemical carcinogenesis by Björkhem-Bergman, Linda, Torndal, Ulla-Britta, Eken, Servet, Nyström, Christina, Capitanio, Arrigo, Larsen, Erik Huusfeldt, Björnstedt, Mikael, Eriksson, Lennart C.

“…Previous studies in animals and humans have shown that selenium compounds can prevent cancer development. In this work we studied the tumor preventive effect…”
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The role of thioredoxin reductase activity in selenium-induced cytotoxicity by Madeja, Zbigniew, Sroka, Jolanta, Nyström, Christina, Björkhem-Bergman, Linda, Nordman, Tomas, Damdimopoulos, Anastasios, Nalvarte, Ivan, Eriksson, Lennart C., Spyrou, Giannis, Olsson, Jerker M., Björnstedt, Mikael

“…The selenoprotein thioredoxin reductase is a key enzyme in selenium metabolism, reducing selenium compounds and thereby providing selenide to synthesis of all…”
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Drug-resistant human lung cancer cells are more sensitive to selenium cytotoxicity: Effects on thioredoxin reductase and glutathione reductase by Björkhem-Bergman, Linda, Jönsson, Kerstin, Eriksson, Lennart C., Olsson, Jerker M., Lehmann, Sören, Paul, Christer, Björnstedt, Mikael

“…The human U-1285 and GLC 4 cell lines, both derived from small cell carcinoma of the lung, are present in doxorubicin-sensitive (U-1285 and GLC 4) and…”
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Selenite is a potent cytotoxic agent for human primary AML cells by Olm, Eric, Jönsson-Videsäter, Kerstin, Ribera-Cortada, Inmaculada, Fernandes, Aristi P, Eriksson, Lennart C, Lehmann, Sören, Rundlöf, Anna-Klara, Paul, Christer, Björnstedt, Mikael

“…Abstract Selenite is a potent inhibitor of malignant cell growth. Although the cytotoxic effects have been extensively investigated in vitro , there are only a…”
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Ubiquinone is reduced by lipoamide dehydrogenase and this reaction is potently stimulated by zinc by Olsson, Jerker M, Xia, Ling, Eriksson, Lennart C, Björnstedt, Mikael

“…Ubiquinol is an endogenously synthesized lipid-soluble antioxidant. Regeneration of ubiquinol from the oxidized form is essential to the maintenance of its…”
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Human sterol 12a-hydroxylase (CYP8B1) is mainly expressed in hepatocytes in a homogenous pattern by Wang, Jin, Greene, Sinead, Eriksson, Lennart C, Rozell, Björn, Reihnér, Eva, Einarsson, Curt, Eggertsen, Gösta, Gåfvels, Mats

“…The liver is the only organ where the complete synthesis of bile acids takes place. The present study was undertaken to investigate whether regional…”
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