Search Results - "ERHARDT, S"

Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [11C]PBR28 by Collste, K, Plavén-Sigray, P, Fatouros-Bergman, H, Victorsson, P, Schain, M, Forsberg, A, Amini, N, Aeinehband, S, Erhardt, S, Halldin, C, Flyckt, L, Farde, L, Cervenka, S

“…Several lines of evidence are indicative of a role for immune activation in the pathophysiology of schizophrenia. Nevertheless, studies using positron emission…”
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The role of inflammation in suicidal behaviour by Brundin, L., Erhardt, S., Bryleva, E. Y., Achtyes, E. D., Postolache, T. T.

“…Objective Over the past decade, clinical data have accumulated showing that inflammation might contribute to the pathophysiology of suicide. To evaluate the…”
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CSF GABA is reduced in first-episode psychosis and associates to symptom severity by Orhan, F, Fatouros-Bergman, H, Goiny, M, Malmqvist, A, Piehl, F, Cervenka, S, Collste, K, Victorsson, P, Sellgren, C M, Flyckt, L, Erhardt, S, Engberg, G

“…Schizophrenia is characterized by a multiplicity of symptoms arising from almost all domains of mental function. γ-Aminobutyric acid (GABA) is the primary…”
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A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder by Sellgren, C M, Kegel, M E, Bergen, S E, Ekman, C J, Olsson, S, Larsson, M, Vawter, M P, Backlund, L, Sullivan, P F, Sklar, P, Smoller, J W, Magnusson, P K E, Hultman, C M, Walther-Jallow, L, Svensson, C I, Lichtenstein, P, Schalling, M, Engberg, G, Erhardt, S, Landén, M

“…Elevated cerebrospinal fluid (CSF) levels of the glia-derived N -methyl- D -aspartic acid receptor antagonist kynurenic acid (KYNA) have consistently been…”
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Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia by LINDERHOLM, Klas R, SKOGH, Elisabeth, OLSSON, Sara K, DAHL, Marja-Liisa, HOLTZE, Maria, ENGBERG, Göran, SAMUELSSON, Martin, ERHARDT, Sophie

“…The kynurenic acid (KYNA) hypothesis for schizophrenia is partly based on studies showing increased brain levels of KYNA in patients. KYNA is an endogenous…”
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Epidemiological, genetic, and clinical characterization by age of newly diagnosed acute myeloid leukemia based on an academic population-based registry study (AMLSG BiO) by Nagel, Gabriele, Weber, D., Fromm, E., Erhardt, S., Lübbert, M., Fiedler, W., Kindler, T., Krauter, J., Brossart, P., Kündgen, A., Salih, H. R., Westermann, J., Wulf, G., Hertenstein, B., Wattad, M., Götze, K., Kraemer, D., Heinicke, T., Girschikofsky, M., Derigs, H.G., Horst, H. A., Rudolph, C., Heuser, M., Göhring, G., Teleanu, V., Bullinger, L., Thol, F., Gaidzik, V. I., Paschka, P., Döhner, K., Ganser, A., Döhner, Hartmut, Schlenk, R. F.

“…We describe genetic and clinical characteristics of acute myeloid leukemia (AML) patients according to age from an academic population-based registry. Adult…”
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An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation by Brundin, L, Sellgren, C M, Lim, C K, Grit, J, Pålsson, E, Landén, M, Samuelsson, M, Lundgren, K, Brundin, P, Fuchs, D, Postolache, T T, Traskman-Bendz, L, Guillemin, G J, Erhardt, S

“…Emerging evidence suggests that inflammation has a key role in depression and suicidal behavior. The kynurenine pathway is involved in neuroinflammation and…”
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The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression by Lavebratt, C, Olsson, S, Backlund, L, Frisén, L, Sellgren, C, Priebe, L, Nikamo, P, Träskman-Bendz, L, Cichon, S, Vawter, M P, Ösby, U, Engberg, G, Landén, M, Erhardt, S, Schalling, M

“…The kynurenine pathway metabolite kynurenic acid (KYNA), modulating glutamatergic and cholinergic neurotransmission, is increased in cerebrospinal fluid (CSF)…”
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Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls by Sellgren, Carl M., Gracias, Jessica, Jungholm, Oscar, Perlis, Roy H., Engberg, Göran, Schwieler, Lilly, Landen, Mikael, Erhardt, Sophie

“…Metabolites of the kynurenine pathway of tryptophan degradation, in particular, the N -Methyl- d -aspartic acid receptor antagonist kynurenic acid (KYNA), are…”
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Low IL-8 is associated with anxiety in suicidal patients: genetic variation and decreased protein levels by Janelidze, S., Suchankova, P., Ekman, A., Erhardt, S., Sellgren, C., Samuelsson, M., Westrin, A., Minthon, L., Hansson, O., Träskman-Bendz, L., Brundin, L.

“…Objective Recent studies indicate that inflammation may play a role in the pathophysiology of suicidality. Interleukin‐8 (IL‐8) is a chemokine that in addition…”
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Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients by Schwieler, Lilly, Samuelsson, Martin, Frye, Mark A, Bhat, Maria, Schuppe-Koistinen, Ina, Jungholm, Oscar, Johansson, Anette G, Landén, Mikael, Sellgren, Carl M, Erhardt, Sophie

“…Neuroinflammation is increasingly recognized as contributing to the pathogenesis of depression. Key inflammatory markers as well as kynurenic acid (KYNA) and…”
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Activation of brain interleukin-1β in schizophrenia by Söderlund, J, Schröder, J, Nordin, C, Samuelsson, M, Walther-Jallow, L, Karlsson, H, Erhardt, S, Engberg, G

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Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes by Mudry, Jonathan M., Alm, Petter S., Erhardt, Sophie, Goiny, Michel, Fritz, Tomas, Caidahl, Kenneth, Zierath, Juleen R., Krook, Anna, Wallberg-Henriksson, Harriet

“…Background Systemic kynurenine levels are associated with resistance to stress‐induced depression and are modulated by exercise. Tryptophan is a precursor for…”
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Increased number of monocytes and plasma levels of MCP‐1 and YKL‐40 in first‐episode psychosis by Orhan, F., Schwieler, L., Fatouros‐Bergman, H., Malmqvist, A., Cervenka, S., Collste, K., Flyckt, L., Farde, L., Sellgren, C. M., Piehl, F., Engberg, G., Erhardt, S., Hedberg, Mikael, Victorsson, Pauliina

“…Objective Accumulating evidence implicates immune activation in the development of schizophrenia. Here, monocyte numbers, monocyte chemoattractant protein‐1…”
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Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll‐like Receptor Stimulation in Peripheral Monocytes by Orhan, F., Bhat, M., Sandberg, K., Ståhl, S., Piehl, F., Svensson, C., Erhardt, S., Schwieler, L., Farde, L., Flyckt, L., Engberg, G., Fatouros‐Bergman, H., Cervenka, S., Agartz, I., Ikonen, P., Collste, K., Malmqvist, A., Hedberg, M.

“…Tryptophan degradation along the kynurenine pathway is of central importance for the immune function. Toll‐like receptors (TLRs), representing the first line…”
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Increased peripheral levels of TARC/CCL17 in first episode psychosis patients by Malmqvist, Anna, Schwieler, Lilly, Orhan, Funda, Fatouros-Bergman, Helena, Bauer, Markus, Flyckt, Lena, Cervenka, Simon, Engberg, Göran, Piehl, Fredrik, Erhardt, Sophie

“…Evidence for a link between the pathophysiology of schizophrenia and the immune system is mounting. Altered levels of chemokines in plasma have previously been…”
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The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood–brain barrier permeability by Ventorp, F, Barzilay, R, Erhardt, S, Samuelsson, M, Träskman-Bendz, L, Janelidze, S, Weizman, A, Offen, D, Brundin, L

“…Abstract Background The glycosaminoglycan hyaluronic acid (HA) is an important component of the extracellular matrix (ECM) in the brain. CD44 is a cell…”
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The polycomb-group gene Ezh2 is required for early mouse development by O'Carroll, D, Erhardt, S, Pagani, M, Barton, S C, Surani, M A, Jenuwein, T

“…Polycomb-group (Pc-G) genes are required for the stable repression of the homeotic selector genes and other developmentally regulated genes, presumably through…”
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Neurogranin as a potential synaptic marker in the cerebrospinal fluid of patients with a first episode psychosis by Santillo, A.F., Lundgren, S., Xu, C., Orhan, F., Fatouros-Bergman, H., Blennow, K., Zetterberg, H., Portelius, E., Cervenka, S., Jönsson, E.G., Erhardt, S., Engberg, G.

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Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice by Larsson, M. K., Faka, A., Bhat, M., Imbeault, S., Goiny, M., Orhan, F., Oliveros, A., Ståhl, S., Liu, X. C., Choi, D. S., Sandberg, K., Engberg, G., Schwieler, L., Erhardt, S.

“…The immune system has been recognized as a potential contributor to psychiatric disorders. In animals, lipopolysaccharide (LPS) is used to induce inflammation…”
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