Search Results - "EREMINA, Vera"

Vegfa Protects the Glomerular Microvasculature in Diabetes by SIVASKANDARAJAH, Gavasker A, JEANSSON, Marie, MAEZAWA, Yoshiro, EREMINA, Vera, BAELDE, Hans J, QUAGGIN, Susan E

“…Vascular endothelial growth factor A (VEGFA) expression is increased in glomeruli in the context of diabetes. Here, we tested the hypothesis that this…”
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Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP by Souma, Tomokazu, Thomson, Benjamin R., Heinen, Stefan, Carota, Isabel Anna, Yamaguchi, Shinji, Onay, Tuncer, Liu, Pan, Ghosh, Asish K., Li, Chengjin, Eremina, Vera, Hong, Young-Kwon, Economides, Aris N., Vestweber, Dietmar, Peters, Kevin G., Jin, Jing, Quaggin, Susan E.

“…The angiopoietin (ANGPT)–TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas…”
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VEGF Inhibition and Renal Thrombotic Microangiopathy by Eremina, Vera, Jefferson, J. Ashley, Kowalewska, Jolanta, Hochster, Howard, Haas, Mark, Weisstuch, Joseph, Richardson, Catherine, Kopp, Jeffrey B, Kabir, M. Golam, Backx, Peter H, Gerber, Hans-Peter, Ferrara, Napoleone, Barisoni, Laura, Alpers, Charles E, Quaggin, Susan E

“…In six patients who received bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), proteinuria subsequently…”
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Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease by McNeill, Helen, Saburi, Sakura, Hester, Ian, Fischer, Evelyne, Pontoglio, Marco, Eremina, Vera, Gessler, Manfred, Quaggin, Sue E, Harrison, Robert, Mount, Richard

“…Tissue organization in Drosophila is regulated by the core planar cell polarity (PCP) proteins Frizzled, Dishevelled, Prickle, Van Gogh and Flamingo. Core PCP…”
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Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function by Welsh, Gavin I., Hale, Lorna J., Eremina, Vera, Jeansson, Marie, Maezawa, Yoshiro, Lennon, Rachel, Pons, Deborah A., Owen, Rachel J., Satchell, Simon C., Miles, Mervyn J., Caunt, Christopher J., McArdle, Craig A., Pavenstädt, Hermann, Tavaré, Jeremy M., Herzenberg, Andrew M., Kahn, C. Ronald, Mathieson, Peter W., Quaggin, Susan E., Saleem, Moin A., Coward, Richard J.M.

“…Diabetic nephropathy (DN) is the leading cause of renal failure in the world. It is characterized by albuminuria and abnormal glomerular function and is…”
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Nephrin Tyrosine Phosphorylation Is Required to Stabilize and Restore Podocyte Foot Process Architecture by New, Laura A, Martin, Claire E, Scott, Rizaldy P, Platt, Mathew J, Keyvani Chahi, Ava, Stringer, Colin D, Lu, Peihua, Samborska, Bozena, Eremina, Vera, Takano, Tomoko, Simpson, Jeremy A, Quaggin, Susan E, Jones, Nina

“…Podocytes are specialized epithelial cells of the kidney blood filtration barrier that contribute to permselectivity via a series of interdigitating actin-rich…”
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Molecular Mechanisms of Anticancer Activity of N-Glycosides of Indolocarbazoles LCS-1208 and LCS-1269 by Zenkov, Roman G, Vlasova, Olga A, Maksimova, Varvara P, Fetisov, Timur I, Karpechenko, Natalia Y, Ektova, Lidiya V, Eremina, Vera A, Popova, Valeriia G, Usalka, Olga G, Lesovaya, Ekaterina A, Belitsky, Gennady A, Yakubovskaya, Marianna G, Kirsanov, Kirill I

“…Novel indolocarbazole derivatives named LCS were synthesized by our research group. Two of them were selected as the most active anticancer agents in vivo. We…”
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Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases by Eremina, Vera, Sood, Manish, Haigh, Jody, Nagy, András, Lajoie, Ginette, Ferrara, Napoleone, Gerber, Hans-Peter, Kikkawa, Yamato, Miner, Jeffrey H, Quaggin, Susan E

“…Kidney disease affects over 20 million people in the United States alone. Although the causes of renal failure are diverse, the glomerular filtration barrier…”
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Targeting VE-PTP phosphatase protects the kidney from diabetic injury by Carota, Isabel A, Kenig-Kozlovsky, Yael, Onay, Tuncer, Scott, Rizaldy, Thomson, Benjamin R, Souma, Tomokazu, Bartlett, Christina S, Li, Yanyang, Procissi, Daniele, Ramirez, Veronica, Yamaguchi, Shinji, Tarjus, Antoine, Tanna, Christine E, Li, Chengjin, Eremina, Vera, Vestweber, Dietmar, Oladipupo, Sunday S, Breyer, Matthew D, Quaggin, Susan E

“…Diabetic nephropathy is a leading cause of end-stage kidney failure. Reduced angiopoietin-TIE2 receptor tyrosine kinase signaling in the vasculature leads to…”
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ShcA Adaptor Protein Promotes Nephrin Endocytosis and Is Upregulated in Proteinuric Nephropathies by Martin, Claire E, Petersen, Kelly A, Aoudjit, Lamine, Tilak, Manali, Eremina, Vera, Hardy, W Rod, Quaggin, Susan E, Takano, Tomoko, Jones, Nina

“…Nephrin is a key structural component of the podocyte slit diaphragm, and proper expression of nephrin on the cell surface is critical to ensure integrity of…”
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Podocytes Contribute to the Formation of Glomerular Crescents by THORNER, Paul S, HO, Michael, EREMINA, Vera, SADO, Yoshikazu, QUAGGIN, Susan

“…The cellular composition of crescents in glomerular disease is controversial. The role of podocytes in crescent formation has been especially difficult to…”
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Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases by Eremina, Vera, Sood, Manish, Haigh, Jody, Nagy, András, Lajoie, Ginette, Ferrara, Napoleone, Gerber, Hans-Peter, Kikkawa, Yamato, Miner, Jeffrey H., Quaggin, Susan E.

“…Kidney disease affects over 20 million people in the United States alone. Although the causes of renal failure are diverse, the glomerular filtration barrier…”
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Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival by EREMINA, Vera, SHIYING CUI, QUAGGIN, Susan E, GERBER, Hanspeter, FERRARA, Napoleone, HAIGH, Jody, NAGY, Andras, EMA, Masatsugu, ROSSANT, Janet, JOTHY, Serge, MINER, Jeffrey H

“…The glomerular filtration barrier separates the blood from the urinary space and consists of two major cell types: podocytes and fenestrated endothelial cells…”
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Loss of the podocyte-expressed transcription factor Tcf21/Pod1 results in podocyte differentiation defects and FSGS by Maezawa, Yoshiro, Onay, Tuncer, Scott, Rizaldy P, Keir, Lindsay S, Dimke, Henrik, Li, Chengjin, Eremina, Vera, Maezawa, Yuko, Jeansson, Marie, Shan, Jingdong, Binnie, Matthew, Lewin, Moshe, Ghosh, Asish, Miner, Jeffrey H, Vainio, Seppo J, Quaggin, Susan E

“…Podocytes are terminally differentiated cells with an elaborate cytoskeleton and are critical components of the glomerular barrier. We identified a bHLH…”
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Biology of Anti-Angiogenic Therapy–Induced Thrombotic Microangiopathy by Eremina, Vera, MD, PhD, Quaggin, Susan E., MD

“…Summary Anti-vascular endothelial growth factor (VEGF) agents are an important component in the treatment of many solid tumors. As the indications for these…”
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The role of VEGF-A in glomerular development and function by Eremina, Vera, Quaggin, Susan E

“…PURPOSE OF REVIEWVascular endothelial growth factor is a major regulator of blood vessel biology and is highly expressed in presumptive and mature podocytes…”
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Role of the VEGF--a signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier by Eremina, Vera, Baelde, Hans J, Quaggin, Susan E

“…Vascular endothelial growth factor is a major regulator of angiogenesis and vascular permeability [Carmeliet et al.: Nature 1996;380:435-439]. The podocyte,…”
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Nck Proteins Maintain the Adult Glomerular Filtration Barrier by JONES, Nina, NEW, Laura A, TAKANO, Tomoko, QUAGGIN, Susan E, PAWSON, Tony, FORTINO, Megan A, EREMINA, Vera, RUSTON, Julie, BLASUTIG, Ivan M, AOUDJIT, Lamine, YOULING ZOU, XIUWEN LIU, YU, Guo-Liang

“…Within the glomerulus, the scaffolding protein nephrin bridges the actin-rich foot processes that extend from adjacent podocytes to form the slit diaphragm…”
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Glomerular Structure and Function Require Paracrine, Not Autocrine, VEGF―VEGFR-2 Signaling by SISON, Karen, EREMINA, Vera, BAELDE, Hans, WANG MIN, HIRASHIMA, Masanori, GEORGE FANTUS, I, QUAGGIN, Susan E

“…VEGF is a potent vascular growth factor produced by podocytes in the developing and mature glomerulus. Specific deletion of VEGF from podocytes causes…”
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Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes by Pawson, Tony, Jones, Nina, Blasutig, Ivan M, Eremina, Vera, Ruston, Julie M, Bladt, Friedhelm, Li, Hongping, Huang, Haiming, Larose, Louise, Li, Shawn S.-C, Takano, Tomoko, Quaggin, Susan E

“…The glomerular filtration barrier in the kidney is formed in part by a specialized intercellular junction known as the slit diaphragm, which connects adjacent…”
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