Search Results - "ERDMANN, Gary"

Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group by Bostrom, Bruce C., Sensel, Martha R., Sather, Harland N., Gaynon, Paul S., La, Mei K., Johnston, Katherine, Erdmann, Gary R., Gold, Stuart, Heerema, Nyla A., Hutchinson, Raymond J., Provisor, Arthur J., Trigg, Michael E.

“…Conventional therapy for childhood acute lymphoblastic leukemia (ALL) includes prednisone and oral 6-mercaptopurine. Prior observations suggested potential…”
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Systemic methotrexate exposure is greater after Intrathecal than after oral administration by BOSTROM, Bruce C, ERDMANN, Gary R, KAMEN, Barton A

“…To compare systemic exposure after intrathecal and oral methotrexate administration. We analyzed red cell methotrexate polyglutamate concentrations with a…”
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Azathioprine metabolism: pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients by Chan, G L, Erdmann, G R, Gruber, S A, Matas, A J, Canafax, D M

“…Despite extensive clinical experience with azathioprine (AZA), the disposition of various AZA metabolites remains obscure. We therefore evaluated the…”
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Possible Advantage of Twice-Daily 6-Mercaptopurine Dosing in Children with Acute Lymphoblastic Leukemia (ALL) by Carson, Thaddeus Y., Bell, Beverly A., Erdmann, Gary, Bostrom, Bruce, Camitta, Bruce M., Devidas, Meenakshi

“…6-Mercaptopurine (MP) has been part of the backbone of ALL treatment for more than 50 years. Hepatic enzymes metabolize MP into two major intracellular…”
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Substitution of oral and intravenous thioguanine for mercaptopurine in a treatment regimen for children with standard risk acute lymphoblastic leukemia: A collaborative Children's Oncology Group/National Cancer Institute pilot trial (CCG-1942) by Jacobs, Shana S., Stork, Linda C., Bostrom, Bruce C., Hutchinson, Ray, Holcenberg, John, Reaman, Gregory H., Erdmann, Gary, Franklin, Janet, Neglia, Joseph P., Steinberg, Seth M., Balis, Frank M., Adamson, Peter C.

“…Background Although mercaptopurine (MP) is conventionally used to treat childhood acute lymphoblastic leukemia (ALL), thioguanine (TG) is a more potent…”
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A reversed phase high performance liquid chromatography approach in determining total red blood cell concentrations of 6-thioguanine, 6-mercaptopurine, methylthioguanine, and methylmercaptopurine in a patient receiving thiopurine therapy by Erdmann, G R, France, L A, Bostrom, B C, Canafax, D M

“…A reversed phase high performance liquid chromatographic procedure was developed to quantify 6-thioguanine, 6-mercaptopurine, methylthioguanine, and…”
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Plasma pharmacokinetics and cerebrospinal fluid penetration of thioguanine in children with acute lymphoblastic leukemia : a collaborative Pediatric Oncology Branch, NCI, and Children's Cancer Group study by LOWE, Elizabeth S, KITCHEN, Brenda J, WIDEMANN, Brigitte C, BALIS, Frank M, MURPHY, Robert F, ADAMSON, Peter C, ERDMANN, Gary, STORK, Linda C, BOSTROM, Bruce C, HUTCHINSON, Ray, HOLCENBERG, John, REAMAN, Gregory H, WOODS, William, FRANKLIN, Janet

“…In preclinical studies, thioguanine (TG) has been shown to be more potent than the standard acute lymphoblastic leukemia (ALL) maintenance agent,…”
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Effect of Streptococcus pneumoniae and influenza A virus on middle ear antimicrobial pharmacokinetics in experimental otitis media by JOSSART, G. H, CANAFAX, D. M, ERDMANN, G. R, LOVDAHL, M. J, RUSSLIE, H. Q, JUHN, S. K, GIEBINK, G. S

“…Antimicrobial treatment failures in children with acute otitis media and concomitant viral respiratory tract infection prompted us to study the effects of…”
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Comparison of two otitis media models for the study of middle ear antimicrobial pharmacokinetics by CANAFAX, D. M, RUSSLIE, H, LOVDAHL, M. J, ERDMANN, G. R, LE, C. T, GIEBINK, G. S

“…We compared two models of acute otitis media that estimate middle ear antimicrobial pharmacokinetics. Using a crossover study design, we compared a systemic…”
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Mizoribine pharmacokinetics and pharmacodynamics in a canine renal allograft model of local immunosuppression by Gruber, S A, Erdmann, G R, Burke, B A, Moss, A, Bowers, L, Hrushesky, W J, Cipolle, R J, Canafax, D M, Matas, A J

“…We utilized a canine renal transplant model to estimate the first-pass extraction of mizoribine (MZB) during renal artery infusion and to compare the efficacy…”
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Experimental animal models for studying antimicrobial pharmacokinetics in otitis media by CANAFAX, D. M, NONOMURA, N, ERDMANN, G. R, LE, C. T, JUHN, S. K, GIEBINK, G. S

“…Antimicrobial treatment of otitis media, especially drug dosing considerations, is largely empiric, with few reported pharmacologic studies of drug…”
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An experimental model for measuring middle ear antimicrobial drug penetration in otitis media by JOSSART, G. H, ERDMANN, G. R, LEVITT, D. G, KUCERA, P, LE, C. T, JUHN, S. K, GIEBINK, G. S, CANAFAX, D. M

“…Bacteria are an important cause of acute otitis media and successful treatment depends on achieving inhibitory or bacteriacidal antimicrobial drug…”
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Local immunosuppression with reduced systemic toxicity in a canine renal allograft model by Gruber, S A, Hrushesky, W J, Cipolle, R J, Erdmann, G R, Burke, B A, Skjei, K L, Mueller, R P, Fryd, D S, Matas, A J, Simmons, R L

“…We compared the efficacy of continuous intraarterial versus intravenous 6-mercaptopurine (6-MP) infusion in a mongrel canine renal allograft model with regard…”
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An implantable pump for intrarenal infusion of immunosuppressants in a canine autotransplant model by GRUBER, S. A, CIPOLLE, R. J, SIMMONS, R. L, HRUSHESKY, W. J. M, CANAFAX, D. M, ERDMANN, G. R, BURKE, B. A, RABATIN, J. T, HYNES, P. E, RITZ, J. A, GOULD, F. H, ASCHER, N. L

“…We developed a canine renal allograft model utilizing implantable infusion pumps and biocompatible catheters to investigate the pharmacokinetics of local…”
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Evaluation of a rapid monitoring system to study heparin pharmacokinetics and pharmacodynamics by Cipolle, R J, Uden, D L, Gruber, S A, Jossart, G H, Taylor, C A, Erdmann, G R, Canafax, D M

“…The pharmacokinetic and pharmacodynamic characteristics of heparin were studied in 10 healthy volunteers using the Hepcon/System B-10. This…”
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The pharmacokinetic advantage of local 6-mercaptopurine infusion in a canine renal transplant model by Gruber, S A, Canafax, D M, Erdmann, G R, Cipolle, R J, Burke, B A, Rabatin, J T, Hynes, P E, Gould, F H, Heil, J E, Ascher, N L

“…In light of recent technologic advances, we developed a canine renal allograft model utilizing implantable, programmable infusion pumps and biocompatible…”
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Analysis of danazol in serum using high-performance liquid chromatography by Nygard, G A, Lovett, L J, Erdmann, G R, Khalil, S K

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Reversed-phase high-performance liquid chromatographic approach to determine total lymphocyte concentrations of 6-thioguanine, methylmercaptopurine and methylthioguanine in humans by Erdmann, G R, Steury, J C, Carleton, B C, Stafford, R J, Bostrom, B C, Canafax, D M

“…A reversed-phase high-performance liquid chromatographic (HPLC) procedure was developed to quantify intracellular lymphocyte 6-thioguanine,…”
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Determination of mizoribine in plasma using ion-pair high-performance liquid chromatography by Erdmann, G R, Gruber, S A, McGuiggan, M M, Cipolle, R J, Canafax, D M

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