Search Results - "ERDAL, ESRA"

Elevated hepatocyte growth factor expression as an autocrine c‐Met activation mechanism in acquired resistance to sorafenib in hepatocellular carcinoma cells by Firtina Karagonlar, Zeynep, Koc, Dogukan, Iscan, Evin, Erdal, Esra, Atabey, Neşe

“…Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and the third leading cause of cancer‐related deaths worldwide. Limitations in…”
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miR-181a-5p is downregulated in hepatocellular carcinoma and suppresses motility, invasion and branching-morphogenesis by directly targeting c-Met by Korhan, Peyda, Erdal, Esra, Atabey, Neşe

“…•miR-181a-5p directly targets c-Met via its 3′-UTR.•miR-181a-5p coordinates c-Met signaling pathway.•miR-181a-5p regulates migration, invasion and…”
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Doxorubicin‐induced senescence promotes stemness and tumorigenicity in EpCAM−/CD133− nonstem cell population in hepatocellular carcinoma cell line, HuH‐7 by Karabicici, Mustafa, Alptekin, Sena, Fırtına Karagonlar, Zeynep, Erdal, Esra

“…The therapeutic induction of senescence is a potential means to treat cancer, primarily acting through the induction of a persistent growth‐arrested state in…”
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Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer by Azbazdar, Yagmur, Karabicici, Mustafa, Erdal, Esra, Ozhan, Gunes

“…Wnt signaling is one of the key signaling pathways that govern numerous physiological activities such as growth, differentiation and migration during…”
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Next-Generation Liver Medicine Using Organoid Models by Akbari, Soheil, Arslan, Nur, Senturk, Serif, Erdal, Esra

“…" " refers to all diagnostic and treatment strategies of diseases and conditions that cause liver failure directly or indirectly. Despite significant advances…”
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Role of Albumin in Growth Inhibition in Hepatocellular Carcinoma by Bağırsakçı, Ezgi, Şahin, Eren, Atabey, Neşe, Erdal, Esra, Guerra, Vito, Carr, Brian I

“…Levels of serum albumin have recently emerged, together with C-reactive protein, as an important prognostic indicator for hepatocellular carcinoma (HCC). It…”
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Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling by Akbari, Soheil, Sevinç, Gülben Gürhan, Ersoy, Nevin, Basak, Onur, Kaplan, Kubra, Sevinç, Kenan, Ozel, Erkin, Sengun, Berke, Enustun, Eray, Ozcimen, Burcu, Bagriyanik, Alper, Arslan, Nur, Önder, Tamer Tevfik, Erdal, Esra

“…Organoid technologies have become a powerful emerging tool to model liver diseases, for drug screening, and for personalized treatments. These applications…”
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Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells by Yuzugullu, Haluk, Benhaj, Khemais, Ozturk, Nuri, Senturk, Serif, Celik, Emine, Toylu, Asli, Tasdemir, Nilgun, Yilmaz, Mustafa, Erdal, Esra, Akcali, Kamil Can, Atabey, Nese, Ozturk, Mehmet

“…beta-catenin mutations that constitutively activate the canonical Wnt signaling have been observed in a subset of hepatocellular carcinomas (HCCs). These…”
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Changes in Wnt and TGF-β Signaling Mediate the Development of Regorafenib Resistance in Hepatocellular Carcinoma Cell Line HuH7 by Karabicici, Mustafa, Azbazdar, Yagmur, Ozhan, Gunes, Senturk, Serif, Firtina Karagonlar, Zeynep, Erdal, Esra

“…Graphical Abstract Wnt and TGF-β pathways mediate the regorafenib resistance. Hepatocellular carcinoma (HCC) is an aggressive, chemo resistant neoplasm with…”
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Silencing of TRPC1 regulates store-operated calcium entry and proliferation in Huh7 hepatocellular carcinoma cells by Selli, Cigdem, Erac, Yasemin, Kosova, Buket, Erdal, Esra S, Tosun, Metiner

“…Abstract Purpose Previously, we observed reciprocal changes in TRPC1 and TRPC6 expression levels in aging rat aorta and A7r5, rat embryonic vascular smooth…”
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Active form of AKT controls cell proliferation and response to apoptosis in hepatocellular carcinoma by KUNTER, IMGE, ERDAL, ESRA, NART, DENIZ, YILMAZ, FUNDA, KARADEMIR, SEDAT, SAGOL, OZGUL, ATABEY, NESE

“…Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality worldwide. Deregulation of the AKT signaling pathway has been found…”
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Spatio-temporal dynamics enhance cellular diversity, neuronal function and further maturation of human cerebral organoids by Saglam-Metiner, Pelin, Devamoglu, Utku, Filiz, Yagmur, Akbari, Soheil, Beceren, Goze, Goker, Bakiye, Yaldiz, Burcu, Yanasik, Sena, Biray Avci, Cigir, Erdal, Esra, Yesil-Celiktas, Ozlem

“…The bioengineerined and whole matured human brain organoids stand as highly valuable three-dimensional in vitro brain-mimetic models to recapitulate in vivo…”
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Reciprocal activating crosstalk between c-Met and caveolin 1 promotes invasive phenotype in hepatocellular carcinoma by Korhan, Peyda, Erdal, Esra, Kandemiş, Emine, Cokaklı, Murat, Nart, Deniz, Yılmaz, Funda, Can, Alp, Atabey, Neşe

“…c-Met, the receptor for Hepatocyte Growth Factor (HGF), overexpressed and deregulated in Hepatocellular Carcinoma (HCC). Caveolin 1 (CAV1), a plasma membrane…”
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Heparin inhibits Hepatocyte Growth Factor induced motility and invasion of hepatocellular carcinoma cells through early growth response protein 1 by Ozen, Evin, Gozukizil, Aysim, Erdal, Esra, Uren, Aykut, Bottaro, Donald P, Atabey, Nese

“…The Hepatocyte Growth Factor (HGF)/c-Met signaling pathway regulates hepatocyte proliferation, and pathway aberrations are implicated in the invasive and…”
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A Novel Function for KLF4 in Modulating the De-differentiation of EpCAM - /CD133 - nonStem Cells into EpCAM + /CD133 + Liver Cancer Stem Cells in HCC Cell Line HuH7 by Karagonlar, Zeynep Firtina, Akbari, Soheil, Karabicici, Mustafa, Sahin, Eren, Avci, Sanem Tercan, Ersoy, Nevin, Ates, Kıvılcım Eren, Balli, Tugsan, Karacicek, Bilge, Kaplan, Kubra Nur, Celiker, Canan, Atabey, Nese, Erdal, Esra

“…The complex and heterogeneous nature of hepatocellular carcinoma (HCC) hampers the identification of effective therapeutic strategies. Cancer stem cells (CSCs)…”
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Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasion by Cokakli, Murat, Erdal, Esra, Nart, Deniz, Yilmaz, Funda, Sagol, Ozgul, Kilic, Murat, Karademir, Sedat, Atabey, Nese

“…Caveolin-1 is the main component of caveolae membrane structures and has different roles during tumorigenesis in different cancer types with varying expression…”
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Genome-wide transcriptional reorganization associated with senescence-to-immortality switch during human hepatocellular carcinogenesis by Yildiz, Gokhan, Arslan-Ergul, Ayca, Bagislar, Sevgi, Konu, Ozlen, Yuzugullu, Haluk, Gursoy-Yuzugullu, Ozge, Ozturk, Nuri, Ozen, Cigdem, Ozdag, Hilal, Erdal, Esra, Karademir, Sedat, Sagol, Ozgul, Mizrak, Dilsa, Bozkaya, Hakan, Ilk, Hakki Gokhan, Ilk, Ozlem, Bilen, Biter, Cetin-Atalay, Rengul, Akar, Nejat, Ozturk, Mehmet

“…Senescence is a permanent proliferation arrest in response to cell stress such as DNA damage. It contributes strongly to tissue aging and serves as a major…”
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Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis by Bozkaya, Giray, Korhan, Peyda, Cokaklı, Murat, Erdal, Esra, Sağol, Ozgül, Karademir, Sedat, Korch, Christopher, Atabey, Neşe

“…Hepatocyte growth factor (HGF) induced c-Met activation is known as the main stimulus for hepatocyte proliferation and is essential for liver development and…”
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Transcriptome Dynamics of Human Neuronal Differentiation From iPSC by Kuruş, Meltem, Akbari, Soheil, Eskier, Doğa, Bursalı, Ahmet, Ergin, Kemal, Erdal, Esra, Karakülah, Gökhan

“…The generation and use of induced pluripotent stem cells (iPSCs) in order to obtain all differentiated adult cell morphologies without requiring embryonic stem…”
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VARS1 mutations associated with neurodevelopmental disorder are located on a short amino acid stretch of the anticodon-binding domain by Hiz, Semra, Kiliç, Seval, Bademci, Güney, Karakulak, Tülay, Erdoğan, Aybike, Özden, Burcu, Eresen, Çiğdem, Erdal, Esra, Yiş, Uluç, Tekin, Mustafa, Karakülah, Gökhan, Karaca, Ezgi, Öztürk, Mehmet

“…Majority of 37 human aminoacyl tRNA synthetases have been incriminated in diverse, mostly recessive, genetic diseases. In accordance with this, we uncovered a…”
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