Search Results - "EPSTEIN, Paul N"

Diminished Autophagy Limits Cardiac Injury in Mouse Models of Type 1 Diabetes by Xu, Xianmin, Kobayashi, Satoru, Chen, Kai, Timm, Derek, Volden, Paul, Huang, Yuan, Gulick, James, Yue, Zhenyu, Robbins, Jeffrey, Epstein, Paul N., Liang, Qiangrong

“…Cardiac autophagy is inhibited in type 1 diabetes. However, it remains unknown if the reduced autophagy contributes to the pathogenesis of diabetic…”
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Protection of Cardiac Mitochondria by Overexpression of MnSOD Reduces Diabetic Cardiomyopathy by XIA SHEN, SHIRONG ZHENG, METREVELI, Naira S, EPSTEIN, Paul N

“…Protection of Cardiac Mitochondria by Overexpression of MnSOD Reduces Diabetic Cardiomyopathy Xia Shen 1 , Shirong Zheng 2 , Naira S. Metreveli 2 and Paul N…”
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Potential role for Nrf2 activation in the therapeutic effect of MG132 on diabetic nephropathy in OVE26 diabetic mice by Cui, Wenpeng, Li, Bing, Bai, Yang, Miao, Xiao, Chen, Qiang, Sun, Weixia, Tan, Yi, Luo, Ping, Zhang, Chi, Zheng, Shirong, Epstein, Paul N, Miao, Lining, Cai, Lu

“…Oxidative stress is a major cause of diabetic nephropathy. Upregulation of the key antioxidative transcription factor, nuclear factor-erythroid 2-related…”
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Cardiac overexpression of 8-oxoguanine DNA glycosylase 1 protects mitochondrial DNA and reduces cardiac fibrosis following transaortic constriction by Wang, Jianxun, Wang, Qianwen, Watson, Lewis J, Jones, Steven P, Epstein, Paul N

“…Cardiac failure is associated with increased levels of oxidized DNA, especially mitochondrial (mtDNA). It is not known if oxidized mtDNA contributes to cardiac…”
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Podocyte-Specific Overexpression of the Antioxidant Metallothionein Reduces Diabetic Nephropathy by SHIRONG ZHENG, CARLSON, Edward C, LU YANG, KRALIK, Patricia M, YUN HUANG, EPSTEIN, Paul N

“…Podocytes are critical components of the selective filtration barrier of the glomerulus and are susceptible to oxidative damage. For investigation of the role…”
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Reduced cardiac fructose 2,6 bisphosphate increases hypertrophy and decreases glycolysis following aortic constriction by Wang, Jianxun, Xu, Jianxiang, Wang, Qianwen, Brainard, Robert E, Watson, Lewis J, Jones, Steven P, Epstein, Paul N

“…This study was designed to test whether reduced levels of cardiac fructose-2,6-bisphosphate (F-2,6-P(2)) exacerbates cardiac damage in response to pressure…”
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FVB mouse genotype confers susceptibility to OVE26 diabetic albuminuria by Xu, Jianxiang, Huang, Yun, Li, Fenge, Zheng, Shirong, Epstein, Paul N

“…OVE26 (OVE) diabetic mice on the inbred strain FVB are a valuable model of diabetic nephropathy that excretes the highest amount of urine albumin of all…”
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Catalase Protects Cardiomyocyte Function in Models of Type 1 and Type 2 Diabetes by Ye, Gang, Metreveli, Naira S, Donthi, Rajakumar V, Xia, Shen, Xu, Ming, Carlson, Edward C, Epstein, Paul N

“…Catalase Protects Cardiomyocyte Function in Models of Type 1 and Type 2 Diabetes Gang Ye 1 , Naira S. Metreveli 1 , Rajakumar V. Donthi 1 , Shen Xia 1 , Ming…”
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Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes by Shen, Xia, Zheng, Shirong, Thongboonkerd, Visith, Xu, Ming, Pierce, Jr, William M, Klein, Jon B, Epstein, Paul N

“…Diabetic cardiomyopathy is a common complication leading to heightened risk of heart failure and death. In the present report, we performed proteomic analysis…”
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Metallothionein Prevents Diabetes-Induced Deficits in Cardiomyocytes by Inhibiting Reactive Oxygen Species Production by Ye, Gang, Metreveli, Naira S, Ren, Jun, Epstein, Paul N

“…Metallothionein Prevents Diabetes-Induced Deficits in Cardiomyocytes by Inhibiting Reactive Oxygen Species Production Gang Ye 1 , Naira S. Metreveli 1 , Jun…”
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Transgenic Overexpression of Aldehyde Dehydrogenase-2 Rescues Chronic Alcohol Intake-Induced Myocardial Hypertrophy and Contractile Dysfunction by DOSER, Thomas A, TURDI, Subat, THOMAS, D. Paul, EPSTEIN, Paul N, LI, Shi-Yan, JUN REN

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Metallothionein Protects Islets from Hypoxia and Extends Islet Graft Survival by Scavenging Most Kinds of Reactive Oxygen Species by Li, Xiaoyan, Chen, Hainan, Epstein, Paul N.

“…Islet transplantation is a promising therapy for Type 1 diabetes, but many attempts have failed due to early graft hypoxia or immune rejection, which generate…”
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Development of Late-Stage Diabetic Nephropathy in OVE26 Diabetic Mice by ZHENG, Shirong, NOONAN, William T, METREVELI, Naira S, COVENTRY, Susan, KRALIK, Patricia M, CARLSON, Edward C, EPSTEINL, Paul N

“…Development of Late-Stage Diabetic Nephropathy in OVE26 Diabetic Mice Shirong Zheng 1 , William T. Noonan 2 , Naira S. Metreveli 1 , Susan Coventry 3 ,…”
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MnSOD and Catalase Transgenes Demonstrate That Protection of Islets From Oxidative Stress Does Not Alter Cytokine Toxicity by Chen, Hainan, Li, Xiaoyan, Epstein, Paul N

“…MnSOD and Catalase Transgenes Demonstrate That Protection of Islets From Oxidative Stress Does Not Alter Cytokine Toxicity Hainan Chen 1 2 , Xiaoyan Li 1 2 and…”
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Metallothionein over-expression in podocytes reduces adriamycin nephrotoxicity by Yang, Lu, Zheng, Shirong, Epstein, Paul N

“…Adriamycin (ADR) is nephrotoxic. One component of ADR-induced nephropathy may be oxidative stress. This study used a recently developed line of transgenic mice…”
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Overexpression of Metallothionein Reduces Diabetic Cardiomyopathy by QIANGRONG LIANG, CARLSON, Edward C, DONTHI, Rajakumar V, KRALIK, Patrica M, XIA SHEN, EPSTEIN, Paul N

“…Overexpression of Metallothionein Reduces Diabetic Cardiomyopathy Qiangrong Liang 1 , Edward C. Carlson 2 , Rajakumar V. Donthi 3 , Patrica M. Kralik 3 , Xia…”
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Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice by Epstein, Paul N., Jala, Venkatakrishna R., Powell, David W., Cai, Lu, Coventry, Susan, Zheng, Shirong, Haribabu, Bodduluri

“…In diabetic nephropathy (DN) proinflammatory chemokines and leukocyte infiltration correlate with tubulointerstitial injury and declining renal function. The…”
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Cardiac phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia by Wang, Qianwen, Donthi, Rajakumar V, Wang, Jianxun, Lange, Alex J, Watson, Lewis J, Jones, Steven P, Epstein, Paul N

“…During ischemia and heart failure, there is an increase in cardiac glycolysis. To understand if this is beneficial or detrimental to the heart, we chronically…”
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C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21 by Wu, Hao, Kong, Lili, Tan, Yi, Epstein, Paul N., Zeng, Jun, Gu, Junlian, Liang, Guang, Kong, Maiying, Chen, Xiangmei, Miao, Lining, Cai, Lu

“…Aims/hypothesis Diabetic nephropathy is the leading cause of end-stage renal disease. Previously we reported that C66, a novel analogue of curcumin with a very…”
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Overexpression of Metallothionein in Pancreatic β-Cells Reduces Streptozotocin-Induced DNA Damage and Diabetes by Chen, H, Carlson, E C, Pellet, L, Moritz, J T, Epstein, P N

“…Overexpression of Metallothionein in Pancreatic β-Cells Reduces Streptozotocin-Induced DNA Damage and Diabetes Hainan Chen 1 , Edward C. Carlson 2 , Lori…”
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