Search Results - "EPANCHINTSEV, Alexey"

Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer by Lodygin, Dmitri, Tarasov, Valery, Epanchintsev, Alexey, Berking, Carola, Knyazeva, Tatjana, Körner, Henrike, Knyazev, Piotr, Diebold, Joachim, Hermeking, Heiko

“…Recently, we and others identified the microRNA miR-34a as a target of the tumor suppressor gene product p53. Ectopic miR-34a induces a G1 cell cycle arrest,…”
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Cockayne’s Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation by Epanchintsev, Alexey, Costanzo, Federico, Rauschendorf, Marc-Alexander, Caputo, Manuela, Ye, Tao, Donnio, Lise-Marie, Proietti-de-Santis, Luca, Coin, Frederic, Laugel, Vincent, Egly, Jean-Marc

“…Cockayne syndrome (CS) is caused by mutations in CSA and CSB. The CSA and CSB proteins have been linked to both promoting transcription-coupled repair and…”
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Defective transcription of ATF3 responsive genes, a marker for Cockayne Syndrome by Epanchintsev, Alexey, Rauschendorf, Marc-Alexander, Costanzo, Federico, Calmels, Nadege, Obringer, Cathy, Sarasin, Alain, Coin, Frederic, Laugel, Vincent, Egly, Jean-Marc

“…Cockayne syndrome (CS) is a rare genetic disorder caused by mutations (dysfunction) in CSA and CSB . CS patients exhibit mild photosensitivity and severe…”
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Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro by Hofrichter, Maxi, Nimtz, Laura, Tigges, Julia, Kabiri, Yaschar, Schröter, Friederike, Royer-Pokora, Brigitte, Hildebrandt, Barbara, Schmuck, Martin, Epanchintsev, Alexey, Theiss, Stephan, Adjaye, James, Egly, Jean-Marc, Krutmann, Jean, Fritsche, Ellen

“…Developmental neurotoxicity (DNT) testing performed in rats is resource-intensive (costs, time, animals) and bears the issue of species extrapolation. Thus,…”
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Functional epigenomics identifies genes frequently silenced in prostate cancer by LODYGIN, Dimitri, EPANCHINTSEV, Alexey, MENSSEN, Antje, DIEBOLD, Joachim, HERMEKING, Heiko

“…In many cases, silencing of gene expression by CpG methylation is causally involved in carcinogenesis. Furthermore, cancer-specific CpG methylation may serve…”
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Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress by Kristensen, Ulrik, Epanchintsev, Alexey, Rauschendorf, Marc-Alexander, Laugel, Vincent, Stevnsner, Tinna, Bohr, Vilhelm A, Coin, Frédéric, Egly, Jean-Marc

“…Cockayne syndrome type B ATPase (CSB) belongs to the SwItch/Sucrose nonfermentable family. Its mutations are linked to Cockayne syndrome phenotypes and…”
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c-MYC Delays Prometaphase by Direct Transactivation of MAD2 and BubR1: Identification of Mechanisms Underlying c-MYC-Induced DNA Damage and Chromosomal Instability by Menssen, Antje, Epanchintsev, Alexey, Lodygin, Dmitri, Rezaei, Nousin, Jung, Peter, Verdoodt, Berlinda, Diebold, Joachim, Hermeking, Heiko

“…Here we show that the human BubR1 and MAD2 genes, which encode inhibitors of the anaphase promoting complex (APC/C), are directly activated by the oncogenic…”
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Digital Karyotyping Reveals Frequent Inactivation of the dystrophin/DMD Gene in Malignant Melanoma by Körner, Henrike, Epanchintsev, Alexey, Berking, Carola, Schuler-Thurner, Beatrice, Speicher, Michael R., Menssen, Antje, Hermeking, Heiko

“…Malignant melanoma is still poorly understood at the genomic level. Recently, a new technique for the high-resolution analysis of copy number changes named…”
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Differential Regulation of microRNAs by p53 Revealed by Massively Parallel Sequencing: miR-34a is a p53 Target That Induces Apoptosis and G1-arrest by Tarasov, Valery, Jung, Peter, Verdoodt, Berlinda, Lodygin, Dmitri, Epanchintsev, Alexey, Menssen, Antje, Meister, Gunter, Hermeking, Heiko

“…In a genome-wide screen for microRNAs regulated by the transcription factor encoded by the p53 tumor suppressor gene we found that after p53-activation the…”
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AMPKβ1 and AMPKβ2 define an isoform-specific gene signature in human pluripotent stem cells, differentially mediating cardiac lineage specification by Ziegler, Nicole, Bader, Erik, Epanchintsev, Alexey, Margerie, Daniel, Kannt, Aimo, Schmoll, Dieter

“…AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism that phosphorylates a wide range of proteins to maintain cellular homeostasis. AMPK…”
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AMPKβ1 and AMPKβ2 define an isoform-specific gene signature in human pluripotent stem cells, differentially mediating cardiac lineage specification by Ziegler, Nicole, Bader, Erik, Epanchintsev, Alexey, Margerie, Daniel, Kannt, Aimo, Schmoll, Dieter

“…AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism that phosphorylates a wide range of proteins to maintain cellular homeostasis. AMPK…”
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IL‐6, IL‐8, MMP‐2, MMP‐9 are overexpressed in Fanconi anemia cells through a NF‐κB/TNF‐α dependent mechanism by Epanchintsev, Alexey, Shyamsunder, Pavithra, Verma, Rama S., Lyakhovich, Alex

“…Fanconi anemia (FA) is a rare autosomal recessive genetic disorder associated with a bone‐marrow failure, genome instability, hypersensitivity to DNA…”
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IL-6, IL-8, MMP-2, MMP-9 are overexpressed in Fanconi anemia cells through a NF-[kappa]B/TNF-[alpha] dependent mechanism by Epanchintsev, Alexey, Shyamsunder, Pavithra, Verma, Rama S, Lyakhovich, Alex

“…Fanconi anemia (FA) is a rare autosomal recessive genetic disorder associated with a bone-marrow failure, genome instability, hypersensitivity to DNA…”
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MED12-related XLID disorders are dose-dependent of immediate early genes (IEGs) expression by Donnio, Lise-Marie, Bidon, Baptiste, Hashimoto, Satoru, May, Melanie, Epanchintsev, Alexey, Ryan, Colm, Allen, William, Hackett, Anna, Gecz, Jozef, Skinner, Cindy, Stevenson, Roger E, de Brouwer, Arjan P M, Coutton, Charles, Francannet, Christine, Jouk, Pierre-Simon, Schwartz, Charles E, Egly, Jean-Marc

“…Mediator occupies a key role in protein coding genes expression in mediating the contacts between gene specific factors and the basal transcription machinery…”
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AMPKβ1 and AMPKβ2 define an isoform-specific gene signature in human pluripotent stem cells, differentially mediating cardiac lineage specification by Ziegler, Nicole, Bader, Erik, Epanchintsev, Alexey, Margerie, Daniel, Kannt, Aimo, Schmoll, Dieter

“…AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism that phosphorylates a wide range of proteins to maintain cellular homeostasis. AMPK…”
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Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress by Kristensen, Ulrik, Epanchintsev, Alexey, Rauschendorf, Marc-Alexander, Laugel, Vincent, Stevnsner, Tinna, Bohr, Vilhelm A., Coin, Frédéric, Egly, Jean-Marc

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Inducible microRNA expression by an all-in-one episomal vector system by Epanchintsev, Alexey, Jung, Peter, Menssen, Antje, Hermeking, Heiko

“…Here we describe an episomal, one-vector system which allows the generation of cell populations displaying homogenous, inducible gene inactivation by RNA…”
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