Search Results - "ENROTH, Stefan"

Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan by Johansson, Asa, Enroth, Stefan, Gyllensten, Ulf

“…DNA methylation plays an important role in development of disease and the process of aging. In this study we examine DNA methylation at 476,366 sites…”
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Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs by Enroth, Stefan, Johansson, Åsa, Enroth, Sofia Bosdotter, Gyllensten, Ulf

“…Ideal biomarkers used for disease diagnosis should display deviating levels in affected individuals only and be robust to factors unrelated to the disease…”
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Nucleosomes are well positioned in exons and carry characteristic histone modifications by Andersson, Robin, Enroth, Stefan, Rada-Iglesias, Alvaro, Wadelius, Claes, Komorowski, Jan

“…The genomes of higher organisms are packaged in nucleosomes with functional histone modifications. Until now, genome-wide nucleosome and histone modification…”
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Distinct genetic regions are associated with differential population susceptibility to chemical exposures by Kosnik, Marissa B., Enroth, Stefan, Karlsson, Oskar

“…•Method demonstrates how GxE interaction potential differs for chemical exposures.•Different consumer product classes are high risk for varied disease…”
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Genome–wide binding of transcription factor ZEB1 in triple‐negative breast cancer cells by Maturi, Varun, Enroth, Stefan, Heldin, Carl‐Henrik, Moustakas, Aristidis

“…Zinc finger E‐box binding homeobox 1 (ZEB1) is a transcriptional regulator involved in embryonic development and cancer progression. ZEB1 induces…”
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Large-scale proteomics reveals precise biomarkers for detection of ovarian cancer in symptomatic women by Ivansson, Emma, Hedlund Lindberg, Julia, Stålberg, Karin, Sundfeldt, Karin, Gyllensten, Ulf, Enroth, Stefan

“…Ovarian cancer is the 8th most common cancer among women and has a 5-year survival of only 30–50%. While the survival is close to 90% for stage I tumours it is…”
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Effects of Long-Term Storage Time and Original Sampling Month on Biobank Plasma Protein Concentrations by Enroth, Stefan, Hallmans, Göran, Grankvist, Kjell, Gyllensten, Ulf

“…The quality of clinical biobank samples is crucial to their value for life sciences research. A number of factors related to the collection and storage of…”
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Evaluation of 92 cardiovascular proteins in dried blood spots collected under field‐conditions by Broberg, Karin, Svensson, Johanna, Grahn, Karin, Assarsson, Eva, Åberg, Mikael, Selander, Jenny, Enroth, Stefan

“…Workplace‐collected blood spots deposited on filter paper were analysed with multiplexed affinity‐based protein assays and found to be suitable for proteomics…”
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The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases by Ahsan, Muhammad, Ek, Weronica E, Rask-Andersen, Mathias, Karlsson, Torgny, Lind-Thomsen, Allan, Enroth, Stefan, Gyllensten, Ulf, Johansson, Åsa

“…Associations between epigenetic alterations and disease status have been identified for many diseases. However, there is no strong evidence that epigenetic…”
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Genome-wide Association Study of Susceptibility Loci for Cervical Cancer by DAN CHEN, JUKO-PECIREP, Ivana, GYLLENSTEN, Ulf, HAMMER, Joanna, IVANSSON, Emma, ENROTH, Stefan, GUSTAVSSON, Inger, FEUK, Lars, MAGNUSSON, Patrik K. E, MCKAY, James D, WILANDER, Erik

“…Cervical carcinoma has a heritable genetic component, but the genetic basis of cervical cancer is still not well understood. We performed a genome-wide…”
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Monte Carlo feature selection for supervised classification by Dramiński, Michał, Rada-Iglesias, Alvaro, Enroth, Stefan, Wadelius, Claes, Koronacki, Jacek, Komorowski, Jan

“…Motivation: Pre-selection of informative features for supervised classification is a crucial, albeit delicate, task. It is desirable that feature selection…”
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Genetic Adaptation of Fatty-Acid Metabolism: A Human-Specific Haplotype Increasing the Biosynthesis of Long-Chain Omega-3 and Omega-6 Fatty Acids by Ameur, Adam, Enroth, Stefan, Johansson, Åsa, Zaboli, Ghazal, Igl, Wilmar, Johansson, Anna C.V., Rivas, Manuel A., Daly, Mark J., Schmitz, Gerd, Hicks, Andrew A., Meitinger, Thomas, Feuk, Lars, van Duijn, Cornelia, Oostra, Ben, Pramstaller, Peter P., Rudan, Igor, Wright, Alan F., Wilson, James F., Campbell, Harry, Gyllensten, Ulf

“…Omega-3 and omega-6 long-chain polyunsaturated fatty acids (LC-PUFAs) are essential for the development and function of the human brain. They can be obtained…”
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Identification of genetic variants influencing the human plasma proteome by Johansson, Åsa, Enroth, Stefan, Palmblad, Magnus, Deelder, André M., Bergquist, Jonas, Gyllensten, Ulf

“…Genetic variants influencing the transcriptome have been extensively studied. However, the impact of the genetic factors on the human proteome is largely…”
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Contribution of rare whole-genome sequencing variants to plasma protein levels and the missing heritability by Kierczak, Marcin, Rafati, Nima, Höglund, Julia, Gourlé, Hadrien, Lo Faro, Valeria, Schmitz, Daniel, Ek, Weronica E., Gyllensten, Ulf, Enroth, Stefan, Ekman, Diana, Nystedt, Björn, Karlsson, Torgny, Johansson, Åsa

“…Despite the success of genome-wide association studies, much of the genetic contribution to complex traits remains unexplained. Here, we analyse high coverage…”
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Long noncoding RNA-mediated maintenance of DNA methylation and transcriptional gene silencing by Mohammad, Faizaan, Pandey, Gaurav Kumar, Mondal, Tanmoy, Enroth, Stefan, Redrup, Lisa, Gyllensten, Ulf, Kanduri, Chandrasekhar

“…Establishment of silencing by noncoding RNAs (ncRNAs) via targeting of chromatin remodelers is relatively well investigated; however, their role in the…”
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Temporal changes in the vaginal microbiota in self-samples and its association with persistent HPV16 infection and CIN2 by Berggrund, Malin, Gustavsson, Inger, Aarnio, Riina, Lindberg, Julia Hedlund, Sanner, Karin, Wikström, Ingrid, Enroth, Stefan, Bunikis, Ignas, Olovsson, Matts, Gyllensten, Ulf

“…The vaginal microbiota has been reported to be associated with HPV infection and cervical cancer. This study was performed to compare the vaginal microbiota at…”
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Genomewide binding of transcription factor Snail1 in triple‐negative breast cancer cells by Maturi, Varun, Morén, Anita, Enroth, Stefan, Heldin, Carl‐Henrik, Moustakas, Aristidis

“…Transcriptional regulation mediated by the zinc finger protein Snail1 controls early embryogenesis. By binding to the epithelial tumor suppressor CDH1 gene,…”
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Combinations of histone modifications mark exon inclusion levels by Enroth, Stefan, Bornelöv, Susanne, Wadelius, Claes, Komorowski, Jan

“…Splicing is a complex process regulated by sequence at the classical splice sites and other motifs in exons and introns with an enhancing or silencing effect…”
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Clinical validation of the HPVIR high-risk HPV test on cervical samples according to the international guidelines for human papillomavirus DNA test requirements for cervical cancer screening by Gustavsson, Inger, Aarnio, Riina, Myrnäs, Mattias, Hedlund-Lindberg, Julia, Taku, Ongeziwe, Meiring, Tracy, Wikström, Ingrid, Enroth, Stefan, Williamson, Anna-Lise, Olovsson, Matts, Gyllensten, Ulf

“…The indicating FTA card is a dry medium used for collection of cervical samples. HPVIR is a multiplex real-time PCR test that detects 12 high-risk human…”
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Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target by Agarwal, Prasoon, Alzrigat, Mohammad, Párraga, Alba Atienza, Enroth, Stefan, Singh, Umashankar, Ungerstedt, Johanna, Österborg, Anders, Brown, Peter J, Ma, Anqi, Jin, Jian, Nilsson, Kenneth, Öberg, Fredrik, Kalushkova, Antonia, Jernberg-Wiklund, Helena

“…Multiple myeloma (MM) is a malignancy of the antibody-producing plasma cells. MM is a highly heterogeneous disease, which has hampered the identification of a…”
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