Search Results - "ENHSEN, A"

Liver-specific drug targeting by coupling to bile acids by KRAMER, W, WESS, G, MÜLLNER, S, NECKERMANN, G, SCHULZ, S, PETZINGER, E, SCHUBERT, G, BICKEL, M, GIRBIG, F, GUTJAHR, U, KOWALEWSKI, S, BARINGHAUS, K.-H, ENHSEN, A, GLOMBIK, H

“…Bile acids are selectively taken up from portal blood into the liver by specific transport systems in the hepatocyte plasma membrane. Therefore, studies were…”
Get full text

Bile acids in drug discovery by ENHSEN, A, KRAMER, W, WESS, G

“…Recent advances have provided important new information on the physiological mechanisms of bile acid transport and metabolism. Bile acids, which are essential…”
Get full text

Substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transporters by Kramer, W, Stengelin, S, Baringhaus, K H, Enhsen, A, Heuer, H, Becker, W, Corsiero, D, Girbig, F, Noll, R, Weyland, C

“…The substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters was determined using brush border membrane vesicles and CHO cell lines…”
Get full text

Modified bile acids as carriers for peptides and drugs by Kramer, Werner, Wess, Günther, Enhsen, Alfons, Falk, Eugen, Hoffmann, Axel, Neckermann, Georg, Schubert, Gerrit, Urmann, Matthias

“…For the development of future drugs two aspects are of major importance, a site-specific drug action without adverse side-effects and a preferably oral…”
Get full text

Intestinal absorption of peptides by coupling to bile acids by KRAMER, W, WESS, G, ENHSEN, A, FALK, E, FRIEDRICH, M, GLOMBIK, H, HOFFMANN, A, PITTIUS, C, URMANN, M, NECKERMANN, G, SCHUBERT, G, FINK, J, GIRBIG, F, GUTJAHR, U, KOWALEWSKI, S, BARINGHAUS, K.-H, BÖGER, G

“…Poor intestinal absorption of peptides greatly limits their use as drugs for the treatment of chronic diseases. Since bile acids are efficiently absorbed by an…”
Get full text

Bile acid derived HMG-CoA reductase inhibitors by Kramer, W, Wess, G, Enhsen, A, Bock, K, Falk, E, Hoffmann, A, Neckermann, G, Gantz, D, Schulz, S, Nickau, L

“…The target organ for HMG-CoA reductase inhibitors to decrease cholesterol biosynthesis in hypercholesterolemic patients is the liver. Since bile acids undergo…”
Get more information

Synthesis of hydroxyquinones and related compounds: semisquaric acids, (.+-.)-terreic acid, (.+-.)-perezone and (.+-.)-isoperezone by Enhsen, Alfons, Karabelas, Kostas, Heerding, Julia M, Moore, Harold W

Get full text

Specific Inhibitors of Ileal Bile Acid Transport by Wess, Guenther, Kramer, Werner, Enhsen, Alfons, Glombik, Heiner, Baringhaus, Karl-Heinz, Boeger, Georg, Urmann, Matthias, Bock, Klaus, Kleine, Horst

Get full text

Synthesis and Biological Activity of Bile Acid-Derived HMG-CoA Reductase Inhibitors. The Role of 21-Methyl in Recognition of HMG-CoA Reductase and the Ileal Bile Acid Transport System by Wess, Guenther, Kramer, Werner, Han, Xiao Bing, Bock, Klaus, Enhsen, Alfons, Glombik, Heiner, Baringhaus, Karl-Heinz, Boeger, Georg, Urmann, Matthias

“…To increase hepatoselectivity of HMG-CoA reductase inhibitors by using the specific bile acid transport systems, deoxycholic acid-derived inhibitors 9 and 11…”
Get full text

Hepatobiliary transport of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors conjugated with bile acids by Petzinger, E, Nickau, L, Horz, J A, Schulz, S, Wess, G, Enhsen, A, Falk, E, Baringhaus, K H, Glombik, H, Hoffmann, A

“…To obtain prodrugs with affinity to liver parenchymal cells, the hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors HR 780 and…”
Get more information

Topological Photoaffinity Labeling of the Rabbit Ileal Na+/Bile‐Salt‐Cotransport System by Kramer, Werner, Wess, Günther, Bewersdorf, Ulrike, Corsiero, Daniel, Girbig, Frank, Weyland, Claudia, Stengelin, Siegfried, Enhsen, Alfons, Bock, Klaus, Kleine, Horst, Dreau, Marie‐Anne, Schäfer, Hans‐Ludwig

“…For the investigation of the topology of the rabbit ileal Na+/bile‐salt‐cotransport system, composed of a 93‐kDa integral membrane protein and a peripheral…”
Get full text

Synthesis of hydroxyquinones and related compounds: semisquaric acids, (±)-terreic acid, (±)-perozone, and (±)-isoperezone by ENHSEN, A, KARABELAS, K, HEERDING, J. M, MOORE, H. W

Get full text