Search Results - "ENGLEMAN, Edgar G"

Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance by Bagchi, Sreya, Yuan, Robert, Engleman, Edgar G

“…Immune checkpoint inhibitors (ICIs) have made an indelible mark in the field of cancer immunotherapy. Starting with the approval of anti-cytotoxic T…”
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High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization by Alcántara-Hernández, Marcela, Leylek, Rebecca, Wagar, Lisa E., Engleman, Edgar G., Keler, Tibor, Marinkovich, M. Peter, Davis, Mark M., Nolan, Garry P., Idoyaga, Juliana

“…Given the limited efficacy of clinical approaches that rely on ex vivo generated dendritic cells (DCs), it is imperative to design strategies that harness…”
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Ablative Tumor Radiation Can Change the Tumor Immune Cell Microenvironment to Induce Durable Complete Remissions by Filatenkov, Alexander, Baker, Jeanette, Mueller, Antonia M S, Kenkel, Justin, Ahn, G-One, Dutt, Suparna, Zhang, Nigel, Kohrt, Holbrook, Jensen, Kent, Dejbakhsh-Jones, Sussan, Shizuru, Judith A, Negrin, Robert N, Engleman, Edgar G, Strober, Samuel

“…The goals of the study were to elucidate the immune mechanisms that contribute to desirable complete remissions of murine colon tumors treated with single…”
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Mechanical Stiffness Controls Dendritic Cell Metabolism and Function by Chakraborty, Mainak, Chu, Kevin, Shrestha, Annie, Revelo, Xavier S., Zhang, Xiangyue, Gold, Matthew J., Khan, Saad, Lee, Megan, Huang, Camille, Akbari, Masoud, Barrow, Fanta, Chan, Yi Tao, Lei, Helena, Kotoulas, Nicholas K., Jovel, Juan, Pastrello, Chiara, Kotlyar, Max, Goh, Cynthia, Michelakis, Evangelos, Clemente-Casares, Xavier, Ohashi, Pamela S., Engleman, Edgar G., Winer, Shawn, Jurisica, Igor, Tsai, Sue, Winer, Daniel A.

“…Stiffness in the tissue microenvironment changes in most diseases and immunological conditions, but its direct influence on the immune system is poorly…”
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An interactive reference framework for modeling a dynamic immune system by Spitzer, Matthew H., Gherardini, Pier Federico, Fragiadakis, Gabriela K., Bhattacharya, Nupur, Yuan, Robert T., Hotson, Andrew N., Finck, Rachel, Carmi, Yaron, Zunder, Eli R., Fantl, Wendy J., Bendall, Sean C., Engleman, Edgar G., Nolan, Garry P.

“…Multiple characteristics of individual cells define cell types and their physiological states. Spitzer et al. quantitated the abundance of 39 different cell…”
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Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents by Luck, Helen, Tsai, Sue, Chung, Jason, Clemente-Casares, Xavier, Ghazarian, Magar, Revelo, Xavier S., Lei, Helena, Luk, Cynthia T., Shi, Sally Yu, Surendra, Anuradha, Copeland, Julia K., Ahn, Jennifer, Prescott, David, Rasmussen, Brittany A., Chng, Melissa Hui Yen, Engleman, Edgar G., Girardin, Stephen E., Lam, Tony K.T., Croitoru, Kenneth, Dunn, Shannon, Philpott, Dana J., Guttman, David S., Woo, Minna, Winer, Shawn, Winer, Daniel A.

“…Obesity has reached epidemic proportions, but little is known about its influence on the intestinal immune system. Here we show that the gut immune system…”
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Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell-Mediated Immunity in Colorectal Cancer by Bhattacharya, Nupur, Yuan, Robert, Prestwood, Tyler R., Penny, Hweixian Leong, DiMaio, Michael A., Reticker-Flynn, Nathan E., Krois, Charles R., Kenkel, Justin A., Pham, Tho D., Carmi, Yaron, Tolentino, Lorna, Choi, Okmi, Hulett, Reyna, Wang, Jinshan, Winer, Daniel A., Napoli, Joseph L., Engleman, Edgar G.

“…Although all-trans-retinoic acid (atRA) is a key regulator of intestinal immunity, its role in colorectal cancer (CRC) is unknown. We found that mice with…”
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An Immunosuppressive Dendritic Cell Subset Accumulates at Secondary Sites and Promotes Metastasis in Pancreatic Cancer by Kenkel, Justin A, Tseng, William W, Davidson, Matthew G, Tolentino, Lorna L, Choi, Okmi, Bhattacharya, Nupur, Seeley, E Scott, Winer, Daniel A, Reticker-Flynn, Nathan E, Engleman, Edgar G

“…Pancreatic ductal adenocarcinoma (PDAC) after complete surgical resection is often followed by distant metastatic relapse for reasons that remain unclear. In…”
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Tolerance and Chimerism after Renal and Hematopoietic-Cell Transplantation by Scandling, John D, Busque, Stephan, Dejbakhsh-Jones, Sussan, Benike, Claudia, Millan, Maria T, Shizuru, Judith A, Hoppe, Richard T, Lowsky, Robert, Engleman, Edgar G, Strober, Samuel

“…A patient received a kidney graft from his HLA-identical brother, followed by an infusion of CD34+ hematopoietic stem cells from the same donor. An apparent…”
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Tolerogenic interactions between CD8+ dendritic cells and NKT cells prevent rejection of bone marrow and organ grafts by Hongo, David, Tang, Xiaobin, Zhang, Xiangyue, Engleman, Edgar G., Strober, Samuel

“…The combination of total lymphoid irradiation and anti-T-cell antibodies safely induces immune tolerance to combined hematopoietic cell and organ allografts in…”
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B-1a lymphocytes attenuate insulin resistance by Shen, Lei, Chng, Melissa Hui Yen, Alonso, Michael N, Yuan, Robert, Winer, Daniel A, Engleman, Edgar G

“…Obesity-associated insulin resistance, a common precursor of type 2 diabetes, is characterized by chronic inflammation of tissues, including visceral adipose…”
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Cancer systems immunology by Reticker-Flynn, Nathan E, Engleman, Edgar G

“…Tumor immunology is undergoing a renaissance due to the recent profound clinical successes of tumor immunotherapy. These advances have coincided with an…”
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Mixed chimerism and acceptance of kidney transplants after immunosuppressive drug withdrawal by Busque, Stephan, Scandling, John D, Lowsky, Robert, Shizuru, Judith, Jensen, Kent, Waters, Jeffrey, Wu, Hsin-Hsu, Sheehan, Kevin, Shori, Asha, Choi, Okmi, Pham, Thomas, Fernandez Vina, Marcelo A, Hoppe, Richard, Tamaresis, John, Lavori, Philip, Engleman, Edgar G, Meyer, Everett, Strober, Samuel

“…Preclinical studies have shown that persistent mixed chimerism is linked to acceptance of organ allografts without immunosuppressive (IS) drugs. Mixed…”
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Brain profiling in murine colitis and human epilepsy reveals neutrophils and TNFα as mediators of neuronal hyperexcitability by Barnes, Sarah E, Zera, Kristy A, Ivison, Geoffrey T, Buckwalter, Marion S, Engleman, Edgar G

“…Patients with chronic inflammatory disorders such as inflammatory bowel disease frequently experience neurological complications including epilepsy,…”
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Identification of Two Subsets of Murine DC1 Dendritic Cells That Differ by Surface Phenotype, Gene Expression, and Function by Hongo, David, Zheng, Pingping, Dutt, Suparna, Pawar, Rahul D, Meyer, Everett, Engleman, Edgar G, Strober, Samuel

“…Classical dendritic cells (cDCs) in mice have been divided into 2 major subsets based on the expression of nuclear transcription factors: a CD8 Irf8 Batf3…”
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Adipose tissue macrophages impair preadipocyte differentiation in humans by Liu, Li Fen, Craig, Colleen M, Tolentino, Lorna L, Choi, Okmi, Morton, John, Rivas, Homero, Cushman, Samuel W, Engleman, Edgar G, McLaughlin, Tracey

“…The physiologic mechanisms underlying the relationship between obesity and insulin resistance are not fully understood. Impaired adipocyte differentiation and…”
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Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency by Moraga, Ignacio, Richter, David, Wilmes, Stephan, Winkelmann, Hauke, Jude, Kevin, Thomas, Christoph, Suhoski, Megan M, Engleman, Edgar G, Piehler, Jacob, Garcia, K Christopher

“…Cytokines dimerize cell surface receptors to activate signaling and regulate many facets of the immune response. Many cytokines have pleiotropic effects,…”
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Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis by Söderström, Kalle, Stein, Emily, Colmenero, Paula, Purath, Ulrich, Müller-Ladner, Ulf, de Matos, Cristina Teixeira, Tarner, Ingo H., Robinson, William H., Engleman, Edgar G., Cantor, Harvey

“…Osteoclasts are bone-eroding cells that develop from monocytic precursor cells in the presence of receptor activator of NF-κB ligand (RANKL) and macrophage…”
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Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma by Penny, Hweixian Leong, Sieow, Je Lin, Gun, Sin Yee, Lau, Mai Chan, Lee, Bernett, Tan, Jasmine, Phua, Cindy, Toh, Florida, Nga, Yvonne, Yeap, Wei Hseun, Janela, Baptiste, Kumar, Dilip, Chen, Hao, Yeong, Joe, Kenkel, Justin A, Pang, Angela, Lim, Diana, Toh, Han Chong, Hon, Tony Lim Kiat, Johnson, Christopher I, Khameneh, Hanif Javanmard, Mortellaro, Alessandra, Engleman, Edgar G, Rotzschke, Olaf, Ginhoux, Florent, Abastado, Jean-Pierre, Chen, Jinmiao, Wong, Siew Cheng

“…Inflammation in the tumor microenvironment has been shown to promote disease progression in pancreatic ductal adenocarcinoma (PDAC); however, the role of…”
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Enteric Glia Play a Critical Role in Promoting the Development of Colorectal Cancer by Yuan, Robert, Bhattacharya, Nupur, Kenkel, Justin A, Shen, Jeanne, DiMaio, Michael A, Bagchi, Sreya, Prestwood, Tyler R, Habtezion, Aida, Engleman, Edgar G

“…Enteric glia are a distinct population of peripheral glial cells in the enteric nervous system that regulate intestinal homeostasis, epithelial barrier…”
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