Search Results - "ENGLEMAN, E. G"

Requirement for Interactions of Natural Killer T Cells and Myeloid‐Derived Suppressor Cells for Transplantation Tolerance by Hongo, D., Tang, X., Baker, J., Engleman, E. G., Strober, S.

“…The goal of the study was to elucidate the cellular and molecular mechanisms by which a clinically applicable immune tolerance regimen of combined bone marrow…”
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Tolerance and Withdrawal of Immunosuppressive Drugs in Patients Given Kidney and Hematopoietic Cell Transplants by Scandling, J. D., Busque, S., Dejbakhsh‐Jones, S., Benike, C., Sarwal, M., Millan, M. T., Shizuru, J. A., Lowsky, R., Engleman, E. G., Strober, S.

“…Sixteen patients conditioned with total lymphoid irradiation (TLI) and antithymocyte globulin (ATG) were given kidney transplants and an injection of CD34+…”
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Development of CD8α-Positive Dendritic Cells from a Common Myeloid Progenitor by Traver, David, Akashi, Koichi, Manz, Markus, Merad, Miriam, Miyamoto, Toshihiro, Engleman, Edgar G., Weissman, Irving L.

“…Dendritic cells (DCs) are critical in both initiating adaptive immune responses and maintaining tolerance to self antigens. These apparently contradictory…”
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Dendritic Cells Injected Via Different Routes Induce Immunity in Cancer Patients by Fong, Lawrence, Brockstedt, Dirk, Benike, Claudia, Wu, Lijun, Engleman, Edgar G

“…Dendritic cells (DC) represent potent APCs that are capable of generating tumor-specific immunity. We performed a pilot clinical trial using Ag-pulsed DC as a…”
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Dendritic Cell-Based Xenoantigen Vaccination for Prostate Cancer Immunotherapy by Fong, Lawrence, Brockstedt, Dirk, Benike, Claudia, Breen, Jami K, Strang, George, Ruegg, Curtis L, Engleman, Edgar G

“…Many tumor-associated Ags represent tissue differentiation Ags that are poorly immunogenic. Their weak immunogenicity may be due to immune tolerance to…”
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Chimerism, Graft Survival, and Withdrawal of Immunosuppressive Drugs in HLA Matched and Mismatched Patients After Living Donor Kidney and Hematopoietic Cell Transplantation by Scandling, J. D., Busque, S., Shizuru, J. A., Lowsky, R., Hoppe, R., Dejbakhsh‐Jones, S., Jensen, K., Shori, A., Strober, J. A., Lavori, P., Turnbull, B. B., Engleman, E. G., Strober, S.

“…Thirty‐eight HLA matched and mismatched patients given combined living donor kidney and enriched CD34+ hematopoietic cell transplants were enrolled in…”
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Clinical transplantation tolerance twelve years after prospective withdrawal of immunosuppressive drugs : Studies of chimerism and anti-donor reactivity by STROBER, S, BENIKE, C, KRISHNASWAMY, S, ENGLEMAN, E. G, GRUMET, F. C

“…Previous studies showed the feasibility of inducing transplantation tolerance to cadaveric renal allografts in patients given pretransplant total lymphoid…”
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Induction of Immunity to Antigens Expressed by Recombinant Adeno-Associated Virus Depends on the Route of Administration by Brockstedt, Dirk G., Podsakoff, Greg M., Fong, Lawrence, Kurtzman, Gary, Mueller-Ruchholtz, Wolfgang, Engleman, Edgar G.

“…Recombinant adeno-associated virus (rAAV) is a replication-defective parvovirus which is being explored as a vector for gene therapy because of its broad host…”
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Granulocyte-macrophage colony-stimulating factor promotes differentiation and survival of human peripheral blood dendritic cells in vitro by MARKOWICZ, S, ENGLEMAN, E. G

“…Interest in human dendritic cells (DC) has been heightened recently by the discovery that this cell type is a primary target of the human immunodeficiency…”
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Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor by GODFREY, W. R, FAGNONI, F. F, HARARA, M. A, BUCK, D, ENGLEMAN, E. G

“…The human OX-40 cell surface antigen is a CD4+ T cell activation marker that acts as a costimulatory receptor and is a member of the nerve growth factor…”
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High-fat diet induces systemic B-cell repertoire changes associated with insulin resistance by Pham, T D, Chng, M H Y, Roskin, K M, Jackson, K J L, Nguyen, K D, Glanville, J, Lee, J-Y, Engleman, E G, Boyd, S D

“…The development of obesity-associated insulin resistance is associated with B-lymphocyte accumulation in visceral adipose tissue (VAT) and is prevented by…”
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Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months by van Vollenhoven, R F, Morabito, L M, Engleman, E G, McGuire, J L

“…To determine whether longterm therapy (up to 1 year) with the weakly androgenic adrenal steroid dehydroepiandrosterone (DHEA) is feasible and beneficial in…”
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Generation of antigen-specific CD8+ CTLs from naive precursors by Mehta-Damani, A, Markowicz, S, Engleman, EG

“…Class I MHC-restricted CTLs are an important component of the host immune response against viral infections, and CTL effectors can often be isolated from…”
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Inhibition of antigen‐presenting cell function by alendronate in vitro by Sansoni, Paolo, Passeri, Giovanni, Fagnoni, Francesco, Mohagheghpour, Nahid, Snelli, Gianluca, Brianti, Vincenzo, Engleman, Edgar G.

“…Bisphosphonates are potent inhibitors of bone resorption in vivo and are emerging as important and widely used drugs for the treatment of a variety of abnormal…”
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Low serum levels of dehydroepiandrosterone may cause deficient IL‐2 production by lymphocytes in patients with systemic lupus erythematosus (SLE) by SUZUKI, T., SUZUKI, N., ENGLEMAN, E. G., MIZUSHIMA, Y., SAKANE, T.

“…SUMMARY The principal cause of IL‐2 deficiency, a common feature of both murine lupus and human SLE, remains obscure. Recent studies of our own as well as…”
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Intracellular processing of the gp160 HIV-1 envelope precursor. Endoproteolytic cleavage occurs in a cis or medial compartment of the Golgi complex by STEIN, B. S, ENGLEMAN, E. G

“…The intracellular processing of the gp160 HIV-1 envelope precursor was characterized in acutely infected CD4+ T cells. Our data show that gp160 undergoes…”
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Langerhans cells renew in the skin throughout life under steady-state conditions by Merad, Miriam, Manz, Markus G, Karsunky, Holger, Wagers, Amy, Peters, Wendy, Charo, Israel, Weissman, Irving L, Cyster, Jason G, Engleman, Edgar G

“…Langerhans cells (LCs) are bone marrow (BM)-derived epidermal dendritic cells (DCs) that represent a critical immunologic barrier to the external environment,…”
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Dendritic Cells in Cancer Immunotherapy by Fong, Lawrence, Engleman, Edgar G

“…The potential to harness the potency and specificity of the immune system underlies the growing interest in cancer immunotherapy. One such approach uses bone…”
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Idiotype Vaccination Using Dendritic Cells After Autologous Peripheral Blood Stem Cell Transplantation for Multiple Myeloma—A Feasibility Study by Reichardt, Volker L., Okada, Craig Y., Liso, Arcangelo, Benike, Claudia J., Stockerl-Goldstein, Keith E., Engleman, Edgar G., Blume, Karl G., Levy, Ronald

“…The idiotype (Id) determinant on the multiple myeloma (MM) protein can be regarded as a tumor-specific marker. Immunotherapy directed at the MM Id may stem the…”
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Message amplification phenotyping (MAPPing): a technique to simultaneously measure multiple mRNAs from small numbers of cells by Brenner, C A, Tam, A W, Nelson, P A, Engleman, E G, Suzuki, N, Fry, K E, Larrick, J W

“…A rapid and highly sensitive technique (MAPPing: message amplification phenotyping) has been developed to simultaneously analyze the array of messenger RNAs…”
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