Search Results - "ENGLEKA, Kurt A"

Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest by Manderfield, Lauren J, Aghajanian, Haig, Engleka, Kurt A, Lim, Lillian Y, Liu, Feiyan, Jain, Rajan, Li, Li, Olson, Eric N, Epstein, Jonathan A

“…Notch signaling has well-defined roles in the assembly of arterial walls and in the development of the endothelium and smooth muscle of the vasculature. Hippo…”
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Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis by Goddard, Lauren M., Duchemin, Anne-Laure, Ramalingan, Harini, Wu, Bingruo, Chen, Mei, Bamezai, Sharika, Yang, Jisheng, Li, Li, Morley, Michael P., Wang, Tao, Scherrer-Crosbie, Marielle, Frank, David B., Engleka, Kurt A., Jameson, Stephen C., Morrisey, Edward E., Carroll, Thomas J., Zhou, Bin, Vermot, Julien, Kahn, Mark L.

“…Hemodynamic forces play an essential epigenetic role in heart valve development, but how they do so is not known. Here, we show that the shear-responsive…”
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Notch Activation of Jagged1 Contributes to the Assembly of the Arterial Wall by MANDERFIELD, Lauren J, HIGH, Frances A, ENGLEKA, Kurt A, FEIYAN LIU, LI LI, RENTSCHLER, Stacey, EPSTEIN, Jonathan A

“…Notch signaling in vascular smooth muscle precursors is required for smooth muscle differentiation. Jagged1 expression on endothelium activates Notch in…”
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Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest by Manderfield, Lauren J, Engleka, Kurt A, Aghajanian, Haig, Gupta, Mudit, Yang, Steven, Li, Li, Baggs, Julie E, Hogenesch, John B, Olson, Eric N, Epstein, Jonathan A

“…Loss of Pax3, a developmentally regulated transcription factor expressed in premigratory neural crest, results in severe developmental defects and embryonic…”
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Somitic Origin of Limb Muscle Satellite and Side Population Cells by Schienda, Jaclyn, Engleka, Kurt A., Jun, Susan, Hansen, Mark S., Epstein, Jonathan A., Tabin, Clifford J., Kunkel, Louis M., Kardon, Gabrielle

“…Repair of mature skeletal muscle is mediated by adult muscle progenitors. Satellite cells have long been recognized as playing a major role in muscle repair,…”
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Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice by Wu, Meilin, Li, Jun, Engleka, Kurt A, Zhou, Bo, Lu, Min Min, Plotkin, Joshua B, Epstein, Jonathan A

“…Transcription factors regulate tissue patterning and cell fate determination during development; however, expression of early regulators frequently abates upon…”
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An Engineered Mouse to Identify Proliferating Cells and Their Derivatives by Jang, Jihyun, Engleka, Kurt A, Liu, Feiyan, Li, Li, Song, Guang, Epstein, Jonathan A, Li, Deqiang

“…Cell proliferation is a fundamental event during development, disease, and regeneration. Effectively tracking and quantifying proliferating cells and their…”
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Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions by Degenhardt, Karl R., Milewski, Rita C., Padmanabhan, Arun, Miller, Mayumi, Singh, Manvendra K., Lang, Deborah, Engleka, Kurt A., Wu, Meilin, Li, Jun, Zhou, Diane, Antonucci, Nicole, Li, Li, Epstein, Jonathan A.

“…Pax3 is a transcription factor expressed in somitic mesoderm, dorsal neural tube and pre-migratory neural crest during embryonic development. We have…”
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Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos by Yzaguirre, Amanda D, Padmanabhan, Arun, de Groh, Eric D, Engleka, Kurt A, Li, Jun, Speck, Nancy A, Epstein, Jonathan A

“…Type I neurofibromatosis (NF1) is caused by mutations in the NF1 gene encoding neurofibromin. Neurofibromin exhibits Ras GTPase activating protein (Ras-GAP)…”
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Pax3 and Hippo Signaling Coordinate Melanocyte Gene Expression in Neural Crest by Manderfield, Lauren J., Engleka, Kurt A., Aghajanian, Haig, Gupta, Mudit, Yang, Steven, Li, Li, Baggs, Julie E., Hogenesch, John B., Olson, Eric N., Epstein, Jonathan A.

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Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction by Ramjee, Vimal, Li, Deqiang, Manderfield, Lauren J, Liu, Feiyan, Engleka, Kurt A, Aghajanian, Haig, Rodell, Christopher B, Lu, Wen, Ho, Vivienne, Wang, Tao, Li, Li, Singh, Anamika, Cibi, Dasan M, Burdick, Jason A, Singh, Manvendra K, Jain, Rajan, Epstein, Jonathan A

“…Ischemic heart disease resulting from myocardial infarction (MI) is the most prevalent form of heart disease in the United States. Post-MI cardiac remodeling…”
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Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves by Jain, Rajan, Engleka, Kurt A, Rentschler, Stacey L, Manderfield, Lauren J, Li, Li, Yuan, Lijun, Epstein, Jonathan A

“…Congenital anomalies of the aortic valve are common and are associated with progressive valvular insufficiency and/or stenosis. In addition, aneurysm,…”
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Islet1 Derivatives in the Heart Are of Both Neural Crest and Second Heart Field Origin by Engleka, Kurt A, Manderfield, Lauren J, Brust, Rachael D, Li, Li, Cohen, Ashley, Dymecki, Susan M, Epstein, Jonathan A

“…RATIONALE:Islet1 (Isl1) has been proposed as a marker of cardiac progenitor cells derived from the second heart field and is utilized to identify and purify…”
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Pax3 functions at a nodal point in melanocyte stem cell differentiation by Epstein, Jonathan A, Lang, Deborah, Lu, Min Min, Huang, Li, Engleka, Kurt A, Zhang, Maozhen, Chu, Emily Y, Lipner, Shari, Skoultchi, Arthur, Millar, Sarah E

“…Most stem cells are not totipotent. Instead, they are partially committed but remain undifferentiated. Upon appropriate stimulation they are capable of…”
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Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives by Engleka, Kurt A., Gitler, Aaron D., Zhang, Maozhen, Zhou, Diane D., High, Frances A., Epstein, Jonathan A.

“…Pax3 is a transcription factor expressed in the dorsal neural tube and somite of the developing embryo. It plays critical roles in pre-migratory neural crest…”
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Menin expression modulates mesenchymal cell commitment to the myogenic and osteogenic lineages by Aziz, Arif, Miyake, Tetsuaki, Engleka, Kurt A., Epstein, Jonathan A., McDermott, John C.

“…Menin plays an established role in the differentiation of mesenchymal cells to the osteogenic lineage. Conversely, whether Menin influences the commitment of…”
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Menin is required in cranial neural crest for palatogenesis and perinatal viability by Engleka, Kurt A., Wu, Meilin, Zhang, Maozhen, Antonucci, Nicole B., Epstein, Jonathan A.

“…Menin is a nuclear protein encoded by a tumor suppressor gene that is mutated in humans with multiple endocrine neoplasia type 1 (MEN1). Menin functions as a…”
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A potential role for the nucleolus in L1 retrotransposition by Goodier, John L., Ostertag, Eric M., Engleka, Kurt A., Seleme, Maria C., Kazazian, Haig H.

“…Determining the subcellular localization of the L1 ORF2 protein (ORF2p) has been impossible to date because of technical limitations in detecting either…”
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Identification of a hypaxial somite enhancer element regulating Pax3 expression in migrating myoblasts and characterization of hypaxial muscle Cre transgenic mice by Brown, Christopher B., Engleka, Kurt A., Wenning, Jennifer, Min Lu, Min, Epstein, Jonathan A.

“…Pax3 encodes a transcription factor that functions in the embryonic central nervous system, neural crest, and somitic mesoderm. Prior studies suggest that…”
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Heat Shock Induces the Release of Fibroblast Growth Factor 1 from NIH 3T3 Cells by Jackson, Anthony, Friedman, Stanley, Zhan, Xi, Engleka, Kurt A., Forough, Reza, Maciag, Thomas

“…Fibroblast growth factor 1 (FGF-1) is a potent angiogenic and neurotrophic factor whose structure lacks a classical signal sequence for secretion. Although the…”
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