Search Results - "ENGELS, Leopold G. J. B"

Red meat intake-induced increases in fecal water genotoxicity correlate with pro-carcinogenic gene expression changes in the human colon by Hebels, Dennie G.A.J., Sveje, Kirstine M., de Kok, Marloes C., van Herwijnen, Marcel H.M., Kuhnle, Gunter G.C., Engels, Leopold G.J.B., Vleugels-Simon, Carla B.E.M., Mares, Wout G.N., Pierik, Marieke, Masclee, Ad A.M., Kleinjans, Jos C.S., de Kok, Theo M.C.M.

“…► Fecal water genotoxicity significantly increased after an increase in red meat intake to 300g/day for 7days. ► Oxidative DNA damage is a large contributor to…”
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Pharmacokinetics of 6-mercaptopurine in patients with inflammatory bowel disease: implications for therapy by Derijks, Luc J J, Gilissen, Lennard P L, Engels, Leopold G J B, Bos, Laurens P, Bus, Paul J, Lohman, Joseph J H M, Curvers, Wouter L, Van Deventer, Sander J H, Hommes, Daniel W, Hooymans, Piet M

“…Proper prospective pharmacokinetic studies of 6-mercaptopurine (6-MP) in inflammatory bowel disease (IBD) patients are lacking. As a result, conflicting…”
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Treatment of irritable bowel syndrome with osteopathy: Results of a randomized controlled pilot study by Hundscheid, Henry WC, Pepels, Manon JAE, Engels, Leopold GJB, Loffeld, Ruud JLF

“…Background and Aim:  Effective treatment for irritable bowel syndrome (IBS) is not yet available. Osteopathy is a manual treatment which relies on mobilizing…”
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Pharmacokinetics of 6-thioguanine in patients with inflammatory bowel disease by DERIJKS, Luc J. J, GILISSEN, Lennard P. L, ENGELS, Leopold G. J. B, BOS, Laurens P, BUS, Paul J, LOHMAN, Joseph J. H. M, VAN DEVENTER, Sander J. H, HOMMES, Daniel W, HOOYMANS, Piet M

“…6-Thioguanine (6-TG) seems to be an attractive alternative in both AZA- and 6-MP-intolerant and -resistant IBD populations. However, little is known of 6-TG…”
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Methylation status of CpG islands in the promoter region of genes differentially expressed in colonic mucosa from adenoma patients and controls in response to altered vegetable intake by van Breda, Simone G. J., van Delft, Joost H. M., Engels, Leopold G. J. B., Kleinjans, Jos C. S., Mathers, John C.

“…Vegetables may protect against colorectal cancer (CRC) via changes in gene expression involved in anticarcinogenic mechanisms. There is considerable evidence…”
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Dose-dependent influence of 5-aminosalicylates on thiopurine metabolism by de Boer, Nanne K H, Wong, Dennis R, Jharap, Bindia, de Graaf, Peer, Hooymans, Piet M, Mulder, Chris J J, Rijmen, Frank, Engels, Leopold G J B, van Bodegraven, Adriaan A

“…Studies indicated that 5-aminosalicylates (5-ASA) may influence the metabolism of thiopurines; however, conclusions were restricted as a result of number of…”
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Therapeutic drug monitoring of thiopurine metabolites in adult thiopurine tolerant IBD patients on maintenance therapy by Gilissen, Lennard P.L., Wong, Dennis R., Engels, Leopold G.J.B., Bierau, Jörgen, Bakker, Jaap A., Paulussen, Aimée D.C., Romberg-Camps, Mariëlle J., Stronkhorst, Arnold, Bus, Paul, Bos, Laurens P., Hooymans, Piet M., Stockbrügger, Reinhold W., Neef, Cees, Masclee, Ad A.M.

“…Therapeutic drug monitoring of active metabolites of thiopurines, azathioprine and 6-mercaptopurine, is relatively new. The proposed therapeutic threshold…”
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N-nitroso compound exposure-associated transcriptomic profiles are indicative of an increased risk for colorectal cancer by Hebels, Dennie G.A.J, Sveje, Kirstine M, de Kok, Marloes C, van Herwijnen, Marcel H.M, Kuhnle, Gunter G.C, Engels, Leopold G.J.B, Vleugels-Simon, Carla B.E.M, Mares, Wout G.N, Pierik, Marieke, Masclee, Ad A.M, Kleinjans, Jos C.S, de Kok, Theo M.C.M

“…Abstract Endogenous formation of N-nitroso compounds (NOCs), which are known animal carcinogens, could contribute to human carcinogenesis but definitive…”
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Psychometric validation of the Dutch translation of the quality of life in reflux and dyspepsia (QOLRAD) questionnaire in patients with gastroesophageal reflux disease by Engels, Leopold G J B, Klinkenberg-Knol, Elly C, Carlsson, Jonas, Halling, Katarina

“…The Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire is one of the best-characterized disease-specific instruments that captures health-related…”
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6-Thioguanine seems promising in azathioprine- or 6-mercaptopurine-intolerant inflammatory bowel disease patients: a short-term safety assessment by Derijks, Luc JJ, de Jong, Dirk J, Gilissen, Lennard PL, Engels, Leopold GJB, Hooymans, Piet M, Jansen, Jan BMJ, Mulder, Chris JJ

“…OBJECTIVE6-Mercaptopurine (6-MP) and azathioprine (AZA) have proven efficacy in the treatment of inflammatory bowel disease (IBD). However, adverse events…”
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On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprine or 6-mercaptopurine intolerant IBD patients by de Boer, Nanne-K-H, Derijks, Luc-J-J, Gilissen, Lennard-P-L, Hommes, Daniel-W, Engels, Leopold-G-J-B, de-Boer, Sybrand-Y, den Hartog, Gijsbertus, Hooymans, Piet-M, Mäkelburg, Anja-B-U, Westerveld, Barend-D, Naber, Anton-H-J, Mulder, Chris-J-J, de Jong, Dirk-J

“…To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant…”
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Neutrophil-mediated formation of carcinogenic N-nitroso compounds in an in vitro model for intestinal inflammation by Vermeer, Ingrid T.M., Henderson, Laila Y., Moonen, Edwin J.C., Engels, Leopold G.J.B., Dallinga, Jan W., van Maanen, Jan M.S., Kleinjans, Jos C.S.

“…In order to study neutrophil-mediated formation of carcinogenic N-nitroso compounds as a mechanism of inflammation-related colon carcinogenesis, we designed an…”
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Some cases demonstrating the clinical usefulness of therapeutic drug monitoring in thiopurine-treated inflammatory bowel disease patients by Gilissen, Lennard PL, Derijks, Luc JJ, Bos, Laurens P, Verhoeven, Herman MJM, Bus, Paul J, Hooymans, Piet M, Engels, Leopold GJB

“…The thiopurines azathioprine and 6-mercaptopurine (6-MP) are effective drugs in steroid-dependent and refractory inflammatory bowel disease patients…”
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Altered vegetable intake affects pivotal carcinogenesis pathways in colon mucosa from adenoma patients and controls by van Breda, Simone G.J., van Agen, Ebienus, Engels, Leopold G.J.B., Moonen, Edwin J.C., Kleinjans, Jos C.S., van Delft, Joost H.M.

“…The evidence from epidemiological and experimental studies that vegetables reduce the risk of colorectal cancer is convincing. However, the involved genes and…”
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Early Assessment of Thiopurine Metabolites Identifies Patients at Risk of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease by Wong, Dennis R, Coenen, Marieke J H, Vermeulen, Sita H, Derijks, Luc J J, van Marrewijk, Corine J, Klungel, Olaf H, Scheffer, Hans, Franke, Barbara, Guchelaar, Henk-Jan, de Jong, Dirk J, Engels, Leopold G J B, Verbeek, André L M, Hooymans, Piet M

“…Only a quarter of thiopurine-induced myelotoxicity in inflammatory bowel disease [IBD] patients is related to thiopurine S-methyltransferase deficiency. We…”
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Dose-Dependent Influence of 5-Aminosalicylates on Thiopurine Metabolism by DE BOER, Nanne K. H, WONG, Dennis R, JHARAP, Bindia, DE GRAAF, Peer, HOOYMANS, Piet M, MULDER, Chris J. J, RIJMEN, Frank, ENGELS, Leopold G. J. B, VAN BODEGRAVEN, Adriaan A

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Intragastric volatile N-nitrosamines, nitrite, pH, and Helicobacter pylori during long-term treatment with omeprazole by Vermeer, Ingrid T.M., Engels, Leopold G.J.B., Pachen, Daniëlle M.F.A., Dallinga, Jan W., Kleinjans, Jos C.S., van Maanen, Jan M.S.

“…Background & Aims: This study evaluated the effect of long-term gastric acid suppressive therapy with omeprazole on intragastric levels of carcinogenic…”
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Upper gastrointestinal endoscopy in patients aged 85 years or more. Results of a feasibility study in a district general hospital by Van Kouwen, Mariëtte C.A., Drenth, Joost P.H., Verhoeven, Herman M.J.M., Bos, Laurens P., Engels, Leopold G.J.B.

“…We performed a cross sectional analysis of the feasibility and yield of upper gastrointestinal endoscopy (UGE) in a cohort of patients aged 85 years or more…”
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