Search Results - "ENGEL, Juan C"

Temporal analysis of the honey bee microbiome reveals four novel viruses and seasonal prevalence of known viruses, Nosema, and Crithidia by Runckel, Charles, Flenniken, Michelle L, Engel, Juan C, Ruby, J Graham, Ganem, Donald, Andino, Raul, DeRisi, Joseph L

“…Honey bees (Apis mellifera) play a critical role in global food production as pollinators of numerous crops. Recently, honey bee populations in the United…”
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Host Metabolism Regulates Intracellular Growth of Trypanosoma cruzi by Caradonna, Kacey L., Engel, Juan C., Jacobi, David, Lee, Chih-Hao, Burleigh, Barbara A.

“…Metabolic coupling of intracellular pathogens with host cells is essential for successful colonization of the host. Establishment of intracellular infection by…”
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A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit by De Muylder, Geraldine, Ang, Kenny K H, Chen, Steven, Arkin, Michelle R, Engel, Juan C, McKerrow, James H

“…The ability to screen compounds in a high-throughput manner is essential in the process of small molecule drug discovery. Critical to the success of screening…”
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A Cysteine Protease Inhibitor Cures Chagas' Disease in an Immunodeficient-Mouse Model of Infection by DOYLE, Patricia S, ZHOU, Yuan M, ENGEL, Juan C, MCKERROW, James H

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The Trypanosoma cruzi protease cruzain mediates immune evasion by Doyle, Patricia S, Zhou, Yuan M, Hsieh, Ivy, Greenbaum, Doron C, McKerrow, James H, Engel, Juan C

“…Trypanosoma cruzi is the causative agent of Chagas' disease. Novel chemotherapy with the drug K11777 targets the major cysteine protease cruzain and disrupts…”
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Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi, the Agent of Chagas' Disease by Engel, Juan C, Ang, Kenny K H, Chen, Steven, Arkin, Michelle R, McKerrow, James H, Doyle, Patricia S

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A Nonazole CYP51 Inhibitor Cures Chagas’ Disease in a Mouse Model of Acute Infection by DOYLE, Patricia S, CHEN, Chiung-Kuang, JOHNSTON, Jonathan B, HOPKINS, Stephanie D, LEUNG, Siegfried S. F, JACOBSON, Matthew P, ENGEL, Juan C, MCKERROW, James H, PODUST, Larissa M

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Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51 by Gunatilleke, Shamila S, Calvet, Claudia M, Johnston, Jonathan B, Chen, Chiung-Kuang, Erenburg, Grigori, Gut, Jiri, Engel, Juan C, Ang, Kenny K H, Mulvaney, Joseph, Chen, Steven, Arkin, Michelle R, McKerrow, James H, Podust, Larissa M

“…Chagas Disease, a WHO- and NIH-designated neglected tropical disease, is endemic in Latin America and an emerging infection in North America and Europe as a…”
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A Contiguous Compartment Functions as Endoplasmic Reticulum and Endosome/Lysosome in Giardia lamblia by Abodeely, Marla, DuBois, Kelly N, Hehl, Adrian, Stefanic, Sasa, Sajid, Mohammed, DeSouza, Wanderley, Attias, Marcia, Engel, Juan C, Hsieh, Ivy, Fetter, Richard D, McKerrow, James H

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Cathepsin Cs Are Key for the Intracellular Survival of the Protozoan Parasite, Toxoplasma gondii by Que, Xuchu, Engel, Juan C., Ferguson, David, Wunderlich, Annette, Tomavo, Stanislas, Reed, Sharon L.

“…Cysteine proteases play key roles in apicomplexan invasion, organellar biogenesis, and intracellular survival. We have now characterized five genes encoding…”
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Mining a cathepsin inhibitor library for new antiparasitic drug leads by Ang, Kenny K H, Ratnam, Joseline, Gut, Jiri, Legac, Jennifer, Hansell, Elizabeth, Mackey, Zachary B, Skrzypczynska, Katarzyna M, Debnath, Anjan, Engel, Juan C, Rosenthal, Philip J, McKerrow, James H, Arkin, Michelle R, Renslo, Adam R

“…The targeting of parasite cysteine proteases with small molecules is emerging as a possible approach to treat tropical parasitic diseases such as sleeping…”
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Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy by Brak, Katrien, Kerr, Iain D, Barrett, Kimberly T, Fuchi, Nobuhiro, Debnath, Moumita, Ang, Kenny, Engel, Juan C, McKerrow, James H, Doyle, Patricia S, Brinen, Linda S, Ellman, Jonathan A

“…A century after discovering that the Trypanosoma cruzi parasite is the etiological agent of Chagas disease, treatment is still plagued by limited efficacy,…”
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Liver Cytochrome P450 3A Ubiquitination in Vivo by gp78/Autocrine Motility Factor Receptor and C Terminus of Hsp70-interacting Protein (CHIP) E3 Ubiquitin Ligases: PHYSIOLOGICAL AND PHARMACOLOGICAL RELEVANCE by Kim, Sung-Mi, Acharya, Poulomi, Engel, Juan C, Correia, Maria Almira

“…CYP3A4 is a dominant human liver cytochrome P450 enzyme engaged in the metabolism and disposition of >50% of clinically relevant drugs and held responsible for…”
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Liver cytochrome P450 3A endoplasmic reticulum-associated degradation: a major role for the p97 AAA ATPase in cytochrome P450 3A extraction into the cytosol by Acharya, Poulomi, Liao, Mingxiang, Engel, Juan C, Correia, Maria Almira

“…The CYP3A subfamily of hepatic cytochromes P450, being engaged in the metabolism and clearance of >50% of clinically relevant drugs, can significantly…”
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Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection by Engel, J C, Doyle, P S, Hsieh, I, McKerrow, J H

“…Trypanosoma cruzi is the causative agent of Chagas' disease. The major protease, cruzain, is a target for the development of new chemotherapy. We report the…”
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Liver Cytochrome P450 3A Endoplasmic Reticulum-associated Degradation by Acharya, Poulomi, Liao, Mingxiang, Engel, Juan C., Correia, Maria Almira

“…The CYP3A subfamily of hepatic cytochromes P450, being engaged in the metabolism and clearance of >50% of clinically relevant drugs, can significantly…”
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Cysteine protease inhibitors as chemotherapy for parasitic infections by McKerrow, James H, Engel, Juan C, Caffrey, Conor R

“…Analysis of the evolution, localization and biologic function of papain family cysteine proteases in metazoan and protozoan parasites has provided important…”
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Cell Biology of Pathogenic Protozoa and Their Interaction with Host Cells by Tan, Kevin S. W., Engel, Juan C., Benchimol, Marlene, de Souza, Wanderley

“…A protein was identified and designated as TvACTN3, the cytoplasmic protein that specifically binds to hairpin RNA structures from trichomonads when the…”
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Liver Cytochrome P450 3A Ubiquitination in Vivo by gp78/Autocrine Motility Factor Receptor and C Terminus of Hsp70-interacting Protein (CHIP) E3 Ubiquitin Ligases by Kim, Sung-Mi, Acharya, Poulomi, Engel, Juan C., Correia, Maria Almira

“…CYP3A4 is a dominant human liver cytochrome P450 enzyme engaged in the metabolism and disposition of >50% of clinically relevant drugs and held responsible for…”
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Biolistic transformation of Schistosoma mansoni: Studies with modified reporter-gene constructs containing regulatory regions of protease genes by Dvořák, Jan, Beckmann, Svenja, Lim, Kee-Chong, Engel, Juan C., Grevelding, Christoph G., McKerrow, James H., Caffrey, Conor R.

“…Biolistics of the flatworm parasite Schistosoma mansoni facilitates the accurate spatial expression of transgenes under the control of gene-specific promoter…”
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