Search Results - "ENGBER, Thomas M."

Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate by Hughes, Robert O., Bosanac, Todd, Mao, Xianrong, Engber, Thomas M., DiAntonio, Aaron, Milbrandt, Jeffrey, Devraj, Rajesh, Krauss, Raul

“…Axonal degeneration is responsible for disease progression and accumulation of disability in many neurodegenerative conditions. The axonal degenerative process…”
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cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons by Sasaki, Yo, Engber, Thomas M., Hughes, Robert O., Figley, Matthew D., Wu, Tong, Bosanac, Todd, Devraj, Rajesh, Milbrandt, Jeffrey, Krauss, Raul, DiAntonio, Aaron

“…SARM1 is the central executioner of pathological axon degeneration, promoting axonal demise in response to axotomy, traumatic brain injury, and neurotoxic…”
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Studies to Assess the Utility of Serum Neurofilament Light Chain as a Biomarker in Chemotherapy-Induced Peripheral Neuropathy by Cavaletti, Guido, Pizzamiglio, Chiara, Man, Albert, Engber, Thomas M, Comi, Cristoforo, Wilbraham, Darren

“…Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common and disabling dose-limiting toxicities of chemotherapy. We report here the results…”
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Synthesis of alkyne derivatives of a novel triazolopyrazine as A2A adenosine receptor antagonists by YAO, Gang, HAQUE, Serajul, PETTER, Russell C, LI SHA, KUMARAVEL, Gnanasambandam, WANG, Joy, ENGBER, Thomas M, WHALLEY, Eric T, CONLON, Patrick R, HEXI CHANG, KIESMAN, William F

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Novel Bicyclic Piperazine Derivatives of Triazolotriazine and Triazolopyrimidines as Highly Potent and Selective Adenosine A2A Receptor Antagonists by PENG, Hairuo, KUMARAVEL, Gnanasambandam, YAO, Gang, SHA, Li, WANG, Joy, VAN VLIJMEN, Herman, BOHNERT, Tonika, HUANG, Carol, VU, Chi B., ENSINGER, Carol L., CHANG, Hexi, ENGBER, Thomas M., WHALLEY, Eric T., PETTER, Russell C.

“…A series of bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines was synthesized. Some of these analogues show high affinity and…”
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Effect of combined treatment with methylprednisolone and soluble Nogo-66 receptor after rat spinal cord injury by Ji, Benxiu, Li, Mingwei, Budel, Stephane, Pepinsky, R. Blake, Walus, Lee, Engber, Thomas M., Strittmatter, Stephen M., Relton, Jane K.

“…Methylprednisolone (MP) is a synthetic glucocorticoid used for the treatment of spinal cord injury (SCI). Soluble Nogo‐66 receptor (NgR) ectodomain is a novel…”
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Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy by Calcutt, Nigel A, Allendoerfer, Karen L, Mizisin, Andrew P, Middlemas, Alicia, Freshwater, Jason D, Burgers, Monica, Ranciato, Rigel, Delcroix, Jean-Dominique, Taylor, Frederick R, Shapiro, Renee, Strauch, Kathy, Dudek, Henryk, Engber, Thomas M, Galdes, Alphonse, Rubin, Lee L, Tomlinson, David R

“…Hedgehog proteins modulate development and patterning of the embryonic nervous system. As expression of desert hedgehog and the hedgehog receptor, patched-1,…”
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D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons by GERFEN, C. R, ENGBER, T. M, MAHAN, L. C, SUSEL, Z, CHASE, T. N, MONSMA, F. J, SIBLEY, D. R

“…The striatum, which is the major component of the basal ganglia in the brain, is regulated in part by dopaminergic input from the substantia nigra. Severe…”
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Motor fluctuations in levodopa treated parkinsonian rats: relation to lesion extent and treatment duration by Papa, S M, Engber, T M, Kask, A M, Chase, T N

“…The pathogenesis of the motor fluctuations that complicate levodopa treatment of most parkinsonian patients remains uncertain. To evaluate the contribution of…”
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Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model by Pepinsky, R Blake, Shapiro, Renee I, Wang, Shaoshan, Chakraborty, Abhijit, Gill, Alan, Lepage, Doreen J, Wen, Dingyi, Rayhorn, Paul, Horan, Gerald S B, Taylor, Frederick R, Garber, Ellen A, Galdes, Alphonse, Engber, Thomas M

“…The therapeutic effects of the Sonic hedgehog (Shh) have been difficult to evaluate because of its relatively short serum half-life. To address this issue…”
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Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil by Engber, Thomas M, Koury, Elizabeth J, Dennis, Shelley A, Miller, Matthew S, Contreras, Patricia C, Bhat, Ratan V

“…We examined the neuronal targets in the rat brain for the novel wakefulness-promoting agent modafinil and for amphetamine using c-Fos immunohistochemistry…”
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NMDA receptor blockade reverses motor response alterations induced by levodopa by Engber, T M, Papa, S M, Boldry, R C, Chase, T N

“…Motor fluctuations that ultimately complicate the response of most parkinsonian patients to levodopa therapy might represent a form of behavioral or neuronal…”
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Motor response complications and the function of striatal efferent systems by Chase, Thomas N, Mouradian, Maral M, Engber, Thomas M

“…Motor response complications eventually appear in most patients with advanced Parkinsonʼs disease being treated with levodopa. The interval between onset of…”
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First Synthesis of Piperazine-derived [1,2,4]Triazolo[1,5-a]pyrazine as an Adenosine A2A Receptor Antagonist by Peng, Hairuo, Sha, Li, Xi Chang, He, T. Vessels, Jeffery, Haque, Serajul, R. Conlon, Patrick, E. Dowling, James, Wang, Joy, M. Engber, Thomas, Kumaravel, Gnanasambandam, M. Scott, Daniel, C. Petter, Russell

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Substance P increases release of acetylcholine in the dorsal striatum of freely moving rats by Anderson, J J, Chase, T N, Engber, T M

“…Little is known about the role that neuropeptides such as substance P play in cell-to-cell interactions in the striatum. The effect of locally perfused…”
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GABAA and GABAB receptors differentially regulate striatal acetylcholine release in vivo by Anderson, J J, Kuo, S, Chase, T N, Engber, T M

“…Microdialysis was used to study the effects of selective GABAergic agents on striatal acetylcholine (ACh) release in awake, freely moving rats. Local perfusion…”
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Identification of insulin-like growth factor binding protein-2 as a biochemical surrogate marker for the in vivo effects of recombinant human insulin-like growth factor-1 in mice by Bhat, R V, Engber, T M, Zhu, Y, Miller, M S, Contreras, P C

“…Recent studies indicate that a daily s.c. injection of 1 mg/kg of recombinant human insulin-like growth factor-1 (rhIGF-1) for 17 days is efficacious in…”
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Region‐Specific Targets of p42/p44MAPK Signaling in Rat Brain by Bhat, Ratan V., Engber, Thomas M., Finn, James P., Koury, Elizabeth J., Contreras, Patricia C., Miller, Matthew S., Dionne, Craig A., Walton, Kevin M.

“…: In vitro studies indicate that p42/p44MAPK phosphorylate both nuclear and cytoplasmic proteins. However, the functional targets of p42/p44MAPK activation in…”
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Controls for Lesions of the Nigrostriatal Dopamine System by Robinson, Terry E., Gerfen, Charles R., Engber, Thomas M.

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Synthesis of alkyne derivatives of a novel triazolopyrazine as A 2A adenosine receptor antagonists by Yao, Gang, Haque, Serajul, Sha, Li, Kumaravel, Gnanasambandam, Wang, Joy, Engber, Thomas M., Whalley, Eric T., Conlon, Patrick R., Chang, Hexi, Kiesman, William F., Petter, Russell C.

“…[Display omitted] A novel [1,2,4]triazolo[1,5- a]pyrazine core was synthesized and coupled with terminal acetylenes. The structure–activity relationship of the…”
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