Search Results - "ENDO, YASUYUKI"

Challenging Approach to the Development of Novel Estrogen Receptor Modulators Based on the Chemical Properties of Guaiazulene by Ohta, Kiminori, Kaise, Asako, Ogawa, Takumi, Endo, Yasuyuki

“…Tamoxifen, a therapeutic agent for breast cancer, has been associated with genetic polymorphisms in the metabolism of , -dialkylaminoethyl substituent, which…”
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Anti-cancer activity of m-carborane-containing trimethoxyphenyl derivatives through tubulin polymerization inhibition by Kaise, Asako, Endo, Yasuyuki, Ohta, Kiminori

“…[Display omitted] m-Carborane-containing compound 1a was identified as a cell growth inhibitor from a random screening of a boron compound library. As 1a is a…”
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Development of Force Field Parameters for p-Carborane to Investigate the Structural Influence of Carborane Derivatives on Drug Targets by Complex Formation by Kato, Koichi, Nakayoshi, Tomoki, Inoue, Hiroki, Fukuyoshi, Shuichi, Ohta, Kiminori, Endo, Yasuyuki, Kurimoto, Eiji, Oda, Akifumi

“…Androgen receptor (AR) has a key role in the development and progression of prostate cancer, and AR antagonists are used for its remedy. Recently, carborane…”
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Design and synthesis of p-carborane-containing sulfamates as multitarget anti-breast cancer agents by Kaise, Asako, Ohta, Kiminori, Shirata, Chinami, Endo, Yasuyuki

“…[Display omitted] The development of multitarget anticancer agents is of high interest to medicinal chemists in terms of overcoming drug resistance and…”
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Structure–activity relationship study of diphenylamine-based estrogen receptor (ER) antagonists by Ohta, Kiminori, Chiba, Yuki, Kaise, Asako, Endo, Yasuyuki

“…[Display omitted] We have reported the design and synthesis of novel estrogen receptor (ER) agonists with a diphenylamine skeleton, which has several…”
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Inflammation-related microRNA expression level in the bovine milk is affected by mastitis by Lai, Yu-Chang, Fujikawa, Takuro, Maemura, Tadashi, Ando, Takaaki, Kitahara, Go, Endo, Yasuyuki, Yamato, Osamu, Koiwa, Masateru, Kubota, Chikara, Miura, Naoki

“…MicroRNA (miRNA) in tissue and liquid samples have been shown to be associated with many diseases including inflammation. We aimed to identify…”
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An automated microliter-scale high-throughput screening system (MSHTS) for real-time monitoring of protein aggregation using quantum-dot nanoprobes by Sasaki, Rina, Tainaka, Reina, Ando, Yuichi, Hashi, Yurika, Deepak, Hadya V., Suga, Yoshiko, Murai, Yuta, Anetai, Masaki, Monde, Kenji, Ohta, Kiminori, Ito, Ikuko, Kikuchi, Haruhisa, Oshima, Yoshiteru, Endo, Yasuyuki, Nakao, Hitomi, Sakono, Masafumi, Uwai, Koji, Tokuraku, Kiyotaka

“…Protein aggregation is the principal component of numerous protein misfolding pathologies termed proteinopathies, such as Alzheimer’s disease, Parkinson’s…”
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Design, synthesis, and anti-proliferative activity of 1-(4-methoxyphenyl)-12-hydroxymethyl-p-carborane derivatives by Kaise, Asako, Ohta, Kiminori, Endo, Yasuyuki

“…1-(4-Methoxyphenyl)-12-hydroxymethyl-p-carborane (2a), which is a precursor to the previously developed potent carborane-containing ER agonist BE120, exhibited…”
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Boron Cluster-based Development of Potent Nonsecosteroidal Vitamin D Receptor Ligands: Direct Observation of Hydrophobic Interaction between Protein Surface and Carborane by Fujii, Shinya, Masuno, Hiroyuki, Taoda, Yoshiyuki, Kano, Atsushi, Wongmayura, Angsuma, Nakabayashi, Makoto, Ito, Nobutoshi, Shimizu, Masato, Kawachi, Emiko, Hirano, Tomoya, Endo, Yasuyuki, Tanatani, Aya, Kagechika, Hiroyuki

“…We report here the design and synthesis of a novel vitamin D receptor (VDR) agonist whose hydrophobic core structure is p-carborane…”
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Identification of Felis catus Gammaherpesvirus 1 in Tsushima Leopard Cats ( Prionailurus bengalensis euptilurus ) on Tsushima Island, Japan by Makundi, Isaac, Koshida, Yushi, Endo, Yasuyuki, Nishigaki, Kazuo

“…gammaherpesvirus 1 (FcaGHV1) is a widely endemic infection of domestic cats. Current epidemiological data identify domestic cats as the sole natural host for…”
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Synthesis and biological evaluation of novel m-carborane-containing estrogen receptor partial agonists as SERM candidates by Ohta, Kiminori, Ogawa, Takumi, Kaise, Asako, Endo, Yasuyuki

“…[Display omitted] We designed and synthesized novel m-carborane-containing selective estrogen receptor modulator (SERM) candidates using previously reported…”
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Design and synthesis of carborane-containing estrogen receptor-beta (ERβ)-selective ligands by Ohta, Kiminori, Ogawa, Takumi, Oda, Akifumi, Kaise, Asako, Endo, Yasuyuki

“…[Display omitted] Candidates for highly selective estrogen receptor-beta (ERβ) ligands (6a–c, 7a–c, 8a and 8b) were designed and synthesized based on…”
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Design and Synthesis of Novel Breast Cancer Therapeutic Drug Candidates Based upon the Hydrophobic Feedback Approach of Antiestrogens by Ohta, Kiminori, Kaise, Asako, Taguchi, Fumi, Aoto, Sayaka, Ogawa, Takumi, Endo, Yasuyuki

“…Based upon hydrophobic feedback approaches, we designed and synthesized novel sulfur-containing ERα modulators ( and ) as breast cancer therapeutic drug…”
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Functional Characterization of Wild-type and 49 CYP2D6 Allelic Variants for N-Desmethyltamoxifen 4-Hydroxylation Activity by Muroi, Yuka, Saito, Takahiro, Takahashi, Masamitsu, Sakuyama, Kanako, Niinuma, Yui, Ito, Miyabi, Tsukada, Chiharu, Ohta, Kiminori, Endo, Yasuyuki, Oda, Akifumi, Hirasawa, Noriyasu, Hiratsuka, Masahiro

“…Genetic variations in cytochrome P450 2D6 (CYP2D6) contribute to interindividual variability in the metabolism of clinically used drugs, e.g., tamoxifen…”
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A molecular epidemiological survey of Babesia, Hepatozoon, Ehrlichia and Anaplasma infections of dogs in Japan by KUBO, Shotaro, TATENO, Morihiro, ICHIKAWA, Yasuaki, ENDO, Yasuyuki

“…Tick-borne diseases are often encountered in canine clinical practice. In the present study, a molecular epidemiological survey of dogs in Japan was conducted…”
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Design and Synthesis of Androgen Receptor Full Antagonists Bearing a p-Carborane Cage: Promising Ligands for Anti-Androgen Withdrawal Syndrome by Goto, Tokuhito, Ohta, Kiminori, Fujii, Shinya, Ohta, Shigeru, Endo, Yasuyuki

“…Pure androgen receptor (AR) full antagonists are candidates to treat anti-androgen refractory prostate cancers. We previously developed a carborane-containing…”
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Detection and molecular characterization of Babesia, Theileria, and Hepatozoon species in hard ticks collected from Kagoshima, the southern region in Japan by Masatani, Tatsunori, Hayashi, Kei, Andoh, Masako, Tateno, Morihiro, Endo, Yasuyuki, Asada, Masahito, Kusakisako, Kodai, Tanaka, Tetsuya, Gokuden, Mutsuyo, Hozumi, Nodoka, Nakadohzono, Fumiko, Matsuo, Tomohide

“…To reveal the distribution of tick-borne parasites, we established a novel nested polymerase chain reaction (PCR) system to detect the most common agents of…”
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A comparative profile of urinary scent signals of two endangered Japanese populations of leopard cat by Ichizawa, Shota, Uenoyama, Reiko, Nakanishi, Nozomi, Endo, Yasuyuki, Suka, Ayaka, Izawa, Masako, Miyazaki, Masao

“…Two subspecies of mainland leopard cats ( Prionailurus bengalensis ), Iriomote cats ( Prionailurus bengalensis iriomotensis ), and Tsushima leopard cats (…”
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Molecular epidemiological study of gammaherpesvirus in domestic cats in Japan by TATENO, Morihiro, TAKAHASHI, Masashi, MIYAKE, Eri, NISHIGAKI, Kazuo, TSUJIMOTO, Hajime, ENDO, Yasuyuki

“…Gammaherpesviruses (GHVs) are members of an emerging subfamily of the family Herpesviridae. A recent study identified a novel GHV in domestic cats (Felis catus…”
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Systemic Inonotus sp. Infection in a dog by FURUSAWA, Yu, TAKAHASHI, Masashi, IWANAGA, Tomoko, YABUKI, Akira, KANO, Rui, HATAI, Hitoshi, SUENO, Wako, ENDO, Yasuyuki, MOMOI, Yasuyuki

“…A 3-years-old male golden retriever was presented for decreased activity (lethargy), anorexia, and titubation. Superficial lymph nodes were enlarged, and…”
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