Search Results - "EMMERICH, Bertold"

Prognostic model for newly diagnosed CLL patients in Binet stage A: results of the multicenter, prospective CLL1 trial of the German CLL study group by Hoechstetter, Manuela A., Busch, Raymonde, Eichhorst, Barbara, Bühler, Andreas, Winkler, Dirk, Bahlo, Jasmin, Robrecht, Sandra, Eckart, Michael J., Vehling-Kaiser, Ursula, Jacobs, Georg, Jäger, Ulrich, Hurtz, Hans Jürgen, Hopfinger, Georg, Hartmann, Frank, Fuss, Harald, Abenhardt, Wolfgang, Blau, Ilona, Freier, Werner, Müller, Lothar, Goebeler, Maria, Wendtner, Clemens, Fischer, Kirsten, Herling, Carmen D., Starck, Michael, Bentz, Martin, Emmerich, Bertold, Döhner, Hartmut, Stilgenbauer, Stephan, Hallek, Michael

“…The heterogeneity of early stage CLL challenges prognostication, and refinement of prognostic indices for risk-adapted management in this population is…”
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The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion–mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase by Schmidmaier, Ralf, Baumann, Philipp, Simsek, Meral, Dayyani, Farshid, Emmerich, Bertold, Meinhardt, Gerold

“…Primary drug resistance is a major problem in multiple myeloma, an incurable disease of the bone marrow. Cell adhesion-mediated drug resistance (CAM-DR) causes…”
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Activation of adenosine monophosphate activated protein kinase inhibits growth of multiple myeloma cells by Baumann, Philipp, Mandl-Weber, Sonja, Emmerich, Bertold, Straka, Christian, Schmidmaier, Ralf

“…The role of adenosine monophosphate activated protein kinase (AMPK) in regulating multiple myeloma (MM) cell growth is not yet clear. In this study, we show…”
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B-Cell Lymphomas Differ in their Responsiveness to CpG Oligodeoxynucleotides by JAHRSDORFER, Bernd, MÜHLENHOFF, Lars, WEINER, George J, HARTMANN, Gunther, BLACKWELL, Sue E, WAGNER, Moritz, POECK, Hendrik, HARTMANN, Evelyn, JOX, Ralf, GIESE, Thomas, EMMERICH, Bertold, ENDRES, Stefan

“…Human B cells detect CpG motifs within microbial DNA via TLR9. Synthetic CpG oligodeoxynucleotides are currently being tested in clinical trials for the…”
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Inhibition of adenosine monophosphate-activated protein kinase induces apoptosis in multiple myeloma cells by Baumann, Philipp, Mandl-Weber, Sonja, Emmerich, Bertold, Straka, Christian, Schmidmaier, Ralf

“…In this study, we show that adenosine monophosphate-activated protein kinase (AMPK) is expressed and activated in multiple myeloma cells. The inhibition of…”
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Bendamustine induces G2 cell cycle arrest and apoptosis in myeloma cells : the role of ATM-Chk2-Cdc25A and ATM-p53-p21-pathways by GAUL, Leander, MANDL-WEBER, Sonja, BAUMANN, Philipp, EMMERICH, Bertold, SCHMIDMAIER, Ralf

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The Src Family Kinase Hck Interacts with Bcr-Abl by a Kinase-independent Mechanism and Phosphorylates the Grb2-binding Site of Bcr by Warmuth, Markus, Bergmann, Manuela, Prieß, Andrea, Häuslmann, Kathrin, Emmerich, Bertold, Hallek, Michael

“…bcr-abl, the oncogene causing chronic myeloid leukemia, encodes a fusion protein with constitutively active tyrosine kinase and transforming capacity in…”
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Evaluation of Chemosensitivity of Human Bone Marrow Stromal Cells - Differences between Common Chemotherapeutic Drugs by SCHMIDMAIER, Ralf, BAUMANN, Philipp, EMMERICH, Bertold, MEINHARDT, Gerold

“…Background: Bone marrow stromal cells (BMSCs) are essential for normal hematopoiesis, but also support the growth and survival of malignant hematopoietic…”
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Autologous stem-cell transplantation restores the functional properties of CD14+CD16+ monocytes in patients with myeloma and lymphoma by Dayyani, Farshid, Joeinig, Anke, Ziegler‐Heitbrock, Löms, Schmidmaier, Ralf, Straka, Christian, Emmerich, Bertold, Meinhardt, Gerold

“…The CD14+CD16+ monocytes appear to be important to immune defense against infection, as these cells are very potent with respect to tumor necrosis factor (TNF)…”
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First-line therapy with fludarabine compared with chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia by Eichhorst, Barbara F., Busch, Raymonde, Stilgenbauer, Stephan, Stauch, Martina, Bergmann, Manuela A., Ritgen, Matthias, Kranzhöfer, Nicole, Rohrberg, Robert, Söling, Ulrike, Burkhard, Oswald, Westermann, Anne, Goede, Valentin, Schweighofer, Carmen D., Fischer, Kirsten, Fink, Anna-Maria, Wendtner, Clemens M., Brittinger, Günter, Döhner, Hartmut, Emmerich, Bertold, Hallek, Michael

“…Although chronic lymphocytic leukemia (CLL) is a disease of elderly patients, subjects older than 65 years are heavily underrepresented in clinical trials. The…”
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Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia by Eichhorst, Barbara F., Busch, Raymonde, Hopfinger, Georg, Pasold, Rita, Hensel, Manfred, Steinbrecher, Cordelia, Siehl, Siegfried, Jäger, Ulrich, Bergmann, Manuela, Stilgenbauer, Stephan, Schweighofer, Carmen, Wendtner, Clemens M., Döhner, Hartmut, Brittinger, Günter, Emmerich, Bertold, Hallek, Michael

“…Combination chemotherapy with fludarabine plus cyclophosphamide (FC) was compared with the standard regimen of fludarabine monotherapy in first-line treatment…”
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Obituary Prof. Dr. med. Johann Rastetter (28th of March 1928–23rd of June 2022)—a leading German hematologist by Berdel, Wolfgang E., Dietzfelbinger, Hermann, Emmerich, Bertold, Fromm, Michael, Hallek, Michael, Maubach, Peter A., Nisenbaum, Jack, Reichle, Albrecht, Schick, Hans D., Serve, Hubert

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Bendamustine induces G2 cell cycle arrest and apoptosis in myeloma cells: the role of ATM-Chk2-Cdc25A and ATM-p53-p21-pathways by Gaul, Leander, Mandl-Weber, Sonja, Baumann, Philipp, Emmerich, Bertold, Schmidmaier, Ralf

“…Purpose Multiple myeloma is a fatal hematological disease caused by malignant transformation of plasma cells. Bendamustine has been proven to be a potent…”
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First clinical experience with simvastatin to overcome drug resistance in refractory multiple myeloma by Schmidmaier, Ralf, Baumann, Philipp, Bumeder, Irmgard, Meinhardt, Gerold, Straka, Christian, Emmerich, Bertold

“…In vitro statins overcome cell adhesion‐mediated drug resistance at non‐toxic concentrations that are achievable in humans by standard dose simvastatin. A…”
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Autotransplant with and without induction chemotherapy in older multiple myeloma patients: long-term outcome of a randomized trial by Straka, Christian, Liebisch, Peter, Salwender, Hans, Hennemann, Burkhard, Metzner, Bernd, Knop, Stefan, Adler-Reichel, Sigrid, Gerecke, Christian, Wandt, Hannes, Bentz, Martin, Bruemmendorf, Tim Hendrik, Hentrich, Marcus, Pfreundschuh, Michael, Wolf, Hans-Heinrich, Sezer, Orhan, Bargou, Ralf, Jung, Wolfram, Trümper, Lorenz, Hertenstein, Bernd, Heidemann, Else, Bernhard, Helga, Lang, Nicola, Frickhofen, Norbert, Hebart, Holger, Schmidmaier, Ralf, Sandermann, Andreas, Dechow, Tobias, Reichle, Albrecht, Schnabel, Brigitte, Schäfer-Eckart, Kerstin, Langer, Christian, Gramatzki, Martin, Hinke, Axel, Emmerich, Bertold, Einsele, Hermann

“…Autologous transplantation is controversial for older patients with multiple myeloma. The role of age-adjusted high-dose melphalan and the impact of induction…”
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Rituximab therapy of patients with B-cell chronic lymphocytic leukemia by Huhn, Dieter, von Schilling, Christoph, Wilhelm, Martin, Ho, Anthony D., Hallek, Michael, Kuse, Rolf, Knauf, Wolfgang, Riedel, Ute, Hinke, Axel, Srock, Stefanie, Serke, Stefan, Peschel, Christian, Emmerich, Bertold

“…Rituximab (IDEC-C2B8) is a chimeric antibody that binds to the B-cell surface antigen CD20. Rituximab has significant activity in follicular non-Hodgkin…”
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Dendritic cell-based vaccination of patients with advanced pancreatic carcinoma: results of a pilot study by Bauer, Christian, Dauer, Marc, Saraj, Samira, Schnurr, Maximilian, Bauernfeind, Franz, Sterzik, Alexander, Junkmann, Jana, Jakl, Veronika, Kiefl, Rosemarie, Oduncu, Fuat, Emmerich, Bertold, Mayr, Doris, Mussack, Thomas, Bruns, Christiane, Rüttinger, Dominik, Conrad, Claudius, Jauch, Karl-Walter, Endres, Stefan, Eigler, Andreas

“…Background and aims Dendritic cell (DC)-based vaccination can induce antitumor T cell responses in vivo. This clinical pilot study examined feasibility and…”
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Efficacy of bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase I/II study of the German CLL Study Group by Bergmann, MA, Goebeler, ME, Herold, M, Emmerich, B, Wilhelm, M, Ruelfs, C, Boening, L, Hallek, MJ, German CLL Study Group

“…Medical Clinic III, University Hospital Grosshadern, Ludwig-Maximilians-University Munich. BACKGROUND AND OBJECTIVES: Although bendamustine has been used for…”
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Synergistic antimyeloma effects of zoledronate and simvastatin by Schmidmaier, Ralf, Simsek, Meral, Baumann, Philipp, Emmerich, Bertold, Meinhardt, Gerold

“…Despite advances in the treatment of multiple myeloma, it remains an incurable disease because of primary and secondary drug resistance. Mevalonate pathway…”
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Overall Survival In Early Stage Chronic Lymphocytic Leukemia Patients With Treatment Indication Due To Disease Progression: Follow-Up Data Of The CLL1 Trial Of The German CLL Study Group (GCLLSG) by Bergmann, Manuela A., Busch, Raymonde, Eichhorst, Barbara, Buehler, Andreas, Fischer, Norbert, Eckart, Michael J, Vehling-Kaiser, Ursula, Jäger, Ulrich, Hopfinger, Georg, Wendtner, Clemens, Fischer, Kirsten, Emmerich, Bertold, Döhner, Hartmut, Hallek, Michael, Stilgenbauer, Stephan

“…Chronic lymphocytic leukemia (CLL) is typically diagnosed at an early stage and a watch & wait (W&W) strategy is applied. Only when the disease progresses to a…”
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