Search Results - "EMI, K"

Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation by Nishimura, Emi K.

“…Summary Most mammals are coated with pigmented hair. Melanocytes in each hair follicle produce melanin pigments for the hair during each hair cycle. The key to…”
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Label‐free quality control and identification of human keratinocyte stem cells by deep learning‐based automated cell tracking by Hirose, Takuya, Kotoku, Jun'ichi, Toki, Fujio, Nishimura, Emi K., Nanba, Daisuke

“…Stem cell‐based products have clinical and industrial applications. Thus, there is a need to develop quality control methods to standardize stem cell…”
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Obesity accelerates hair thinning by stem cell-centric converging mechanisms by Morinaga, Hironobu, Mohri, Yasuaki, Grachtchouk, Marina, Asakawa, Kyosuke, Matsumura, Hiroyuki, Oshima, Motohiko, Takayama, Naoya, Kato, Tomoki, Nishimori, Yuriko, Sorimachi, Yuriko, Takubo, Keiyo, Suganami, Takayoshi, Iwama, Atsushi, Iwakura, Yoichiro, Dlugosz, Andrzej A., Nishimura, Emi K.

“…Obesity is a worldwide epidemic that predisposes individuals to many age-associated diseases, but its exact effects on organ dysfunction are largely unknown 1…”
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EGFR-mediated epidermal stem cell motility drives skin regeneration through COL17A1 proteolysis by Nanba, Daisuke, Toki, Fujio, Asakawa, Kyosuke, Matsumura, Hiroyuki, Shiraishi, Ken, Sayama, Koji, Matsuzaki, Kyoichi, Toki, Hiroshi, Nishimura, Emi K

“…Skin regenerative capacity declines with age, but the underlying mechanisms are largely unknown. Here we demonstrate a functional link between epidermal growth…”
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Stem cell competition orchestrates skin homeostasis and ageing by Liu, Nan, Matsumura, Hiroyuki, Kato, Tomoki, Ichinose, Shizuko, Takada, Aki, Namiki, Takeshi, Asakawa, Kyosuke, Morinaga, Hironobu, Mohri, Yasuaki, De Arcangelis, Adèle, Geroges-Labouesse, Elisabeth, Nanba, Daisuke, Nishimura, Emi K.

“…Stem cells underlie tissue homeostasis, but their dynamics during ageing—and the relevance of these dynamics to organ ageing—remain unknown. Here we report…”
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p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress by Karigane, Daiki, Kobayashi, Hiroshi, Morikawa, Takayuki, Ootomo, Yukako, Sakai, Mashito, Nagamatsu, Go, Kubota, Yoshiaki, Goda, Nobuhito, Matsumoto, Michihiro, Nishimura, Emi K., Soga, Tomoyoshi, Otsu, Kinya, Suematsu, Makoto, Okamoto, Shinichiro, Suda, Toshio, Takubo, Keiyo

“…Hematopoietic stem cells (HSCs) maintain quiescence by activating specific metabolic pathways, including glycolysis. We do not yet have a clear understanding…”
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Stratification of Companion Animal Life Stages from Electronic Medical Record Diagnosis Data by Salt, Carina, Saito, Emi K, O’Flynn, Ciaran, Allaway, David

“…Abstract Aging is a complex, multifactorial process, where different life stages reflect changes in metabolic processes, immune capacities, and…”
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Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway by Fujino, Takeshi, Goyama, Susumu, Sugiura, Yuki, Inoue, Daichi, Asada, Shuhei, Yamasaki, Satoshi, Matsumoto, Akiko, Yamaguchi, Kiyoshi, Isobe, Yumiko, Tsuchiya, Akiho, Shikata, Shiori, Sato, Naru, Morinaga, Hironobu, Fukuyama, Tomofusa, Tanaka, Yosuke, Fukushima, Tsuyoshi, Takeda, Reina, Yamamoto, Keita, Honda, Hiroaki, Nishimura, Emi K., Furukawa, Yoichi, Shibata, Tatsuhiro, Abdel-Wahab, Omar, Suematsu, Makoto, Kitamura, Toshio

“…Somatic mutations of ASXL1 are frequently detected in age-related clonal hematopoiesis (CH). However, how ASXL1 mutations drive CH remains elusive. Using…”
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Mitf is required for T cell maturation by regulating dendritic cell homing to the thymus by Karigane, Daiki, Haraguchi, Miho, Toyama-Sorimachi, Noriko, Nishimura, Emi K., Takubo, Keiyo

“…Thymic dendritic cells (DCs) promote immune tolerance by regulating negative selection of autoreactive T cells in the thymus. How DC homing to the thymus is…”
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A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease by Sun, Qi, Lee, Wendy, Mohri, Yasuaki, Takeo, Makoto, Lim, Chae Ho, Xu, Xiaowei, Myung, Peggy, Atit, Radhika P., Taketo, M. Mark, Moubarak, Rana S., Schober, Markus, Osman, Iman, Gay, Denise L., Saur, Dieter, Nishimura, Emi K., Ito, Mayumi

“…Melanoma, the deadliest skin cancer, remains largely incurable at advanced stages. Currently, there is a lack of animal models that resemble human melanoma…”
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Serious surgical complications of canine cryptorchid castration are associated with surgical approach: a case-control study of 202 dogs by Faulkner, Emma B, Kimmerlein, Anne, Morrison, JoAnn, Beal, Tricia, Kerl, Marie, Saito, Emi K

“…The purpose of this study was to compare a cohort of dogs with serious or life-threatening complications following cryptorchid castration to dogs without…”
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Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the Niche by Nishimura, Emi K., Cranter, Scott R., Fisher, David E.

“…Hair graying is the most obvious sign of aging in humans, yet its mechanism is largely unknown. Here, we used melanocyte-tagged transgenic mice and aging human…”
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Dynamic stem cell selection safeguards the genomic integrity of the epidermis by Kato, Tomoki, Liu, Nan, Morinaga, Hironobu, Asakawa, Kyosuke, Muraguchi, Taichi, Muroyama, Yuko, Shimokawa, Mariko, Matsumura, Hiroyuki, Nishimori, Yuriko, Tan, Li Jing, Hayano, Motoshi, Sinclair, David A., Mohri, Yasuaki, Nishimura, Emi K.

“…Maintaining genomic integrity and stability is crucial for life; yet, no tissue-driven mechanism that robustly safeguards the epithelial genome has been…”
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IGF-1R deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance by Muraguchi, Taichi, Nanba, Daisuke, Nishimura, Emi K., Tashiro, Tomoko

“…Epidermal stem cells (ESCs) are keratinocytes that reside in the basal layer of the epidermis and mediate epidermal homeostasis. Insulin-like growth factor 1…”
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Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells by Tanimura, Shintaro, Tadokoro, Yuko, Inomata, Ken, Binh, Nguyen Thanh, Nishie, Wataru, Yamazaki, Satoshi, Nakauchi, Hiromitsu, Tanaka, Yoshio, McMillan, James R., Sawamura, Daisuke, Yancey, Kim, Shimizu, Hiroshi, Nishimura, Emi K.

“…In most stem cell systems, the organization of the stem cell niche and the anchoring matrix required for stem cell maintenance are largely unknown. We report…”
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Breed, smaller weight, and multiple injections are associated with increased adverse event reports within three days following canine vaccine administration by Moore, George E, Morrison, JoAnn, Saito, Emi K, Spofford, Nathaniel, Yang, Mike

“…To evaluate patient and vaccine factors associated with adverse events (AEs) recorded within 3 days of vaccine administration in a large cohort of dogs…”
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Younger dogs of specific breeds are more likely to experience a rare adverse event after administration of extended-release injectable moxidectin heartworm preventive by Saito, Emi K, Moore, George E, Morrison, JoAnn, Spofford, Nathaniel, Yang, Mike

“…To estimate the incidence of and identify patient risk factors for an acute adverse event in dogs after administration of a sustained-release injectable…”
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Key Roles for Transforming Growth Factor β in Melanocyte Stem Cell Maintenance by Nishimura, Emi K., Suzuki, Misa, Igras, Vivien, Du, Jinyan, Lonning, Scott, Miyachi, Yoshiki, Roes, Jürgen, Beermann, Friedrich, Fisher, David E.

“…Melanocyte stem cells in the bulge area of hair follicles are responsible for hair pigmentation, and defects in them cause hair graying. Here we describe the…”
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Automated collective motion analysis validates human keratinocyte stem cell cultures by Kinoshita, Koji, Munesue, Takuya, Toki, Fujio, Isshiki, Masaharu, Higashiyama, Shigeki, Barrandon, Yann, Nishimura, Emi K., Yanagihara, Yoshio, Nanba, Daisuke

“…Identification and quality assurance of stem cells cultured in heterogeneous cell populations are indispensable for successful stem cell therapy. Here we…”
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Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation by Inomata, Ken, Aoto, Takahiro, Binh, Nguyen Thanh, Okamoto, Natsuko, Tanimura, Shintaro, Wakayama, Tomohiko, Iseki, Shoichi, Hara, Eiji, Masunaga, Takuji, Shimizu, Hiroshi, Nishimura, Emi K.

“…Somatic stem cell depletion due to the accumulation of DNA damage has been implicated in the appearance of aging-related phenotypes. Hair graying, a typical…”
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