Search Results - "EMERSON, D. L"

Flow cytometric assay of modulation of P-glycoprotein function in whole blood by the multidrug resistance inhibitor GG918 by WITHERSPOON, S. M, EMERSON, D. L, KERR, B. M, LLOYD, T. L, DALTON, W. S, WISSEL, P. S

“…We sought to develop an assay for measuring the inhibition of P-glycoprotein (Pgp) function in whole blood as an indicator of in vivo drug activity. Since the…”
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Antitumor Efficacy, Pharmacokinetics, and Biodistribution of NX 211: A Low-Clearance Liposomal Formulation of Lurtotecan by EMERSON, D. L, BENDELE, R, MOYNIHAN, K, RICHARDSON, F. C, TOMKINSON, B, LUZZIO, M. J, BACCANARI, D, BROWN, E, SUMING CHIANG, DESJARDINS, J. P, DIHEL, L. C, GILL, S. C, HAMILTON, M, LERAY, J. D, MOON-MCDERMOTT, L

“…Lurtotecan is a clinically active water-soluble camptothecin analogue that has been formulated into a low-clearance unilamellar liposome, NX 211. Comparative…”
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Synthesis, Topoisomerase I Inhibitory Activity, and in Vivo Evaluation of 11-Azacamptothecin Analogs by Uehling, David E, Nanthakumar, Suganthini S, Croom, Dallas, Emerson, David L, Leitner, Peter P, Luzzio, Michael J, McIntyre, Gordon, Morton, Bradley, Profeta, Salvadore

“…A series of analogs based on a novel template, 11-aza-(20S)-camptothecin, were obtained from total synthesis and tested as potential anticancer drugs in the…”
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Biodistribution of NX211, liposomal lurtotecan, in tumor-bearing mice by Desjardins, John P, Abbott, Elizabeth A, Emerson, David L, Tomkinson, Blake E, Leray, Jeremy D, Brown, Eric N, Hamilton, Marta, Dihel, Larry, Ptaszynski, Mieke, Bendele, Raymond A, Richardson, Frank C

“…Prolonging tumor exposure to topoisomerase I inhibitors has been correlated to enhance the efficacy of those agents. Lurtotecan, a water-soluble camptothecin…”
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Flow cytometry versus urinary cytology in the evaluation of patients with bladder cancer by Murphy, W M, Emerson, L D, Chandler, R W, Moinuddin, S M, Soloway, M S

“…We compared the roles of urinary cytology and flow cytometry in the evaluation of patients with bladder cancer in clinical practice situations at a large…”
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Water Soluble Inhibitors of Topoisomerase I:  Quaternary Salt Derivatives of Camptothecin by Lackey, Karen, Sternbach, Daniel D, Croom, Dallas K, Emerson, David L, Evans, Michael G, Leitner, Peter L, Luzzio, Michael J, McIntyre, Gordon, Vuong, Alain, Yates, Julie, Besterman, Jeffrey M

“…Eleven water soluble 7-substituted quaternary ammonium salt derivatives of 10,11-(methylenedioxy)- and 10,11-(ethylenedioxy)-(20S)-camptothecin were…”
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In vivo antitumor activity of two new seven-substituted water-soluble camptothecin analogues by EMERSON, D. L, BESTERMAN, J. M, BROWN, H. R, EVANS, M. G, LEITNER, P. P, LUZZIO, M. J, SHAFFER, J. E, STERNBACH, D. D, UEHLING, D, VUONG, A

“…The development of camptothecin-like compounds as inhibitors of topoisomerase I for the treatment of resistant tumors has generated clinical excitement in this…”
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Aspiration biopsy of the kidney. Simultaneous collection of cytologic and histologic specimens by Murphy, W M, Zambroni, B R, Emerson, L D, Moinuddin, S, Lee, L H

“…Aspiration biopsy of mass lesions of the kidney is a diagnostic procedure whose potential benefit to patients with equivocal radiologic findings, suspected…”
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Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I by Luzzio, Michael J, Besterman, Jeffrey M, Emerson, David L, Evans, Michael G, Lackey, Karen, Leitner, Peter L, McIntyre, Gordon, Morton, Bradley, Myers, Peter L, Peel, Michael, Sisco, Jay M, Sternbach, Daniel D, Tong, Wei-Qin, Truesdale, Ann, Uehling, David E, Vuong, Alan, Yates, Julie

“…The synthesis and antitumor activities of the novel water soluble camptothecin derivatives 7-[(4-methylpiperazino)methyl]-10,11-(methylenedioxy)-(20S)-campto…”
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OSI-211, a novel liposomal topoisomerase I inhibitor, is active in SCID mouse models of human AML and ALL by Tomkinson, Blake, Bendele, Ray, Giles, Francis J., Brown, Eric, Gray, Atherton, Hart, Karen, LeRay, Jeremy D., Meyer, Denny, Pelanne, Michelle, Emerson, David L.

“…OSI-211 (liposomal lurtotecan), was evaluated using several different dose schedules (1 mg/kg, d1–5, 1.75 mg/kg d1, 3, 5 and 6 mg/kg d1, 8) in severe combined…”
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Decreased serum group-specific component protein levels and complexes with actin in fulminant hepatic necrosis by Lee, W M, Emerson, D L, Werner, P A, Arnaud, P, Goldschmidt-Clermont, P, Galbraith, R M

“…Monomeric G-actin has recently been shown to form high-affinity complexes with group-specific component protein (Gc), and this process might be expected to…”
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Distinct sites on the G-actin molecule bind group-specific component and deoxyribonuclease I by Goldschmidt-Clermont, P J, Galbraith, R M, Emerson, D L, Marsot, F, Nel, A E, Arnaud, P

“…Addition of group-specific component (Gc) to G-actin with or without deoxyribonuclease I (DNAase) led to formation of binary complexes (Gc-G-actin) and ternary…”
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Structural studies of T lymphocyte Fc receptors. Association of Gc protein with IgG binding to Fc gamma by Petrini, M, Galbraith, R M, Emerson, D L, Nel, A E, Arnaud, P

“…To obtain further information concerning the structure of Fc IgG-binding sites on human peripheral blood lymphocytes, enriched T-cells were…”
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Group-specific component (vitamin D binding protein) prevents the interaction between G-actin and profilin by Goldschmidt-Clermont, Pascal J, Van Alstyne, Eldwin L, Day, Joseph R, Emerson, David L, Nel, Andre E, Lazarchick, John, Galbraith, Robert M

“…Profilin purified from human platelets formed a 1:1 molar ratio complex with rabbit skeletal muscle G-actin but was displaced by purified serum Gc (vitamin D…”
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Diminished serum Gc (vitamin D-binding protein) levels and increased Gc:G-actin complexes in a hamster model of fulminant hepatic necrosis by Lee, W M, Emerson, D L, Young, W O, Goldschmidt-Clermont, P J, Jollow, D J, Galbraith, R M

“…Evidence for increased plasma levels of complexes containing Gc (vitamin D-binding protein) and cellular actin has been previously reported during fulminant…”
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Liposomal delivery of camptothecins by Emerson, David L

“…The use of liposomal drug delivery systems to improve the therapeutic index of pharmaceutical agents is exemplified by camptothecin-based drugs. This highly…”
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Antibodies to polymerized human serum albumin in acute and chronic liver disease by Lee, W M, McLeod, L, Martin, K, Emerson, D L, Galbraith, R M

“…Since antibodies to polyalbumin have been noted to occur in patients with hepatitis or cirrhosis, we investigated sera from 219 patients with a variety of…”
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Inhibition of establishment of primary and micrometastatic tumors by a urokinase plasminogen activator receptor antagonist by Ignar, D M, Andrews, J L, Witherspoon, S M, Leray, J D, Clay, W C, Kilpatrick, K, Onori, J, Kost, T, Emerson, D L

“…Tumor establishment and metastasis are dependent on extracellular matrix proteolysis, tumor cell migration, and angiogenesis. Urokinase plasminogen activator…”
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Gc (vitamin D-binding protein) binds the 33.5 K tryptic fragment of actin by Goldschmidt-Clermont, P J, Allen, R C, Nel, A E, Emerson, D L, Day, J R, Galbraith, R M

“…Limited proteolysis of G-actin was performed with trypsin and chymotrypsin to compare the binding sites for Gc and DNase. DNase I bound to the N-terminal area…”
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Linkage between surface immunoglobulin and cytoskeleton of B lymphocytes may involve Gc protein by Petrini, Mario, Emerson, David L, Galbraith, Robert M

“…The membrane immunoglobulin (MIg) of B lymphocytes is thought to have an important role in antigen recognition and cellular activation. In common with many…”
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