Search Results - "EMERICH, D. F"

Increased encapsulated cell biodelivery of nerve growth factor in the brain by transposon-mediated gene transfer by Fjord-Larsen, L, Kusk, P, Emerich, D F, Thanos, C, Torp, M, Bintz, B, Tornøe, J, Johnsen, A H, Wahlberg, L U

“…Nerve growth factor (NGF) is a potential therapeutic agent for Alzheimer's disease (AD) as it has positive effects on the basal forebrain cholinergic neurons…”
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The development of encapsulated cell technologies as therapies for neurological and sensory diseases by Zanin, M.P., Pettingill, L.N., Harvey, A.R., Emerich, D.F., Thanos, C.G., Shepherd, R.K.

“…Cell encapsulation therapies involve the implantation of cells that secrete a therapeutic factor to provide clinical benefits. The transplanted cells are…”
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Facilitation of drug entry into the CNS via transient permeation of blood brain barrier: laboratory and preliminary clinical evidence from bradykinin receptor agonist, Cereport by Borlongan, C.V., Emerich, D.F.

“…One novel approach of transporting drugs into the central nervous system (CNS) involves the activation of receptors on the endothelial cells comprising the…”
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Intraperitoneal Alginate-Encapsulated Neonatal Porcine Islets in a Placebo-Controlled Study With 16 Diabetic Cynomolgus Primates by Elliott, R.B., Escobar, L., Tan, P.L.J., Garkavenko, O., Calafiore, R., Basta, P., Vasconcellos, A.V., Emerich, D.F., Thanos, C., Bambra, C.

“…A nonhuman primate model of diabetes is valuable for assessing porcine pancreatic islet transplants that might have clinical benefits in humans. Neonatal…”
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CNS grafts of rat choroid plexus protect against cerebral ischemia in adult rats by Borlongan, C. V, Skinner, S. J. M, Geaney, M, Vasconcellos, A. V, Elliott, R. B, Emerich, D. F

“…The present study examined the neuroprotective effects of choroid plexus isolated from adult rats and encapsulated within alginate microcapsules. In vitro,…”
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Functional modulation of choroid plexus epithelial clusters in vitro for tissue repair applications by Thanos, C G, Bintz, B E, Goddard, Moses, Boekelheide, K, Hall, Susan, Emerich, D F

“…One of the primary obstacles in the restoration or repair of damaged tissues is the temporospatial orchestration of biological and physiological events…”
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Genetically engineered Sertoli cells are able to survive allogeneic transplantation by DUFOUR, J. M, HEMENDINGER, R, HALBERSTADT, C. R, GORES, P, EMERICH, D. F, KORBUTT, G. S, RAJOTTE, R. V

“…The immunoprotective nature of the testis has led to numerous investigations for its ability to protect cellular grafts. Sertoli cells (SCs) are at least…”
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Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease by Emerich, Dwaine F, Winn, Shelley R, Hantraye, Philippe M, Peschanski, Marc, Chen, Er-Yun, Chu, Yaping, McDermott, Patricia, Baetge, E. Edward, Kordower, Jeffrey H

“…Huntington's disease is a genetic disorder that results from degeneration of striatal neurons, particularly those containing GABA (gamma-aminobutyric acid)…”
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Enhanced delivery of carboplatin into brain tumours with intravenous Cereport (RMP-7): dramatic differences and insight gained from dosing parameters by EMERICH, D. F, SNODGRASS, P, DEAN, R, AGOSTINO, M, HASLER, B, PINK, M, XIONG, H, KIM, B. S, BARTUS, R. T

“…Cereport (RMP-7) is a selective bradykinin B2 receptor agonist which increases the permeability of the 'blood-brain tumour barrier' (BBTB) to increase delivery…”
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Secreted products from the porcine choroid plexus accelerate the healing of cutaneous wounds by Thanos, C G, Emerich, D F, Bintz, B E, Goddard, M, Mills, J, Jensen, R, Lombardi, M, Hall, S, Boekelheide, K

“…The choroid plexus (CP), located at the blood-brain interface, is partially responsible for maintaining the composition of cerebrospinal fluid. Epithelial cell…”
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The development of the bradykinin agonist labradimil as a means to increase the permeability of the blood-brain barrier from concept to clinical evaluation by EMERICH, Dwaine F, DEAN, Reginald L, OSBORN, Chester, BARTUS, Raymond T

“…Labradimil (Cereport; also formerly referred to as RMP-7) is a 9-amino-acid peptide designed for selectivity for the bradykinin B2 receptor and a longer plasma…”
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Primary Choroid Plexus Tissue for Use in Cellular Therapy by Sandrof, M A, Emerich, D F, Thanos, Chris G

“…The choroid plexus (CP) has been explored as a cellular therapeutic due to its broad-ranging secretome and demonstrated longevity in a variety of encapsulation…”
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Biomaterial-based technologies for brain anti-cancer therapeutics and imaging by Orive, G., Ali, O.A., Anitua, E., Pedraz, J.L., Emerich, D.F.

“…Treating malignant brain tumors represents one of the most formidable challenges in oncology. Contemporary treatment of brain tumors has been hampered by…”
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Sustained Delivery of Proteins for Novel Therapeutic Products by Bartus, Raymond T., Tracy, Mark A., Emerich, Dwaine F., Zale, Stephen E.

“…New protein therapies have been developed for many conditions, including hepatitis C, multiple sclerosis and various cancers…”
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Cellular Delivery of Trophic Factors for the Treatment of Huntington's Disease: Is Neuroprotection Possible? by Kordower, Jeffrey H., Isacson, Ole, Emerich, Dwaine F.

“…The elucidation of the genetic defect in patients with Huntington's disease (HD) has allowed for the detection of individuals at risk for HD prior to the onset…”
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Injectable chemotherapeutic microspheres and glioma. II : Enhanced survival following implantation into deep inoperable tumors by EMERICH, D. F, WINN, S. R, SNODGRASS, P, LAFRENIERE, D, AGOSTINO, M, WIENS, T, HUA XIONG, BARTUS, R. T

“…Delivery of chemotherapeutics using implantable, biodegradable polymers provides a potentially powerful method of treating brain tumors. The present studies…”
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Polymer-Encapsulated Cells Genetically Modified to Secrete Human Nerve Growth Factor Promote the Survival of Axotomized Septal Cholinergic Neurons by Winn, Shelley R., Hammang, Joseph P., Emerich, Dwaine F., Lee, Alice, Palmiter, Richard D., Baetge, E. Edward

“…Effective treatments for neurodegenerative disorders are limited by our inability to alter the progression of the diseases. A number of proteins have specific…”
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Injectable chemotherapeutic microspheres and glioma. I : Enhanced survival following implantation into the cavity wall of debulked tumors by EMERICH, D. F, WINN, S. R, YUNHUA HU, MARSH, J, SNODGRASS, P, LAFRENIERE, D, WIENS, T, HASLER, B. P, BARTUS, R. T

“…Implantation of biodegradable polymers provides a powerful method to deliver high, sustained concentrations of chemotherapeutics to brain tumors. The present…”
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Article Commentary: Cell Transplantation for Parkinson's Disease by D. F. Emerich Ph.D.

“…Hype slang. n. 1. Excessive publicity and the ensuing commotion. 2. Exaggerated or extravagant claims made especially in advertising or promotional material…”
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Cell transplantation for Parkinson's disease by Emerich, D F

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