Search Results - "EMBO reports"

Mitochondrial DNA in inflammation and immunity by Riley, Joel S, Tait, Stephen WG

“…Mitochondria are cellular organelles that orchestrate a vast range of biological processes, from energy production and metabolism to cell death and…”
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Antibiotic resistance and persistence—Implications for human health and treatment perspectives by Huemer, Markus, Mairpady Shambat, Srikanth, Brugger, Silvio D, Zinkernagel, Annelies S

“…Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of treatment failure and relapsing infections. They are thus important…”
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The integrated stress response by Pakos-Zebrucka, Karolina, Koryga, Izabela, Mnich, Katarzyna, Ljujic, Mila, Samali, Afshin, Gorman, Adrienne M

“…In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular…”
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ChIP‐Atlas: a data‐mining suite powered by full integration of public ChIP‐seq data by Oki, Shinya, Ohta, Tazro, Shioi, Go, Hatanaka, Hideki, Ogasawara, Osamu, Okuda, Yoshihiro, Kawaji, Hideya, Nakaki, Ryo, Sese, Jun, Meno, Chikara

“…We have fully integrated public chromatin chromatin immunoprecipitation sequencing (ChIP‐seq) and DNase‐seq data ( n > 70,000) derived from six representative…”
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Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/β‐catenin modulator Annexin A1 by Rubinstein, Mara Roxana, Baik, Jung Eun, Lagana, Stephen M, Han, Richard P, Raab, William J, Sahoo, Debashis, Dalerba, Piero, Wang, Timothy C, Han, Yiping W

“…Fusobacterium nucleatum , a Gram‐negative oral anaerobe, is a significant contributor to colorectal cancer. Using an in vitro cancer progression model, we…”
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Human METTL16 is a N 6 -methyladenosine (m 6 A) methyltransferase that targets pre-mRNAs and various non-coding RNAs by Warda, Ahmed S, Kretschmer, Jens, Hackert, Philipp, Lenz, Christof, Urlaub, Henning, Höbartner, Claudia, Sloan, Katherine E, Bohnsack, Markus T

“…-methyladenosine (m A) is a highly dynamic RNA modification that has recently emerged as a key regulator of gene expression. While many m A modifications are…”
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CircHIPK3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells by Li, Yawei, Zheng, Fuxin, Xiao, Xingyuan, Xie, Fei, Tao, Dan, Huang, Chao, Liu, Dong, Wang, Miao, Wang, Liang, Zeng, Fuqing, Jiang, Guosong

“…Increasing evidences suggest that circular RNAs (circRNAs) exert crucial functions in regulating gene expression. In this study, we perform RNA‐seq and…”
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The extracellular matrix modulates the hallmarks of cancer by Pickup, Michael W, Mouw, Janna K, Weaver, Valerie M

“…The extracellular matrix regulates tissue development and homeostasis, and its dysregulation contributes to neoplastic progression. The extracellular matrix…”
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The economic costs of mental disorders: Do our societies react appropriately to the burden of mental disorders? by Trautmann, Sebastian, Rehm, Jürgen, Wittchen, Hans‐Ulrich

“…Graphical Abstract Mental disorders affect a huge number of people and have a major economic impact due to treatment costs and lost productivity. Society and…”
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The interplay of histone modifications - writers that read by Zhang, Tianyi, Cooper, Sarah, Brockdorff, Neil

“…Histones are subject to a vast array of posttranslational modifications including acetylation, methylation, phosphorylation, and ubiquitylation. The writers of…”
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PKM2, cancer metabolism, and the road ahead by Dayton, Talya L, Jacks, Tyler, Vander Heiden, Matthew G

“…A major metabolic aberration associated with cancer is a change in glucose metabolism. Isoform selection of the glycolytic enzyme pyruvate kinase has been…”
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Protein palmitoylation and cancer by Ko, Pin‐Joe, Dixon, Scott J

“…Protein S‐palmitoylation is a reversible post‐translational modification that alters the localization, stability, and function of hundreds of proteins in the…”
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FKBP8 recruits LC3A to mediate Parkin‐independent mitophagy by Bhujabal, Zambarlal, Birgisdottir, Åsa B, Sjøttem, Eva, Brenne, Hanne B, Øvervatn, Aud, Habisov, Sabrina, Kirkin, Vladimir, Lamark, Trond, Johansen, Terje

“…Mitophagy, the selective removal of damaged or excess mitochondria by autophagy, is an important process in cellular homeostasis. The outer mitochondrial…”
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Senescence and apoptosis: dueling or complementary cell fates? by Childs, Bennett G, Baker, Darren J, Kirkland, James L, Campisi, Judith, van Deursen, Jan M

“…In response to a variety of stresses, mammalian cells undergo a persistent proliferative arrest known as cellular senescence. Many senescence‐inducing…”
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Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures by Sousa, Carole, Golebiewska, Anna, Poovathingal, Suresh K, Kaoma, Tony, Pires‐Afonso, Yolanda, Martina, Silvia, Coowar, Djalil, Azuaje, Francisco, Skupin, Alexander, Balling, Rudi, Biber, Knut, Niclou, Simone P, Michelucci, Alessandro

“…Microglia are specialized parenchymal‐resident phagocytes of the central nervous system (CNS) that actively support, defend and modulate the neural…”
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Exosomes and other extracellular vesicles in host-pathogen interactions by Schorey, Jeffrey S, Cheng, Yong, Singh, Prachi P, Smith, Victoria L

“…An effective immune response requires the engagement of host receptors by pathogen‐derived molecules and the stimulation of an appropriate cellular response…”
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Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response by Court, Angela C, Le‐Gatt, Alice, Luz‐Crawford, Patricia, Parra, Eliseo, Aliaga‐Tobar, Victor, Bátiz, Luis Federico, Contreras, Rafael A, Ortúzar, María Ignacia, Kurte, Mónica, Elizondo‐Vega, Roberto, Maracaja‐Coutinho, Vinicius, Pino‐Lagos, Karina, Figueroa, Fernando E, Khoury, Maroun

“…Mesenchymal stem cells (MSCs) have fueled ample translation for the treatment of immune‐mediated diseases. They exert immunoregulatory and tissue‐restoring…”
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AI revolutions in biology: The joys and perils of AlphaFold by Perrakis, Anastassis, Sixma, Titia K

“…Graphical Abstract AlphaFold is the most ground-breaking application of AI in science so far; it will revolutionize structural biology, but caution is…”
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SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer by Chen, Xiu‐Fei, Tian, Meng‐Xin, Sun, Ren‐Qiang, Zhang, Meng‐Li, Zhou, Li‐Sha, Jin, Lei, Chen, Lei‐Lei, Zhou, Wen‐Jie, Duan, Kun‐Long, Chen, Yu‐Jia, Gao, Chao, Cheng, Zhou‐Li, Wang, Fang, Zhang, Jin‐Ye, Sun, Yi‐Ping, Yu, Hong‐Xiu, Zhao, Yu‐Zheng, Yang, Yi, Liu, Wei‐Ren, Shi, Ying‐Hong, Xiong, Yue, Guan, Kun‐Liang, Ye, Dan

“…Peroxisomes account for ~35% of total H 2 O 2 generation in mammalian tissues. Peroxisomal ACOX1 (acyl‐CoA oxidase 1) is the first and rate‐limiting enzyme in…”
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The composition of the gut microbiota shapes the colon mucus barrier by Jakobsson, Hedvig E, Rodríguez-Piñeiro, Ana M, Schütte, André, Ermund, Anna, Boysen, Preben, Bemark, Mats, Sommer, Felix, Bäckhed, Fredrik, Hansson, Gunnar C, Johansson, Malin EV

“…Two C57BL/6 mice colonies maintained in two rooms of the same specific pathogen‐free (SPF) facility were found to have different gut microbiota and a mucus…”
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