Search Results - "ELMROTH, K"

Synthesis and structures of a pincer-type rhodium(iii) complex: reactivity toward biomolecules by Milutinović, Milan M, Bogojeski, Jovana V, Klisurić, Olivera, Scheurer, Andreas, Elmroth, Sofi K C, Bugarčić, Živadin D

“…A novel rhodium(iii) complex [Rh (H L )Cl ] (1) (H L = 2,6-bis(5-tert-butyl-1H-pyrazol-3-yl)pyridine) containing a pincer type, tridentate nitrogen-donor…”
Get more information

Radiosensitivity: Gender and Order of Administration of G-CSF, An Experimental Study in Mice by Hultborn, R., Albertsson, P., Ottosson, S., Warnhammar, E., Palm, Å., Palm, S., Elmroth, K.

“…To elucidate the potential influence of stimulating bone marrow before cell-cycle-dependent irradiation, we sought to determine overall survival in mice…”
Get full text

Kinetics of cisplatin binding to short r(GG) containing miRNA mimics - influence of Na(+)versus K(+), temperature and hydrophobicity on reactivity by Alshiekh, Alak, Clausén, Maria, Elmroth, Sofi K C

“…Nucleic acids are well recognized targets for platinum-based anticancer drugs, with RNA and DNA being kinetically comparable. In the case of RNA, previous…”
Get more information

Platinum Interference with siRNA Non-seed Regions Fine-Tunes Silencing Capacity by Hedman, Hanna K, Kirpekar, Finn, Elmroth, Sofi K. C

“…Knowledge concerning the molecular mechanisms governing the influence of non-coding RNAs on protein production has emerged rapidly during the past decade…”
Get full text

Time dependence of cisplatin-induced duplex dissociation of 15-mer RNAs and mature miR-146a by Polonyi, Christopher, Elmroth, Sofi K C

“…The kinetics for the binding of cisplatin to duplex RNAs, two fully complementary model systems and mature miR-146a, exhibits a linear dependence on cisplatin…”
Get more information

Light-Induced Anticancer Activity of [RuCl2(DMSO)4] Complexes by Brindell, Małgorzata, Kuliś, Ewa, Elmroth, Sofi K. C, Urbańska, Krystyna, Stochel, Grażyna

“…The cytotoxicity and photocytotoxicity of trans-[RuCl2(DMSO)4] and cis-[RuCl2(DMSO)4] complexes was tested in two melanoma cell lines, human (SK-MEL 188) and…”
Get full text

Cisplatin-induced duplex dissociation of complementary and destabilized short GG-containing duplex RNAs by Polonyi, Christopher, Alshiekh, Alak, Sarsam, Lamya A, Clausén, Maria, Elmroth, Sofi K C

“…The ability of the anticancer active drug cisplatin to exert biological activity through interference with nucleic acid function is well documented. Since…”
Get more information

Design, synthesis and DNA interactions of a chimera between a platinum complex and an IHF mimicking peptide by Rao, Harita, Damian, Mariana S, Alshiekh, Alak, Elmroth, Sofi K C, Diederichsen, Ulf

“…Conjugation of metal complexes with peptide scaffolds possessing high DNA binding affinity has shown to modulate their biological activities and to enhance…”
Get more information

More pronounced salt dependence and higher reactivity for platination of the hairpin r(CGCGUUGUUCGCG) compared with d(CGCGTTGTTCGCG) by Hägerlöf, Margareta, Papsai, Pal, Chow, Christine S, Elmroth, Sofi K C

“…The DNA interference pathways exhibited by cisplatin and related anticancer active metal complexes have been extensively studied. Much less is known to what…”
Get full text

Cleavage of cellular DNA by calicheamicin γ1 by Elmroth, Kecke, Nygren, Jonas, Mårtensson, Susanne, Ismail, Ismail Hassan, Hammarsten, Ola

“…It is assumed that the efficient antitumor activity of calicheamicin γ1 is mediated by its ability to introduce DNA double-strand breaks in cellular DNA. To…”
Get full text

Comparison of Cis- and Oxaliplatin-induced Destabilization of 15-mer DNA- and RNA Duplexes by Binding to Centrally Located GG- and GNG Sequences by Polonyi, Christopher, Albertsson, Ingrid, Damian, Mariana S., Elmroth, Sofi K. C.

“…Thermodynamic parameters are presented here illustrating the effects caused by the two anticancer active metal complexes cisplatin and oxaliplatin after…”
Get full text

Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex by Mello, Lucilene D, Ribeiro, Emerson S, Kubota, Lauro T, Elmroth, Sofi K. C, Pereira, Regina M. S

“…The interaction of Pt(II)(dppf)-complex, namely [Pt(dppf)(H₂O)₂]²⁺ with DNA was investigated by DPV and ¹H-NMR techniques. The results showed that the…”
Get full text

Influence of Sodium Ions on the Dynamics and Structure of Single-Stranded DNA Oligomers:  A Molecular Dynamics Study by Martínez, José M, Elmroth, Sofi K. C, Kloo, Lars

“…The effects of sodium counterion presence and chain length on the structure and dynamics of single DNA strands of polythymidylate were studied by means of…”
Get full text

Construction of polyamine-modified uridine and adenosine derivatives—evaluation of DNA binding capacity and cytotoxicity in vitro by Ghatnekar, Johannes, Hägerlöf, Margareta, Oredsson, Stina, Alm, Kersti, Elmroth, Sofi K.C., Persson, Tina

“…Two novel nucleoside-based polyamine derivatives were synthesized. Their cell growth inhibitory effects and their structural and thermodynamic influence on DNA…”
Get full text

Chromosomal Damage in Two X-ray Irradiated Cell Lines: Influence of Cell Cycle Stage and Irradiation Temperature by LARSSON, D. E, GUSTAVSSON, S, HULTBORN, R, NYGREN, J, DELLE, U, ELMROTH, K

“…The aim of this study was to investigate if irradiation with X-rays in different cell cycle phases resulted in a different response as measured with the…”
Get full text

Chromatin- and temperature-dependent modulation of radiation-induced double-strand breaks by Elmroth, K., Nygren, J., Stenerlöw, B., Hultborn, R.

“…Purpose: To investigate the influence of chromatin organization and scavenging capacity in relation to irradiation temperature on the induction of…”
Get full text

Influence of Temperature on Radiation-Induced Inhibition of DNA Supercoiling by Elmroth, K., Erkell, L. J., Hultborn, R.

“…The influence of subnormal temperatures (2, 15 and 28°C) on the effects of radiation in MCF-7 cell cultures was studied using the fluorescent (halo) nucleoid…”
Get full text

Synthesis and DNA Interaction of Platinum Complex/Peptide Chimera as Potential Drug Candidates by Damian, Mariana S., Hedman, Hanna K., Elmroth, Sofi K. C., Diederichsen, Ulf

“…Modification and optimization of the anticancer drug cisplatin is of interest with respect to selective cell targeting and DNA binding efficiency. Attractive…”
Get full text

Effect of hypothermic irradiation of the growth characteristics of two human cell lines by Elmroth, K, Nygren, J, Erkell, L J, Hultborn, R

“…The effect of hypothermic irradiation on the growth characteristics of two human cell lines was investigated. Low temperature (2 degrees C) X-irradiation of…”
Get more information

Expanding the chemical nature of siRNAs: Oxaliplatin as metalation reagent by Snygg, Åse Sykfont, Elmroth, Sofi K.C.

“…Short interfering RNAs (siRNAs) can down-regulate protein production by site specific degradation of mRNA. We here report the in vitro efficiency of three…”
Get full text