Search Results - "ELMER, G. I"

Disruption of conditioned reward association by typical and atypical antipsychotics by Danna, C.L., Elmer, G.I.

“…Antipsychotic drugs are broadly classified into typical and atypical compounds; they vary in their pharmacological profile however a common component is their…”
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Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception by Mogil, J S, Wilson, S G, Bon, K, Lee, S E, Chung, K, Raber, P, Pieper, J O, Hain, H S, Belknap, J K, Hubert, L, Elmer, G I, Chung, J M, Devor, M

“…It is generally acknowledged that humans display highly variable sensitivity to pain, including variable responses to identical injuries or pathologies. The…”
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Brain stimulation and morphine reward deficits in dopamine D2 receptor-deficient mice by ELMER, G. I, PIEPER, J. O, LEVY, J, RUBINSTEIN, M, LOW, M. J, GRANDY, D. K, WISE, R. A

“…The rewarding effects of lateral hypothalamic brain stimulation, various natural rewards, and several drugs of abuse are attenuated by D1 or D2 dopamine…”
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Cognitive effects of psychotomimetic drugs in rats discriminating number cues by Willmore, C. B., Krall, D. M., Spears, F. M., Makriyannis, A., Elmer, G. I.

“…Rationale Deficits in memory and attention are broadly acknowledged during psychosis; however, experiments on modeled psychosis often test working memory…”
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Discrimination and self-administration of nicotine by inbred strains of mice by STOLERMAN, I. P, NAYLOR, C, ELMER, G. I, GOLDBERG, S. R

“…These studies aim to characterize the discriminative stimulus effects of nicotine in two inbred strains of mice that differ in many pharmacological responses,…”
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The rostromedial tegmental nucleus modulates the development of stress-induced helpless behavior by Elmer, G.I., Palacorolla, H., Mayo, C.L., Brown, P.L., Jhou, T.C., Brady, D., Shepard, P.D.

“…•Functional changes in the habenula (Hb) are associated with depression.•A major projection from the Hb targets the rostromedial tegmentum (RMTg).•RMTg lesions…”
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Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis by Mogil, J S, Wilson, S G, Bon, K, Lee, S E, Chung, K, Raber, P, Pieper, J O, Hain, H S, Belknap, J K, Hubert, L, Elmer, G I, Chung, J M, Devor, M

“…Clinical pain syndromes, and experimental assays of nociception, are differentially affected by manipulations such as drug administration and exposure to…”
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Live predator stress in adolescence results in distinct adult behavioral consequences and dorsal diencephalic brain activation patterns by Tapocik, J.D., Schank, J.R., Mitchell, J.R., Damazdic, R., Mayo, C.L., Brady, D., Pincus, A.B., King, C.E., Heilig, M., Elmer, G.I.

“…Exposure to traumatic events during childhood increases the risk of adult psychopathology, including anxiety, depression, alcohol use disorders and their…”
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Altered prepulse inhibition in rats treated prenatally with the antimitotic Ara-C: an animal model for sensorimotor gating deficits in schizophrenia by ELMER, G. I, SYDNOR, J, GUARD, H, HERCHER, E, VOGEL, M. W

“…Sensorimotor gating disruption is one of many neurocognitive deficits seen in schizophrenia. Disorganized thought is one of the cardinal symptoms associated…”
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Texture of locomotor path: a replicable characterization of a complex behavioral phenotype by Kafkafi, N., Elmer, G. I.

“…A database of mouse locomotor path in spatial tests can be used to search in silico for behavioral measures that better discriminate between genotypes and are…”
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Differential neuroendocrine responsiveness to morphine in Lewis, Fischer 344, and ACI inbred rats by Baumann, Michael H., Elmer, Gregory I., Goldberg, Steve R., Ambrosio, Emilio

“…Preclinical evidence suggests there is a link between the responsiveness to stress and the propensity to self-administer drugs of abuse. Our previous findings,…”
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Opioid operant self-administration, analgesia, stimulation and respiratory depression in μ-deficient mice by ELMER, G. I, PIEPER, J. O, GOLDBERG, S. R, GEORGE, F. R

“…It is commonly thought that mu-receptors play an important role in the reinforcing effects of opioids. In the present study, inbred strains widely divergent in…”
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Cocaine cross-sensitization to dopamine uptake inhibitors: Unique effects of GBR12909 by Elmer, G.I., Brockington, A., Gorelick, D.A., Carrol, F.I., Rice, K.C., Matecka, D., Goldberg, S.R., Rothman, R.B.

“…Repeated administration of cocaine will cross-sensitize the locomotor response to a variety of psychomotor stimulants. The ability of cocaine to…”
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Ethanol self-administration in long sleep and short sleep mice indicates reinforcement is not inversely related to neurosensitivity by Elmer, G I, Meisch, R A, Goldberg, S R, George, F R

“…Studies of ethanol drinking suggest an inverse correlation between innate sensitivity to ethanol and behavior reinforced by this drug. The present study…”
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The role of specific eicosanoids in mediating the acute narcotic effects of ethanol by Elmer, G I, George, F R

“…The pharmacological effects of ethanol may be in part due to increased membrane fluidity, resulting in increased phospholipase A2 activity and the subsequent…”
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The role of prostaglandin synthetase in the rate depressant effects and narcosis caused by ethanol by Elmer, G I, George, F R

“…Ethanol is proposed to exert its pharmacological effects by increasing membrane fluidity. Support for this hypothesis comes from strong correlations between in…”
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Acute sensitivity vs. context-specific sensitization to cocaine as a function of genotype by Elmer, Gregory I., Gorelick, David A., Goldberg, Steven R., Rothman, Richard B.

“…Individual variability in the acute and chronic effects of psychomotor stimulants is due, in part, to genetic factors. The purpose of this series of studies…”
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Cardiovascular effects of cocaine during operant cocaine self-administration by Ambrosio, Emilio, Tella, Srihari R., Goldberg, Steven R., Schindler, Charles W., Erzouki, Hashim, Elmer, Gregory I.

“…The aim of this study was to investigate the acute and chronic effects of cocaine self-administration behavior on cardiovascular function. Mean blood pressure…”
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Mice Show Strain Differences in Social Affiliation Implications for Open Field Behavior by PIEPER, J. O., FORESTER, D. C., ELMER, G. I.

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The use of pharmacogenetic techniques in drug abuse research by Marley, R J, Elmer, G I, Goldberg, S R

“…Pharmacogenetics, the study of genetic factors underlying individual differences in response to drugs, has proven useful for demonstrating that there are large…”
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