Search Results - "ELLIOTT, Jason M."

4,4-Disubstituted cyclohexylamine NK1 receptor antagonists II by COOPER, Laura C, CARLSON, Emma J, RYCROFT, Wayne, TSAO, Kwei-Lan, SWAIN, Christopher J, CASTRO, Jose L, CHICCHI, Gary G, DINNELL, Kevin, DI SALVO, Jerry, ELLIOTT, Jason M, HOLLINGWORTH, Gregory J, KURTZ, Marc M, RIDGILL, Mark P

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N',2-Diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists by ELLIOTT, Jason M, CARTING, Robert W, MURRAY, Fraser, RIGBY, Michael, ROYO, Inmaculada, RUSSELL, Michael G. N, SOHAL, Bindi, KWEI LAN TSAO, WILLIAMS, Brian, CHAMBERS, Mark, CHICCHI, Gary G, HUTSON, Peter H, JONES, A. Brian, MACLEOD, Angus, MARWOOD, Rose, MENESES-LORENTE, Georgina, MEZZOGORI, Elena

“…A new class of potent NK3R antagonists based on the N',2-diphenylquinoline-4-carbohydrazide core is described. In an ex vivo assay in gerbil, the lead compound…”
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Regioselective synthesis of 4-(2-alkyl-5-methyl-2 H-pyrazol-3-yl)-piperidines by Dirat, Olivier, Clipson, Alex, Elliott, Jason M., Garrett, Sasha, Brian Jones, A., Reader, Michael, Shaw, Duncan

“…The regioselective, scaleable synthesis of 1, 2 and 3 is discussed. The regioselective, scaleable synthesis of three 4-(2-alkyl-5-methyl-2…”
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Synthesis of Vinylogous Carbamates by Rhodium(II)-Catalyzed Olefination of Tertiary Formamides with a Silylated Diazoester by Nandra, Gurdeep S, Pang, Pui Shan, Porter, Michael J, Elliott, Jason M

“…Treatment of tertiary formamides with a silylated diazoester in the presence of a rhodium(II) catalyst leads to the formation of 3-amino-2-silyloxyacrylates in…”
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N',2-Diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II by ELLIOTT, Jason M, CARTING, Robert W, MURRAY, Fraser, RIGBY, Michael, ROYO, Inmaculada, RUSSELL, Michael G. N, SHAW, Duncan, SOHAL, Bindi, KWEI LAN TSAO, WILLIAMS, Brian, CHICCHI, Gary G, CRAWFORTH, James, HUTSON, Peter H, JONES, A. Brian, KELLY, Sarah, MARWOOD, Rose, MENESES-LORENTE, Georgina, MEZZOGORI, Elena

“…Introduction of selected amine containing side chains into the 3-position of N',2-diphenylquinoline-4-carbohydrazide based NK3 antagonists abolishes unwanted…”
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2-Aryl indole NK1 receptor antagonists : Optimisation of indole substitution by COOPER, Laura C, CHICCHI, Gary G, WATT, Alan P, WILLIAMS, Angela R, SWAIN, Christopher J, DINNELL, Kevin, ELLIOTT, Jason M, HOLLINGWORTH, Gregory J, KURTZ, Mare M, LOCKER, Karen L, MORRISON, Denise, SHAW, Duncan E, TSAO, Kwei-Lan

“…The synthesis and biological evaluation of a series of 2-aryl indoles with high affinity for the human neurokinin-1 (hNK1) receptor are reported, concentrating…”
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NK1 antagonists based on seven membered lactam scaffolds by ELLIOTT, Jason M, CARLSON, Emma J, WHEELDON, Alan, CHICCHI, Gary G, DIRAT, Olivier, DOMINGUEZ, Maria, GERHARD, Ute, JELLEY, Richard, JONES, A. Brian, KURTZ, Marc M, TSAO, Kwei Lan

“…A new class of high affinity hNK1R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact structures,…”
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Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide by Selnick, Harold G, Liverton, Nigel J, Baldwin, John J, Butcher, John W, Claremon, David A, Elliott, Jason M, Freidinger, Roger M, King, Stella A, Libby, Brian E, McIntyre, Charles J, Pribush, David A, Remy, David C, Smith, Garry R, Tebben, Andrew J, Jurkiewicz, Nancy K, Lynch, Joseph J, Salata, Joseph J, Sanguinetti, Michael C, Siegl, Peter K. S, Slaughter, Donald E, Vyas, Kamlesh

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2-Aryl indole NK1 receptor antagonists : Optimisation of the 2-aryl ring and the indole nitrogen substituent by DINNELL, Kevin, CHICCHI, Gary G, SWAIN, Christopher J, DHAR, Madhumeeta J, ELLIOTT, Jason M, HOLLINGWORTH, Gregory J, KURTZ, Marc M, RIDGILL, Mark P, RYCROFT, Wayne, TSAO, Kwei-Lan, WILLIAMS, Angela R

“…Novel 2-aryl indole hNK1 receptor ligands were prepared utilising palladium cross-coupling chemistry of a late intermediate as a key step. Compounds with high…”
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Novel lactam NK1 antagonists with anti-emetic activity by HOLLINGWORTH, Gregory J, CARLSON, Emma J, KURTZ, Marc M, RYCROFT, Wayne, TATTERSALL, F. David, TSAO, Kwei-Lan, SWAIN, Christopher J, CASTRO, José L, CHICCHI, Gary G, CLARK, Natalie, COOPER, Laura C, DIRAT, Olivier, DI SALVO, Jerry, ELLIOTT, Jason M, KILBURN, Ruth

“…A series of 4,4-disubstituted cyclohexylamine NK(1) antagonists containing a lactam ring is described. The compounds are brain penetrant and activity is…”
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2-aryl indole NK1 antagonists : Optimisation of the amide substituent by SHAW, Duncan, CHICCHI, Gary G, ELLIOTT, Jason M, KURTZ, Marc, MORRISON, Denise, RIDGILL, Mark P, SZETO, Nicola, WATT, Alan P, WILLIAMS, Angela R, SWAIN, Christopher J

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4,4-Disubstituted cyclohexylamine NK1 receptor antagonists I by ELLIOTT, Jason M, CASTRO, Jose L, SWAIN, Christopher J, TSAO, Kwei-Lan, LIHU YANG, CHICCHI, Gary G, COOPER, Laura C, DINNELL, Kevin, HOLLINGWORTH, Gregory J, RIDGILL, Mark P, RYCROFT, Wayne, KURTZ, Marc M, SHAW, Duncan E

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Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide by SELNICK, Harold G., LIVERTON, Nigel J., BALDWIN, John J., BUTCHER, John W., CLAREMON, David A., ELLIOTT, Jason M., FREIDINGER, Roger M., KING, Stella A., LIBBY, Brian E., MCINTYRE, Charles J., PRIBUSH, David A., REMY, David C., SMITH, Garry R., TEBBEN, Andrew J., JURKIEWICZ, Nancy K., LYNCH, Joseph J., SALATA, Joseph J., SANGUINETTI, Michael C., SIEGL, Peter K. S., SLAUGHTER, Donald E., VYAS, Kamlesh

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4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-one (L-691,121) by Elliott, Jason M, Selnick, Harold G, Claremon, David A, Baldwin, John J, Buhrow, Susan A, Butcher, John W, Habecker, Charles N, King, Stella W, Lynch, Joseph J

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Expeditious synthesis of novel NK 1 antagonists based on a 1,2,4-trisubstituted cyclohexane by Dirat, Olivier, Elliott, Jason M., Jelley, Richard A., Jones, A. Brian, Reader, Michael

“…A stereoselective asymmetric route to novel potent NK 1 antagonists based on a 1,2,4-trisubstituted cyclohexane core is discussed…”
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Expeditious synthesis of novel NK1 antagonists based on a 1,2,4-trisubstituted cyclohexane by Dirat, Olivier, Elliott, Jason M., Jelley, Richard A., Jones, A. Brian, Reader, Michael

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NK sub(1) antagonists based on seven membered lactam scaffolds by Elliott, Jason M, Carlson, Emma J, Chicchi, Gary G, Dirat, Olivier, Dominguez, Maria, Gerhard, Ute, Jelley, Richard, Jones, ABrian, Kurtz, Marc M, Tsao, Kwei lan, Wheeldon, Alan

“…A new class of high affinity hNK sub(1)R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact…”
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NK 1 antagonists based on seven membered lactam scaffolds by Elliott, Jason M., Carlson, Emma J., Chicchi, Gary G., Dirat, Olivier, Dominguez, Maria, Gerhard, Ute, Jelley, Richard, Jones, A. Brian, Kurtz, Marc M., Tsao, Kwei lan, Wheeldon, Alan

“…A new class of high affinity hNK 1R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact…”
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Novel lactam NK 1 antagonists with anti-emetic activity by Hollingworth, Gregory J., Carlson, Emma J., Castro, José L., Chicchi, Gary G., Clark, Natalie, Cooper, Laura C., Dirat, Olivier, Salvo, Jerry Di, Elliott, Jason M., Kilburn, Ruth, Kurtz, Marc M., Rycroft, Wayne, Tattersall, F. David, Tsao, Kwei-Lan, Swain, Christopher J.

“…The discovery of potent NK 1 antagonists such as 8a is reported. Compound 8a displays good activity in a ferret emesis model. A series of 4,4-disubstituted…”
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Novel lactam NK sub(1) antagonists with anti-emetic activity by Hollingworth, Gregory J, Carlson, Emma J, Castro, Jose L, Chicchi, Gary G, Clark, Natalie, Cooper, Laura C, Dirat, Olivier, Di Salvo, Jerry, Elliott, Jason M, Kilburn, Ruth, Kurtz, Marc M, Rycroft, Wayne, Tattersall, FDavid, Tsao, Kwei-Lan, Swain, Christopher J

“…A series of 4,4-disubstituted cyclohexylamine NK sub(1) antagonists containing a lactam ring is described. The compounds are brain penetrant and activity is…”
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