Search Results - "ELKAHLOUN, Abdel"

Functional and Epigenetic Studies Reveal Multistep Differentiation and Plasticity of In Vitro-Generated and In Vivo-Derived Follicular T Helper Cells by Lu, Kristina T., Kanno, Yuka, Cannons, Jennifer L., Handon, Robin, Bible, Paul, Elkahloun, Abdel G., Anderson, Stacie M., Wei, Lai, Sun, Hongwei, O'Shea, John J., Schwartzberg, Pamela L.

“…Follicular T helper (Tfh) cells provide critical help to B cells for germinal center (GC) formation. Mutations affecting SLAM-associated protein (SAP) prevent…”
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Differentiation of human and murine induced pluripotent stem cells to microglia-like cells by Pandya, Hetal, Shen, Michael J, Ichikawa, David M, Sedlock, Andrea B, Choi, Yong, Johnson, Kory R, Kim, Gloria, Brown, Mason A, Elkahloun, Abdel G, Maric, Dragan, Sweeney, Colin L, Gossa, Selamawit, Malech, Harry L, McGavern, Dorian B, Park, John K

“…Pandya et al . describe a protocol to differentiate human and mouse iPSCs into cells with the phenotype, transcriptional profile and functional properties of…”
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Candesartan could ameliorate the COVID-19 cytokine storm by Elkahloun, Abdel G., Saavedra, Juan M.

“…[Display omitted] •Candesartan downregulates expression of many glutamate upregulated genes in cultured neurons.•Glutamate upregulated genes in neurons…”
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Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis by Elkahloun, Abdel G., Saavedra, Juan M.

“…Preclinical experiments and clinical trials demonstrated that angiotensin II AT 1 receptor overactivity associates with aging and cellular senescence and that…”
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Chronic social defeat reduces myelination in the mouse medial prefrontal cortex by Lehmann, Michael L., Weigel, Thaddeus K., Elkahloun, Abdel G., Herkenham, Miles

“…The medial prefrontal cortex (mPFC) plays a key role in top-down control of the brain’s stress axis, and its structure and function are particularly vulnerable…”
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Temporal dynamics and genetic control of transcription in the human prefrontal cortex by Colantuoni, Carlo, Lipska, Barbara K., Ye, Tianzhang, Hyde, Thomas M., Tao, Ran, Leek, Jeffrey T., Colantuoni, Elizabeth A., Elkahloun, Abdel G., Herman, Mary M., Weinberger, Daniel R., Kleinman, Joel E.

“…Gene expression in the human brain Gene expression controls and dictates everything from development and plasticity to ongoing neurogenesis in the brain, yet…”
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Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy by Chandler, Randy J, LaFave, Matthew C, Varshney, Gaurav K, Trivedi, Niraj S, Carrillo-Carrasco, Nuria, Senac, Julien S, Wu, Weiwei, Hoffmann, Victoria, Elkahloun, Abdel G, Burgess, Shawn M, Venditti, Charles P

“…The use of adeno-associated virus (AAV) as a gene therapy vector has been approved recently for clinical use and has demonstrated efficacy in a growing number…”
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Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response by Oskvig, Devon B, Elkahloun, Abdel G, Johnson, Kory R, Phillips, Terry M, Herkenham, Miles

“…Highlight ► Maternal immune activation induces a maternal cytokine response and selectively targets the fetal expression of neuronal migration and…”
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Analysis of cerebrovascular dysfunction caused by chronic social defeat in mice by Lehmann, Michael L., Poffenberger, Chelsie N., Elkahloun, Abdel G., Herkenham, Miles

“…•Chronic social defeat caused behavioral deficits and blood–brain barrier breaks.•Breaks showed tiny bleeds, fibrinogen deposition, and angiogenesis…”
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Decoding microglia responses to psychosocial stress reveals blood-brain barrier breakdown that may drive stress susceptibility by Lehmann, Michael L., Weigel, Thaddeus K., Cooper, Hannah A., Elkahloun, Abdel G., Kigar, Stacey L., Herkenham, Miles

“…An animal’s ability to cope with or succumb to deleterious effects of chronic psychological stress may be rooted in the brain’s immune responses manifested in…”
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miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia by Jiang, Xi, Hu, Chao, Arnovitz, Stephen, Bugno, Jason, Yu, Miao, Zuo, Zhixiang, Chen, Ping, Huang, Hao, Ulrich, Bryan, Gurbuxani, Sandeep, Weng, Hengyou, Strong, Jennifer, Wang, Yungui, Li, Yuanyuan, Salat, Justin, Li, Shenglai, Elkahloun, Abdel G., Yang, Yang, Neilly, Mary Beth, Larson, Richard A., Le Beau, Michelle M., Herold, Tobias, Bohlander, Stefan K., Liu, Paul P., Zhang, Jiwang, Li, Zejuan, He, Chuan, Jin, Jie, Hong, Seungpyo, Chen, Jianjun

“…MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast to the oncogenic role of miR-22 reported in myelodysplastic…”
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TET1 plays an essential oncogenic role in MLL-rearranged leukemia by Huang, Hao, Jiang, Xi, Li, Zejuan, Li, Yuanyuan, Song, Chun-Xiao, He, Chunjiang, Sun, Miao, Chen, Ping, Gurbuxani, Sandeep, Wang, Jiapeng, Hong, Gia-Ming, Elkahloun, Abdel G., Arnovitz, Stephen, Wang, Jinhua, Szulwach, Keith, Lin, Li, Street, Craig, Wunderlich, Mark, Dawlaty, Meelad, Neilly, Mary Beth, Jaenisch, Rudolf, Yang, Feng-Chun, Mulloy, James C., Jin, Peng, Liu, Paul P., Rowley, Janet D., Xu, Mingjiang, He, Chuan, Chen, Jianjun

“…The ten-eleven translocation 1 (TET1) gene is the founding member of the TET family of enzymes (TET1/2/3) that convert 5-methylcytosine to…”
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Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway by Ricciardi, Alessandra, Bennuru, Sasisekhar, Tariq, Sameha, Kaur, Sukhbir, Wu, Weiwei, Elkahloun, Abdel G, Arakelyan, Anush, Shaik, Jahangheer, Dorward, David W, Nutman, Thomas B, Tolouei Semnani, Roshanak

“…We have previously shown that the microfilarial (mf) stage of Brugia malayi can inhibit the mammalian target of rapamycin (mTOR; a conserved serine/threonine…”
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Telmisartan Protects a Microglia Cell Line from LPS Injury Beyond AT1 Receptor Blockade or PPARγ Activation by Elkahloun, Abdel G., Rodriguez, Yara, Alaiyed, Seham, Wenzel, Erin, Saavedra, Juan M.

“…The Angiotensin II Receptor Blocker (ARB) Telmisartan reduces inflammation through Angiotensin II AT1 receptor blockade and peroxisome proliferator-activated…”
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Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer by Solomon, David A., Kim, Taeyeon, Diaz-Martinez, Laura A., Fair, Joshlean, Elkahloun, Abdel G., Harris, Brent T., Toretsky, Jeffrey A., Rosenberg, Steven A., Shukla, Neerav, Ladanyi, Marc, Samuels, Yardena, James, C. David, Yu, Hongtao, Kim, Jung-Sik, Waldman, Todd

“…Most cancer cells are characterized by aneuploidy, an abnormal number of chromosomes. We have identified a clue to the mechanistic origins of aneuploidy…”
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Human endogenous retrovirus K contributes to a stem cell niche in glioblastoma by Shah, Ashish H, Rivas, Sarah R, Doucet-O'Hare, Tara T, Govindarajan, Vaidya, DeMarino, Catherine, Wang, Tongguang, Ampie, Leonel, Zhang, Yong, Banasavadi-Siddegowda, Yeshavanth Kumar, Walbridge, Stuart, Maric, Dragan, Garcia-Montojo, Marta, Suter, Robert K, Lee, Myoung-Hwa, Zaghloul, Kareem A, Steiner, Joseph, Elkahloun, Abdel G, Chandar, Jay, Seetharam, Deepa, Desgraves, Jelisah, Li, Wenxue, Johnson, Kory, Ivan, Michael E, Komotar, Ricardo J, Gilbert, Mark R, Heiss, John D, Nath, Avindra

“…Human endogenous retroviruses (HERVs) are ancestral viral relics that constitute nearly 8% of the human genome. Although normally silenced, the most recently…”
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Cell-penetrating, antioxidant SELENOT mimetic protects dopaminergic neurons and ameliorates motor dysfunction in Parkinson's disease animal models by Alsharif, Ifat, Boukhzar, Loubna, Lefranc, Benjamin, Godefroy, David, Aury-Landas, Juliette, Rego, Jean-Luc do, Rego, Jean-Claude do, Naudet, Frédéric, Arabo, Arnaud, Chagraoui, Abdeslam, Maltête, David, Benazzouz, Abdelhamid, Baugé, Catherine, Leprince, Jérôme, Elkahloun, Abdel G., Eiden, Lee E., Anouar, Youssef

“…Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction for which there is an unmet need for better treatment options…”
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The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration by Sinclair, Jason W., Hoying, David R., Bresciani, Erica, Nogare, Damian Dalle, Needle, Carli D., Berger, Alexandra, Wu, Weiwei, Bishop, Kevin, Elkahloun, Abdel G., Chitnis, Ajay, Liu, Paul, Burgess, Shawn M.

“…Throughout their lifetime, fish maintain a high capacity for regenerating complex tissues after injury. We utilized a larval tail regeneration assay in the…”
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B-cells are abnormal in psychosocial stress and regulate meningeal myeloid cell activation by Lynall, Mary-Ellen, Kigar, Stacey L., Lehmann, Michael L., DePuyt, Allison E., Tuong, Zewen Kelvin, Listwak, Samuel J., Elkahloun, Abdel G., Bullmore, Edward T., Herkenham, Miles, Clatworthy, Menna R.

“…In stress (middle panel), in the periphery, we observed increased numbers of classical monocytes, neutrophils, plasma cells and regulatory B cells; plasma cell…”
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CD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells by Kaur, Sukhbir, Singh, Satya P., Elkahloun, Abdel G., Wu, Weiwei, Abu-Asab, Mones S., Roberts, David D.

“…Intercellular communication is critical for integrating complex signals in multicellular eukaryotes. Vascular endothelial cells and T lymphocytes closely…”
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