Prevalence and Risk of Colorectal Neoplasia in Consumers of Alcohol in a Screening Population

Although studies suggest a positive association between alcohol consumption and risk for colorectal neoplasia, the impact on screening has not been fully examined. It is also unclear whether all types of alcohol are associated with an increased risk. We performed a cross-sectional study to examine t...

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Bibliographic Details
Published in:	The American journal of gastroenterology Vol. 100; no. 9; pp. 2049 - 2055
Main Authors:	ANDERSON, Joseph C, ALPERN, Zvi, SETHI, Gurvinder, MESSINA, Catherine R, MARTIN, Carole, HUBBARD, Patricia M, GRIMSON, Roger, ELIS, Peter F, SHAW, Robert D
Format:	Journal Article
Language:	English
Published:	Oxford Blackwell Publishing 01-09-2005 Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
Subjects:	Adenocarcinoma - diagnosis Adenocarcinoma - etiology Adenoma - diagnosis Adenoma - etiology Alcohol Drinking - adverse effects Biological and medical sciences Colonoscopy Colorectal Neoplasms - diagnosis Colorectal Neoplasms - epidemiology Colorectal Neoplasms - etiology Digestive system. Abdomen Endoscopy Female Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Precancerous Conditions - diagnosis Precancerous Conditions - etiology Prevalence Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Dysplasia Rectal disease Prevalence Colorectal adenocarcinoma Alcohol Malignant tumor Adenoma Medical screening Epidemiology Colonic disease Colonoscopy Risk factor Gastroenterology Rectum Digestive diseases Intestinal disease Benign neoplasm Colon Endoscopy
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Summary:	Although studies suggest a positive association between alcohol consumption and risk for colorectal neoplasia, the impact on screening has not been fully examined. It is also unclear whether all types of alcohol are associated with an increased risk. We performed a cross-sectional study to examine the impact of regular alcohol consumption on the detection of significant colorectal neoplasia in a screening population. Data collected for 2,291 patients presenting for screening colonoscopy: known risk factors for colorectal neoplasia and alcohol drinking pattern. Our outcome was the endoscopic detection of significant colorectal neoplasia, which included adenocarcinoma, high-grade dysplasia, villous tissue, adenomas 1 cm or greater and multiple (>2) adenomas of any size. When compared to abstainers, we found an increased risk for significant neoplasia in those patients who consumed more than eight drinks of spirits alcohol (26.3%; OR = 2.53; 95% CI = 1.10-4.28; p < 0.01) and those who drank more than eight servings of beer per week (21.7%; OR = 2.43; 95% CI = 1.11-5.32; p= 0.02). Consuming one to eight glasses of wine per week was associated with a decreased risk for significant neoplasia (OR = 0.55; 95% CI = 0.34-0.87; p < 0.01). While there was a more than twofold increased risk of significant colorectal neoplasia in people who drink spirits and beer, people who drank wine had a lower risk. In our sample, people who drank more than eight servings of beer or spirits per week had at least a one in five chance of having significant colorectal neoplasia detected by screening colonoscopy.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9270 1572-0241
DOI:	10.1111/j.1572-0241.2005.41832.x