Search Results - "ELFORD, H. L"

Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells by Raje, N., Kumar, S., Hideshima, T., Ishitsuka, K., Yasui, H., Chhetri, S., Vallet, S., Vonescu, E., Shiraishi, N., Kiziltepe, T., Elford, H.L., Munshi, N.C., Anderson, K.C.

“…Summary Ribonucleotide reductase (RR) is the enzyme that catalyses the rate‐limiting step in DNA synthesis, the production of deoxynucleotides. RR activity is…”
Get full text

Enhancement of hemoglobin and F‐cell production by targeting growth inhibition and differentiation of K562 cells with ribonucleotide reductase inhibitors (didox and trimidox) in combination with streptozotocin by Iyamu, W.E., Adunyah, S.E., Fasold, H., Horiuchi, K., Elford, H.L., Asakura, T., Turner, E.A.

“…Upon appropriate drug treatment, the human erythroleukemic K562 cells have been shown to produce hemoglobin and F‐cells. Fetal hemoglobin (Hb F) inhibits the…”
Get full text

Short-Term Treatment with Novel Ribonucleotide Reductase Inhibitors Trimidox and Didox Reverses Late-Stage Murine Retrovirus-Induced Lymphoproliferative Disease with Less Bone Marrow Toxicity Than Hydroxyurea by Mayhew, CN, Phillips, JD, Cibull, ML, Elford, HL, Gallicchio, VS

“…We evaluated the ability of a short course of treatment with the ribonucleotide reductase (RR) inhibitor hydroxyurea (HU) and two novel RR inhibitors Trimidox…”
Get full text

Antimalarial Activities of Polyhydroxyphenyl and Hydroxamic Acid Derivatives by HOLLAND, K. P, ELFORD, H. L, BRACCHI, V, ANNIS, C. G, SCHUSTER, S. M, CHAKRABARTI, D

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells by SKEKERES, T, FRITZER, M, STROBL, H, GHAREHBAGHI, K, FINDENIG, G, ELFORD, H. L, LHOTKA, C, SCHOEN, H. J, JAYARAM, H. N

“…Increased ribonucleotide reductase (RR) activity has been linked with malignant transformation and tumor cell growth. Therefore, this enzyme is considered to…”
Get full text

Interaction of gallium nitrate with other inhibitors of ribonucleotide reductase: effects on the proliferation of human leukemic cells by Myette, Michael S, Elford, Howard L, Chitambar, Christopher R

“…Ribonucleotide reductase, a key enzyme in deoxyribonucleotide synthesis, is an important target for cancer chemotherapy. Drugs that inhibit its individual…”
Get full text

DNA-protective activity of new ribonucleotide reductase inhibitors by Rauko, P, Romanova, D, Miadokova, E, Macakova, K, Novotny, L, Elford, H L, Szekeres, T

“…The DNA-protective activity of hydroxyurea (HU) and novel ribonucleotide reductase (RR) inhibitors amidox (AX), didox (DX) and trimidox (TX) was examined using…”
Get more information

Transgenic mouse model of pharmacologic induction of fetal hemoglobin: studies using a new ribonucleotide reductase inhibitor, Didox by Pace, B S, Elford, H L, Stamatoyannopoulos, G

“…Evaluation of pharmacologic agents that stimulate fetal hemoglobin production has been done mainly in baboons and macaques. We investigated whether results in…”
Get more information

Apoptosis-inducing cleavage of caspases by trimidox, an inhibitor of ribonucleotide reductase by Fritzer-Szekeres, M, Luxbacher, C, Horvath, Z, Grusch, M, Krupitza, G, Elford, H L, Szekeres, T

Get more information

A phase 1 and pharmacokinetic study of didox: A ribonucleotide reductase inhibitor by VEALE, D, CARMICHAEL, J, CANTWELL, B. M. J, ELFORD, H. L, BLACKIE, R, KERR, D. J, KAYE, S. B, HARRIS, A. L

“…A phase 1 study of a new ribonucleotide reductase inhibitor, didox, was performed by administration of escalating doses of the drug by slow i.v. injection…”
Get full text

A Combination of Hydroxyurea and Isobutyramide to Induce Fetal Hemoglobin in Transgenic Mice Is More Hematotoxic Than the Individual Agents by Buller, Arlene M, Elford, Howard L, DuBois, Charles C, Meyer, Joanne, Lloyd, Joyce A

“…Pharmacologic agents such as hydroxyurea (HU), N, 3–4 trihydroxybenzamide (didox), and isobutyramide (ISB) can elevate γ-globin as a potential treatment for…”
Get full text

Effective use of ribonucleotide reductase inhibitors (Didox and Trimidox) alone or in combination with didanosine (ddI) to suppress disease progression and increase survival in murine acquired immunodeficiency syndrome (MAIDS) by Mayhew, C, Oakley, O, Piper, J, Hughes, N K, Phillips, J, Birch, N J, Elford, H L, Gallicchio, V S

“…Ribonucleotide reductase inhibitors (RRIs) have been recently shown to inhibit retroviral replication. We examined a new series of RRIs,…”
Get more information

The new inhibitors of ribonucleotide reductase—comparison of some physico-chemical properties by Romanova, Darina, Vachalkova, Anna, Szekeres, Thomas, Elford, Howard L., Novotny, Ladislav

“…Amidox (AX), didox (DX) and trimidox (TX), compounds synthetized as new ribonucleotide reductase inhibitors, have been investigated by ultraviolet (UV)…”
Get full text

A phase I and pharmacokinetic study of didox administered by 36 hour infusion by CARMICHAEL, J, CANTWELL, B. M. J, MANNIX, K. A, VEALE, D, ELFORD, H. L, BLACKIE, R, KERR, D. J, KAYE, S. B, HARRIS, A. L

Get full text

Inhibition of nucleoside diphosphate reductase by hydroxybenzohydroxamic acid derivatives by Elford, H L, van't Riet, B

Get more information

Combination of inhibitors of lymphocyte activation (hydroxyurea, trimidox, and didox) and reverse transcriptase (didanosine) suppresses development of murine retrovirus-induced lymphoproliferative disease by Mayhew, Christopher N., Sumpter, Ryan, Inayat, Mohammed, Cibull, Michael, Phillips, Jonathan D., Elford, Howard L., Gallicchio, Vincent S.

“…The ribonucleotide reductase inhibitor hydroxyurea (HU) has demonstrated some benefit as a component of drug cocktails for the treatment of HIV-1 infection…”
Get full text

Activation of caspases and induction of apoptosis by novel ribonucleotide reductase inhibitors amidox and didox by Grusch, Michael, Fritzer-Szekeres, Monika, Fuhrmann, Gerhard, Rosenberger, Georg, Luxbacher, Cornelia, Elford, Howard L, Smid, Kees, Peters, Godefridus J, Szekeres, Thomas, Krupitza, Georg

“…Amidox and didox are two polyhydroxy-substituted benzohydroxamic acid derivatives that belong to a new class of ribonucleotide reductase (RR) inhibitors. RR is…”
Get full text

The Enzyme Ribonucleotide Reductase: Target for Antitumor and Anti-HIV Therapy by Szekeres, Thomas, Fritzer-Szekeres, Monika, Elford, Howard L., Jayaram, H. M.

“…Abstract Ribonucleotide reductase is the rate-limiting enzyme of DNA synthesis, and it has been shown to be linked with malignant transformation and tumor cell…”
Get full text

Adenosine deaminase impairment and ribonucleotide reductase activity and levels in HeLa cells by Lin, A L, Elford, H L

“…Adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4)-deficient patients recently were found to have abnormally high levels of dATP, a negative allosteric…”
Get full text

Suppression of retrovirus-induced immunodeficiency disease (murine AIDS) by trimidox and didox: Novel ribonucleotide reductase inhibitors with less bone marrow toxicity than hydroxyurea by Mayhew, Christopher N, Mampuru, Leseilane J, Chendil, Damodoran, Ahmed, Mansoor M, Phillips, Jonathan D, Greenberg, Richard N, Elford, Howard L, Gallicchio, Vincent S

“…Recently, the use of the ribonucleotide reductase (RR) inhibitor hydroxyurea (HU) in combination with nucleoside analogs has gained attention as a potential…”
Get full text