Search Results - "ELFERINK, R. P. J. O"

The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's Syndrome by Bosma, Piter J, Chowdhury, Jayanta Roy, Chowdhury, Namita Roy, Bakker, Conny, Gantla, Shailaja, de Boer, Anita, Oostra, Ben A, Lindhout, Dick, Tytgat, Guido N.J, Jansen, Peter L.M, Elferink, Ronald P.J. Oude

“…People with Gilbert's syndrome have mild, chronic unconjugated hyperbilirubinemia in the absence of liver disease or overt hemolysis. 1 , 2 Although the…”
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A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin‐Johnson syndrome by Paulusma, C C, Kool, M, Bosma, P J, Scheffer, G L, ter Borg, F, Scheper, R J, Tytgat, G N, Borst, P, Baas, F, Elferink, R O

“…The human Dubin‐Johnson syndrome (DJS) is a rare autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. Patients have…”
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Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance- Associated Protein Gene by Paulusma, Coen C., Bosma, Piter J., Guido J. R. Zaman, Conny T. M. Bakker, Otter, Marlies, Scheffer, George L., Scheper, Rik J., Borst, Piet, Ronald P. J. Oude Elferink

“…The human Dubin-Johnson syndrome and its animal model, the TR$^-$ rat, are characterized by a chronic conjugated hyperbilirubinemia. TR$^-$ rats are defective…”
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The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man by PAULUSMA, C. C, ELFERINK, R. P. J. O

“…The human Dubin-Johnson syndrome is an autosomal recessive liver disease characterized by a chronic conjugated hyperbilirubinemia. Patients have impaired…”
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Influence of biliary cirrhosis on the detoxification and elimination of a food derived carcinogen by Dietrich, C G, Geier, A, Wasmuth, H E, Matern, S, Gartung, C, de Waart, D R, Elferink, R P J O

“…Background and aims: The liver is the central organ for the detoxification of numerous xenobiotics, including carcinogens. We studied the influence of…”
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Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice by Voshol, Peter J., Havinga, Rick, Wolters, Henk, Ottenhoff ‡, Roel, Princen §, Hans M.G., Oude Elferink ‡, Ronald P.J., Groen ‡, Albert K., Kuipers, Folkert

“…Background & Aims: mdr2 P-glycoprotein (Pgp) deficiency in mice leads to the absence of biliary phospholipids and cholesterol in the presence of normal bile…”
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Postprandial chylomicron formation and fat absorption in multidrug resistance gene 2 P-glycoprotein–deficient mice by Voshol, Peter J., Minich, Deanna M., Havinga, Rick, Elferink, Ronald P.J.Oude, Verkade, Henkjan J., Groen, Albert K., Kuipers, Folkert

“…Background & Aims: It has been proposed that biliary phospholipids fulfill specific functions in the absorption of dietary fat from the intestine, but the…”
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Lack of enteral nutrition during critical illness is associated with profound decrements in biliary lipid concentrations by DE VREE, J. M. L, ROMIJN, J. A, MOK, K. S, MATHUS-VLIEGEN, L. M. H, STOUTENBEEK, C. P, OSTROW, J. D, TYTGAT, G. N. J, SAUERWEIN, H. P, ELFERINK, R. P. J. O, GROEN, A. K

“…Food in the intestine drives the enterohepatic circulation of bile components. We investigated whether parenteral or enteral delivery of nutrients alters serum…”
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Redistribution of canalicular organic anion transport activity in isolated and cultured rat hepatocytes by Roelofsen, H, Bakker, C T, Schoemaker, B, Heijn, M, Jansen, P L, Elferink, R P

“…The hepatocanalicular transport of a large number of organic anions, such as bilirubin glucuronides and glutathione conjugates in the rat, is mediated by an…”
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Liver gene disruptions : winners by KO? by SMITH, A. J, ELFERINK, R. P. J. O

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Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter by Oude Elferink, R P, Bakker, C T, Roelofsen, H, Middelkoop, E, Ottenhoff, R, Heijn, M, Jansen, P L

“…Transport of organic anions within hepatocytes and the possible involvement of intracellular vesicles were studied with fluorescence microscopy. For this…”
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Regulation of canalicular transport activities: The Hochhausen experience : report of a European research network on hepatobiliary transport by ELFERINK, R. P. J. O, FRIJTERS, C. M. G, PAULUSMA, C, GROEN, A. K

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Regulation of protein secretion into bile: studies in mice with a disrupted mdr2 p-glycoprotein gene by Groen, A K, Van Wijland, M J, Frederiks, W M, Smit, J J, Schinkel, A H, Oude Elferink, R P

“…Protein is secreted into bile via several independent pathways. The aim of this study was to investigate whether these pathways are influenced by secretion of…”
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Defects in synthesis, phosphorylation, and maturation of acid alpha-glucosidase in glycogenosis type II by Reuser, A J, Kroos, M, Oude Elferink, R P, Tager, J M

“…Glycogenosis type II is an inherited lysosomal storage disease with acid alpha-glucosidase deficiency as the primary defect. Using cultured skin fibroblasts,…”
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Immunocytochemical demonstration of the lysosomal enzyme alpha-glucosidase in the brush border of human intestinal epithelial cells by Fransen, J A, Ginsel, L A, Cambier, P H, Klumperman, J, Oude Elferink, R P, Tager, J M

“…In investigations on the intracellular transport route(s) of lysosomal enzymes in polarized epithelial cells, we used immunocytochemical methods to localize…”
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Reversed-phase liquid chromatographic method for the determination of 7-nitrobenz-2-oxa-1,3-diazol-4-yl-labelled lipid analogues by Frijters, Charles M.G, Tuijn, Coosje J, Hoek, Frans J, Groen, Albert K, Oude Elferink, Ronald P.J, N. Zegers, Bart

“…This paper reports the development of a dual column system for the simultaneous separation of fluorescent short-chain ceramide,…”
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